|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients显示文摘AIM:To investigate possible associations of anti-nuclear envelope antibody(ANEA)with disease severity and survival in Greek primary biliary cirrhosis(PBC)patients.METHODS:Serum samples were collected at diagnosis from 147 PBC patients(85%female),who were followed-up for a median 89.5 mo(range 1-240).ANEA were detected with indirect immunofluorescence on 1% formaldehyde fixed Hep2 cells,and anti-gp210 antibodies were detected using an enzyme linked immunosorbent assay.Findings were correlated with clinical data,histology,and survival.RESULTS:ANEA were detected in 69/147(46.9%) patients and 31/147(21%)were also anti-gp210 positive.The ANEA positive patients were at a more advanced histological stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ56.5%/43.5% vs 74.4%/25.6%,P=0.005)compared to the ANEA negative ones.They had a higher antimitochondrial antibodies(AMA)titer(≤1:160/>1:160 50.7%/49.3%vs 71.8%/28.2%,P=0.001)and a lower survival time(91.7 ±50.7 mo vs 101.8±55 mo,P=0.043).Moreover,they had more advanced fibrosis,portal inflammation,interface hepatitis,and proliferation of bile ductules(P =0.008,P=0.008,P=0.019,and P=0.027,respectively).They also died more frequently of hepatic failure and/or hepatocellular carcinoma(P=0.016).ANEA positive,anti-gp210 positive patients had a difference in stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ54.8%/45.2%vs 74.4%/25.6%,P= 0.006),AMA titer(≤1:160/>1:160 51.6%/48.4%vs 71.8%/28.2%,P=0.009),survival(91.1±52.9 mo vs 101.8±55 mo,P=0.009),and Mayo risk score(5.5 ±1.9 vs 5.04±1.3,P=0.04)compared to the ANEA negative patients.ANEA positive,anti-gp210 negative patients had a difference in AMA titer(≤1:160/>1:160 50%/50%vs 71.8%/28.2%,P=0.002),stage(Ⅰ-Ⅱ/Ⅲ -Ⅳ57.9%/42.1%vs 74.4%/25.6%,P=0.033),fibrosis(P=0.009),portal inflammation(P=0.018),interface hepatitis(P=0.032),and proliferation of bile ductules(P=0.031).Anti-gp210 positive patients had a worse Mayo risk score(5.5±1.9 vs 4.9±1.7,P=0.038)than the anti-gp210 negative ones.CONCLUSION:The presence of ANEA and anti-gp210 identifies a subgroup of PBC patients with advanced disease severity and poor prognosis. | Ourania Sfakianaki Meri Koulentaki Maria Tzardi Elena Tsangaridou Panayotis A Theodoropoulos Elias Castanas Elias A Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，39： | 11 |
| 2 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 3 | 雅漾活泉水用于499例中国人激光光子术后皮肤护理的有效性研究显示文摘目的观察雅漾活泉水对中国人激光光子术后皮肤护理的有效性。方法采用多中心开放式研究,收集中国13个城市、19所医院、499名有美容需求的病例,采用点阵激光、IPL等进行治疗。激光光子术后即刻开始使用雅漾活泉水,每天使用至少4次,连续7天,医生和患者分别进行5次和7次记录。通过填写10cm视觉模拟尺和有效性及耐受性评分评估患者治疗后不适感的改善情况。结果首次使用雅漾活泉水15分钟后所有激光术后不适感的临床症状都有显著改善(P<0.001)。术后第7天评价总有效率达100%,患者刺痛、疼痛、红斑的改善高于80%;84%的患者认为有效和非常有效;99%的患者认为耐受性好。结论雅漾活泉水能减轻中国人激光光子术后皮肤的不适感,有良好的辅助治疗作用。 | 徐阳 杨蓉娅 赵小忠 涂平 孙秋宁 赵俊英 卢忠 陈向东 王秀丽 周展超 许爱娥 杨森 高天文 郝飞 李利 何黎 杨慧兰 高兴华 刘晓明 王玮蓁 沈新 朱晓丹 Sophie Mery | 2011 | 实用皮肤病学杂志2011，4，2： | 7 |
| 4 | Physiology of gangliosides and the role of antiganglioside antibodies in human diseases显示文摘Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human body.They play important roles in protecting us against immune attacks,yet they can become targets for autoimmunity and act as receptors for microbes,like the influenza viruses,and toxins,such as the cholera toxin.The expression patterns of gangliosides vary in different tissues,during different life periods,as well as in different animals.Antibodies against gangliosides(AGA)can target immune attack e.g.,against neuronal cells and neutralize their complement inhibitory activity.AGAs are important especially in acquired demyelinating immune-mediated neuropathies,like Guillain–Barrésyndrome(GBS)and its variant,the Miller–Fisher syndrome(MFS).They can emerge in response to different microbial agents and immunological insults.Thereby,they can be involved in a variety of diseases.In addition,antibodies against GM3 were found in the sera of patients vaccinated with Pandemrix®,who developed secondary narcolepsy,strongly supporting the autoimmune etiology of the disease. | Gianni Cutillo Anna-Helena Saariaho Seppo Meri | 2020 | Cellular & Molecular Immunology2020，17，4： | 6 |
| 5 | STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation显示文摘 | Hazel Tye Catherine L. Kennedy Meri Najdovska Louise McLeod William McCormack Norman Hughes Anouk Dev William Sievert Chia Huey Ooi Tomo-o Ishikawa Hiroko Oshima Prithi S. Bhathal Andrew E. Parker Masanobu Oshima Patrick Tan Brendan J. Jenkins | 2012 | Cancer Cell2012，，4： | 3 |
| 6 | Evaluation of Weather Research and Forecasting Model Parameterizations under Sea-Breeze Conditions in a North Sea Coastal Environment显示文摘Three atmospheric boundary layer(ABL) schemes and two land surface models that are used in the Weather Research and Forecasting(WRF) model, version 3.4.1, were evaluated with numerical simulations by using data from the north coast of France(Dunkerque). The ABL schemes YSU(Yonsei University),ACM2(Asymmetric Convective Model version 2), and MYJ(Mellor–Yamada–Janjic) were combined with two land surface models, Noah and RUC(Rapid Update Cycle), in order to determine the performances under sea-breeze conditions. Particular attention is given in the determination of the thermal internal boundary layer(TIBL), which is very important in air pollution scenarios. The other physics parameterizations used in the model were consistent for all simulations. The predictions of the sea-breeze dynamics output from the WRF model were compared with observations taken from sonic detection and ranging, light detection and ranging systems and a meteorological surface station to verify that the model had reasonable accuracy in predicting the behavior of local circulations. The temporal comparisons of the vertical and horizontal wind speeds and wind directions predicted by the WRF model showed that all runs detected the passage of the sea-breeze front. However, except for the combination of MYJ and Noah, all runs had a time delay compared with the frontal passage measured by the instruments. The proposed study shows that the synoptic wind attenuated the intensity and penetration of the sea breeze. This provided changes in the vertical mixing in a short period of time and on soil temperature that could not be detected by the WRF model simulations with the computational grid used. Additionally, among the tested schemes, the combination of the localclosure MYJ scheme with the land surface Noah scheme was able to produce the most accurate ABL height compared with observations, and it was also able to capture the TIBL. | SALVADOR Nadir REIS Jr. Neyval Costa SANTOS Jane Meri ALBUQUERQUE Taciana Toledo de Almeida LORIATO Ayres Geraldo DELBARRE Herve AUGUSTIN Patrick SOKOLOV Anton MOREIRA Davidson Martins | 2016 | Journal of Meteorological Research2016，30，6： | 3 |
| 7 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 8 | Contrast-enhanced coronary artery visualization by dual-source computed tomography—Initial experience显示文摘 | Stephan Achenbach Dieter Ropers Axel Kuettner Thomas Flohr Bernd Ohnesorge Herbert Bruder Heike Theessen Meri Karakaya Werner G. Daniel Werner Bautz Willi A. Kalender Katharina Anders | 2005 | European Journal of Radiology2005，，3： | 3 |
| 9 | 合并心力衰竭和(或)左室功能障碍的心肌梗死患者中的二尖瓣反流:预后意义及其与左室大小和功能的关系显示文摘目的:二尖瓣反流(MR)是急性心肌梗死患者的独立危险因素。用来自VALIANT(缬沙坦在急性心肌梗死中的应用)超声研究的数据来分析基线MR与左室(LV)大小、形状和功能之间的关系,并评估基线MR及MR进展和心血管(CV)预后间的关系。方法和结果:研究了496例在心肌梗死(MI)后中位期5d接受超声心动图检查的合并心力衰竭(HF)和(或)收缩功能障碍的MI后患者。分别在基线、MI后1个月和MI后20个月时检测MR严重程度(通过反流喷射面积/左房面积比值定量),将该指标与LV大小、形状、功能和临床预后进行相关性分析。 | Amigoni M. Meris A. Thune J.J. 刘少伟 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，3，7： | 2 |
| 10 | Accumulation of heavy metals from contaminated soil to plants and evaluation of soil remediation by vermiculite显示文摘 | Mery Malandrino Ornella Abollino Sandro Buoso Agnese Giacomino Carmela La Gioia Edoardo Mentasti | 2010 | Chemosphere2010，，2： | 2 |
| 11 | Presence of disease specific autoantibodies against liver sinusoidal cells in primary biliary cirrhosis显示文摘AIM: To investigate the presence of autoantibodies directed against liver sinusoidal cells in primary biliary cirrhosis(PBC).METHODS: Liver biopsies from 21 PBC patients were studied and compared with 12 liver biopsies from disease controls [3 patients with hepatitis B(HBV) virus,3 patients with hepatitis C virus(HCV), 3 patients with non-alcoholic steatohepatitis and 3 patients with acute alcoholic hepatitis(AAH)]. As healthy controls, we used tissue specimens adjacent to metastatic liver adenocarcinoma. Normal serum was taken from staff members of the unit. The determination of the cell type targetedby autoantibodies present in the patients sera was performed by indirect immunofluorescence(IIF) analysis using paraffin-embedded liver sections as a substrate.Sera from homologous or heterologous PBC patients or sera from the disease control group were used as primary antibodies. The presence of autoantibodies was identified using confocal microscopy.RESULTS: In total, 18/21(85.7%) PBC patients exhibited positive staining in the sinusoidal cells, 10/21(47.6%) in lymphocytes, 8/21(38%) in cholangiocytes and 7/21(33.3%) in hepatocytes, when homologous serum and fluorescein isothiocyanate-conjugated immunoglobulin type G(IgG) secondary antibody were used. PBC sections incubated with heterologous PBC serum showed reduced staining(20% for sinusoidal cells, 20% for lymphocytes, 20% for cholangiocytes and 13.3% for hepatocytes). When IgM immunoglobulin, instead of IgG, was used as secondary antibody,positive staining was observed in 75% of lymphocytes,62.5% of cholangiocytes, 37.5% of hepatocytes and50% of the sinusoidal cells with a much stronger staining intensity. No staining was observed when either normal or PBC sera were used as a primary antibody on liver sections from the disease control group. When PBC sera were incubated with healthy control sections,weak positive staining of cholangiocytes was observed in 3/21(14.3%) PBC serum samples. Steatohepatitis serum on PBC sections gave a positive staining of some hepatocytes and lymphocytes but no staining on viral hepatitis sections. Incubation with HBV sera stained some hepatocytes, cholangiocytes and intra-sinusoidal or portal lymphocytes of PBC, HBV and AAH patients but not HCV patients.CONCLUSION: In this study, for the first time in diseased liver tissue, we have demonstrated that a large proportion of PBC patients have disease specific autoantibodies against liver sinusoidal cells. | Ourania Sfakianaki Maria Tzardi Argyro Voumvouraki Aikaterini Afgoustaki Meri Koulentaki Elias Kouroumalis | 2013 | World Journal of Hepatology2013，5，10： | 2 |
| 12 | Association of Early Repolarization and Sudden Cardiac Death During an Acute Coronary Event显示文摘 | Jani T. Tikkanen Viktor Wichmann M. Juhani Junttila Meri Rainio Eeva Hookana Olli-Pekka Lappi Marja-Leena Kortelainen Olli Anttonen Heikki V. Huikuri | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，4： | 2 |
| 13 | Overview of in-situ applicable nitrate removal processes显示文摘 | Claudio Della Rocca Vincenzo Belgiorno Sureyya Meri? | 2006 | Desalination2006，，1： | 2 |
| 14 | Android fat ditribution as predictor of severity in acute pancreatitis 显示文摘 | Mery CM Rubio V Duarte - Rojo A | 2002 | Pancreatology2002，2，6： | 1 |
| 15 | A peptide carrier for the delivery of biologically active proteins into mammalian cells显示文摘 | Morris MC Depdlier J Mery J | 2001 | Nat Biotechnol2001，19，12： | 1 |
| 16 | B-type natriuretic peptide(BNP)and N-terminal proBNP in patients with end-stage heart failure supported by a left ventricular assist device显示文摘 | Hans K Mery B Hans K | 2004 | Clin Chem2004，50，9： | 1 |
| 17 | A peptide carrier for the delivery of biologically active proteins into mammalian cells显示文摘 | Morris MC Depollier J Mery J | 2001 | Nat Biotechnol2001，19，12： | 1 |
| 18 | B-type natriuretic peptide (BNP) and N-terminal proBNP in patients with end-stage heart failure supported by a leftventricular assist device显示文摘 | Hans K Mery B | 2004 | Clin Chem2004，50，： | 1 |
| 19 | A novel potent strategy for gene delivery using a single peptide vector as a carrier显示文摘 | Morris M C Chaloin L Mery J | 1999 | Nucleic Acids Res1999，27，17： | 1 |
| 20 | Polycyclic Aromatic Hydrocarbons (PAHs) Slurry Phase Bioremediation of a Manufacturing Gas Plant (MGP) Site Aged Soil显示文摘 | Sabrina Saponaro Luca Bonomo Gianniantonio Petruzzelli Laura Romele Meri Barbafieri | 2002 | Water Air and Soil Pollution2002，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员