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| 1 | Hypothalamic paraventricular nucleus stimulation reduces intestinal injury in rats with ulcerative colitis显示文摘AIM: To investigate the effect and mechanism of stimulation of the hypothalamic paraventricular nucleus with glutamate acid in rats with ulcerative colitis(UC).METHODS: The rats were anesthetized with 10% chloral hydrate via abdominal injection and treated with an equal volume of TNBS + 50% ethanol enema, injected into the upper section of the anus with the tail facing up. Colonic damage scores were calculated after injecting a certain dose of glutamic acid into the paraventricular nucleus(p VN), and the effect of the nucleus tractus solitarius(NTS) and vagus nerve in alleviating UC injury through chemical stimulation of the p VN was observed in rats. Expression changes of C-myc, Apaf-1, caspase-3, interleukin(IL)-6, and IL-17 during the protection against UC injury through chemical stimulation of the p VN in rats were detected by Western blot. Malondialdehyde(MDA) content and superoxide dismutase(SOD) activity in colon tissues of rats were measured by colorimetric methods. RESULTS: Chemical stimulation of the PVN significantly reduced UC in rats in a dose-dependent manner. The protective effects of the chemical stimulationof the p VN on rats with UC were eliminated after chemical damage to the p VN. After glutamate receptor antagonist kynurenic acid was injected into the p VN, the protective effects of the chemical stimulation of the p VN were eliminated in rats with UC. After AVpVl receptor antagonist([Deamino-penl, val4, D-Arg8]-vasopressin) was injected into NTS or bilateral chemical damage to NTS, the protective effect of the chemical stimulation of p VN on UC was also eliminated. After chemical stimulation of the p VN, SOD activity increased, MDA content decreased, C-myc protein expression significantly increased, caspase-3 and Apaf-1 protein expression significantly decreased, and IL-6 and IL-17 expression decreased in colon tissues in rats with UC. CONCLUSION: Chemical stimulation of the hypothalamic p VN provides a protective effect against UC injury in rats. Hypothalamic p VN, NTS and vagus nerve play key roles in this process. | Quan-Jun Deng Ding-Jing Deng Jin Che Hai-Rong Zhao Jun-Jie Yu Yong-Yu Lu | 2016 | World Journal of Gastroenterology2016，22，14： | 7 |
| 2 | Sirtuins在缺血再灌注损伤中的作用显示文摘缺血再灌注损伤是临床上一种复杂的病理生理过程,在器官移植中尤为重要。许多因素都能导致缺血再灌注损伤,如缺血过程中能量的缺失,再灌注过程中氧化应激的损伤均能启动一系列的机制,最终导致细胞死亡和器官的衰竭。由于能广泛调控细胞功能,sirtuins家族受到日益的关注。哺乳动物有7种sirtuins,在胞核和胞浆中表达的sirtuin 1(SIRT1)和在线粒体中表达的sirtuin 3(SIRT3)在多种组织器官中有广泛的表达。在缺血再灌注损伤(IRI)过程中,Sirtuins通过抵抗细胞应激和调节代谢发挥着重要的保护性作用。本文主要综述SIRT1和SIRT3在缺血的过程中抵御能量耗竭发挥的调节作用,及在再灌注过程中如何发挥其抗氧化、抗凋亡及抗炎的功能。 | 李魏芳 杨康 黄卫锋 | 2016 | 海南医学2016，27，16： | 1 |
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