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| 1 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 2 | The process of mediated aging-in-place: a theoretically and empirically based model显示文摘 | Malcolm P Cutchin | 2003 | Social Science & Medicine2003，，6： | 2 |
| 3 | Capsaicin-evoked brain activation and central sensitization in anaesthetised rats:A functional magnetic resonance imaging study显示文摘 | Ricardo J M G Peter G M Malcolm J W P | 2006 | Pain2006，126，13： | 1 |
| 4 | The use of the holmium laser in the treatment of benign prostatic hyperplasia显示文摘 | Gilling P J Cass C B Malcolm A R | 1998 | Urology1998，51，： | 1 |
| 5 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 6 | Design, implementation and simulation analysis of a single-wellchemical tracer test to measure the residual oil saturation tohydroearbonmiscible gas atprudhoe bay 显示文摘 | Cockin A P Malcolm L T McGuire P L | 1998 | SPE 489511998，，： | 1 |
| 7 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 8 | HIV/AIDS and Injecting drug use : information, education and communication 显示文摘 | Aggleton P Jenkins P Malcolm A | 2005 | Int J Drug Policy2005，16，： | 1 |
| 9 | Chlorination of humicmaterials: byproduct formation and chemical interpretations 显示文摘 | Reckhow D A Singer P C Malcolm R L | 1990 | Environmental Science and Technology1990，24，： | 1 |
| 10 | Combination holmium and Nd:YAG laser ablation of the prostate:initial clinical experience显示文摘 | Gilling P J Cass C B Malcolm A R | 1995 | J Endcurol1995，9，： | 1 |
| 11 | Chlorination of humic materials: Byproduct formation and chemical interpretations显示文摘 | Reckhow D A Singer P C Malcolm R L | 1990 | Environmental Science & Technology1990，24，11： | 1 |
| 12 | Effect of seed size and testa colour on saponin content of Spanish lentil seed显示文摘 | RAQUEL G R KEITH R P MALCOLM E R | 1997 | Food Chem1997，58，3： | 1 |
| 13 | Combination holmium and Nd:YAG laser ablation of the prostate:initial clinical experience显示文摘 | Gilling P Cass C Malcolm A | 1995 | J Endourol1995，9，2： | 1 |
| 14 | Heavy Metal Distribution and Controlling Factors within Coastal Plain Sediments,Bells Creek Catchment,Southeast Queensland,Australia显示文摘 | Tania L Micaela P Malcolm C | 2003 | Environment International2003，29，： | 1 |
| 15 | Variables selection methods in near-infrared spectroscopy 显示文摘 | Zou Xiaobo Zhao Jiewen Malcolm J W P | 2010 | Analytica Chimica Acta2010，667，12： | 1 |
| 16 | Chlorination of Humic Materials:Byproduct Formation and Chemical Interpretations显示文摘 | RECKHOW D A SINGER P C MALCOLM R L | 1990 | Environ Sci Technol1990，24，： | 1 |
| 17 | Anti-MRSA β-lactams in development显示文摘 | Malcolm P | 2006 | Current Opinion in Pharmacology2006，6，5： | 1 |
| 18 | Assessing chronic toxicity of bisphenol A to larvae of the African clawed frog (Xenopus laevis) in a flow-through exposure system显示文摘 | Daniel B P Malcolm J H John E C | 2003 | Chemosphere2003，53，： | 1 |
| 19 | Biomedical research: increasing value, reducing waste显示文摘 | Malcolm R Macleod Susan Michie Ian Roberts Ulrich Dirnagl Iain Chalmers John P A Ioannidis Rustam Al-Shahi Salman An-Wen Chan Paul Glasziou | 2014 | The Lancet . 2014 (9912)2014，，9912： | 1 |
| 20 | Global warming and extinctions of endemic species from biodiversity hotspots显示文摘 | MALCOLM J R LIU C NEILSON R P | 2006 | Conservation Biology2006，20，2： | 1 |
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