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| 1 | Cellular and molecular aspects of gastric cancer显示文摘胃的癌症与变的负担仍然是一个全球杀手从发展了到发展中的世界。癌症沿着被定义由的一个多级式的过程发展不同组织学并且 pathophysiological 阶段。几基因、渐成说的改变调停从一个的转变上演到另外一个,这些在 oncogenes 包括变化,瘤压制或基因和房间骑车并且错配修理基因。在对胃的癌症的战斗的最重要的进展为这癌症作为最重要的获得的病因论的代理人与 Helicobacter pylori (H pylori ) 的角色的识别来了。最近的工作在阐明上集中了位于肿瘤的过程下面的复杂 host/microbial 相互作用。现在进这癌症的致病和阻止并且根除的前景有可观的卓见疾病成为了现实。也许更重要地, H 导致 pylori 的胃的致癌作用的学习为理解更复杂的人的癌症提供一个范例。在这评论,我们检验位于 H 下面的分子、细胞的事件导致 pylori 的胃的癌症。 | Malcolm G Smith Georgina L Hold Eiichi Tahara Emad M El-Omar | 2006 | World Journal of Gastroenterology2006，12，19： | 29 |
| 2 | Submucosal tunneling and endoscopic resection of submucosal tumors at the esophagogastric junction显示文摘AIM: To evaluate the safety and efficacy of submucosal tunneling and endoscopic resection(STER) for treating submucosal tumors(SMTs).METHODS: Between August 2012 and October 2013, 21 patients with SMTs originating from the muscularis propria(MP) layer at the esophagogastric junction were treated by STER of their tumors. Key steps of the procedure include:(1) mucosal incision: a 2-cm longitudinal mucosal incision was made 5 cm proximal to the tumor;(2) submucosal tunneling: a submucosal tunnel was created 5 cm proximal to and 1 to 2 cm distal to the tumor;(3) tumor resection: the SMT was resected under direct endoscopic viewing;(4) hemostasis: while finishing the tumor resection, careful hemostasis of the MP defect and the tunnel was performed; and(5) mucosal closure: the mucosal incision site was closed by using hemostatic clips. During the operation, equipment used included a cap-fitted endoscope, an insulatedtip knife, a hook knife, hemostatic forceps, an injection needle, a snare, an endoclip, and a high-frequency generator. Carbon dioxide(CO2) insufflation was achieved by using a CO2 insufflator.RESULTS: The median age of the patients was 46.2 years(range, 35-59 years), and the majority were male(18 male vs 3 female). Complete resection rate was 100%(21/21). Eighteen lesions were resected en bloc. Mean tumor size was 23 mm(range, 10-40 mm), and mean procedure time was 62.9 min(range, 45-90 min). Pathological diagnosis of these tumors included leiomyoma(15 out of 21) and gastrointestinal stromal tumor(6 out of 21). Full-thickness MP resection was performed in 9 of 21 patients(42.9%), with mediastinal and subcutaneous emphysema occurring in all nine. At the completion of the procedure, all patients received closure of the incision with hemoclips. One patient required percutaneous drainage. The remaining 20patients required no further endoscopic or surgical intervention. There were no incidents of massive or delayed bleeding. The median follow-up period after the procedure was 6 mo(range, 2-14 mo). During followup, no patients were found to have residual or recurrent tumor or esophageal stricture.CONCLUSION: STER is safe, effective and feasible, which provides accurate histopathologic evaluation and curative treatment for SMTs originating from the MP layer at the esophagogastric junction. | De-Jun Zhou Zhen-Bo Dai Malcolm M Wells Dan-Lei Yu Jing Zhang Lei Zhang | 2015 | World Journal of Gastroenterology2015，21，2： | 20 |
| 3 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 4 | Ki67 in breast cancer: prognostic and predictive potential显示文摘 | Rinat Yerushalmi Ryan Woods Peter M Ravdin Malcolm M Hayes Karen A Gelmon | 2010 | Lancet Oncology2010，，2： | 4 |
| 5 | Standardized measurement of the future liver remnant prior to extended liver resection: Methodology and clinical associations显示文摘 | Jean-Nicolas Vauthey Amin Chaoui Kim-Anh Do Malcolm M Bilimoria Marc J Fenstermacher Chuslip Charnsangavej Marshall Hicks Guido Alsfasser Gregory Lauwers Irvin F Hawkins James Caridi | 2000 | Surgery2000，，5： | 2 |
| 6 | Stroke显示文摘 | Geoffrey A Donnan Marc Fisher Malcolm Macleod Stephen M Davis | 2008 | The Lancet . 2008 (9624)2008，，9624： | 2 |
| 7 | Stroke显示文摘 | Geoffrey A Donnan Marc Fisher Malcolm Macleod Stephen M Davis | 2008 | The Lancet2008，，9624： | 2 |
| 8 | Capsaicin-evoked brain activation and central sensitization in anaesthetised rats:A functional magnetic resonance imaging study显示文摘 | Ricardo J M G Peter G M Malcolm J W P | 2006 | Pain2006，126，13： | 1 |
| 9 | A comparison of the fine root component of a pure and mixed Coniferous stand显示文摘 | Mckay H M Malcolm D C | 1988 | CanadianJournal of Forestry Research1988，18，： | 1 |
| 10 | Preparative isolation of aquatic humic substances显示文摘 | Thurman E M Malcolm R L | | 0，，04： | 1 |
| 11 | Rumination syndrome显示文摘 | Malcolm A Thumshirn MB Camilleri M | 1997 | Mayo Clin Proc1997，72，7： | 1 |
| 12 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 13 | Assessing the impact of nutrient enrichment inestuaries:Susceptibility to eutrophication显示文摘 | Painting S J Devlin M J Malcolm S J | 2007 | MarinePollution Bulletin2007，55，： | 1 |
| 14 | Examining the Effects of Alternative Management Strategies on Landscape-scale Forest Patterns in Northeastern Minnesota Using LANDIS 显示文摘 | SMITA M LEE E F MALCOLM T J | 2004 | Ecological Modelling2004，，5： | 1 |
| 15 | Three-dimensional structure of the 'long' neurotoxin from cobra venom 显示文摘 | Malcolm D Wolfram S Alfred M | 1980 | Biochemistry1980，77，5： | 1 |
| 16 | Comparison of XAD macroporous resins for the concentration of fulvic acid from aqueous solution显示文摘 | Aiken G R Thurman E M Malcolm R L | 1979 | Analytical Chemistry1979，51，11： | 1 |
| 17 | The effects of varying fluid volume and rate of resuscitation during uncontrolled hemorrhage显示文摘 | Dana M Soucy Malcolm Rude Wen C Hsia | 1999 | J Trauma1999，46，2： | 1 |
| 18 | LightowlersI-dentification and characterization of myophilin,a muscle- specific antigen of Echinoeoceus granulosus 显示文摘 | Roland M Martin Malcolm K Jones Marshall W | 1995 | Molecular and Biochemical Parasitology1995，70，： | 1 |
| 19 | Reliability and validity of the BTE Primus grip tool 显示文摘 | Schechtman O Davenport R Malcolm M | 2003 | J Hand Ther2003，16，1： | 1 |
| 20 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
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