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| 1 | Endoscopicultrasonographyforsurveillanceofindividualsathighriskfor pancreaticcancer显示文摘Pancreatic cancer is a highly lethal disease with a ge-netic susceptibility and familial aggregation found in 3%-16% of patients. Early diagnosis remains the only hope for curative treatment and improvement of prog-nosis. This can be reached by the implementation of an intensive screening program, actually recommended for individuals at high-risk for pancreatic cancer de-velopment. The aim of this strategy is to identify pre-malignant precursors or asymptomatic pancreatic can-cer lesions, curable by surgery. Endoscopic ultrasound (EUS) with or without fine needle aspiration(FNA) seems to be the most promising technique for early de-tection of pancreatic cancer. It has been described as a highly sensitive and accurate tool, especially for small and cystic lesions. Pancreatic intraepithelial neoplasia, a precursor lesion which is highly represented in high-risk individuals, seems to have characteristics chronic pancreatitis-like changes well detected by EUS. Many screening protocols have demonstrated high diagnostic yields for pancreatic pre-malignant lesions, allowing prophylactic pancreatectomies. However, it shows a high interobserver variety even among experienced en-dosonographers and a low sensitivity in case of chronic pancreatitis. Some new techniques such as contrast-en-hanced harmonic EUS, computer-aided diagnostic tech-niques, confocal laser endomicroscopy miniprobe andthe detection of DNA abnormalities or protein markersby FNA, promise improvement of the diagnostic yield ofEUS. As the resolution of imaging improves and as ourknowledge of precursor lesions grows, we believe thatEUS could become the most suitable method to detectcurable pancreatic neoplasms in correctly identifiedasymptomatic at-risk patients. | Lami G Biagini MR Galli A | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 8 |
| 2 | Robotic rectal surgery: State of the art显示文摘Laparoscopic rectal surgery has demonstrated its superiority over the open approach, however it still has some technical limitations that lead to the development of robotic platforms. Nevertheless the literature on this topic is rapidly expanding there is still no consensus about benefits of robotic rectal cancer surgery over the laparoscopic one. For this reason a review of all the literature examining robotic surgery for rectal cancer was performed. Two reviewers independently conducted a search of electronic databases(Pub Med and EMBASE) using the key words 'rectum', 'rectal', 'cancer', 'laparoscopy', 'robot'. After the initial screen of 266 articles, 43 papers were selected for review. A total of 3013 patients were included in the review. The most commonly performed intervention was low anterior resection(1450 patients, 48.1%), followed by anterior resections(997 patients, 33%), ultra-low anterior resections(393 patients, 13%) and abdominoperineal resections(173 patients, 5.7%). Robotic rectal surgery seems to offer potential advantages especially in low anterior resections with lower conversions rates and better preservation of the autonomic function. Quality of mesorectum and status of and circumferential resection margins are similar to those obtained with conventional laparoscopy even if robotic rectal surgery is undoubtedly associated with longer operative times. This review demonstrated that robotic rectal surgery is both safe and feasible but there is no evidence of its superiority over laparoscopy in terms of postoperative, clinical outcomes and incidence of complications. In conclusion robotic rectal surgery seems to overcome some of technical limitations of conventional laparoscopic surgery especially for tumors requiring low and ultralow anterior resections but this technical improvement seems not to provide, until now, any significant clinical advantages to the patients. | Fabio Staderini Caterina Foppa Alessio Minuzzo Benedetta Badii Etleva Qirici Giacomo Trallori Beatrice Mallardi Gabriele Lami Giuseppe Macrì Andrea Bonanomi Siro Bagnoli Giuliano Perigli Fabio Cianchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，11： | 7 |
| 3 | 从地震资料到储层特征的地质统计学反演显示文摘本文陈述的方法是综合利用地震数据、地质知识和测井资料来生成储层参数模型和与之相关的不确定性。利用地质统计学反演技术,一个三维地震数据集在地质和地层模型中被转换。得到了一些储层尺度的波阻抗数据体,并且通过对这些三维数据体进行统计学计算来量化其不确定性。把这些统计量与储层参数的克里格相结合,利用测井资料可以把波阻抗转换为储层参数。这一结合过程类似于对波阻抗进行配置协克里格。 | Philippe Lamy 刘芳 | 2000 | 国外油气勘探2000，12，4： | 5 |
| 4 | Pro-gastrin-releasing peptide, neuron specific enolase and chromogranin A as serum markers of small cell lung cancer显示文摘 | Pierre-Jean Lamy Jean Grenier Andrew Kramar Jean-Louis Pujol | 2000 | Lung Cancer2000，，3： | 2 |
| 5 | Practice and complications of liver biopsy显示文摘 | Dr. F. Froehlich MD O. Lamy MD M. Fried MD J. J. Gonvers MD | 1993 | Digestive Diseases and Sciences1993，，8： | 2 |
| 6 | An alternative,zeaxanthin epoxidase-independent abscisic acid biosynthetic pathway in plants显示文摘Abscisic acid(ABA)is an important carotenoid-derived phytohormone that plays essential roles in plant response to biotic and abiotic stresses as well as in various physiological and developmental processes.In Arabidopsis,ABA biosynthesis starts with the epoxidation of zeaxanthin by the ABA DEFICIENT 1(ABA1)enzyme,leading to epoxycarotenoids;e.g.,violaxanthin.The oxidative cleavage of 9-cis-epoxycaro-tenoids,a key regulatory step catalyzed by 9-C/S-EPOXYCAROTENOID DIOXYGENASE,forms xanthoxin,which is converted in further rea.ctions mediated by ABA DEFICIENT 2(ABA2),ABA DEFICIENT 3(ABA3),and ABSCISIC ALDEHYDE OXIDASE 3(AAO3)into ABA.By combining genetic and biochemical approaches,we unravel here an ABA1-independent ABA biosynthetic pathway starting upstream of zeaxanthin.We iden-tified the carotenoid cleavage products(i.e.,apocarotenoids,β-apo-11-carotenal,9-cis-β-apo-11-carotenal,3-OH-β-apo-11-carotenal,and 9-cis-3-OH-β-apo-11-carotenal)as intermediates of this ABA1-independent ABA biosynthetic pathway.Using labeled compounds,we showed thatβ-apo-11-carotenal,9-cis-β-apo-11-carotenal,and 3-OH-β-apo-11-carotenal are successively converted into 9-cis-3-OH-β-apo-11-carotenal,xanthoxin,and finally into ABA in both Arabidopsis and rice.When applied to Arabidopsis,theseβ-apo-11-carotenoids exert ABA biological functions,such as maintaining seed dormancy and inducing the expression of ABA-responsive genes.Moreover,the transcdptomic analysis revealed a high overlap of differentially expressed genes regulated byβ-apo-11-carotenoids and ABA,suggesting thatβ-apo-11-carot-enoids exert ABA-independent regulatory activities.Taken together,our study identifies a biological function for the common plant metabolites,β-apo-11-carotenoids,extends our knowledge about ABA biosynthesis,and provides new insights into plant apocarotenoid metabolic networks. | Kun-Peng Jia Jianing Mi Shawkat Ali Hajime Ohyanagi Juan C.Moreno Abdugaffor Ablazov Aparna Balakrishna Lamis Berqdar Alessia Fiore Gianfranco Diretto Claudio Martínez Angel R.de Lera Takashi Gojobori Salim Al-Babili | 2022 | Molecular Plant2022，15，1： | 2 |
| 7 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 8 | EUS-guided gold fiducial placement and migration rate显示文摘 | Lorenzo Fuccio Gabriele Lami Alessandra Guido Carlo Fabbri | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 9 | Performance of American Society for Gastrointestinal Endoscopy guidelines for dyspepsia in Saudi population: Prospective observational study显示文摘AIM: To evaluate adherence of primary care physicians(PCPs) to international guidelines when referring patients for upper-gastrointestinal endoscopy(UGE), evaluate the importance of alarm symptoms and the performance of the American Society for Gastrointestinal Endoscopy(ASGE) guidelines in a Saudi population.METHODS: A prospective, observational cross-sectional study on dyspeptic patients undergoing UGE who were referred by PCPs over a 4 mo period. Refer-rals were classified as appropriate or inappropriate according to adherence to ASGE guidelines.RESULTS: Total of 221 dyspeptic patients was enrolled; 161 patients met our inclusion criteria. Mean age was 40.3 years(SD ± 18.1). Females comprised 70.1%. Alarm symptoms included low hemoglobin level(39%), weight loss(18%), vomiting(16%), loss of appetite(16%), difficulty swallowing(3%), and gastrointestinal bleeding(3%). Abnormal endoscopy findings included gastritis(52%), duodenitis(10%), hiatus hernia(7.8%), features suggestive of celiac disease(6.5%), ulcers(3.9%), malignancy(2.6%) and gastroesophageal reflux disease(GERD: 17%). Among patients who underwent UGE, 63% met ASGE guidelines, and 50% had abnormal endoscopic findings. Endoscopy was not indicated in remaining 37% of patients. Among the latter group, endoscopy was normal in 54% of patients. There was no difference in proportion of abnormal endoscopic findings between two groups(P = 0.639).CONCLUSION: Dyspeptic patients had a low prevalence of important endoscopic lesions, and none of the alarm symptoms could significantly predict abnormalendoscopic findings. | Nahla A Azzam Majid A Almadi Hessah Hamad Alamar Lamis Atyah Almalki Rehab Nawaf Alrashedi Rawabi Saleh Alghamdi Waleed Al-hamoudi | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 10 | Physiological and pathologi- cal regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors显示文摘 | Dumont JE Lamy F Roger P | 1992 | Physiol Rev1992，72，3： | 1 |
| 11 | International Prognostic Index, Type of Transplant and Response to Rituximab Are Key Parameters to Tailor Treatment in Adults With CD20‐Positive B Cell PTLD: Clues From the PTLD‐1 Trial显示文摘 | R. U. Trappe S. Choquet D. Dierickx P. Mollee J. M. Zaucha M. H. Dreyling U. Dührsen C. Tarella O. Shpilberg M. Sender G. Salles F. Morschhauser A. Jaccard T. Lamy P. Reinke R. Neuhaus H. Lehmkuhl H. A. Horst M. Leith?user P. Schlattmann I. Anagnostopoulo | 2015 | American Journal of Transplantation2015，，4： | 1 |
| 12 | Neutrophil myeloperoxidase revisited : It's role in health and disease 显示文摘 | Deby-Dupont G Deby C Lamy M | 1999 | Intensivmedizin und Notfallmedizin1999，36，6： | 1 |
| 13 | Late Quaternary rapid climate change in northern Chile 显示文摘 | Lamy F Klump J Hebbeln D | 2000 | Terra Nova2000，12，1： | 1 |
| 14 | Neuro endocrine and cytokeratinserum markers as prognostic determinantsof small cell lung cancer显示文摘 | Pujol J L Ouantin X Jaeot M Boher J M GrenierJ Lamy P J | 2003 | Lung Cancer2003，39，： | 1 |
| 15 | Ultrasound and environment:sonochemical destruction of chloromatic derivatives显示文摘 | PETTIER C JIANG Y LAMY M F | 1998 | Environ Sci Technol1998，32，9： | 1 |
| 16 | The flavonols quercetin,kaempferol,and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration显示文摘 | LABBE D PROVENCAL M LAMY S | 2009 | J Nutr2009，139，4： | 1 |
| 17 | Is sepsis a mediator-inhibitor mismatch显示文摘 | Lamy M Deby-Dupont G | 1995 | Intensive Care Med1995，21，2： | 1 |
| 18 | Measles virus exploits den-dritic cells to suppress CD4+T-cell proliferation via expression ofsurface viral lycoproteins independently of T-cell trans-infection显示文摘 | Dubois B Lamy PJ Chemin K | 2001 | Cell Immunol2001，214，2： | 1 |
| 19 | Adaptive hyperphagia in patients with post-surgical malabsorption 显示文摘 | Cosnes J Lamy P Beaugerie L | 1990 | Gastroenterology1990，99，6： | 1 |
| 20 | Platinum electrodeposition on graphite:Electrochemical study and STM imaging显示文摘 | Gloaguen F Léger J M Lamy C | 1999 | Electrochim Acta1999，44，11： | 1 |
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