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| 1 | Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings显示文摘Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level. | Ting Lei Meng Zhang Yuru Li Ping Jia Gordon Ning Liu Xiaogeng Xu Zhaohui Li Changjun Min Jiao Lin Changyuan Yu Hanben Niu Xiaocong Yuan | 2015 | Light(Science & Applications)2015，4，1： | 47 |
| 2 | Progress and recent trend in MILD combustion显示文摘Moderate or intense low oxygen dilution(MILD)combustion plays a significant role in the mitigation of combustion-generated pollutants and greenhouse gases whilst meeting thermal efficiency needs.However,due to the lack of the fundamental knowledge on this combustion,there is a misconception that MILD combustion should be established by high preheating of the air,which has limited its application.Our research and development on this combustion has been performed for several years. We have found that the requirements for establishing the MILD combustion are more relaxed than previously.It is also revealed that this combustion of different type,i.e.,non-premixed,partially premixed and fully premixed,can be achieved by firing various fuels(i.e.,gaseous,liquid and solid fuels).It is suggested that the application of the MILD combustion can be expanded significantly.The present review summarizes the progress and recent trend made in the R&D of this combustion and recommends further fundamental studies for improving our knowledge and widening its applications. | LI PengFei MI JianChun DALLY B B WANG FeiFei WANG Lin LIU ZhaoHui CHEN Sheng ZHENG ChuGuang | 2011 | Science China(Technological Sciences)2011，54，2： | 31 |
| 3 | A Review of Seasonal Climate Prediction Research in China显示文摘The ultimate goal of climate research is to produce climate predictions on various time scales. In China, efforts to predict the climate started in the 1930 s. Experimental operational climate forecasts have been performed since the late 1950 s,based on historical analog circulation patterns. However, due to the inherent complexity of climate variability, the forecasts produced at that time were fairly inaccurate. Only from the late 1980 s has seasonal climate prediction experienced substantial progress, when the Tropical Ocean and Global Atmosphere project of the World Climate Research program(WCRP) was launched. This paper, following a brief description of the history of seasonal climate prediction research, provides an overview of these studies in China. Processes and factors associated with the climate variability and predictability are discussed based on the literature published by Chinese scientists. These studies in China mirror aspects of the climate research effort made in other parts of the world over the past several decades, and are particularly associated with monsoon research in East Asia. As the climate warms, climate extremes, their frequency, and intensity are projected to change, with a large possibility that they will increase. Thus, seasonal climate prediction is even more important for China in order to effectively mitigate disasters produced by climate extremes, such as frequent floods, droughts, and the heavy frozen rain events of South China. | WANG Huijun FAN Ke SUN Jianqi LI Shuanglin LIN Zhaohui ZHOU Guangqing CHEN Lijuan LANG Xianmei LI Fang ZHU Yali CHEN Hong ZHENG Fei | 2015 | Advances in Atmospheric Sciences2015，32，2： | 20 |
| 4 | ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome显示文摘OBJECTIVES:Anti-citrullinated protein antibodies(ACPAs)are a group of autoantibodies targeted against citrullinated proteins/peptides and are informative rheumatoid arthritis(RA)biomarkers.ACPAs also play a crucial role in RA pathogenesis,and their underlying mechanism merits investigation.METHODS:Immunohistochemical(IHC)assays were carried out to determine IL-1βlevels in ACPA+and ACPA−RA patients.PBMCderived monocytes were differentiated into macrophages before stimulation with ACPAs purified from RA patients.The localization and interaction of molecules were analyzed by confocal microscopy,co-IP,and surface plasmon resonance.RESULTS:In our study,we found that IL-1βlevels were elevated in ACPA+RA patients and that ACPAs promoted IL-1βproduction by PBMC-derived macrophages.ACPAs interacted with CD147 to enhance the interaction between CD147 and integrinβ1 and,in turn,activate the Akt/NF-κB signaling pathway.The nuclear localization of p65 promoted the expression of NLRP3 and pro-IL-1β,resulting in priming.Moreover,ACPA stimulation activated pannexin channels,leading to ATP release.The accumulated ATP bound to the P2X7 receptor,leading to NLRP3 inflammasome activation.CONCLUSIONS:Our study suggests a new hypothesis regarding IL-1βproduction in RA involving ACPAs,which may be a potential therapeutic target in RA treatment. | Xiwen Dong Zhaohui Zheng Peng Lin Xianghui Fu Fanni Li Jianli Jiang Ping Zhu | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 5 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 6 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 7 | Temporal-spatial characteristics of vegetation cover and desertification of China by using remote sensing data | XU Xingkui , LIN Zhaohui, LI Jianping and ZENG Qingcun(LASG, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China) | 2002 | Progress in Natural Science:Materials International2002，12，1： | 4 |
| 8 | Treatment of spinal tuberculosis with ultrashort-course chemotherapy in conjunction with partial excision of pathologic vertebrae显示文摘 | Zili Wang Zhaohui Ge Weidong Jin Yongdong Qiao Huiqiang Ding Haoning Zhao Zhikai Lin Jun Chen Weiyu Yang | 2007 | The Spine Journal2007，，6： | 3 |
| 9 | Tailoring the Meso-Structure of Gold Nanoparticles in Keratin-Based Activated Carbon Toward High-Performance Flexible Sensor显示文摘Flexible biosensors with high accuracy and reliable operation in detecting pH and uric acid levels in body fluids are fabricated using well-engineered metaldoped porous carbon as electrode material.The gold nanoparticles@N-doped carbon in situ are prepared using wool keratin as both a novel carbon precursor and a stabilizer.The conducting electrode material is fabricated at 500℃ under customized parameters,which mimics A-B type(two different repeating units) polymeric material and displays excellent deprotonation performance(pH sensitivity).The obtained pH sensor exhibits high pH sensitivity of 57 mV/pH unit and insignificant relative standard deviation of 0.088%.Conversely,the composite carbon material with sp^2 structure prepared at 700℃ is doped with nitrogen and gold nanoparticles,which exhibits good conductivity and electrocatalytic activity for uric acid oxidation.The uric acid sensor has linear response over a range of 1-150 μM and a limit of detection 0.1 μM.These results will provide new avenues where biological material will be the best start,which can be useful to target contradictory applications through molecular engineering at mesoscale. | Aniruddha BPatil Zhaohui Meng Ronghui Wu Liyun Ma Zijie Xu Chenyang Shi Wu Qiu Qiang Liu Yifan Zhang Youhui Lin Naibo Lin Xiang Yang Liu | 2020 | Nano-Micro Letters2020，12，9： | 3 |
| 10 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 11 | High-performance polarization management devices based on thin-film lithium niobate显示文摘High-speed polarization management is highly desirable for many applications,such as remote sensing,telecommunication,and medical diagnosis.However,most of the approaches for polarization management rely on bulky optical components that are slow to respond,cumbersome to use,and sometimes with high drive voltages.Here,we overcome these limitations by harnessing photonic integrated circuits based on thin-film lithium niobate platform.We successfully realize a portfolio of thin-film lithium niobate devices for essential polarization management functionalities,including arbitrary polarization generation,fast polarization measurement,polarization scrambling,and automatic polarization control.The present devices feature ultra-fast control speeds,low drive voltages,low optical losses and compact footprints.Using these devices,we achieve high fidelity polarization generation with a polarization extinction ratio up to 41.9 dB and fast polarization scrambling with a scrambling rate up to 65 Mrad s−1,both of which are best results in integrated optics.We also demonstrate the endless polarization state tracking operation in our devices.The demonstrated devices unlock a drastically new level of performance and scales in polarization management devices,leading to a paradigm shift in polarization management. | Zhongjin Lin Yanmei Lin Hao Li Mengyue Xu Mingbo He Wei Ke Heyun Tan Ya Han Zhaohui Li Dawei Wang X.Steve Yao Songnian Fu Siyuan Yu Xinlun Cai | 2022 | Light(Science & Applications)2022，11，5： | 3 |
| 12 | Effects of Nitrogen and Phosphorus on the Growth of Levanderina fissa:How It Blooms in Pearl River Estuary显示文摘Effects of nitrogen(N) and phosphorus(P) from different sources and at different concentrations on the growth of Levanderina fissa(= Gyrodinium instriatum) were studied in laboratory conditions. The findings might explain the recurrent blooms of this species in Pearl River Estuary, China. Results showed that nutrient limitation significantly inhibited the growth of L. fissa. The values of specific growth rate(μmax) and half-saturation nutrient concentration(KS) were 0.37 divisions/d and 8.49 μmol L^(-1) for N, and 0.39 divisions/d and 1.99 μmol L^(-1) for P, respectively. Based on KS values, dissolved inorganic N level in PRE was sufficient to support the high proliferation of L. fissa, while dissolved inorganic P concentration was far lower than the minimum requirement for its effective growth. L. fissa was not able to utilize dissolved organic N(DON) compounds such as urea, amino acids, and uric acid. However, it grew well by using a wide variety of dissolved organic P(DOP) sources like nucleotides, glycerophosphate, and 4-nitrophenylphosphate. The results from this study suggested that the ability in DOP utilization of L. fissa offers this species a competitive advantage in phytoplankton communities. The high level and continuous supply of DIN, enrichment of DOP, together with warm climate and low salinity in the Pearl River Estuary provided a suitable nutrient niche for the growth of L. fissa, and resulted in the recurrent blooms in the estuary. | WANG Zhaohui GUO Xin QU Linjian LIN Langcong | 2017 | Journal of Ocean University of China2017，16，1： | 3 |
| 13 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 14 | Tumor suppressor p53:new functions of an old protein显示文摘p53 was discovered 30 years ago.Extensive studies have been done on p53 since then,which makes p53 one of the most extensively studied genes.p53 has long been recognized as a key tumor suppressor.Cell cycle arrest,apoptosis and senescence have been traditionally recognized as the main functions of p53 in tumor suppression.Recently,some novel functions of p53 have been identified,including the regulation of energy metabolism,antioxidant defense,and microRNA expression and maturation,which all contribute to the role of p53 in tumor suppression.Furthermore,the contribution of p53 to normal biologic processes(e.g.reproduction and aging)and some other aspects of diseases(e.g.neurodegenerative diseases)is only now being appreciated.Here we will review recent advances in the study of some new functions of p53. | Zhaohui FENG Rui WU Meihua LIN Wenwei HU | 2011 | Frontiers in Biology2011，6，1： | 2 |
| 15 | Glycogen synthase kinase-3: a key kinase in retinal neuron apoptosis in early diabetic retinopathy显示文摘 | Li Zhaohui Ma Ling Chen Xiaodong Li Yonghao Li Shiyi Zhang Jinglin Lu Lin | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 16 | Dynamical framework with blocking topography coordinates for atmospheric GCM and its validation显示文摘The dynamical framework with Blocking To-pography Coordinates (hereafter, BTC), which is suited tohandle the steep topography for the atmospheric generalcirculation models, is presented in this paper, together withits validation results. The integral properties of both the dif-ferential and finite-difference equations for the BTC dy-namical core are: gross mass conservation, quadratic con-servation for advection terms, Coriolis force does not changethe kinetic energy, conservation of total available energy. Theimproved nonlinear iteration scheme is utilized for thetime-integration. The energy conservation for BTC dynami-cal core is validated by using the integration results from9-layer and 21-layer version respectively. Comparison resultsshow that, the changes of the kinetic energy and total avail-able potential energy during the integration are quite closefor both the BTC dynamical framework and the dynamicalframework of IAP 9-level and IAP 21-level AGCM, and thismay suggest that the BTC dynamical core can be used forlong-term integration with good computational stability.Furthermore, the BTC dynamical core has the advantageover the terrain following (sigma) coordinates in its betterrepresentation of the influence of the large-scale topographyon the atmospheric general circulation. Finally, the correct-ness and reasonableness of the BTC dynamical core has beenfurther proved by the numerical simulation of the topogra-phy influence on the quasi-stationary planetary wave with21-layer version of BTC dynamical framework. | LIN Zhaohui~1, ZHANG Ming~(1,2), LIANG Danqing~(1,2) WANG Aihui~1, ZHANG Dongling~1 & ZENG Qingcun~1 1. ICCES, Institute of Atmospheric Physics, Chinese Academy of Sciences. Beijing 100029. China 2. College of Meteorology. PLA University of Science and Technology, Nanjing 211101. China | 2003 | Chinese Science Bulletin2003，48，S2： | 2 |
| 17 | Introduction and systematic assessment for IAP numerical annual climate prediction system显示文摘The IAP numerical annual climate predictionsystem has been presented in this paper. In order to evaluatethis annual prediction system, annual ensemble hindcastexperiments over a 21-year period from 1980 to 2000 havebeen done. Systematic assessment shows that this annualprediction system has higher predictability for summer cli-mate in tropic than in extra-tropic area, and higher predict-abilities over ocean than over land for the fields of precipita-tion, sea level pressure and surface air temperature; for 500hPa geopotential height field, the predictability assuming azonal distribution decreases from tropic to middle-high lati-tudes, and in China it is the highest among those of all fields.Correlation analysis shows that the prediction ability of IAPannual prediction system to summer temperature is higherthan that to precipitation, and the prediction skill can beremarkably improved by the correction system. Furthermore,the comparison between annual and extraseasonal hindcastsindicates that precipitation hindcasted extraseasonally isbetter than that done annually, and the major discrepancyexists in middle-high latitudes. | CHEN Hong, LIN Zhaohui & ZENG Qingcun International Center for Climate and Environmental Sciences (ICCES), Institute of Atnlospheric Physics, Chinese Academy of Sciences, Bcijing 100029, China | 2003 | Chinese Science Bulletin2003，48，S2： | 2 |
| 18 | A solution on identification and rearing files in smallhold production显示文摘 | Xiong Benhai Fu Runting Lin Zhaohui | 2009 | Computer and Computing Technologies in Agriculture 2/springer2009，，3： | 1 |
| 19 | Experimental and numerical investigation of the flow field in the tip region of an axial ventilation fan显示文摘 | Zhu Xiaocheng Lin Wanlai Du Zhaohui | 2005 | Journal of Fluid Engineering2005，127，3： | 1 |
| 20 | Numerical Flow and Performance Analysis of A Water-Jet Axial Flow Pump 显示文摘 | GAO Hong LIN Wanlan DU Zhaohui | 2008 | Ocean Engineering2008，35，16： | 1 |
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