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| 1 | Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer显示文摘AIM:To investigate feasibility,morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer.METHODS:Patients suffering from locally-advanced(T3-4 any N M0 or any T N1-3 M0)gastric carcinoma,staged with endoscopic ultrasound,bone scan,computed tomography,and laparoscopy,were assigned to receive four 21 d/cycles of TCF(docetaxel 75 mg/m 2 day 1,cisplatin 75 mg/m 2 day 1,and fluorouracil 300 mg/m 2 per day for days 1-14),either before(Arm A)or after(Arm B)gastrectomy.Operative morbidity,overall mortality,and severe adverse events were compared by intention-to-treat analysis.RESULTS:From November 1999 to November 2005,70 patients were treated.After preoperative TCF(Arm A),thirty-two(94%)resections were performed,85% of which were R0.Pathological response was complete in 4 patients(11.7%),and partial in 18(55%).No surgical mortality and 28.5%morbidity rate were observed,similar to those of immediate surgery arm(P= 0.86).Serious chemotherapy adverse events tended to be more frequent in arm B(23%vs 11%,P=0.07),with a single death per arm.CONCLUSION:Surgery following docetaxel-based chemotherapy was safe and with similar morbidity to immediate surgery in patients with locally-advanced resectable gastric carcinoma. | Roberto Biffi Nicola Fazio Fabrizio Luca Antonio Chiappa Bruno Andreoni Maria Giulia Zampino Arnaud Roth Jan Christian Schuller Giancarla Fiori Franco Orsi Guido Bonomo Cristiano Crosta Olivier Huber | 2010 | World Journal of Gastroenterology2010，16，7： | 43 |
| 2 | Combined locoregional treatment of patients withhepatocellular carcinoma: state of the art显示文摘In recent years, a combination of intervention therapies has been widely applied in the treatment of hepatocellular carcinoma(HCC). One such combined strategy is based on the combination of the percutaneous approach, such as radiofrequency ablation(RFA), and the intra-arterial locoregional approach, such as trans-arterial chemoembolization(TACE). Several types of evidence have supported the feasibility and benefit of combined therapy, despite some studies reporting conflicting results and outcomes. The aim of this review was to explain the technical aspects of different combined treatments and to comprehensively analyze and compare the clinical efficacy and safety of this combined treatment option and monotherapy, either as TACE or RFA alone, in order to provide clinicians with an unbiased opinion and valuable information. Based on a literature review and our experience, combined treatment seems to be a safe and effective option in the treatment of patients with early/intermediate HCC when surgical resection is not feasible; furthermore, this approach provides better results than RFA and TACE alone for the treatment of large HCC, defined as those exceeding 3 cm in size. It can also expand the indication for RFA to previously contraindicated 'complex cases', with increased risk of thermal ablation related complications due to tumor location, or to 'complex patients' with high bleeding risk. | Roberto Iezzi Maurizio Pompili Alessandro Posa Giuseppe Coppola Antonio Gasbarrini Lorenzo Bonomo | 2016 | World Journal of Gastroenterology2016，22，6： | 15 |
| 3 | Definitive palliation for neoplastic colonic obstruction using enteral stents:Personal case-series with literature review显示文摘Acute colonic obstruction due to malignancies is an emergency that requires surgical treatment. Elderly patients or inoperable tumors require intestinal decompression that is a simple colostomy in almost all cases. This “manoeuvre” leads the patient to a percentage of mortality/morbidity and to a bad quality of life due to acceptance of stoma. The introduction of enteral metal stent inserted endoscopically has, in our opinion, provided a new way to obtaining the definitive palliation of inoperable colo-rectal cancer with a simple method. We reported our case-series and we analyzed the current literature and costs of treatments. | Giuseppe Piccinni Anna Angrisano Mario Testini G.Martino Bonomo | 2004 | World Journal of Gastroenterology2004，10，5： | 7 |
| 4 | Eumelanins as free radical trap and superoxide dismutase activities in amphibia显示文摘 | Geremia Corsaro C Bonomo R | 1984 | Comp Priochem Physiol1984，98，1： | 1 |
| 5 | Acid-activated etal from Peanut Shells:Synthesis,Eharacterization and uptake of organic compounds from aqueous solutions 显示文摘 | Luis C Romero Antonio Bonomo Elio E Gonzo | 2003 | Adsorption Science & Tech- nology2003，21，7： | 1 |
| 6 | Enhanced electron screening in D(d, p)T for deuterated metals 显示文摘 | RAIOLA F LIAN G BONOMO C | 2004 | Eur Phys J A2004，19，： | 1 |
| 7 | Gestational diabetes mellitus in Italy:a multicenter study显示文摘 | Lapolla A Dalfra MG Bonomo M | 2009 | Eur J Obstet Gynecol Reprod Biol2009，145，2： | 1 |
| 8 | Advantages and limitations of duckweed -based wastewater treatment systems 显示文摘 | Bonomo L Pastorelli G Zambon N | 1997 | Water SciTechnol1997，35，： | 1 |
| 9 | Group lI metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain显示文摘 | Di Liberto V Bonomo A Frinchi M | 2010 | Neuroseience2010，165，3： | 1 |
| 10 | Status report on carbapenemases: challenges and prospects显示文摘 | PatelG Bonomo RA | 2011 | Expert Rev Anti Infect Ther2011，9，5： | 1 |
| 11 | Polycyclic Aromatic Hydrocarbons (PAHs) Slurry Phase Bioremediation of a Manufacturing Gas Plant (MGP) Site Aged Soil显示文摘 | Sabrina Saponaro Luca Bonomo Gianniantonio Petruzzelli Laura Romele Meri Barbafieri | 2002 | Water Air and Soil Pollution2002，，1： | 1 |
| 12 | Influence of autochthonousstarter cultures on microbial dynamics and chimica-physicalfeatures of traditional fermented sausages of Basilicata region显示文摘 | BONOMO M G RICCIARDI A SALZANO G | 2011 | World J Microbiol Biotechnol2011，27，1： | 1 |
| 13 | In central obesity, weight loss restores platelet sensitivity to nitric oxide and prostacyclin显示文摘 | Russo I Traversa M Bonomo K | 2010 | Obesity2010，18，4： | 1 |
| 14 | Why are we afraid of Acinetobacter baumannii显示文摘 | Perez F Endimiani A Bonomo RA | 2008 | Expert Rev Anti Infect Ther2008，6，3： | 1 |
| 15 | Genetic analysis of surfacemotility in Acinetobacter baumannii显示文摘 | Clemmer KM Bonomo RA Rather PN | 2011 | Microniology2011，157，9： | 1 |
| 16 | Multiple antibiotic resistant bacteria in longterm carefacilities:an emerging problem in the practice of infectious diseases显示文摘 | Bonomo R A | 2000 | Clin Infect Dis2000，31，： | 1 |
| 17 | Extended-spectrum beta-lactamases: a clinical update 显示文摘 | Paterson DL Bonomo RA | 2005 | Clin Microbiol Rev2005，18，4： | 1 |
| 18 | Extended-spectrum beta-lactamases: a clinical update 显示文摘 | Paterson D L Bonomo R A | 2005 | Clin Microbiol Rev2005，18，4： | 1 |
| 19 | Prepregnancy BMI influences maternal and fetal outcomes in women with isolated gestational hyperglycaemia:a multicentre study显示文摘 | Lapolla A Bonomo M Dalfra MG | 2010 | Diabetes Metab2010，36，： | 1 |
| 20 | Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease显示文摘 | Racke MK Bonomo A | 1994 | J Exp Med1994，180，： | 1 |
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