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| 1 | 中药免疫调节作用的研究进展显示文摘研究表明中药具有免疫促进和免疫抑制的双向免疫调节作用,本文就中药免疫调节作用的相关研究进行总结,从中药对免疫细胞、细胞因子、免疫器官发育的促进作用及其抗肿瘤的功效,到中药在炎症反应、超敏反应、自身免疫性疾病以及移植排斥反应中所起的免疫抑制作用进行论述,并对中药在免疫调节中的应用前景进行了展望。 | 马洪第 卢芳汀 陶艳艳 M.Eric Gershwin 廉哲雄 | 2011 | 临床肝胆病杂志2011，27，5： | 56 |
| 2 | Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4^(+) T cells显示文摘Liver-resident NK cells are distinct from conventional NK cells and play an important role in the maintenance of liver homeostasis.How liver-resident NK cells participate in autoimmune cholangitis remains unclear.Here,we extensively investigated the impact of NK cells in the pathogenesis of autoimmune cholangitis utilizing the well-established dnTGFβRII cholangitis model,NK cell-deficient(Nfil3−/−)mice,adoptive transfer and in vivo antibody-mediated NK cell depletion.Our data demonstrated that disease progression was associated with a significantly reduced frequency of hepatic NK cells.Depletion of NK cells resulted in exacerbated autoimmune cholangitis in dnTGFβRII mice.We further confirmed that the DX5−CD11c^(hi) liver-resident NK cell subset colocalized with CD4^(+) T cells and inhibited CD4^(+) T cell proliferation.Gene expression microarray analysis demonstrated that liver-resident NK cells had a distinct gene expression pattern consisting of the increased expression of genes involved in negative regulatory functions in the context of the inflammatory microenvironment. | Zhi-Bin Zhao Fang-Ting Lu Hong-Di Ma Yin-Hu Wang Wei Yang Jie Long Qi Miao Weici Zhang Zhigang Tian William M.Ridgway Jie Cao M.Eric Gershwin Zhe-Xiong Lian | 2020 | Cellular & Molecular Immunology2020，17，2： | 4 |
| 3 | 原发性胆汁性肝硬化的细胞免疫学发病机制显示文摘原发性胆汁性肝硬化(PBC)是一种器官特异性的进行性自身免疫疾病,常见于女性,以肝脏门脉周围的淋巴细胞浸润,胆管上皮细胞特异性损伤以及血清中高滴度抗线粒体抗体(AMA)为主要特征。最新的PBC研究采用了CD4启动子控制下的TGFβ受体2显性失活(dnTGFβRⅡ)小鼠模型,这种小鼠模型很好地模拟了PBC患者的典型特征。在这种小鼠的基因背景下,通过分别敲除Rag1,μ以及CD1d基因建立了多种双基因缺陷鼠,通过研究发现T细胞,B细胞以及CD1d限制的NKT细胞等对肝脏淋巴细胞浸润,胆管上皮细胞损伤以及AMA的产生发挥着重要的作用。一系列的细胞免疫学实验结果显示,是CD8+T细胞而非CD4+T细胞在肝脏损伤过程中起着决定性的作用,而B细胞除分泌抗自身抗体之外,还具有抑制PBC发生的免疫调节作用。这些机制的研究为揭示人类PBC疾病的细胞免疫学致病机理提供了有力的证据和依托。 | 王寅虎 杨微 M.Eric Gershwin 廉哲雄 | 2011 | 临床肝胆病杂志2011，27，6： | 4 |
| 4 | Exosomal microRNA in autoimmunity显示文摘Exosomes are small extracellular vesicles that contain a potpourri of nucleic acids,including microRNAs(miRNAs).Importantly,exosomes and these miRNAs are actively secreted from multiple cell populations and play a critical role in intercellular communication.The exosomal miRNA profile reflects the cellular pathophysiological status and modulates multiple biological processes.Accumulating evidence indicates that exosomes and miRNAs are biomarkers for disease diagnosis and may have therapeutic targets.Research studies on exosomal miRNAs have brought new insights into understanding autoimmune diseases.This article summarizes the detection methodologies and updates the potential applications of exosomal miRNAs in autoimmune diseases. | Weijia Duan Weici Zhang Jidong Jia Qianjin Lu M.Eric Gershwin | 2019 | Cellular & Molecular Immunology2019，16，12： | 2 |
| 5 | 原发性胆汁性胆管炎:探索个体化诊疗的最优选择显示文摘Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that is characterized by inflammation of the interlobular bile ducts. Although PBC is a slowly progressive disease, with a natural history of 10–15 years leading to end-stage liver disease, highrisk cases may rapidly progress to decompensated cirrhosis or even death. As the most common autoimmune liver disease, the prevalence of PBC has been increasing globally, largely due to increased disease awareness, improved diagnosis, and treatment with ursodeoxycholic acid (UDCA). PBC is more likely to occur in middle-aged women, with a female-to-male ratio ranging from 1.6 to10;however, men have a higher disease severity [1,2]. | 尚玉龙 Patrick S.C.Leung M.Eric Gershwin 韩英 | 2022 | Science Bulletin2022，67，24： | 1 |
| 6 | Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection显示文摘 | Georgios N Dalekos Petra Obermayer-Straub Moritz Bartels Takashi Maeda Anne Kayser Sabine Braun Stephanie Loges Eleonore Schmidt M.Eric Gershwin Michael P Manns | 2003 | Journal of Hepatology2003，，5： | 1 |
| 7 | Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression显示文摘The interferon(IFN)signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of autoimmunity.We have generated a unique murine model named ARE-Del,with chronic overexpression of IFNγ,by altering IFNγmetabolism.Importantly,these mice develop an immunologic and clinical profile similar to patients with primary biliary cholangitis,including high titers of autoantibodies and portal inflammation.We hypothesized that the downregulation of IFN signaling pathways with a JAK1/2 inhibitor would inhibit the development and progression of cholangitis.To study this hypothesis,ARE-Del^(+/−)mice were treated with the JAK1/2 inhibitor ruxolitinib and serially studied.JAK inhibition resulted in a significant reduction in portal inflammation and bile duct damage,associated with a significant reduction in splenic and hepatic CD4^(+)T cells and CD8^(+)T cells.Functionally,ruxolitinib inhibited the secretion of the proinflammatory cytokines IFNγand TNF from splenic CD4^(+)T cells.Additionally,ruxolitinib treatment also decreased the frequencies of germinal center B(GC B)cells and T follicular helper(Tfh)cells and led to lower serological AMA levels.Of note,liver and peritoneal macrophages were sharply decreased and polarized from M1 to M2 with a higher level of IRF4 expression after ruxolitinib treatment.Mechanistically,ruxolitinib inhibited the secretion of IL-6,TNF and MCP1 and the expression of STAT1 but promoted the expression of STAT6 in macrophages in vitro,indicating that M1 macrophage polarization to M2 occurred through activation of the STAT6-IRF4 pathway.Our data highlight the significance,both immunologically and clinically,of the JAK/STAT signaling pathway in autoimmune cholangitis. | Tihong Shao Patrick S.C.Leung Weici Zhang Koichi Tsuneyama William M.Ridgway Howard A.Young Zongwen Shuai Aftab A.Ansari M.Eric Gershwi | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 8 | Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis显示文摘 | Olivia M. Martinez Janeth C. Villanueva M.Eric Gershwin Sheri M. Krams | 1995 | Hepatology1995，，1： | 1 |
| 9 | IgE reactivity against a cross-reactive allergen in crustacea and mollusca: Evidence for tropomyosin as the common allergen显示文摘 | Patrick S.C. Leung Wing Kuen Chow Sean Duffey Hoi Shan Kwan M.Eric Gershwin Ka Hou Chu | 1996 | The Journal of Allergy and Clinical Immunology1996，，5： | 1 |
| 10 | Abnormal expression of PDC-E 2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody—negative primary biliary cirrhosis显示文摘 | Koichi Tsuneyama Judy Van De Water David Van Thiel Ross Coppel Boris Ruebner Yasuni Nakanuma E.Rolland Dickson M.Eric Gershwin | 1995 | Hepatology1995，，5： | 1 |
| 11 | Serum autoantibodies in patients with primary sclerosing cholangitis显示文摘 | Paul Angulo James B Peter M.Eric Gershwin Carolee K DeSotel Yehuda Shoenfeld Alaa E.E Ahmed Keith D Lindor | 2000 | Journal of Hepatology2000，，2： | 1 |
| 12 | A roadmap for breeding orphan leafy vegetable species: a case study of Gynandropsis gynandra (Cleomaceae)显示文摘Despite an increasing awareness of the potential of“orphan”or unimproved crops to contribute to food security and enhanced livelihoods for farmers,coordinated research agendas to facilitate production and use of orphan crops by local communities are generally lacking.We provide an overview of the current knowledge on leafy vegetables with a focus on Gynandropsis gynandra,a highly nutritious species used in Africa and Asia,and highlight general and species-specific guidelines for participatory,genomics-assisted breeding of orphan crops.Key steps in genome-enabled orphan leafy vegetables improvement are identified and discussed in the context of Gynandropsis gynandra breeding,including:(1)germplasm collection and management;(2)product target definition and refinement;(3)characterization of the genetic control of key traits;(4)design of the‘process’for cultivar development;(5)integration of genomic data to optimize that‘process’;(6)multi-environmental participatory testing and end-user evaluation;and(7)crop value chain development.The review discusses each step in detail,with emphasis on improving leaf yield,phytonutrient content,organoleptic quality,resistance to biotic and abiotic stresses and post-harvest management. | E.O.Deedi Sogbohossou Enoch G.Achigan-Dako Patrick Maundu Svein Solberg Edgar M.S.Deguenon Rita H.Mumm Iago Hale Allen Van Deynze M.Eric Schranz | 2018 | Horticulture Research2018，5，1： | 1 |
| 13 | Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection显示文摘 | Georgios N Dalekos Petra Obermayer-Straub Moritz Bartels Takashi Maeda Anne Kayser Sabine Braun Stephanie Loges Eleonore Schmidt M.Eric Gershwin Michael P Manns | 2003 | Journal of Hepatology2003，，5： | 1 |
| 14 | Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis显示文摘 | Sylvaine F.A Bruggraber Patrick S.C Leung Katsushi Amano Chao Quan Mark J Kurth Michael H Nantz Gordon D Benson Judy Van de Water Velimer Luketic Thomas E Roche Aftab A Ansari Ross L Coppel M.Eric Gershwin | 2003 | Gastroenterology2003，，6： | 1 |
| 15 | The long and latent road to autoimmunity显示文摘Autoimmune diseases affect nearly 5%of the general population,yet etiology remains poorly understood.Genomic factors are clearly necessary but remain insufficient to explain the loss of tolerance;environmental and stochastic factors fill this gap.This paradigm is indicated by the concordance rates(ranging between 4 and 63%)for autoimmune diseases among monozygotic twins,who share an identical genome,compared to the invariably lower rates in dizygotic twins.The term“exposome”cumulatively refers to the non-hereditary(i.e.,environmental)factors that account for the remaining susceptibility and include endogenous factors such as hormones.Accumulating evidence suggests that exposure to infections,drugs,vaccines,and chemicals may contribute to the loss of tolerance.The mechanisms by which environmental factors can shape the immune system to generate autoimmunity include molecular mimicry,self-antigen modification,bystander activation,and immune reactivity modulation.In all cases,we should first consider the prolonged time between an environmental trigger and the appearance of autoreactivity and subsequent clinical disease.In this special issue,several excellent reviews discuss the potential mechanisms linking environmental factors and autoimmunity. | Carlo Selmi Bin Gao M.Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，6： | 0 |
| 16 | 流程:游走于科学与艺术之间显示文摘是该把一个在欧洲取得成功的销售流程推广到全球各地,还是让各地的团队八仙过海各显神通?对一家制造商来说,开发和记录符合最新ISO标准的精细流程,和对员工多进行一些培训和授权相比,哪种方法更能改善产品品质?以管理护士的方式管理外科医生,或是以管理维修工的方式管理审计人员,能否提升质量水平? | 约瑟夫·霍尔(Joseph M.Hall) 埃里克·约翰逊(M.Eric Johnson) 徐广彤(翻译) | 2009 | 商业评论2009，，7： | 0 |
| 17 | 达特茅斯大学塔克商学院联盟采购还是电子采购?显示文摘随着外包和网络下单的迅速普及,很多公司建立具有专业的采购团队以及和一些核心供应商建立长期关系,而有的公司使用网上招标采购战略。采购经理经常面临着这样的问题:战略联盟关系应该继续吗?还是应该网上招标采购?什么样的产品和服务更适合网上招标? | David F.Pyke M.Eric Johnson | 2008 | 董事会2008，，3： | 0 |
| 18 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
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