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150篇 您的检索式:作者名="Isakson"
    题名 作者 年代 出处 被引量
1塞来昔布治疗骨关节炎的随机对照试验显示文摘目的 :比较塞来昔布、萘普生以及安慰剂在治疗膝关节骨关节炎时的疗效、安全性。方法 :10 0 3名有症状的膝关节骨关节炎患者随机接受塞来昔布 5 0 ,10 0 ,2 0 0mg ,bid ;萘普生 5 0 0mg ,bid或安慰剂 12周。患者在停用既往NSAID药或止痛治疗后 2~ 7d以及服用受试药物治疗后 2 ,6 ,12周 ,根据标准疗效判定方法进行评估。结果 :塞来昔布在改善骨关节炎的症状和体征上有显著效果。在治疗后的 2d内疼痛明显缓解 ,最大抗炎和镇痛作用出现在 2周内并持续至 12周。各剂量的塞来昔布与安慰剂比较均有效 ,但 5 0mg ,bid的剂量效果较差 ;较大剂量的塞来昔布 (10 0和 2 0 0mg ,bid)疗效相似 ,所观察到的改善程度与萘普生 5 0 0mg ,bid相当。各剂量的塞来昔布和萘普生均有良好的耐受性。结论 :COX 2抑制剂塞来昔布是治疗骨关节炎的有效药物 ,对骨关节炎临床症状和体征的改善与萘普生相当。Bensen WG Fiechtner JJ Mcmillen JI Zhao WW Yu SS Woods EM Hubbard RC Isakson PC Verburg KM Geis GS 2000中国新药杂志2000,9,8:17
2Heterocellular contact at the myoendothelial junction influences gap junction organization显示文摘Isakson B E Duling B R 2005Circ Res2005,97,1:1
3Oxidized p-hospholipids alter vascular connexin expression,phosphorylation,and heterocellular communication显示文摘ISAKSON BE KRONKE G KADL A 2006Arterioscler Thromb Vasc Biol2006,26,10:1
4Diagnostic ability of B natriuretic peptide and impedance cardiography:testing to identify left ventricular dysfunction in hypertensive patients 显示文摘Bhalla V Isakson S Bhalla MA 2005AM J Hypertens2005,18,2:1
5Oxidized Phospholipid Species Promote in Vivo Differential Cx43 Phosphorylation and Vascular Smooth Muscle Cell Proliferation显示文摘Scott R. Johnstone Jeremy Ross Michael J. Rizzo Adam C. Straub Paul D. Lampe Norbert Leitinger Brant E. Isakson 2009The American Journal of Pathology2009,,2:1
6Serial sampling of ST2 predicts 90-day mortality following destabilized heart failure 显示文摘Boisot S Beede J Isakson S 2008J Card Fail2008,14,9:1
7The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy显示文摘Filimonenko M Isakson P Finley K D 2010Mol Cell2010,38,2:1
8Connexins in vas- cular physiology and pathology 显示文摘BRISSET AC ISAKSON BE AND KWAK BR 2009Antioxid Redox Sigual2009,11,2:1
9Serial sampling of ST2 predicts 90 -day mortality following destabilized heart failure 显示文摘BOISOT S BEEDE J ISAKSON S 2008J Card Fail2008,14,9:1
10Diagnostic ability of B- nat to uretic and left peptide impedance cardiography;testing identify in ventricular dysfunction hypei'tensive patients显示文摘Bhalla V Isakson S Bhalla MA 2005Am J Hypertens2005,18,22:1
11Oxidized Phospholipids Alter Vascular Connexin Expression, Phosphorylation, and Heterocellular Communication显示文摘Isakson B E Kronke G Kadl A 2006Arterioscler Thromb Vasc Biol2006,26,10:1
12The selective macroautophagic degradation of aggregated proteins requires the pi3pbinding protein alfy显示文摘Filimonenko M Isakson P Finley K D 2010Mol Cell2010,38,2:1
13Biological and biophysical prop-erties of vascular connexin channels 显示文摘Johnstone S Isakson B Locke D 2009Int RevCell Mol Biol2009,278,:1
14Connexins in vascular physiology and pathology 显示文摘Brisset AC Isakson BE Kwak BR 2009Antioxid Redox Signal2009,11,2:1
15Serial sampling of ST2 predicts 90-day mortality following destabilized heart failure显示文摘Boisot S Beede J Isakson S 2008J Card Fail2008,14,:1
16Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia 显示文摘Tverskoy M Oz Y Isakson A 1994Anesth Analg1994,78,:1
17Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia 显示文摘Tverskoy M Oz Y Isakson A 1994Anesth Analg1994,78,:1
18Connexins;gaps in our knowledgeof vascular function显示文摘Figueroa XF Isakson BE Duling BR 2004Physiology(Bethesda)2004,19,:1
19The discovery and function of COX-2显示文摘Needleman P Isakson PC 1997J Rheumatol1997,24,49:1
20Connexins in vascular physiology and pathology 显示文摘Brisset A C Isakson B E Kwak B R 2009Antioxid Redox Signal2009,11,2:1
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