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| 1 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 2 | T cells in sputum of asthmatic patients are activated independently of disease severity or control 显示文摘 | Lourenco O Mafalda Fonseca A Taborda-Barata L | 2009 | Allergol hnmunopathol2009，37，6： | 1 |
| 3 | Obesity and body fat distribution induce endothelial dysfunction by oxidative stress显示文摘 | Francesco Roberto Mafalda | 2001 | Diabetes2001，50，： | 1 |
| 4 | Tibia Valga due to Focal Fibrocartilaginous Dysplasia: Case Report显示文摘 | Mafalda Santos Eugénio Valente António Almada José Neves | 2002 | Journal of Pediatric Orthopaedics B2002，，2： | 1 |
| 5 | Fragmented limestone wastes as a constructed wetland substrate for phosphorus removal显示文摘 | Dina M.R. Mateus Mafalda M.N. Vaz Henrique J.O. Pinho | 2012 | Ecological Engineering2012，，： | 1 |
| 6 | Bioactive compounds of red grapes from Dao region(Portugal):Evaluation of phenolic and organic profile显示文摘Objective:To improve the knowledge on the metabolite profile of five red grapes from D?o region(Portugal),concerning to the phenolic characteristics(coloured and non-coloured phenolics) and organic acid composition.Methods:Five red grapes collected from D?o region were studied.The profiles of phenolic compounds and organic acids were estimated by high-performance liquid chromatography with diode-array detection and high-performance liquid chromatography with UV detector,respectively.Results:Totally 24 phenolic compounds were identified,and distributed by several classes:8 anthocyanins,1 hydroxybenzoic acid,4 hydroxycinnamic acids,1 stilbene,4flavan-3-ols,6 flavonols.Additionally,10 organic acids were detected in all samples.Total contents of each phenolic class and organic acids amounts varied significantly among the different grape cultivars investigated.The principal components analysis differentiates the Touriga Nacional from the other varieties due to their high contents in anthocyanins,non-coloured phenolics and organic acids.Touriga Nacional is an important red grape cultivar,highly esteemed in D?o region for its ability to produce high quality wines.Conclusions:The results suggest that the red grapes from D?o region present a good composition in bioactive compounds,being important for the production of wines with superior quality. | Luís Rodrigues Silva Mafalda Queiroz | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，4： | 1 |
| 7 | Microbial performance in soils along a salinity gradient under acidic conditions显示文摘 | Mafalda Sardinha Torsten Muller Helge Schmeisky | 2003 | Applied Soil Ecology2003，23，： | 1 |
| 8 | The use of Chironomus riparius larvae to assess effects of pesticides from rice fields in adjacent freshwater ecosystems显示文摘 | Mafalda S Antonio J A Nogueira | 2006 | Ecotoxlcol Environ Saf2006，67，2： | 1 |
| 9 | Hospital nurses tasks and work-related musculoskeletal disorders symp- toms: A detailed analysis 显示文摘 | Serranbeira Florentino Sousa-Uva Mafalda Sousa-Uva | 2014 | Galley Proof2014，8，： | 1 |
| 10 | Identification of DNA markers linked to an induced mutated gene conferring resistance to powdery mildew in pea ( Pisum sativum L.)显示文摘 | Gra?a Pereira Cátia Marques Rui Ribeiro Sandra Formiga Mafalda Damaso M. Tavares Sousa Mário Farinhó José M. Leit?o | 2010 | Euphytica2010，，3： | 1 |
| 11 | Hospital nurses tasks and work-related musculaskeletal disorders symptoms: A de- tailed analysis 显示文摘 | Serranbeira Florentino Sousa-Uva Mafalda Sousa-Uva | 2014 | Galley Proof2014，8，： | 1 |
| 12 | Flavour Development via Lipolysis of Milkfats:Changes in Free Fatty Acid Pool 显示文摘 | MAFALDA A R BETINA M C | 2007 | International Journal of Food Science and Technology2007，42，8： | 1 |
| 13 | A studyon the aqueous dispersion mechanism of CuO powdersusing Tiron显示文摘 | Mafalda Guedes Jose M F Alberto C Ferro | 2009 | J Colloids Interface Sci2009，330，： | 1 |
| 14 | Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours显示文摘 | Andrew Rowland Mafalda M. Dias Michael D. Wiese Ganessan Kichenadasse Ross A. McKinnon Christos S. Karapetis Michael J. Sorich | 2015 | European Journal of Cancer2015，，： | 1 |
| 15 | XANTHINE OXIDASE RELEASED FROM REPERFUSED HIND LIMBS MEDIATE KüPFFER CELL ACTIVATION, NEUTROPHIL SEQUESTRATION, AND HEPATIC OXIDATIVE STRESS IN RATS SUBJECTED TO TOURNIQUET SHOCK显示文摘 | Virginia L. Vega Lorena Mardones Mafalda Maldonado Sandra Nicovani Verónica Manríquez Jorge Roa Peter H. Ward | 2000 | Shock2000，，5： | 1 |
| 16 | Physico-chemical characterization of chitosan-based edible films incorporating bioactive compounds of different molecular weight显示文摘 | Ana I. Bourbon Ana C. Pinheiro Miguel A. Cerqueira Cristina M.R. Rocha Maria C. Avides Mafalda A.C. Quintas António A. Vicente | 2011 | Journal of Food Engineering2011，，2： | 1 |
| 17 | Fate and effects of octylphenol in a microcystis aerug- inosa culture medium 显示文摘 | BAPTISTA - MAFALDA S TEODOR S BASTO M | 2009 | Aquatic Toxicology2009，92，2： | 1 |
| 18 | New Family of Bluish Pyranoanthocyanins显示文摘 | Nuno Mateus Joana Oliveira Mafalda Haettich-Motta Victor de Freitas | 2004 | Journal of Biomedicine and Biotechnology2004，，5： | 1 |
| 19 | Flavour Development via Lipolysis of Milkfats- Changes in Free Fatty Acid Pool显示文摘 | MAFALDA A R BETINA M C | 2007 | International Journal of Food Science and Technology2007，42，8： | 1 |
| 20 | Impact of the UGT1A1*28 allele on response to irinotecan: a systematic review and meta-analysis显示文摘 | Mafalda M Dias Ross A McKinnon Michael J Sorich | 2012 | Pharmacogenomics2012，，8： | 1 |
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