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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 3 | Epidemiological Status of Chronic Diabetic Complications in China显示文摘With the booming development of industrialization and urbanization, popularization of high calorie diet and sedentary lifestyle, and the rapid growth of aging, the prevalence of diabetes increased nearly 10 times during the past three decades in China.[1-3] China has become the country with the largest number of people with diabetes and thus will face considerable challenge of chronic complications in the next 10-20 years.Diabetes-associated chronic complications, such as vision disorder, kidney disease, neuropathy, peripheral vascular disease, cardiopathy, and stroke, are the major causes of physical disability and mortality, making it a nonnegligible problem of social healthcare system.Therefore, it is of importance to summarize and update current prevalence and risk factors of diabetic complications in China, not only to establish the strategy of prevention and treatment to delay the development of chronic complications, but also to improve the living quality of patients and alleviate the burden of medical cost. | Jian-Ping Weng Yan Bi | 2015 | Chinese Medical Journal2015，，24： | 37 |
| 4 | Physical Location of the Rice Pi-5(t), Glh and RTSV Genes by ISH of BAC Clones显示文摘Mapplng of low of slngle-copy sequences on plant chromosomes has proven dirricult because ofvery low frequency or slgnal detectlon. Rlce BAC Ilbrary ls belng used wldely ln rlce genome research due tolts distlnctlve advantages over other llbrary systems. In tkls study, two blotln-Iabeled rice BAC clones closelylinked to a rlce blast reslstance, green Ieaf hopper reslstance and tungro spherlcal virus resistance gene,Pi-5(t),Glh, RTSV, were in situ hybrldlred to rlce ckromosomes. They were located on the long arm andshort arm of ckromosome 4 with FL value of 40% and 100% respectively-The rrequency of signal detectionreacked 46. 8% and 59- 2%- The slgnal location were conslstent wltk the selectlve marker on rice saturatedm0Iecular map. The results demonstrated the advautages to Iocate BAC cIones to ckromosomes by in sho hybrldization and will racilitate tke rlce low of slngle-copy gene Iocation by using the BAC library. | Yan Huimin, Song Yunchun, Li Lijia, Bi Xuezhi, Fu Binying(College of Life Sciences, Wuhan University, Wuhan 430072, China) | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 24 |
| 5 | Postharvest Treatment with β-Aminobutyric Acid Induces Resistance Against Dry Rot Caused by Fusarium sulphureum in Potato Tuber显示文摘The effectiveness of postharvest β-aminobutyric acid (BABA) treatment was studied for inducing resistance against dry rot caused by Fusarium sulphureum in tubers and slices of two potato cultivars (resistant cultivar Shepody and susceptible cultivar Xindaping). The results showed that BABA at 100 mmol L-1 significantly reduced lesion diameter in inoculated both tubers and slices. The chemical at 100 mmol L-1 showed an effective reduction in infection ability of F. sulphureum inoculated 48 and 72 h after treatment in slices of resistant cultivar, and 72 and 96 h in susceptible ones. BABA increased the activitives of peroxidase (POD), polyphenoloxidase (PPO) and phenylalanine ammonialyase (PAL), and accumulated the contents of lignin, flavonoids and phenolics in slices. The resistant cultivar had a stronger resistant response than the susceptible one. These findings suggest that the BABA treatment can induce the resistance in potato tubers, however, the inducing degree depends on the original level of resistance present in each cultivar. | YIN Yan LI Yong-cai BI Yang CHEN Song-jiang LI Ying-chao YUAN Li WANG Yi WANG Di | 2010 | Agricultural Sciences in China2010，9，9： | 24 |
| 6 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 7 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 8 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 9 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 10 | Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation显示文摘化疗经常被知道导致严重的胃肠的道毒性,但是内在的机制仍然保持不清楚。这研究作为一个代表性的代理人认为广泛地应用的细胞毒素的代理人是 irinotecan (CPT-11 ) 并且证明治疗从说明混合物的限制剂量的肠的毒性的肠导致双海滨 DNA 的巨大的版本。明确地,通过 exosome 分泌物释放的 self-DNA 进入天生的有免疫力的房间的 cytosol 并且激活 AIM2 (在黑瘤 2 不在) inflammasome。这导致成熟 IL-1 和 IL-18 分泌物并且导致肠的 mucositis 和迟了发作的腹泻。有趣地,在 AIM2 缺乏的老鼠或由象镇静药那样的一个药理学禁止者,没有影响 CPT-11 的 anticancer 功效, AIM2 发信号的废除显著地减少导致药的腹泻的发生。这些调查结果提供化疗怎么触发引起肠的毒性的天生的有免疫力的回答的机械学的卓见,并且揭示维持反瘤效果,但是围绕联系不利煽动性的反应的新化疗政体。 | Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu | 2017 | Cell Research2017，27，6： | 18 |
| 11 | Predictive role of interleukin-6 and CAT score in mechanical ventilation in patients with chronic obstructive pulmonary disease at the acute exacerbation stage in the emergency department显示文摘BACKGROUND:The study aimed to evaluate the predictive role of interleukin-6(IL-6)and chronic obstructive pulmonary disease(COPD)assessment test(CAT)score in mechanical ventilation(MV)in COPD patients at the acute exacerbation stage in the emergency department(ED).METHODS:For a one-year period,among adult patients in the ED who met the criteria of acute exacerbation of COPD,158 who received MV within 48 hours after admission were compared to 294 who didn't require MV within the same period after admission.IL-6 level and CAT score were compared between the two groups.The predicted value of IL-6 and CAT score was assessed by logistic regression analysis and a receiver operating characteristic(ROC)curve.RESULTS:The IL-6 and CAT scores in the 158 MV patients were much higher than those without.IL-6 and CAT scores were independent predictors of MV within 48 hours using logistic regression analysis(IL-6:odds ratio[OR]1.053,95%confidence interval[CI]1.039–1.067,P<0.001;CAT score:OR 1.122,95%CI 1.086–1.159,P<0.001).The combination of IL-6 and CAT scores(area under ROC curve[AUC]0.826,95%CI 0.786–0.866,P<0.001)improved the accuracy of predicting MV within 48 hours when compared with IL-6(AUC 0.752,95%CI 0.703–0.800,P<0.001)and CAT scores alone(AUC 0.739,95%CI 0.692–0.786,P<0.001).The sensitivity and specificity were 69.6%,74.1%,75.32%and 63.6%,respectively.CONCLUSION:The combined of IL-6 and CAT scores is useful for evaluating the risk of COPD patients at acute exacerbation in ED,and can provide a predictive value for MV or not within 48 hours. | Wei Bi Yan Sun Lin-qin Ma Cai-jun Wu | 2020 | World Journal of Emergency Medicine2020，11，2： | 17 |
| 12 | Characteristics of rare-earth elements (REE),strontium and neodymium isotopes in hydrothermal fluorites from the Bailashui tin deposit in the Furong ore field,southern Hunan Province,China显示文摘In this paper the authors present the REE concentrations and Sr and Nd isotopic compositions of fluorites from the Bailashui tin deposit of the Furong ore field,southern Hunan Province. The results showed that the total amount of REE in fluorites is usually low,ranging from 0.705 to 8.785 μg/g with the chondrite-normalized REE dis-tribution patterns similar to those of the Qitianling granites in the study area,characterized by LREE-enrichment patterns with pronounced negative Eu anomalies. The fluorites vary in Sr isotopic composition within the range of 0.7083-0.7091,the values are lower than those of the granites and higher than those of the host carbonate rocks in this area. The εNd(t) values of fluorites vary between -9.4 and +10.3,revealing that both the crust-and mantle-source materials were involved in the ore-forming hydrothermal fluids. Combined with previous studies on this ore deposit,the Bailashui tin deposit is temporally and spatially closely related with granitic magmatism in this area. The hydro-thermal fluorites are the product of fluid/rock interactions between granitic magmatic hydrothermal fluid and marine carbonate rocks. The REE and F in the ore-forming fluid were derived from the granites,whereas Sr in the ore-forming fluid came mainly from the granitic magmatic hydrothermal fluid and marine carbonate rocks,although variations in Sr isotopic composition cannot be explained by a simple mixture of these two end-members. Evidence demonstrated that the ore-forming fluids are of crustal-mantle mixing origin,but that the fluids were probably in-completely homogenized and this may be caused by inhomogeneous mixing of the fluids of different sources. | YUAN Shunda PENG Jiantang HU Ruizhong BI Xianwu QI Liang LI Zhaoli LI Xiaomin SHUANG Yan | 2008 | Chinese Journal Of Geochemistry2008，27，4： | 16 |
| 13 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 14 | Genesis of the Wulong gold deposit,Liaoning Province,NE China:Constrains from noble gases,radiogenic and stable isotope studies显示文摘TheWulong lode deposit contains over 80 tonnes of gold with an average grade of 5.35 g/t.It is one of the largest deposits in Dandong City,Liaoning Province in northeast China.Previous studies on the deposit focused on its geological characteristics,geochemistry,fluid inclusions,and the timing of gold mineralization.However,controversy remains regarding the origin of the ore-forming fluids and metals,and the genesis of the gold deposit.This paper presents zircon UePb and pyrite RbeSr ages and S,Pb,He,and Ar isotopic results along with quartz H and O isotopic data for all litho-units associated with the deposit.Laser ablation inductively coupled mass spectrometry measurements yielded zircon UePb dates for samples of pre-mineralization rocks like granite porphyry dike,the Sanguliu granodiorite,fine-grained diorite,and syn-mineralization diorite,as well as post-mineralization dolerite,and lamprophyre;their emplacement ages are 1261 Ma,1241 Ma,1231 Ma,1201 Ma,1192 Ma,and 1152 Ma,respectively.The pyrite RbeSr isochron age is 1191 Ma,indicating that both magmatism and mineralization occurred during the Early Cretaceous.The d18OH2O values of ore-forming hydrothermal fluids from the quartzepolymetallic sulfide vein stage vary from 4.8&to 6.5&,and the dDV-SMOW values are between67.7&and75.9&,indicating that the ore-forming fluids were primarily magmatic.The noble gas isotope compositions of fluid inclusions hosted in pyrite suggest that the ore-forming fluids were dominantly derived from crustal sources with minor mantle input.Sulfur isotopic values of pyrite vary between 0.2&and 3.5&,suggesting that S was derived from a homogeneous magmatic source or possibly from fluids derived from the crust.The Pb isotopic compositions of sulfides(207Pb/204Pb?15.51 e15.71,206Pb/204Pb?17.35e18.75,208Pb/204Pb?38.27e40.03)indicate that the Pb of the Wulong gold deposit is a mixture of crust and mantle components.Geochronological and geochemical data,together with the regional geological history,indicate that Early Cretaceous magmatism and mineralization of the Wulong gold deposit occurred during the rollback of the subducting Paleo-Pacific Plate,which resulted in lithospheric thinning and the destruction of the North China Craton(NCC),which indicates that the deposit is of magmaticehydrothermal origin. | Peng Zhang Linlin Kou Yan Zhao Zhongwei Bi Deming Sha Renping Han Zhumin Li | 2020 | Geoscience Frontiers2020，11，2： | 13 |
| 15 | VIBRATION CHARACTERISTICS OF FLUID-STRUCTURE INTERACTION OF CONICAL SPIRAL TUBE BUNDLE显示文摘Heat transfer enhancement is achieved by flow-induced vibration in elastic tube bundles heat exchangers.For a further understanding of heat transfer enhancement mechanism and tube structure optimization,it is of importance to study the vibration characteristics of fluid-structure interaction of tube bundles.The finite element method is applied in the study of fluid-structure interaction of a new type elastic heat transfer element,i.e.,the dimensional conical spiral tube bundle.The vibration equation and element matrix for the tube are set up by the regulation of different helical angles and coordinate transformation,together with the simplification of the joint body of the two pipes.The vibration characteristics of conical spiral tube bundle are analyzed at different velocities of the tube-side flow,and the critical velocity of vibration buckling is obtained.The results show that the natural frequency of the tube bundle decreases as the flow speed increases,especially for the first order frequency,and the critical velocity of vibration buckling is between 1.2665 m/s-1.2669 m/s.The vibration mode of conical spiral tube bundle is mainly z-axial,which is feasible to be induced and controlled. | YAN Ke GE Pei-qi BI Wen-bo SU Yan-cai HU Rui-rong | 2010 | Journal of Hydrodynamics2010，22，1： | 13 |
| 16 | Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes显示文摘Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes. Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases(ASCVD) among 8,252 participants aged ≥ 40 years without diabetes from Jiading district, Shanghai, China. Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid(all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia(all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios(ORs) [95% confidence intervals(CIs)] for the highest quartiles for high Framingham risk were 3.00(2.00-4.50) in men and 2.95(1.08-8.43) in women. The multivariate adjusted ORs(95% CIs) for the highest quartile for high ASCVD risk were 1.93(1.17-3.17) in men and 4.53(2.57-7.98) in women. Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes. | CHENG Di DU Rui WU Xue Yan LIN Lin PENG Kui MA Li Na XU Yu XU Min CHEN Yu Hong BI Yu Fang WANG Wei Qing DAI Meng LU Jie Li | 2018 | Biomedical and Environmental Sciences2018，31，2： | 13 |
| 17 | An experimental study of fracture initiation mechanisms during hydraulic fracturing显示文摘破裂开始的机制是为水力的破裂技术的基本问题。因为在为不同水库的破裂开始机制的巨大的差别,成功的断裂技术用于孔水库的一些为折断的水库是徒劳的。用一台过程模拟设备的实验室测试被执行在不同水库证实破裂开始和繁殖的特征。破裂开始和繁殖上的外壳的压力地,限制压力,和自然破裂的影响被讨论。试验性的结果证明在洞附近的压力集中将显著地增加岩石的破裂压力。同时,在地上凿穿墙中的自然破裂将消除压力集中,它在破裂开始压力导致减少。 | Yan Tie Li Wei Bi Xueliang | 2011 | Petroleum Science2011，8，1： | 12 |
| 18 | SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer显示文摘SIRT7,a sirtuin family member implicated in aging and disease,is a regulator of metabolism and stress responses.It remains elusive how human somatic stem cell populations might be impacted by SIRT7.Here,we found that SIRT7 expression declines during human mesenchymal stem cell(hMSC)aging and that SIRT7 deficiency accelerates senescence.Mechanistically,SIRT7 forms a complex with nuclear lamina proteins and heterochromatin proteins,thus maintaining the repressive state of heterochromatin at nuclear periphery.Accordingly,deficiency of SIRT7 results in loss of heterochromatin,derepression of the LINE1 retrotransposon(LINE1),and activation of innate immune signaling via the cGAS-STING pathway.These agingassociated cellular defects were reversed by overexpression of heterochromatin proteins or treatment with a LINE1 targeted reverse-transcriptase inhibitor.Together,these findings highlight how SIRT7 safeguards chromatin architecture to control innate immune regulation and ensure geroprotection during stem cell aging. | Shijia Bi Zunpeng Liu Zeming Wu Zehua Wang Xiaoqian Liu Si Wang Jie Ren Yan Yao Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2020 | Protein & Cell2020，11，7： | 10 |
| 19 | Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure显示文摘AIM: To investigate the protective effect of stronger neo-minophafen C (SNMC) on fulminant hepatic failure (FHF) and its underlying mechanism. METHODS: A mouse model of FHF was established by intraperitoneal injection of galactosamine (D-Gal N) and lipopolysaccharide (LPS). The survival rate, liver function, inflammatory factor and liver pathological change were obtained with and without SNMC treatment. Hepatocyte survival was estimated by observing the stained mitochondria structure with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling (TUNEL) method and antibodies against cytochrome C (Cyt-C) and caspase-3. RESULTS: The levels of plasma tumor necrosis factor alpha (TNF-α), nitric oxide (NO), ET-1, interleukin-6 (IL-6), and the degree of hepatic tissue injury were decreased in the SNMC-treated groups compared with those in the model group (P < 0.01). However, there were no differences after different dosages administered at different time points. There was a significant difference in survival rates between the SNMC-treated groups and the model group (P < 0.01). The apoptosis index was 32.3% at 6 h after a low dose of SNMC, which was considerably decreased from 32.3% ± 4.7% vs 5% ± 2.83% (P < 0.05) to 5% on d 7. The expression of Cyt-C and caspase-3 decreased with the prolongation of therapeutic time. Typical hepatocyte apoptosis was obviously ameliorated under electron microscope with the prolongation of therapeutic time. CONCLUSION: SNMC can effectively protect liver against FHF induced by LPS/D-Gal N. SNMC can prevent hepatocyte apoptosis by inhibiting inflammatory reactionand stabilizing mitochondria membrane to suppress the release of Cyt-C and sequent activation of caspase-3. | Bao-Shan Yang Ying-Ji Ma Yan Wang Li-Yan Chen Man-Ru Bi Bing-Zhu Yan Lu Bai Hui Zhou Fu-Xiang Wang | 2007 | World Journal of Gastroenterology2007，13，3： | 10 |
| 20 | Preliminary assessing no-surgical treatment response in bronchogenic carcinoma with double-phase contrast material-enhanced computed tomography显示文摘评估双阶段的功效的目的在 preliminarily 在 bronchogenic 癌估计没有外科的治疗反应对比提高材料的计算断层摄影术(CT ) 。有在没有外科的治疗以后的 bronchogenic 癌的 52 个病人经历了双阶段的方法对比提高材料的计算断层摄影术。在非离子的对比材料经由赌注被管理以后,二螺线 CT 扫描分别地在 25 和 90 秒点被获得以由使用一个汽车注射者的 4 mL/s 的率的肘的静脉。每扫描上的 Precontrast 和柱子对比变细被记录,山峰高度是计算的。改进模式在在对比媒介的注射以后在 25 和 90 秒点获得的图象上被评估。结果 Precontrast 变细,在 25 和 90 秒点的柱子对比变细是 42.20 ± 7.43 胡, 57.35 ± 10.09 胡和 71.85 ± 12.45 胡分别地。在 precontrast 变细的统计上重要的差别都没在我们在治疗前在情况中被获得的旧学习(吝啬的 precontrast 变细 40.70 胡) 在学习和结果在我们的结果之间被发现(t = 1.455, P = 0.152 >
0.05 ) 。在没有外科的治疗以后的 bronchogenic 癌的山峰高度(29.46 ± 10.85 胡) 是比在在我们的旧学习获得的治疗前的 bronchogenic 癌的显著地低的(吝啬的山峰高度 35.79 胡;t = 4.206, P = 0.001 <
0.05 ) 。52 个盒子中的 32 个在 90 秒点显示出同类的改进。32 个盒子,与不同类的改进有 21, 7 与不同类的改进, 2 与中央改进并且 2 与在 25 秒点的外部改进。在没有外科的处理以后的结论 Bronchogenic 癌在对比材料的管理以后显示出渐渐的增加到山峰高度。山峰高度能反映 bronchogenic 癌的血供应并且可能是为在 bronchogenic 癌的没有外科的治疗反应的评估的索引。 | Shenjiang Li Yong Zhao Yan Zhu Feng Zhu Debin Liu Wenjie Liang Xuefeng Cui Wenjie Bi | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 9 |
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