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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices显示文摘AIM:To evaluate the efficacy and safety of undiluted N-butyl-2 cyanoacrylate plus methacryloxysulfolane(NBCM)as a prophylactic treatment for gastric varices(GV)bleeding.METHODS:This prospective study was conducted at a single tertiary-care teaching hospital between October 2009 and March 2013.Patients with portal hypertension(PH)and GV,with no active gastrointestinal bleeding,were enrolled in primary prophylactic treatment with NBCM injection without lipiodol dilution.Initial diagnosis of GV was based on endoscopy and confirmed with endosonography(EUS); the same procedure was used after treatment to confirm eradication of GV.After puncturing the GV with a regular injection needle,1 mL of undiluted NBCM was injected intranasally into GV.The injection was repeated as necessary to achieve eradication or until a maximum total volume of 3 mL of NBCM had been injected.Patients were followed clinically and evaluated with endoscopy at 3,6 and 12 mo.Later follow-ups were performed yearly.The main outcome measures were efficacy(GV eradication),safety(adverse events related to cyanoacrylate injection),recurrence,bleeding from GV and mortality related to GV treatment.RESULTS:A total of 20 patients(15 male)with PH and GV were enrolled in the study and treated with undiluted NBCM injection.Only 2(10%)patients had no esophageal varices(EV); 18(90%)patients were treated with endoscopic band ligation to eradicate EV before inclusion in the study.The patients were followed clinically and endoscopically for a median of 31 mo(range:6-40 mo).Eradication of GV was observed in all patients(13 patients were treated with 1 session and 7 patients with 2 sessions),with a maximum injected volume of 2 mL NBCM.One patient had GV recurrence,confirmed by EUS,at 6-mo follow-up,and another had late recurrence with GV bleeding after 35 mo of follow-up; overall,GV recurrence was observed in 2 patients(10%),after 6 and 35 mo of follow-up,and GV bleeding rate was 5%(1 patient).Mild epigastric pain was reported by 3 patients(15%).No mortality or major complications,including embolism,or damage to equipment were observed.CONCLUSION:Endoscopic injection with NBCM,without lipiodol,may be a safe and effective treatment for primary prophylaxis of gastric variceal bleeding. | Matheus Cavalcante Franco Gustavo Flores Gomes Frank Shigeo Nakao Gustavo Andrade de Paulo Angelo Paulo Ferrari Jr Ermelindo Della Libera Jr | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，6： | 16 |
| 3 | Therapy with stem cells in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) affects a part of the young population and has a strong impact upon quality of life. The underlying etiology is not known, and the existing treatments are not curative. Furthermore, a significant percentage of patients are refractory to therapy. In recent years there have been great advances in our knowledge of stem cells and their therapeutic applications. In this context, autologous hematopoietic stem cell transplantation(HSCT) has been used in application to severe refractory Crohn's disease(CD), with encouraging results. Allogenic HSCT would correct the genetic defects of the immune system, but is currently not accepted for the treatment of IBD because of its considerable risks. Mesenchymal stem cells(MSCs) have immune regulatory and regenerative properties, and low immunogenicity(both autologous and allogenic MSCs). Based on these properties, MSCs have been used via the systemic route in IBD with promising results, though it is still too soon to draw firm conclusions. Their local administration in perianal CD is the field where most progress has been made in recent years, with encouraging results. The next few years will be decisive for defining the role of such therapy in the management of IBD. | María del Pilar Martínez-Montiel Gonzalo Jesús Gómez-Gómez Ana Isabel Flores | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 4 | Stem cell mechanisms during left ventricular remodeling post-myocardial infarction:Repair and regeneration显示文摘Post-myocardial infarction(MI),the left ventricle(LV)undergoes a series of events collectively referred to as remodeling.As a result,damaged myocardium is replaced with fibrotic tissue consequently leading to contractile dysfunction and ultimately heart failure.LV remodeling post-MI includes inflammatory,fibrotic,and neovascularization responses that involve regulated cell recruitment and function.Stem cells(SCs)have been transplanted post-MI for treatment of LV remodeling and shown to improve LV function by reduction in scar tissue formation in humans and animal models of MI.The promising results obtained from the application of SCs post-MI have sparked a massive effort to identify the optimal SC for regeneration of cardiomyocytes and the paradigm for clinical applications.Although SC transplantations are generally associated with new tissue formation,SCs also secrete cytokines,chemokines and growth factors that robustly regulate cell behavior in a paracrine fashion during the remodeling process.In this review,the different types of SCs used for cardiomyogenesis,markers of differentiation,paracrine factor secretion,and strategies for cell recruitment and delivery are addressed. | Rogelio Zamilpa Mary M Navarro Iris Flores Sy Griffey | 2014 | World Journal of Cardiology2014，6，7： | 11 |
| 5 | Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms显示文摘AIM To assess the rate of matrix Gla-protein carboxylation in patients with small intestinal bacterial overgrowth(SIBO) and to decipher its association with subclinical atherosclerosis.METHODS Patients with suspected SIBO who presented with a low risk for cardiovascular disease and showed no evidence of atherosclerotic plaques were included in the study. A glucose breath test was performed in order to confirm the diagnosis of SIBO and vascular assessment was carried out by ultrasound examination. Plasma levels of the inactive form of MGP(dephosphorylateduncarboxylated matrix Gla-protein) were quantified by ELISA and vitamin K2 intake was estimated using a food frequency questionnaire.RESULTS Thirty-nine patients were included in the study. SIBO was confirmed in 12/39(30.8%) patients who also presented with a higher concentration ofdephosphorylated-uncarboxylated matrix Gla-protein(9.5 μg/L vs 4.2 μg/L; P = 0.004). Arterial stiffness was elevated in the SIBO group(pulse-wave velocity 10.25 m/s vs 7.68 m/s; P = 0.002) and this phenomenon was observed to correlate linearly with the levels of dephosphorylated-uncarboxylated matrix Gla-protein(β = 0.220, R2 = 0.366, P = 0.03). Carotid intima-media thickness and arterial calcifications were not observed to be significantly elevated as compared to controls.CONCLUSION SIBO is associated with reduced matrix Gla-protein activation as well as arterial stiffening. Both these observations are regarded as important indicators of subclinical atherosclerosis. Hence, screening for SIBO, intestinal decontamination and supplementation with vitamin K2 has the potential to be incorporated into clinical practice as additional preventive measures. | Francesca Romana Ponziani Maurizio Pompili Enrico Di Stasio Maria Assunta Zocco Antonio Gasbarrini Roberto Flore | 2017 | World Journal of Gastroenterology2017，23，7： | 9 |
| 6 | Risk assessment of chemical substances of safety concern generated in processed meats显示文摘This manuscript is reviewing the presence of substances of safety concern that may be generated in different types of meat products.Such substances include N-nitrosamines that can be generated under certain conditions when using nitrite as preservative,the polycyclic aromatic hydrocarbons generated as a consequence of particular smoking processes,heterocyclic aromatic amines generated under particular cooking conditions,compounds released from the oxidation of lipids and proteins,Maillard reaction products like acrylamide and carboxymethyl lysine,and amines that can be generated and accumulated in fermented meats.These hazardous compounds,their mechanisms of generation,risks for health and ways of preventing its presence in meat products are briefly described in this review. | Monica Flores Leticia Mora Milagro Reig Fidel Toldra | 2019 | Food Science and Human Wellness2019，8，3： | 7 |
| 7 | Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?显示文摘Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells(regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient's immune system, and repairs the injured tissue. | Ana I Flores Gonzalo J Gómez-Gómez ángeles Masedo-González M Pilar Martínez-Montiel | 2015 | World Journal of Stem Cells2015，7，2： | 7 |
| 8 | Recent Advances in Synthesis and Properties of Hybrid Halide Perovskites for Photovoltaics显示文摘The progress made by the scientific community in emerging photovoltaic technologies over the past two decades has been outstanding. Numerous methods have been developed for the preparation of hybrid organic–inorganic perovskite solar cells. The power conversion efficiency has been up to 14% by a one-step vacuum deposition technique. A serious concern is the toxicity of the materials. In this review, several methods aimed at resolving these problems to some extent have been compiled, including eco-friendly synthesis. Further efficiency enhancements are expected following optimization, and a better fundamental understanding of the internal electron charge transfer, electron–hole diffusion to the corresponding layers, flexibility, and stability-dependent bandgaps is reported. This paper explores the green synthesis of organic–inorganic perovskites for industrialization. Concerning the above facts, a simple low-cost model called‘‘dispersed photovoltaic cells' ' is presented. | C.C.Vidyasagar Blanca M.Muoz Flores Víctor M.Jimnez Prez | 2018 | Nano-Micro Letters2018，10，4： | 6 |
| 9 | 利用图像和机器学习检测大豆作物幼苗期玉米杂苗显示文摘在大豆-玉米轮作生产过程中,玉米杂苗会与大豆苗竞争水和肥料,而且很容易遮住大豆苗,影响害虫(如玉米根虫)的防控,降低大豆品质。因此,在大豆幼苗期及时检测出玉米杂苗并对其进行处理非常重要。传统的人工检测方法主观性强、效率低,传感器和算法的发展为自动检测玉米杂苗提供了更好的解决方案。本研究在温室环境下模仿田间条件,待玉米和大豆发芽后,连续5天用因特尔RealSense D435相机采集彩色图像,并人工裁剪幼苗图像区域,在此基础上对图像进行分割和去噪。在采集图像形状、色彩和纹理特征值后,对所采集的特征值进行权重分析,保留前10种重要的特征值导入基于特征的机器学习算法中进行模型训练和预测。预测结果表明,支持向量机模型(SVM)、神经网络(NN)和随机森林(RF)的预测精度分别为85.3%,81.5%和82.6%。将数据集导入GoogLeNet和VGG-16两种深度学习模型进行训练,预测精度分别为96.0%和96.2%。VGG-16模型在区分大豆幼苗和玉米杂苗中有较好的表现,彩色图像和VGG-16模型组成的系统可以自动检测大豆生长过程中玉米杂苗的情况,为农民提供准确的信息,帮助其进行生产决策和田间管理。 | Paulo FLORES 张昭 Jithin MATHEW Nusrat JAHAN John STENGER | 2020 | 智慧农业(中英文)2020，2，3： | 6 |
| 10 | 放电等离子烧结添加TiC开孔钛基复合材料的磨损模式(英文)显示文摘采用放电等离子烧结法制备具有开孔隙的钛基复合材料(TMCs),研究添加TiC增强颗粒对材料摩擦性能的影响。材料中含有同等摩尔比的Ti和TiH2以及不同体积分数的TiC(0、3%、10%和30%),烧结温度为850℃。采用纳米压痕和磨损试验评估材料的纳米硬度和耐磨性能,摩擦试验采用球-平面接触往复滑动模式。结果显示,随着TiC含量的增加,材料的纳米硬度从5 GPa增加到14 GPa。当TiC含量为10%时,材料的摩擦因数最低(0.2),磨损率也最低。当TiC含量较低时,样品发生粘着磨损,并伴随严重的塑性变形;当TiC含量适中时,样品表面形成机械混合层(MML);当TiC含量较高时,样品的主要磨损机制为磨粒磨损。总之,随着TiC含量的变化,材料的磨损机制、摩擦因数和磨损量也随之变化。 | I. FARíAS L. OLMOS O. JIMéNEZ M. FLORES A. BRAEM J. VLEUGELS | 2019 | Transactions of Nonferrous Metals Society of China2019，29，8： | 5 |
| 11 | Ubiquitin-proteasome system and oxidative stress in liver transplantation显示文摘A major issue in organ transplantation is the development of a protocol that can preserve organs under optimal conditions. Damage to organs is commonly a consequence of flow deprivation and oxygen starvation following the restoration of blood flow and reoxygenation. This is known as ischemia-reperfusion injury(IRI): a complex multifactorial process that causes cell damage. While the oxygen deprivation due to ischemia depletes cell energy, subsequent tissue oxygenation due to reperfusion induces many cascades, from reactive oxygen species production to apoptosis initiation. Autophagy has also been identified in the pathogenesis of IRI, although such alterations and their subsequent functional significance are controversial. Moreover, proteasome activation may be a relevant pathophysiological mechanism. Different strategies have been adopted to limit IRI damage, including the supplementation of commercial preservation media with pharmacological agents or additives. In this review, we focus on novel strategies related to the ubiquitin proteasome system and oxidative stress inhibition, which have been used to minimize damage in liver transplantation. | Norma Alva Arnau Panisello-Roselló Marta Flores Joan Roselló-Catafau Teresa Carbonell | 2018 | World Journal of Gastroenterology2018，24，31： | 5 |
| 12 | Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis显示文摘干细胞(hPSC ) 人口着急地在基本研究并且在基于房间的治疗应用为质量控制被需要的为孤立人的 pluripotent 的快速、可靠的方法。用 lectin 数组,我们分析了从 26 件 hPSC 样品和 22 件区分的房间样品提取的 glycoproteins,并且与是足够的把 hPSCs 与许多 non-pluripotent 房间类型区分开来的特殊有约束力的签名识别了 lectins 的一个小组。这些特定的 biomarkers 被所有 12 人的胚胎的干细胞和检验的 14 件人的导致的 pluripotent 干细胞样品分享,不管起源,文化条件,体的房间类型 reprogrammed,或使用的 reprogramming 方法的实验室。我们演示了由检测有调停 lectin 的染色的一张区分的房间人口由荧光显微镜学和流动 cytometry,并且由充实并且清除跟随了的在内的 hPSCs 有约束力的特定的 lectin 的一个实际应用程序从用调停 lectin 的房间分离的混合房间人口的可行 hPSCs。全球基因表示分析显示出特定的 fucosyltransferases 和 sialyltransferases 的联系 pluripotency 的微分表示,它可以在蛋白质 glycosylation 和 lectin 绑定位于这些差别下面。一起拿,我们的结果证明蛋白质 glycosylation 在 pluripotent 和 non-pluripotent 房间之间更加不同,并且证明 lectins 可以被用作 biomarkers 从混合房间人口在干细胞人口并且为可行 hPSCs 的移动监视 pluripotency。 | Yu-ChiehWang MasatoNakagawa IbonGaritaonandia IleanaSlavin GulsahAltun Robert MLacharite Kristopher LNazor Ha TTran Candace LLynch Trevor RLeonardo YingLiu Suzanne EPeterson Louise CLaurent ShinyaYamanaka Jeanne FLoring | 2011 | Cell Research2011，21，11： | 5 |
| 13 | Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development显示文摘 | Maria Assunta Zocco Enrico Di Stasio Raimondo De Cristofaro Marialuisa Novi Maria Elena Ainora Francesca Ponziani Laura Riccardi Stefano Lancellotti Angelo Santoliquido Roberto Flore Maurizio Pompili Gian Lodovico Rapaccini Paolo Tondi Giovanni Battista G | 2009 | Journal of Hepatology2009，，4： | 5 |
| 14 | Biomass derived porous nitrogen doped carbon for electrochemical devices显示文摘Biomass derived porous nanostructured nitrogen doped carbon(PNC) has been extensively investigated as the electrode material for electrochemical catalytic reactions and rechargeable batteries. Biomass with and without containing nitrogen could be designed and optimized to prepare PNC via hydrothermal carbonization, pyrolysis, and other methods. The presence of nitrogen in carbon can provide more active sites for ion absorption, improve the electronic conductivity, increase the bonding between carbon and sulfur, and enhance the electrochemical catalytic reaction. The synthetic methods of natural biomass derived PNC, heteroatomic co-or tri-doping into biomass derived carbon and the application of biomass derived PNC in rechargeable Li/Na batteries, high energy density Li-S batteries, supercapacitors, metal-air batteries and electrochemical catalytic reaction(oxygen reduction and evolution reactions, hydrogen evolution reaction) are summarized and discussed in this review. Biomass derived PNCs deliver high performance electrochemical storage properties for rechargeable batteries/supercapacitors and superior electrochemical catalytic performance toward hydrogen evolution, oxygen reduction and evolution, as promising electrodes for electrochemical devices including battery technologies, fuel cell and electrolyzer. | Litao Yan Jiuling Yu Jessica Houston Nancy Flores Hongmei Luo | 2017 | Green Energy & Environment2017，2，2： | 4 |
| 15 | Cytotoxic effect of Spirulina platensis extracts on human acute leukemia Kasumi-1 and chronic myelogenous leukemia K-562 cell lines显示文摘Objective: To evaluate the cytotoxic effects of Spirulina platensis extracts on acute leukemia Kasumi-1 and chronic leukemia K-562 cancer cell lines.Methods: Various concentrations of Spirulina platensis extracts(0.25–50.00 mg/m L)obtained with different solvents were used to treat cell lines for 72 h. For cytotoxic effect studies, cell viability test with trypan blue solution, MTT assay and microscopic cytomorphological assessment were done.Results: Spirulina extract obtained with 70% ethanol showed significant cytotoxicity in K562 and Kasumi-1 cell lines. With trypan blue solution, IC_(50) values were found to be4.64 mg/m L for K-562 and 3.68 mg/m L for Kusumi-1 cell lines. Spirulina aqueous extract also showed cytotoxicity with trypan blue method, at a slightly higher dose; where IC_(50) values were 12.68 mg/m L for K-562 and 2.13 mg/m L for Kusumi-1 cell lines. The IC_(50) values were found 0.40 mg/m L for K-562 and 0.31 mg/m L for Kusumi-1 cell lines for the 70% ethanol extract according to the MTT assay. Spirulina extract obtained with water also showed cytotoxicity but the dose was a little higher where IC_(50) values were15.77 mg/m L for K-562 and 9.44 mg/m L for Kusumi-1 cell lines. The effect of cytotoxicity with ethanol extract is quite comparable with that observed for cyclophosphamide, which is a chemical used as anticancer agent.Conclusions: The cytotoxicity exhibited by Spirulina extract to cancer cell lines might be due to the presence of phytopigments(carotenoids, chlorophyll, phycocyanin) as well as polysaccharides that were reported previously as constituents of the extract. So crude extracts of Spirulina can be used as a source to develop anticancer drugs. | Flor Yohana Flores Hernandez Sanghamitra Khandual Inocencia Guadalupe Ramírez López | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，1： | 4 |
| 16 | Facilitation by nurse plants contributes to vegetation recovery in human-disturbed desert ecosystems显示文摘Aims Facilitation by nurse plants is a common interaction in harsh environments and this positive plant-plant interaction may promote vegetation recovery in ecosystems affected by human activities.Determining the relevance of this process,however,requires assessing how nurse plants influence the establishment of other species,as well as the proportion of species in the regional species pool that would benefit from the presence of nurse plants in human-disturbed areas.Further,since vegetation recovery is a time-dependent process,the community-level consequences of facilitation are likely to vary among landscapes with different disturbance history.Thus,an integrative perspective of the relevance of nurse plants for vegetation recovery could be obtained by measuring their effects across different human-disturbed landscapes of the target region.This study focuses on these issues and uses a regional-scale approach to assess the community-level effects of a widespread nurse plant of American deserts,the creosotebush(Larrea tridentata).Methods This study was conducted in the southernmost portion of Chihuahuan Desert because most floodplain valleys of this region have been affected by human activities during the past centuries.For this study,we selected 10 floodplain valleys differing in their age(i.e.the time elapsed after human activities were ceased).At each landscape,we measured the cover of creosotebushes and the proportion of plant species positively associated with them,as well as the density of seeds in the soil beneath creosotebush canopies.All these data were regressed against the age of the landscapes.Further,to assess whether positive association patterns were due to facilitation or other processes,we conducted field experiments and measured the ecophysiological performance of plant species established beneath and outside creosotebush canopies.Important Findings Most plant species from the target region were positively associated to creosotebushes,and our field experiments and ecophysiological measures indicated that these distribution patterns can be attributed to facilitative interactions.In most landscapes,the density of seeds was higher beneath creosotebushes than in the surrounding habitats,suggesting that these shrubs may also act as seed traps.The community-level effects of creosotebushes increased with landscape age and creosotebush cover,indicating that magnitude of these effects depends on the disturbance history of each site.These results highlight the relevance of performing large-scale assessments for identifying the consequences of facilitation on vegetation recovery across space and time.We then propose that this kind of large-scale approach should be taken into account in the development of conservation programs aimed at the recovery and preservation of plant biodiversity in harsh environments. | Ernesto I.Badano Omar R.Samour-Nieva Joel Flores JoséL.Flores-Flores Jorge A.Flores-Cano Juan P.Rodas-Ortíz | 2016 | Journal of Plant Ecology2016，9，5： | 4 |
| 17 | Association of Nutrition Parameters Including Bioelectrical Impedance and Systemic Inflammatory Response With Quality of Life and Prognosis in Patients With Advanced Non-Small-Cell Lung Cancer: A Prospective Study显示文摘 | Karla Sánchez-Lara JennyG Turcott Eva Juárez Patricia Guevara Carolina Nú?ez-Valencia LuisF. O?ate-Oca?a Diana Flores Oscar Arrieta | 2012 | Nutrition and Cancer2012，，4： | 3 |
| 18 | A Study of the Structural, Optical and Electrical Properties of SnS Thin Films Modified by Plasma显示文摘 | Aar6n Gomez Horacio Martinez Manuela Calixto-Rodriguez David Avellaneda Pedro Guillermo Reyes Osvaldo Flores | 2013 | 材料科学与工程(中英文B版)2013，3，6： | 3 |
| 19 | Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma显示文摘Objective: To examine the effect of metanol extract of Petiveria alliacea(PM) on airway inflammation in a murine model of chronic asthma. Methods: Two-month-old male BALB/c mice(n=6–8/group) were sensitized on days 0 and 14 by intraperitoneal injection of 20 μg ovalbumin(OVA). On day 25, the mice received an airway challenge with OVA(3%, w/v, in phosphate buffered saline). PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline(PBS) to induce a model of asthma. At the end of the test, respiratory reactivity was assayed, the total cell number, interleukin-4(IL-4), IL-5, IL-13, tumor necrosis factor-alpha(TNF-α) and reactive oxygen species(ROS) in the bronchoalveolar lavage fluid(BALF) were determined and the levels of serum IgE, intercellular cell adhesion molecule 1(ICAM-1) and eotoxin were measured. In addition, lung tissue was used to qualify the IL-4, IL-5, IL-13, TNF-α and transforming growth factor beta 1(TGF-β1). Histologic examination was performed to observe inflammatory cellular infiltration. Results: The administration of PM in comparison with the OVA-only treated group significantly attenuated the infiltration of eosinophils and other inflammatory cells(P<0.01). Airway resistance(RI) in the OVA-only induced group was significantly higher than that of the PBS control group(P<0.01) when methacholine was added. TNF-α, IgE, TGF-β1 and cytokine levels IL-4, IL-5, IL-13 in the BALF decreased compared to control mice(P<0.01 or P<0.05). PM treatment also inhibited the production of chemokines, eotaxin and ICAM-1 in BALF(P<0.01), which improved lung function. Histopathological examination revealed that the sensitized treated PM groups had significant lower in inflammatory scores similar to dexamethasone treatments and the untreated group. Conclusion: Administration of PM could inhibit airway inflammation, regulate cytokines, chemokines and enhance pulmonary conditions in allergic murine model of asthma. | Rosa Martha Perez Gutierrez Jose Maria Mota Flores | 2018 | Chinese Journal of Integrative Medicine2018，24，12： | 3 |
| 20 | Comparative efficacy of sorafenib versus best supportive care in recurrent hepatocellular carcinoma after liver transplantation: A case-control study<.-- Doctopic: TAS -->显示文摘 | Carlo Sposito Luigi Mariani Alessandro Germini Maria Flores Reyes Marco Bongini Glenda Grossi Sherrie Bhoori Vincenzo Mazzaferro | 2013 | Journal of Hepatology2013，，1： | 3 |
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