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| 1 | Liver cirrhosis and left ventricle diastolic dysfunction: Systematic review显示文摘BACKGROUND Liver cirrhosis is a chronic hepatic disease which is associated with cardiovascular abnormalities.Hyperdynamic circulation in liver cirrhosis causes functional and structural cardiac alterations.The prevalence of left ventricle diastolic dysfunction(LVDD)in cirrhotic patients ranges from 25.7%to as high as 81.4%as reported in different studies.In several studies the severity of diastolic dysfunction(DD)correlated with a degree of liver failure and the rate of dysfunction was higher in patients with decompensated cirrhosis compared with compensated.Future directions of comprehensive assessment of cardiac function in cirrhotic patients might provide a better prognosis for these patients.AIM To clarify the correlation between the severity of liver cirrhosis and left ventricle diastolic dysfunction in the existing literature.METHODS Through January and February of 2019 at Vilnius University we conducted a systematic review of the global existing literature on the prevalence of left ventricle diastolic dysfunction in patients with liver cirrhosis.We searched for articles in PubMed,Medline and Web of science databases.Articles were selected by using adequate inclusion and exclusion criteria.Our interest was the outcome of likely correlation between the severity of cirrhosis[evaluated by Child-Pugh classes,Model For End-Stage Liver Disease(MELD)scores]and left ventricle diastolic dysfunction[classified according to American Society of Echocardiography(ASE)guidelines(2009,2016)],as well as relative risk of dysfunction in cirrhotic patients.Subgroup analyses were performed to evaluate the ratio and grades of left ventricle diastolic dysfunction with respect to cirrhosis severity.RESULTS A total of 1149 articles and abstracts met the initial search criteria.Sixteen articles which met the predefined eligibility criteria were included in the final analysis.Overall,1067 patients(out of them 723 men)with liver cirrhosis were evaluated for left ventricle diastolic dysfunction.In our systemic analysis we have found that 51.2%of cirrhotic patients had left ventricle diastolic dysfunction diagnosed and the grade 1 was the most prevalent(59.2%,P<0.001)among them,the grade 3 had been rarely diagnosed-only 5.1%.The data about the prevalence of diastolic dysfunction in cirrhotic patients depending on Child-Pugh Classes was available from 5 studies(365 patients overall)and only in 1 research diastolic dysfunction was found being associated with severity of liver cirrhosis(P<0.005).We established that diastolic dysfunction was diagnosed in 44.6%of Child-Pugh A class patients,in 62%of Child B class and in 63.3%of Child C patients(P=0.028).The proportion of patients with higher diastolic dysfunction grades increases in more severe cirrhosis presentation(P<0.001).There was no difference between mean MELD scores in patients with and without diastolic dysfunction and in different diastolic dysfunction groups.In all studies diastolic dysfunction was more frequent in patients with ascites.CONCLUSION This systemic analysis suggests that left ventricle diastolic dysfunction is an attribute of liver cirrhosis which has not received sufficient attention from clinicians so far.Future suggestions of a comprehensive assessment of cardiac function in cirrhotic patients might provide a better prognosis for these patients and give hint for better understanding of the left ventricle diastolic dysfunction pathogenesis in liver cirrhosis. | Ieva Stundiene Julija Sarnelyte Ausma Norkute Sigita Aidietiene Valentina Liakina Laura Masalaite Jonas Valantinas | 2019 | World Journal of Gastroenterology2019，25，32： | 3 |
| 2 | Reverse Structural and Gap-Junctional Remodeling After Prolonged Atrial Fibrillation in the Goat显示文摘 | Jannie Ausma Huub M.W. van der Velden Marie-Hélène Lenders Erwin P. van Ankeren Habo J. Jongsma Frans C.S. Ramaekers Marcel Borgers Maurits A. Allessie | 2003 | Circulation: Journal of the American Heart Association2003，，15： | 2 |
| 3 | Changes in ultrastructural calcium distribution in goat atrial during atrial Hbriilation显示文摘 | Dispersyn GD Duimel H | 2000 | J Mol Cell Cardiol2000，32，： | 1 |
| 4 | Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat显示文摘 | Ausma J Wijffels M Thone F | 1997 | Circulation1997，96，9： | 1 |
| 5 | Dedifferentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation显示文摘 | AUSMA J WIJFFELS M VAN EYS G | 1997 | Am J Pathol1997，151，： | 1 |
| 6 | Dedifferentiation of atrial eardiomyocytes as a result of chronic atrial fibrillation显示文摘 | Ausma J Wijffels M Van Eys G | 1997 | Am J Pathol1997，151，4： | 1 |
| 7 | Electrical,contractile and structural remodeling during atrial fibrillation显示文摘 | Allessie M Ausma J Schotten U | 2002 | Cardiovasc Res2002，54，： | 1 |
| 8 | Time course of atrial fibrillation induced cellular structural remodeling in atria of the goat显示文摘 | Ausma J Lirjens N Lenders MH | 2001 | J Mol Cell Cardiol2001，33，： | 1 |
| 9 | Reverse structural and gap-junctional after prolonged atrial fibrillation in the goat显示文摘 | Ausma J van der Velden HM Lenders MH | 2003 | Circulation2003，107，15： | 1 |
| 10 | Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation显示文摘 | Brundel B J Ausma J Van Gelder I C | 2002 | Cardiovase Res2002，54，2： | 1 |
| 11 | Cardiomyocyte remodeling during myocardial hibernation and atrial fibrillation: prelude to apoptosis显示文摘 | DISPERSYN G D AUSMA J THONE F | 1999 | Cardiovasc Res1999，43，： | 1 |
| 12 | Activation of proteolysis by calpains and structural changes in human paroxysmal and persistent atrial fibrillation显示文摘 | Brundel BJ Ausma J van Gelder IC | 2002 | Cardiovasc Res2002，54，2： | 1 |
| 13 | Electrical, contractile and structural remodeling during atrial fibriliation显示文摘 | Allessie M Ausma J Schotten U | 2002 | Cardiovasc Res2002，54，2： | 1 |
| 14 | Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat显示文摘 | AUSMA J WIJFFLES M THONE F | 1997 | Circulation1997，96，： | 1 |
| 15 | Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat显示文摘 | Ausma J Wijffels M Thone F | 1997 | Circulation1997，96，： | 1 |
| 16 | Cellular mechanisms of depressed atrial contractility in patients with chronic atrial fibrillation 显示文摘 | SCHOTTEN U AUSMA J STELLBRINK C | 2001 | Circulation2001，103，： | 1 |
| 17 | Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat显示文摘 | Ausma J Wijffels M Thone F | 1997 | Circulation1997，96，： | 1 |
| 18 | Reverse structural and gap-junctional remodeling after prolonged atrial fibrillation in the goat显示文摘 | Ausma J van der Velden HM Lenders MH | 2003 | Circulation2003，107，15： | 1 |
| 19 | Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat显示文摘 | Ausma J Wijffels M Thone F | 1997 | Circulation1997，96，9： | 1 |
| 20 | Cellular mechanisms of depressed atrial contractility in patients with chronic atrial fibrillation显示文摘 | Schotten U Ausma J Stellbrink C | 2001 | Circulation2001，103，： | 1 |
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