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| 1 | Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms显示文摘Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow diverters.Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications afterwards.We sought to determine the safety of tirofiban and DAPT in these cases.Methods We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow diversion.The tirofiban-DAPT protocol used is described.Data regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and analysed.results One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 electively.Minor and major haemorrhagic events were recognised in 20%(30/148)aneurysms.Only 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 EVD-related.The average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were symptomatic.Most haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was documented.Concomitant administration of heparin did not increase haemorrhagic events.Conclusion The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was safe.Tirofiban and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications. | Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan | 2019 | Stroke & Vascular Neurology2019，4，1： | 17 |
| 2 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 3 | A common neural progenitor for the CNS and PNP 显示文摘 | Mujataba T Mayer PM Roa MS | 1998 | Dev Biol1998，200，1： | 1 |
| 4 | Laparoscopic sleeve gastrectomy as treatment for morbid obesity:technique and short-term outcome显示文摘 | Roa PE Kaidar-Person O Pinto D | 2006 | Obes Surg2006，16，10： | 1 |
| 5 | Synthesis of a CrCoAPO-5(AFI) molecular sieve and its activity in cyclohexane oxidation in the liquid phase显示文摘 | Masters A F Beattie James K Roa Adriana L | 2001 | Catal Lett2001，75，34： | 1 |
| 6 | Prognostic factors of phyllodes tumor of the breast 显示文摘 | Roa JC Tapia O Carrasco P | 2006 | Pathol Int2006，56，6： | 1 |
| 7 | Sexual differentiation of Kissl gene expression in the brain of the rat 显示文摘 | Kauffman AS Gottsch ML Roa J | 2007 | Endocrinology2007，148，4： | 1 |
| 8 | The impact of cy- clic wettingand drying on the swelling behaviour of stabilized expansive soils 显示文摘 | Roa S M Reddy B V V Muttharam M | 2001 | Engineering Geology2001，60，： | 1 |
| 9 | Synthesis of a CrCo-APO-5(AFI) molecular sieve and its activi- ty in cyelohexane oxidation in the liquid phase显示文摘 | MASTERS A F BEATTIE J K ROA A L | 2001 | Catal Lett2001，75，34： | 1 |
| 10 | Squamous cell andanalysis of 34 cases identified in 606 carcinomas 显示文摘 | Roa J C Tapia 0 Cakir A | 2011 | ModPathol2011，24，8： | 1 |
| 11 | Magnetic targeting of aerosol particles for cancer therapy显示文摘 | Javed Ally Benjamin Martin Mir Behrad Khamesee Wilson Roa Alidad Amirfazli | 2005 | Journal of Magnetism and Magnetic Materials2005，，1： | 1 |
| 12 | A novel mathematical method based on urea kinetic modeling for computing the dialysis dose 显示文摘 | Prado M Roa L Palma A | 2004 | Comput Methods Programs Biomed2004，74，： | 1 |
| 13 | Differentiation of benign from malignant superficial lympholenopathy the role of high - resolution US 显示文摘 | VASSALLO P WERNECKE K ROAS N | 1992 | Radiology1992，183，： | 1 |
| 14 | Calcium/ealmodulin-dependent protein kinase II regulation of c-FLIP expression and phospho rylation in modulation of Fas-mediated signaling in malignant glioma cells显示文摘 | Yang BF Xiao C Roa WH | 2003 | J Biol Chem2003，278，9： | 1 |
| 15 | 显示文摘 | Udaya V Roa S | 1983 | Zeolites1983，3，： | 1 |
| 16 | Prognatic factor of phyllodes tumor of the breast显示文摘 | Juan carlos Roa Oscar Tapia Paula Carrasco | 2006 | Pathol Inter2006，56，2： | 1 |
| 17 | Ki SS-1/kisspeptins and the metabolic control of reproduction:physiologic roles and putative physiopathological implications显示文摘 | Castellano JM Roa J Luque RM | 2009 | Peptides2009，30，1： | 1 |
| 18 | Comparison of three image segmentation techniques for target volume delineation in positron emission tomography显示文摘 | Drever LA Roa W McEwan A | | 0，，： | 1 |
| 19 | Use of 5% hdoealne medicated plaster to treat localized neuropathic pain secondary to traumatic injury of peripheral nerves显示文摘 | Correa IG Roa R Pineros JL | 2012 | Local Reg Anesth2012，5，： | 1 |
| 20 | Recent advances in electrochemistry of diamond 显示文摘 | ROA T N FUJISHIMA A | 2000 | Diamond and Related Materials2000，9，： | 1 |
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