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| 1 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 2 | Genome tagging project: tag every protein in mice through ’artificial spermatids’显示文摘The Human Genome Project(HGP),launched in 1990 and finished in 2004,has not only provided the complete human genome sequence of more than 2.85 billion nucleotides and evidence of 20 000-25 000 protein-coding genes[1];but has also been making huge impacts on biomedical research.One major task of the post-genomic era is to develop the definitive catalog of proteincoding genes,and illustrate proteins*in vivo dynamic localization and physical interaction. | Jing Jiang Meng Yan Dangsheng Li Jinsong Li | 2019 | National Science Review2019，6，3： | 9 |
| 3 | The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4+CD25+ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment显示文摘 | Jiezuan Yang Guoping Sheng Dangsheng Xiao Haiyan Shi Wei Wu Haifeng Lu Ping Yi Hongcui Cao Lanjuan Li | 2016 | Cellular & Molecular Immunology2016，13，5： | 9 |
| 4 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 5 | Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells显示文摘规章的 T 房间(Treg ) 在免疫系统动态平衡起重要作用,并且可以被压制涉及反肿瘤免疫的 Th1 免疫反应也涉及肿瘤免疫忍耐。我们以前报导了有稀释激活的自体同源的 T 房间的那免疫导致提高的反肿瘤免疫并且在调整 Th1 回答 invivo 上面。然而,内在的分子的机制很好没被理解。这里,我们证明 Tregfunction 是显著地, down 在老鼠调整了稀释激活的自体同源的 T 房间的那收到的免疫。我们发现那 Foxp3 表情从使免疫的老鼠在 CD4+CD25+ T 房间减少了。而且,从使免疫的老鼠获得的 CD4+CD25+Foxp3+ Treg 从天真的老鼠与那些相比展出了减少的免疫力的抑制能力。进一步的分析证明使免疫的鼠标的浆液包含 anti-CD25 抗体(大约 30 ng/ml, p<0.01 对控制) 的高水平。与在 Treg 的 down 规定的 anti-CD25 反应的一个角色一致,到天真的鼠标的从使免疫的鼠标的浆液的采纳转移在接受者鼠标在 Treg 人口和功能导致了重要减少。在使免疫的老鼠被触发 anti-CD25 反应能被 CD25 在激活的自体同源的 T 房间为免疫使用了的 ConA 被导致到高水平的事实解释。我们的结果第一次证明有稀释激活的自体同源的 T 房间的那免疫唤起 anti-CD25 抗体生产,它导致阻碍的 CD4+CD25+Foxp3+Treg 扩大和功能体内。我们建议那阻抑的 Treg 功能多半在使免疫的老鼠贡献提高的 Th1 反应并且是位于 boostedanti 肿瘤免疫下面的机制的至少部分。 | Qi Cao Li Wang Fang Du Huiming Sheng Yan Zhang Juanjuan Wu Baihua Shen TianweiShen Jingwu Zhang Dangsheng Li Ningli Li | 2007 | Cell Research2007，17，7： | 5 |
| 6 | More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells显示文摘在 pluripotency 的正式就职的核心管理者最近在体的房间 reprogramming 期间被发现了的 Yamanaka 因素的角色。我们的以前的学习发现 Yamanaka 因素在维持胚胎的茎(ES ) 房间 pluripotency 调整一个发展发信号网络。这里,我们完全证实 reprogrammed 导致了 pluripotent 茎(iPS ) 细胞并且由薄片薄片试金在这些细胞分析了 Yamanaka 因素的全球倡导者占有。我们发现 565 基因的倡导者是由在 iPS 房间的四个 Yamanaka 因素的合作界限, 10 褶层增加什么时候与他们在 ES 房间的绑定相比。,在 ES 房间 Oct4, Sox2,或 Klf4 在 iPS 房间在激活并且镇压的基因同等地散布的一个单个 Yamanaka 因素占据的倡导者在激活的主要在镇压基因和 c-Myc 散布了。薄片薄片数据的小径分析表明 Yamanaka 因素在 iPS 房间, 12 在之中是普通的调整了 16 条发展发信号小径, 4 与在 ES 房间调整的小径相比是唯一的。我们进一步在 iPS 房间分析了另一最近出版的薄片薄片数据集并且观察了类似的结果,显示出为揭示 pluripotency 维护和新生的性质的薄片薄片正小径分析的力量。下次,我们试验性地测试了压抑的发信号小径之一并且发现它的抑制确实改进了房间 reprogramming 的效率。一起拿,我们建议有一个核心为 pluripotency 必要的发展发信号网络与 TGF- ,刺猬, Wnt,是的 p53 压抑(殷) 管理者和 Jak-STAT,房间周期,焦点的粘附, adherens 连接作为活跃(杨) ;并且 Yamanaka 因素 synergistically 在 Yin-Yang 调整他们导致 pluripotency 的平衡方法。 | Jinyan Huang Taotao Chen Xiaosong Liu Jing Jian Jinsong Li Dangsheng Li X Shirley Liu Wei Li Jiuhong Kang Gang Pei | 2009 | Cell Research2009，19，10： | 4 |
| 7 | Surface texturing for adaptive Ag/MoS_2 solid lubricant plating显示文摘The objective of this research is to prepare specially designed surface texture on hard steel surface by electrochemical micromachining (EM) and to incorporate electroless plated Ag/MoS2 solid lubricant coating into the dimples of EM textured steel surface to effectively reduce friction and wear of steel-steel contacts. The friction and wear behavior of the Ag/MoS2 solid lubricant coating on EM textured steel surface was evaluated in relation to the size and spacing of the dimples thereon. The microstructure of as-plated Ag/MoS2 solid lubricant coating and the morphology and elemental composition of the worn coating surface and counterface steel surface were analyzed by means of optical microscopy, scanning electron microscopy, and energy dispersive spectrometry. It is found that electroless plated Ag/MoS2 coating is able to greatly reduce the friction and wear of the EM textured steel disc coupled with GCr15 steel ring, mainly because of the formation of solid self-lubricating layer on the EM textured steel surface and of transferred lubricating film on counterface steel surface. The diameter and spacing of the dimples are suggested as 500 μm for acquiring the best wear resistance of the hard steel discs after electrochemical micromachining treatment and electroless plating of Ag/MoS2 solid lubricating coating. | Huang Zhongjia Liu Minglang Xiong Dangsheng Li Jianliang | 2012 | Rare Metals2012，31，6： | 3 |
| 8 | The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility显示文摘PIWI-clade proteins harness pi RNAs of 24–33 nt in length.Of great puzzles are how PIWI-clade proteins incorporate pi RNAs of different sizes and whether the size matters to PIWI/pi RNA function.Here we report that a PIWI-Ins module unique in PIWIclade proteins helps define the length of pi RNAs.Deletion of PIWI-Ins in Miwi shifts MIWI to load with shorter pi RNAs and causes spermiogenic failure in mice,demonstrating the functional importance of this regulatory module.Mechanistically,we show that longer pi RNAs provide additional complementarity to target m RNAs,thereby enhancing the assembly of the MIWI/e IF3f/Hu R super-complex for translational activation.Importantly,we identify a c.1108C>T(p.R370W)mutation of HIWI(human PIWIL1)in infertile men and demonstrate in Miwi knock-in mice that this genetic mutation impairs male fertility by altering the property of PIWI-Ins in selecting longer pi RNAs.These findings reveal a critical role of PIWI-Ins-ensured longer pi RNAs in fine-tuning MIWI/pi RNA targeting capacity,proven essential for spermatid development and male fertility. | Xin Wang Di-Hang Lin Yue Yan An-Hui Wang Jiaoyang Liao Qian Meng Wen-Qing Yang Heng Zuo Min-Min Hua Fengjuan Zhang Hongwen Zhu Hu Zhou Tian-Yu Huang Rui He Guangyong Li Yue-Qiu Tan Hui-Juan Shi Lan-Tao Gou Dangsheng Li Ligang Wu Yonggang Zheng Xiang-Dong Fu Jinsong Li Rujuan Liu Guo-Hui Li Mo-Fang Liu | 2023 | Science China(Life Sciences)2023，66，7： | 2 |
| 9 | Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9显示文摘 | Yuxuan Wu Dan Liang Yinghua Wang Meizhu Bai Wei Tang Shiming Bao Zhiqiang Yan Dangsheng Li Jinsong Li | 2013 | Cell Stem Cell2013，，6： | 2 |
| 10 | Peaking of MMP-26 and TIMP-4 marks invasive transition in prostate cancer显示文摘Prostate cancer is one of the leading health threats to man,and like many other cancers,early detection and treatment iscrucial to improving the prognosis of patients.Progression of the disease from noninvasive high-grade prostatic intraepi-thelial neoplasia (HGPIN) to invasive adenocarcinoma is linked to the action of a group of proteolytic enzymes calledmatrix metalloproteinases (MMPs),which digest various components of the extracellular matrix and thus open waysfor tumor metastasis.Previous studies have shown that one MMP,MMP-26,is expressed at a significantly higher levelin human prostate carcinoma than in normal prostate tissues,and that it appears to play an important role in promotinginvasion of prostate cancer cells [1].In this issue of Cell Research,Lee et al.report detailed analyses of the expressionpattern of MMP-26,along with its most potent endogenous inhibitor,TIMP-4 (TIMP stands for tissue inhibitor ofmetal-loproteinases),in a number of prostate cancer samples derived from human patients [2].Interestingly,they found | Dangsheng Li | 2006 | Cell Research2006，16，9： | 1 |
| 11 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 12 | Friction and wear properties of Ni-Cr-W-A1-Ti-MoSz at elevated temperatures and self consumption phenomena显示文摘 | Li Jianliang Xiong Dangsheng Huo Mingfeng | 2008 | Wear2008，265，34： | 1 |
| 13 | Effect of surface laser texture on friction properties of nicked- based composite 显示文摘 | Li Jianliang Xiong Dangsheng Dai Jihui | 2010 | Tribology International2010，43，： | 1 |
| 14 | GSK-3β as a driving force in ovarian cancer显示文摘Ovarian cancer is one of the most lethal malignancies in women.Identification of new therapeutic targets would provideopportunities for developing potentially more effective treatment regimes.In the July issue of Cell Research,Cao et al.reports that glycogen synthase kinase-3β(GSK-3β)plays an important role in positively regulating the proliferation ofhuman ovarian cancer cells,and thus it may represent such a target[1].GSK-3β is a serine/threonine kinase that is knownto be involved in regulation ofβ-catenin signaling,where it participates in the formation of a multi-component destructioncomplex that promotes the phosphorylation and subsequent degradation of β-catenin.Given that overactive β-cateninsignaling is involved in many forms of human cancer,this classic mode of GSK-3β action should qualify it as a'tumorsuppressor'.Intriguingly,however,two recent studies have implicated that GSK-3β may actually play a pro-tumor rolein pancreatic and colorectal cancers[2,3].Since ovarian tumors often exhibit increased expression of GSK-3β,theserecent findings prompted Cao et al.to examine the potential role of GSK-3β in ovarian cancer cells. | Dangsheng Li | 2006 | Cell Research2006，16，7： | 1 |
| 15 | piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis显示文摘 | Shuang Zhao Lan-Tao Gou Man Zhang Li-Dong Zu Min-Min Hua Ye Hua Hui-Juan Shi Yong Li Jinsong Li Dangsheng Li En-Duo Wang Mo-Fang Liu | 2012 | Developmental Cell2012，，： | 1 |
| 16 | Friction and wear properties of MoS2-overcoated laser surface-textured silver-containing nickel-based alloy at elevated temperatures 显示文摘 | Li Jianliang Xiong Dangsheng Zhang Yongkang | 2011 | Tribol Lett2011，43，： | 1 |
| 17 | 人Piwi基因泛素化修饰缺陷突变通过削弱精子形成过程中组蛋白-鱼精蛋白转换致男性不育显示文摘文章简介遗传学研究表明,Piwi蛋白对于动物生殖系细胞发育至关重要,Piwi基因敲除致动物不育。人Piwi(Hiwi)基因特异性地在雄性生殖细胞表达,但目前对其在人精子发生中的作用及其与男性不育的联系还知之甚少。 | Lan-Tao Gou Jun-Yan Kang Peng Dai Xin Wang Feng Li Shuang Zhao Man Zhang Min-Min Hua Yi Lu Yong Zhu Zheng Li Hong Chen Li-Gang Wu Dangsheng Li Xiang-Dong Fu Jinsong Li 施惠娟 刘默芳 | 2018 | 科学新闻2018，0，4： | 1 |
| 18 | Tribological behavior of graphite-containing nickel-based composite as function of temperature,load and counterface显示文摘 | Li Jianliang Xiong Dangsheng | 2009 | Wear2009，266，： | 1 |
| 19 | Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-κB Signaling and Protects against Endotoxin Shock显示文摘 | Yanbo Zhang Yao Lu Li Ma Xudong Cao Jun Xiao Jiexia Chen Shaozhuo Jiao Yunzhen Gao Chang Liu Zhaojun Duan Dangsheng Li Yulong He Bin Wei Hongyan Wang | 2014 | Immunity2014，，： | 1 |
| 20 | Effect of load and sliding speed on friction and wear behavior of silver/h- BN containing Ni-base P/M composites显示文摘 | Rajnesh Tyagi Dangsheng Xiong Jianliang Li | 2011 | Wear2011，270，78： | 1 |
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