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| 1 | Role of left ventricular twist mechanics in cardiomyopathies, dance of the helices显示文摘Left ventricular twist is an essential part of left ventricular function. Nevertheless, knowledge is limited in 'the cardiology community' as it comes to twist mechanics. Fortunately the development of speckle tracking echocardiography, allowing accurate, reproducible and rapid bedside assessment of left ventricular twist, has boosted the interest in this important mechanical aspect of left ventricular deformation. Although the fundamental physiological role of left ventricular twist is undisputable, the clinical relevance of assessment of left ventricular twist in cardiomyopathies still needs to be established. The fact remains; analysis of left ventricular twist mechanics has already provided substantial pathophysiological understanding on a comprehensive variety of cardiomyopathies. It has become clear that increased left ventricular twist in for example hypertrophic cardiomyopathy may be an early sign of subendocardial(microvascular) dysfunction. Furthermore, decreased left ventricular twist may be caused by left ventricular dilatation or an extensive myocardial scar. Finally, the detection of left ventricular rigid body rotation in noncompaction cardiomyopathy may provide an indispensible method to objectively confirm this difficult diagnosis. All this endorses the value of left ventricular twist in the field of cardiomyopathies and may further encourage the implementation of left ventricular twist parameters in the 'diagnostic toolbox' for cardiomyopathies. | Floris Kauer Marcel Leonard Geleijnse Bastiaan Martijn van Dalen | 2015 | World Journal of Cardiology2015，7，8： | 9 |
| 2 | Comparative analysis of Solanum stoloniferum responses to probing by the green peach aphid Myzus persicae and the potato aphid Macrosiphum euphorbiae显示文摘抽象植物由种类特定的防卫机制保护自己免于蚜虫攻击。以前,我们证明了茄属 stoloniferum Schlechtd 有抵抗因素到 Myzus persicae Sulzer (Homoptera:Aphididae ) 在 epidermal/mesophyll 水平,那不对 Macrosiphum euphorbiae 托马斯是有效的(Homoptera:Aphididae ) 。这里,我们比较 nymph 的死亡, pre 繁殖的发展时间,和 M 的探查的行为。persicae 和 M。S 上的 euphorbiae。stoloniferum 和茄属 tuberosum L。而且,我们在 S 在基因表示分析变化。stoloniferum 96 个小时由也张贴群袭蚜虫种类。尽管 M。探查蚜虫遇到更多的探查的行为表演的 euphorbiae 在韧皮部 activitieslonger 在 S 上探查和分泌唾液时间上抑制。stoloniferum 比在 S 上。tuberosum,蚜虫成功了在两植物上到达韧皮部树液的持续摄取。由 M 探查。S 上的 persicae。stoloniferum 植物导致了仅仅的有限的喂。M 的幸存。euphorbiae 和 M。persicae 在年轻叶子,然而并非在 S 的衰老的叶子被影响。stoloniferum。由 M 的群袭。euphorbiae 比 M 改变了更多的基因的表示。persicae 做了。在全身的水平,两个蚜虫得到了弱回答。S 的群袭。有很多 M 的 stoloniferum 植物。persicae 在叶子导致了词法变化,导致被破坏脉管的实质引起并且包围织物的色点的发展。相反,由 M 的群袭。euphorbiae 没有词法效果。两个都,植物种类能为 M 被认为是好主人。euphorbiae,而仅仅 S。tuberosum 是为 M 的一位好主人。persicae 和 S。stoloniferum 不是。S 的群袭。由 M 的 stoloniferum。persicae 或 M。euphorbiae 象一套普通基因一样改变了为每蚜虫特定的一套植物基因的表示。 | Adriana E. Alvarez Viviana G. Broglia Anahi M. Alberti D'Amato Doret Wouters Edwin van der Vossen Elisa Garzo W. Fred Tjallingii Marcel Dicke Ben Vosman | 2013 | Insect Science2013，20，2： | 5 |
| 3 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 4 | Integration of Known Transcription Factor Binding Site Information and Gene Expression Data to Advance from Co-Expression to Co-Regulation显示文摘The common approach to find co-regulated genes is to cluster genes based on gene expression. However, due to the limited information present in any dataset, genes in the same cluster might be co-expressed but not necessarily co-regulated. In this paper, we propose to integrate known transcription factor binding site information and gene expression data into a single clustering scheme. This scheme will find clusters of co-regulated genes that are not only expressed similarly under the measured conditions, but also share a regulatory structure that may explain their common regulation. We demonstrate the utility of this approach on a microarray dataset of yeast grown under different nutrient and oxygen limitations. Our integrated clustering method not only unravels many regulatory modules that are consistent with current biological knowledge, but also provides a more profound understanding of the underlying process. The added value of our approach, compared with the clustering solely based on gene expression, is its ability to uncover clusters of genes that are involved in more specific biological processes and are evidently regulated by a set of transcription factors. | Maarten Clements Eugene P. van Someren Theo A. Knijnenburg Marcel J.T. Reinders | 2007 | Genomics, Proteomics & Bioinformatics2007，5，2： | 4 |
| 5 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 6 | Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population显示文摘AIM: To describe the characteristics of Dutch patients with chronic inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease (SCAD). METHODS: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (5%) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn’s disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients. CONCLUSION: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical featuressuggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli. | Muhammed Hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven | 2008 | World Journal of Gastroenterology2008，14，20： | 3 |
| 7 | The 5-HT2c receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation显示文摘有终生的早泄(LPE ) 的人的坚持的短 intravaginal 射精潜伏时间(IELT ) 与 5-hydroxytryptamine (HT ) 有关是 2C 受体工作,这被要求了。这研究的目的是与 LPE 在人调查 Cys23Ser 5-HT 2C 受体基因多型性和 IELT 的持续时间的关系。因此,未来的研究与 LPE 在 64 个荷兰的白种人人被进行。基线 IELT 被秒表在一个 1 月的时期上在性交期间估计。所有人是为 Cys23Ser 5-HT 2C 受体基因多型性的 genotyped。Cys 的等位基因频率和 5-HT 2C 受体基因多型性的重量的单位变体是坚定的。在 Cys/Cys 和重量的单位 / 重量的单位遗传型和在有 LPE 的人的 IELT 的自然对数之间的协会被调查。作为结果,几何吝啬、中部、自然的吝啬的 IELT 是 25.2, 27.0, 33.9 s 分别地。所有人, 20.0% , 10.8% , 23.1% 和 41.5% 在 10 以内射精,在阴道穿入以后的 10-20, 20-30 和 30-60 s。64 个人,为 5-HT 2C 受体基因的 Cys23Ser 多型性的 Cys/Cys 和重量的单位 / 重量的单位遗传型频率分别地是 81% 和 19% 。wildtypes (Cys/Cys ) 的几何吝啬的 IELT 显著地更低(22.6 s;95% CI 18.3-27.8 s ) 比在男同型结合的异种(重量的单位 / 重量的单位)(40.4 s;95% CI 20.3-80.4 s )(P = 0.03 ) 。Cys23Ser 5-HT 2C 受体基因多型性与 LPE 在人与 IELT 被联系,这被结束。有 Cys/Cys 遗传型的人与重量的单位 / 重量的单位遗传型比人有更短的 IELT。 | Paddy KC Janssen Ron van Schaik Berend Olivier Marcel D Waldinger | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 8 | Efficacy and safety of the new WallFlex enteral stent in palliative treatment of malignant gastric outlet obstruction (DUOFLEX study): a prospective multicenter study显示文摘 | Jeanin E. van Hooft Madeleen J. Uitdehaag Marco J. Bruno Robin Timmer Peter D. Siersema Marcel G.W. Dijkgraaf Paul Fockens | 2009 | Gastrointestinal Endoscopy2009，，6： | 2 |
| 9 | Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering显示文摘 | Liliana S. Moreira Teixeira Jan Feijen Clemens A. van Blitterswijk Pieter J. Dijkstra Marcel Karperien | 2011 | Biomaterials2011，，5： | 2 |
| 10 | Attraction of Colorado Potato Beetle to Herbivore-Damaged Plants During Herbivory and After Its Termination显示文摘 | Caroline J. Bolter Marcel Dicke Joop J. A. Van Loon J. H. Visser Maarten A. Posthumus | 1997 | Journal of Chemical Ecology1997，，4： | 2 |
| 11 | Thrombolytic Therapy for Acute Superior Mesenteric Artery Occlusion显示文摘 | Ivo G. Schoots Marcel M. Levi Jim A. Reekers Johan S. Lameris Thomas M. van Gulik | 2005 | Journal of Vascular and Interventional Radiology2005，，： | 2 |
| 12 | Reverse Structural and Gap-Junctional Remodeling After Prolonged Atrial Fibrillation in the Goat显示文摘 | Jannie Ausma Huub M.W. van der Velden Marie-Hélène Lenders Erwin P. van Ankeren Habo J. Jongsma Frans C.S. Ramaekers Marcel Borgers Maurits A. Allessie | 2003 | Circulation: Journal of the American Heart Association2003，，15： | 2 |
| 13 | Quantitative resistance against Bemisia tabaci in Solanum pennellii:Genetics and metabolomics显示文摘The whitefly Bemisia tabaci is a serious threat in tomato cultivation worldwide as all varieties grown today are highly susceptible to this devastating herbivorous insect.Many accessions of the tomato wild relative Solanum pennellii show a high resistance towards B. tabaci. A mapping approach was used to elucidate the genetic background of whiteflyresistance related traits and associated biochemical traits in this species. Minor quantitative trait loci(QTLs) for whitefly adult survival(AS) and oviposition rate(OR) were identified and some were confirmed in an F2BC1 population, where they showed increased percentages of explained variance(more than 30%). Bulked segregant analyses on pools of whiteflyresistant and-susceptible F2 plants enabled the identification of metabolites that correlate either with resistance or susceptibility. Genetic mapping of these metabolites showed that a large number of them co-localize with whiteflyresistance QTLs. Some of these whitefly-resistance QTLs are hotspots for metabolite QTLs. Although a large number of metabolite QTLs correlated to whitefly resistance or susceptibility, most of them are yet unknown compounds and further studies are needed to identify the metabolic pathways and genes involved. The results indicate a direct genetic correlation between biochemical-based resistance characteristics and reduced whitefly incidence in S. pennellii. | Floor van den Oever-van den Elsen Alejandro F.Lucatti Sjaak van Heusden Colette Broekgaarden Roland Mumm Marcel Dicke Ben Vosman | 2016 | Journal of Integrative Plant Biology2016，58，4： | 2 |
| 14 | Bidirectional Relation Between Inflammation and Coagulation显示文摘 | Marcel Levi Tom van der Poll Harry R. Büller | 2004 | Circulation: Journal of the American Heart Association2004，，22： | 2 |
| 15 | Fractional Flow Reserve Versus Angiography for Guiding Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease显示文摘 | Nico H.J. Pijls William F. Fearon Pim A.L. Tonino Uwe Siebert Fumiaki Ikeno Bernhard Bornschein Marcel van't Veer Volker Klauss Ganesh Manoharan Thomas Engstr?m Keith G. Oldroyd Peter N. Ver Lee Philip A. MacCarthy Bernard De Bruyne | 2010 | Journal of the American College of Cardiology2010，，3： | 2 |
| 16 | Delayed Left Ventricular Untwisting in Hypertrophic Cardiomyopathy显示文摘 | Bas M. van Dalen Floris Kauer Michelle Michels Osama I.I. Soliman Wim B. Vletter Heleen B. van der Zwaan Folkert J. ten Cate Marcel L. Geleijnse | 2009 | Journal of the American Society of Echocardiography2009，，12： | 2 |
| 17 | Left ventricular twist and untwist in aortic stenosis显示文摘 | Bas M. van Dalen Apostolos Tzikas Osama I.I. Soliman Floris Kauer Helena J. Heuvelman Wim B. Vletter Folkert J. ten Cate Marcel L. Geleijnse | 2009 | International Journal of Cardiology2009，，3： | 2 |
| 18 | A Novel Experimental Approach for Three-Dimensional Geometry Assessment of Calcified Human Stenotic Arteries In Vitro显示文摘 | Renate W. Boekhoven Richard G.P. Lopata Marc R. van Sambeek Frans N. van de Vosse Marcel C.M. Rutten | 2013 | Ultrasound in Medicine & Biology2013，，： | 1 |
| 19 | Effect of the factor V Leiden mutation on the incidence and outcome of severe infection and sepsis 显示文摘 | Marcel Schouten C Van't Veer T Van Der Poll | 2012 | Neth J Med2012，70，7： | 1 |
| 20 | Lipases in the Preparation of β-blockers 显示文摘 | Vincent H M E van Lersel J | 1988 | TIBTECH1988，6，： | 1 |
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