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| 1 | Segmental duodenectomy for gastrointestinal stromal tumor of the duodenum显示文摘AIM: To evaluate the results of segmental duodenectomy (SD) and pancreaticoduodenectomy (PD) for duodenal gastrointestinal stromal tumor (GIST) and help clinicians with surgical management. METHODS: All patients who underwent surgery for non-metastatic GIST of the duodenum in a single institution since 2000 were prospectively followed up. Seven patients (median age 51 years, range: 41-73 years) were enrolled: five underwent SD and two underwent PD. RESULTS: All the patients had a complete resection (R0), with no postoperative morbidity and mortality. Among the SD group, GIST was classified as low risk in two patients, intermediate risk in two, and high risk in one, according to the Fletcher scale, (vs two high risk patients in the PD group). With a median followup of 41 (18-85) mo, disease-free survival (DFS) rateswere 100% after SD and 0% after PD (P < 0.05). The median DFS was 13 mo in the PD group. CONCLUSION: Whenever associated with clear surgical margins, SD is a reliable and curative option for most duodenal GISTs, and is compatible with longterm DFS. | Nicolas Christian Buchs Pascal Bucher Pascal Gervaz Sandrine Ostermann Franois Pugin Philippe Morel | 2010 | World Journal of Gastroenterology2010，16，22： | 13 |
| 2 | Nitric Oxide in Plants: Production and Cross-talk with Ca^2+ Signaling显示文摘氮的氧化物(没有) 是在动物在生理的过程的一个宽数组执行关键功能的两价的气体。过去的几年在植物关于它的角色揭示了大部分。被硝酸盐 reductase (NR ) 并且经由化学小径不从亚硝酸根综合,这很好被建立。为没有生产是从由到目前为止非识别的酶的 L 精氨酸的 catalysed 的一条其他的在小径的出现正在增加证据。矛盾的结果处于特定的生理的条件关于这些酶的各自的参与被报导了。尽管大部分尚待被证明,我们假设这些矛盾能被说明因为由过去常不压制合成的药理学代理人的有限特性而且由象在硝酸盐的硝酸盐可渗透的阴离子隧道的迟钝一样的 L 精氨酸的减少的内容 reductase- 或 nitrate/nitrite-deficient 种。另一个未解决的问题使不在植物位于效果下面的分子的机制担心。这里,我们提供证据包括 MAPK 和 SnRK2 的第二送信人 Ca2+ ,以及蛋白质 kinases,是很嘴巧的调停人没有信号。这些调查结果关于在植物的不基于的发信号的开的新观点。 | Angelique Besson-Bard Cecile Courtois Adrien Gauthier Jennifer Dahan Grazyna Dobrowolska Sylvain Jeandroz Alain Pugin David Wendehenne | 2008 | Molecular Plant2008，1，2： | 9 |
| 3 | Transumbilical single-incision laparoscopic intracorporeal anastomosis for gastrojejunostomy:case report显示文摘 | Bucher P Pugin F Morel P | 2009 | Surg Endosc2009，23，7： | 1 |
| 4 | Proinflammatory activity in bronchoalveolar lavage fluids from patient with ARDS,a prominent role for interleukin-1显示文摘 | Pugin J Ricou B Steinberg K P | 1996 | Am J Respir Crit Care Med1996，153，： | 1 |
| 5 | Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic 'blind' bronchoalveolar lavage fluid显示文摘 | Pugin J Auckenthaler R Mili N | 1991 | Am Rev Respir Dis1991，143，51： | 1 |
| 6 | Diagnosis of ventilator-associ- ated pneumonia by bacteriologic analysis of bronchoscopic and non- bronchoscopic ' blind' bronchoalveolar lavage fluid显示文摘 | Pugin J Auckenthaler R Mill N | 1991 | Am Rev Re- spir Dis1991，143，5： | 1 |
| 7 | Robot-assisted g&,:trcctomy for cancer 显示文摘 | BuGhs N C Bucher P Pugin F | 2011 | MinervaGastroenterol Dietol2011，，： | 1 |
| 8 | Inappropriate initi-al antimicrobial therapy and its effect on survival in a clin-ical trial of immunomodulating therapy for severe sepsis显示文摘 | Harbarth S Garbino J Pugin J | 2003 | AmJMed2003，115，7： | 1 |
| 9 | CD1 4 is a pattern recognition receptor显示文摘 | Pugin J Heumann ID Tomasz A | 1994 | Immunity1994，1，6： | 1 |
| 10 | Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia 显示文摘 | Pastor CM Pugin J Kwak B | 2004 | Crit Care Med2004，32，8： | 1 |
| 11 | Reducing cost of surgery by avoiding complications:the model of robotic Roux-en-Y gastric bypass显示文摘 | Hagen ME Pugin F Chassot G | 2012 | Obes Surg2012，22，1： | 1 |
| 12 | Single port access laparoscopic fight hemi-colectomy显示文摘 | Bucher P Pugin F Morel P | 2008 | Int J Colorectal Dis2008，23，10： | 1 |
| 13 | Minimally invasive necrosectomy for infected necrotizing pancreatitis显示文摘 | Bucher P Pugin F Morel P | 2008 | Pancreas2008，36，2： | 1 |
| 14 | Beta - adrenergic agonistsexert their 'anfiinflammation' effects in monocytic cells through the IKB / NF-κb pathway显示文摘 | Famer P Pugin J | 2000 | Am J Physiol Lung cell Mol Physiol2000，279，： | 1 |
| 15 | Cytokine-mediated in- flammation in acute lung injury 显示文摘 | Goodman RB Pugin J Lee JS | 2003 | Cytokine Growth Factor Rev2003，14，6： | 1 |
| 16 | Three-dimensional laparoscopy:a step toward advanced surgical navigation显示文摘 | Buchs NC Volonte F Pugin F | 2013 | Surg Endosc2013，27，2： | 1 |
| 17 | Diagnosis of ventila2 tor2associated p neumonia by bacteriologic analysis of broncho scopic and nonbronchoscopic blind bronchoalveolar lavage fluid显示文摘 | Pugin J Auckent haler R Mili N | 1991 | Arn Rev Respir Dis1991，143，： | 1 |
| 18 | Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia显示文摘 | Pastor CM Pugin J Kwak B | 2004 | Crit Care Med2004，32，8： | 1 |
| 19 | Transumbilical single incision laparoscopic siglnoidectomy for benign disease 显示文摘 | BUCHER P PUGIN F MOREL P | 2010 | Colorectal Dis2010，12，： | 1 |
| 20 | Activation of human macrophages by mechanical ventilation in vitro显示文摘 | Pugin J Dumn I Jolliet P | 1998 | Am J Physiol1998，275，61： | 1 |
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