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| 1 | Applicability of the PRECISE-DAPT score in elderly patients with myocardial infarction显示文摘Background Elderly patients with acute coronary syndromes(ACS)are at higher risk both for ischemic and bleeding complications.Current guidelines recommend the PRECISE-DAPT score for bleeding risk stratification in this setting,but no study assessed its applicability in elderly patients.This study aimed to assess the performance of the PRECISE-DAPT score in a series of non-selected elderly patients with ACS from routine clinical practice.Methods The IFFANIAM registry included prospectively patients aged>75 years with ST segment elevation myocardial infarction(STEMI).Main outcome measured was the incidence of relevant bleeding after discharge(bleeding leading to hospital readmission,need for transfusion,intervention,stop of antithrombotic drugs or death).Bleeding risk was classified:(A)according to PRECISE-DAPT values above or not the recommended cut-off point(>25);and(B)according to the quartiles of PRECISE-DAPT values observed in the IFFANIAM series(QI:<30;Q2:30-35;Q3:36-44;Q4:>45).Results A total of 208 patients were included.Mean age was 81.9±4.5 years.Most patients(92.6%)had a PRECISE-DAPT value>25.A total of 25 patients(12.0%)had bleeding events and 49 patients(23.6%)died.No significant differences regarding the incidence of bleeding were observed according to the recommended cutt of point>25.However,a progressive increase in the incidence of bleeding was observed across PRECISE-DAPT quartiles observed in this series(P=0.038).Conclusions The vast majority of elderly patients have PRECISE-DAPT values above the recommended cut-off point for bleeding risk.Using different cut-off points could be a more rational approach for predicting bleeding risk in these complex patients. | Albert Ariza-Sole Francesc Formiga Manuel Martinez-Selles Maria T Vidan Jaime Aboal | 2018 | Journal of Geriatric Cardiology2018，15，12： | 5 |
| 2 | Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes显示文摘Background Elderly patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS)may present delirium but its clinical relevance is unknown.This study aimed at detennining the clinical associated factors,and prognostic implications of delirium in old-aged patients admitted for NSTE-ACS.Methods LONGEVO-SCA is a prospective multicenter registry including unselected patients with NSTE-ACS aged>80 years.Clinical variables and a complete geriatric evaluation were assessed during hospitalization.The association between delirium and 6-month mortality was assessed by a Cox regression model weighted for a propensity score including the potential confounding variables.We also analysed its association with 6-month bleeding and cognitive or functional decline.Results Among 527 patients included,thirty-seven(7%)patients presented delirium during the hospitalization.Delirium was more frequent in patients with dementia or depression and in those from nursing homes(27.0%vs.3.1%,24.3%vs.11.6%,and 11.1%V5.2.2%,respectively;all P<0.05).Delirium was significantly associated with in-hospital infections(27.0%vs.5.3%,P<0.001)and usage of diuretics(70.3%vs.49.8%,P=0.02).Patients with delirium had longer hospitalizations[median 8.5(5.5-14)vs.6.0(4.0-10)days,P=0.02]and higher incidence of 6-month bleeding and mortality(32.3%vs.10.0%and 24.3%vs.10.8%,respectively;both P<0.05)but similar cognitive or functional decline.Delirium was independently associated with 6-month mortality(HR=1.47,95%CI:1.02-2.13,P=0.04)and 6-month bleeding events(OR=2.87;95%CI:1.98-4」6,P<0.01).Conclusions In-hospital delirium in elderly patients with NSTE-ACS is associated with some preventable risk factors and it is an independent predictor of 6-month mortality. | Miquel Vives-Borras Manuel Martinez-Selles Albert Ariza-Sole Maria T.Vidan Francesc Formiga Hector Bueno Juan Sanchis Oriol Alegre Albert Duran-Cambra Ramon Lopez-Palop Emad Abu-Assi Alessandro Sionis LONGEVO-SCA Investigators | 2019 | Journal of Geriatric Cardiology2019，16，2： | 3 |
| 3 | Elderly patients with acute coronary syndromes: a continuous tsunami显示文摘The progressive ageing of the population and the high incidence of acute coronary syndromes(ACS)in the elderly is leading to an important increase in the number of elderly patients admitted for ACS.[1]Nevertheless,the information about the optimal clinical management in this age group is scarce due to the exclusion of older patients from clinical trials.[2]Higher comorbidity and frailty are common in this clinical setting and they are associated with higher rates of complications and consumption of healthcare resources.[3]These are the main reasons for launching this special issue about management of ACS in the elderly,in which several experts in the field address some of the most important questions about how to deal with ACS in patients at older ages. | Francesc Formiga Albert Ariza-Sole | 2019 | Journal of Geriatric Cardiology2019，16，2： | 2 |
| 4 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 5 | Inter-rater reliability of the Barthel Index显示文摘 | Formiga F Mascaro J Pujol R | 2005 | Age and Ageing2005，34，： | 1 |
| 6 | Diagnosis of heart failure with preserved ejection fraction: still a challenge显示文摘 | Perez-Calvo JI Montero-Perez-Barquero M Formiga F | 2013 | J Am Coil Cardiol2013，61，16： | 1 |
| 7 | Antiproliferative and apoptotic potencies of glucocorticoids:nonconcordance with their antiinflammatory and immunosuppressive properties显示文摘 | Longui CA Santos MC Formiga CB | 2005 | Arq Bras Endocrinol Metabol2005，49，： | 1 |
| 8 | Maytenus erythroxylon Reissek(Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms显示文摘AIM To investigate the acute toxicity,phytochemical profile,antidiarrheal activity and mechanisms of action of Maytenus erythroxylon(M.erythroxylon)ethanol extract.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to evaluate a possible antimotility effect.KATP channels,nitric oxide,presynapticα2-adrenergic and tissue adrenergic receptors were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.RESULTS All tested doses of the extract(62.5,125,250 and 500 mg/kg)possessed antidiarrheal activity,with a significant decrease of the evacuation index.This activity is possibly related to a reduced gastric emptying(125,250 and 500 mg/kg)and to a decreased percentage of intestinal transit for all tested doses.That last effect seems to be modulated by nitric oxide,KATP channels and tissue adrenergic receptors.Besides,the extract also presented antisecretory effect due to a decrease of intestinal fluid accumulation.CONCLUSION The antidiarrheal effect of M.erythroxylon found in this study involves antimotility and antisecretory mechanisms that may be attributed to the chemical compounds found in this species:saponins,flavonoids,tannins,triterpenes and steroids. | Rodrigo de Oliveira Formiga Zelma Glebya Maciel Quirino Margareth de Fátima Formiga Melo Diniz Alexsandro Fernandes Marinho Josean Fechine Tavares Leonia Maria Batista | 2017 | World Journal of Gastroenterology2017，23，24： | 1 |
| 9 | Extracting user prelerences by GTM for AiGA weight tuning in unit selection text to speech synthesis显示文摘 | Formiga L Alias F | 2007 | Lecture Notes in Computer Science2007，4507，： | 1 |
| 10 | Spironolactone in patients with heart failure and preserved ejection fraction显示文摘 | Smchez-S6nchez C Mendoza-Ruiz de Zuazu HF Formiga F | 2015 | Rev Clin Esp2015，215，6： | 1 |
| 11 | The im- pact of obesity in the kinematic parameters of gait in young women 显示文摘 | da Silva-Hamu TC Formiga CK Gervsio FM | 2013 | Int J Gen Med2013，6，： | 1 |
| 12 | Multifactorial assessment and targeted intervention in nutritional status among theolder a dults: a randomized controlled trial: the Octabaix study显示文摘 | Badia T Formiga F Ferrer A | 2015 | BMC Geriatrics2015，15，： | 1 |
| 13 | Spontaneous formation of highly dispersed spheroidal metallic silver nanoparticles in surfactant-free N, N-dimethylacetamide 显示文摘 | COSTADA L P FORMIGA A L B MAZALI I O | 2011 | Synthetic Metals2011，32，5： | 1 |
| 14 | Patterns of comorbidityand multimorbidity in the oldest old: the Octabaix study显示文摘 | Formiga F Ferrer A Sanz H | 2013 | Eur J Intern Med2013，24，1： | 1 |
| 15 | PEGylated-PLGA microparticles containing VEGF for long term drug delivery 显示文摘 | Simon-Yarza T Formiga FR Tamayo E | 2013 | Int J Pharmaceut2013，440，1： | 1 |
| 16 | Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegrada- ble microparticles promotes cardiac repair in a rat myocardial in- farction model through activation of endogenous regeneration 显示文摘 | Formiga FR Pelacho B Garbayo E | 2014 | J Control Release2014，173，： | 1 |
| 17 | Conduction and photoelcctrochemical properties of monomeric and electropolymerized tetraruthenated porphyrin films 显示文摘 | Nogueira A F Formiga A L B Winnischofer H | 2005 | Photochem Photobio Sci2005，4，： | 1 |
| 18 | Evaluation of potential indicators of viral contamination in shellfish and their applicability to diverse geographical areas显示文摘 | Formiga CM Allard AK Conden-Hansson AC | 2003 | Appl Environ Microbiol2003，69，： | 1 |
| 19 | Prevalence of malnutrition in Spanish elders: systematicreview显示文摘 | Mila Villarroel R Formiga F Duran Alert P | 2012 | Med Clin (Barc)2012，139，11： | 1 |
| 20 | Cell surface hydrophobicity of sucrose fermenting and nonfermenting Corynebacterium diphtheriae strains evaluated by different methods显示文摘 | Mattos-Guaraldi A L Formiga L C D Andrade A F B | 1999 | Curr Microbiol1999，38，1： | 1 |
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