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| 1 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 2 | Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin显示文摘LRP16 以前在乳癌房间作为导致雌激素的基因被识别。到在子宫内膜的癌症(EC ) 的雌激素和它的功能的效果的 LRP16 的应答的海角房间仍然是不清楚的。这里,我们证明 LRP16 基因的信使 rna 水平和倡导者活动被 17beta-estradiol (E2 ) 显著地在雌激素受体高山增加哈(嗯高山哈)-positiveIshikawa 人 EC 房间。尽管 Ishikawa 细胞的生长率没被 LRP16 的宫外的表示显然影响, Transwell 试金的结果显示出 LRP16-overexpressing 细胞的侵略能力的近似 one-thirdincrease。由于分子的屏蔽,我们观察到 E-cadherin 的表示,与肿瘤转移联系的一个必要粘附分子,被 LRP16 镇压。进一步的倡导者分析以一种剂量依赖者方式表明了那 LRP16 inhibitedE-cadherin transactivation。然而,抑制被雌激素剥夺废除,显示由 LRP16requires 的 E-cadherin 抄写的 down 规定嗯高山哈调停。染色质免疫降水分析表明到 E-cadherin 倡导者的 ERalpha 的绑定被 LRP16 反对,建议那 LRP16 能防碍嗯调停 alpha 的抄写。这些结果建议起来由雌激素的 LRP16 的规定能被在人的 EC 调整 E-cadherin 的 down 涉及侵略生长。 | Yuan Guang Meng Wei Dong Han Ya Li Zhao Ke Huang Yi Ling Si Zhi Qiang Wu Yi Ming Mu | 2007 | Cell Research2007，17，10： | 27 |
| 3 | Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics显示文摘An amphiphilic polymer bearing tetraphenylethene (TPE) moiety was synthesized by convenient reactions. The polymer exhibits unique aggregation-induced emission (AIE) characteristics and can self-assemble to size-tunable particles in DMF/water mixtures. The polymer nanoparticles can be used for cell imaging, which provides a potential stable fluorescent tool to monitor the distribution of drugs and bioconjugates in living cells. | QIN AnJun ZHANG Ya HAN Ning MEI Ju SUN JingZhi FAN WeiMin TANG Ben Zhong | 2012 | Science China Chemistry2012，55，5： | 16 |
| 4 | Study of parachute inflation process using fluid–structure interaction method显示文摘A direct numerical modeling method for parachute is proposed firstly, and a model for the star-shaped folded parachute with detailed structures is established. The simplified arbitrary Lagrangian–Eulerian fluid–structure interaction(SALE/FSI) method is used to simulate the inflation process of a folded parachute, and the flow field calculation is mainly based on operator splitting technique. By using this method, the dynamic variations of related parameters such as flow field and structure are obtained, and the load jump appearing at the end of initial inflation stage is captured. Numerical results including opening load, drag characteristics, swinging angle, etc. are well consistent with wind tunnel tests. In addition, this coupled method can get more space–time detailed information such as geometry shape, structure, motion, and flow field. Compared with previous inflation time method, this method is a completely theoretical analysis approach without relying on empirical coefficients, which can provide a reference for material selection, performance optimization during parachute design. | Yu Li Cheng Han Zhan Ya'nan Li Shaoteng | 2014 | Chinese Journal of Aeronautics2014，27，2： | 13 |
| 5 | Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population显示文摘The effects of genetic factors on the noise-induced hearing loss(NIHL)are still unclear.In the present study,eight single-nucleotide polymorphisms(SNPs)included rs1227049 and rs3802711(CDH23),rs1695(GSTP1),rs137852540(GJB2),rs2289274(PMCA2),rs4880(SOD2),rs7943316,and rs769214 within CAT that might associated with NIHL were further validated | WANG Sheng Li YU Lu Gang LIU Ren Ping ZHU Wan Zhan GAO Wei Min XUE Li Ping JIANG Xu ZHANG Ya Han YI Ding CHEN Dong ZHANG Yong Hong | 2014 | Biomedical and Environmental Sciences2014，27，12： | 12 |
| 6 | Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages显示文摘Silicosis caused by inhalation of silica particles leads to more than ten thousand new occupational exposure-related deaths yearly.Exacerbating this issue,there are currently few drugs reported to effectively treat silicosis.Tetrandrine is the only drug approved for silicosis treatment in China,and despite more than decades of use,its efficacy and mechanisms of action remain largely unknown.Here,in this study,we established silicosis mouse models to investigate the effectiveness of tetrandrine of early and late therapeutic administration.To this end,we used multiple cardiopulmonary function test,as well as markers for inflammation and fibrosis.Moreover,using single cell RNA sequencing and transcriptomics of lung tissue and quantitative microarray analysis of serum from silicosis and control mice,our results provide a novel description of the target pathways for tetrandrine.Specifically,we found that tetrandrine attenuated silicosis by inhibiting both the canonical and non-canonical NLRP3 inflammasome pathways in lung macrophages.Taken together,our work showed that tetrandrine yielded promising results against silicosis-associated inflammation and fibrosis and further lied the groundwork for understanding its molecular targets.Our results also facilitated the wider adoption and development of tetrandirne,potentially accelerating a globally accepted therapeutic strategy for silicosis. | Mei-yue Song Jia-xin Wang You-liang Sun Zhi-fa Han Yi-tian Zhou Ying Liu Tian-hui Fan Zhao-guo Li Xian-mei Qi Ya Luo Pei-ran Yang Bai-cun Li Xin-ri Zhang Jing Wang Chen Wang | 2022 | Acta Pharmacologica Sinica2022，43，5： | 12 |
| 7 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 8 | Joint land-sea seismic survey and research on the deep structures of the Bohai Sea areas显示文摘This paper presents the survey and research work of two land-sea profiles in the Bohai Sea,China,carried out in 2010–2011,including the seismic sources on land and in the sea,the ocean bottom seismographs(OBS)and their recovery,the coupling of OBS and the environment noise in sea area,the data quality of OBSs,and the result of data analysis.We focused on the investigation of crustal structures revealed by the two NE\EW-trending joint land-sea profiles.In combination with the Pn-velocity distribution and gravitymagnetic inversion results in the North China Craton,we propose that the undulation of the Moho interface in the Bohai and surrounding areas is not strong,and the lithospheric thinning is mainly caused by the thinning of its mantle part.The research result indicates that obvious lateral variations of Moho depth and seismic velocity appear nearby all the large-scale faults in Bohai Sea,and there is evidence of underplating and reforming of the lower crust by mantle material in the Bohai area.However,geophysical evidence does not appear to support the'mantle plume'or'delamination'model for the North China Craton destruction.The crustal structure of the Bohai Sea revealed'a relatively normal crust and obviously thinned mantle lid',local velocity anomalies and instability phenomena in the crust.These features may represent a combined effect of North China-Yangtze collision at an early stage and the remote action of Pacific plate subduction at a late stage. | HAO Tianyao YOU Qingyu LIU Lihua LV Chuanchuan XU Ya LI Zhiwei ZHAO Chunlei ZHENG Yanpeng LIU Chenguang HAN Guozhong | 2013 | Acta Oceanologica Sinica2013，32，12： | 11 |
| 9 | Appraisal of the Quality and Contents of Clinical Practice Guidelines for Hypertension Management in Chinese Medicine: A Systematic Review显示文摘Objective: To evaluate the quality and consistency of recommendations in the clinical practice guidelines(CPGs) for hypertension in Chinese medicine(CM). Methods: CM CPGs were identified from 5 electronic databases and hand searches through related handbooks published from January 1990 to December 2013. Three reviewers independently appraised the CPGs based on the Appraisal of Guidelines for Research and Evaluation(AGREE Ⅱ) instrument, and compared the CPGs' recommendations on CM syndrome pattern classification and treatment. Results: Five CM CPGs for hypertension were included. The quality score of the evidence-based(EB) guideline was higher than those of the consensus-based with no explicit consideration of evidence-based(CB-EB) and the consensus-based(CB) guidelines. Three out of five patterns in the CPGs were recommended by the EB guideline. Tianma Gouteng Formula(天麻钩藤复方) in the EB guideline was recommended mostly for hypertension patients with pattern of ascendant hyperactivity of Gan(Liver)-yang and pattern of yin deficiency with yang hyperactivity in the CPGs. Acupuncture and massage were recommended for Grade Ⅰ and Grade Ⅱ hypertension with severe symptoms weakening the quality of life in the EB guideline. For Grade Ⅰ and Grade Ⅱ hypertension, CM could be used alone, while for Grade Ⅲ hypertension, they should be used in combination with Western medicines. Conclusion: The quality of EB guideline was higher than those of CB and CB-EB CPGs in CM for hypertension and CM should be prescribed alone or combined with Western medicines based on the grade of hypertension. | YUWEN Ya HAN Xue-jie WENG Wei-liang ZHAO Xue-yao LIU Yu-qi LI Wei-qiang LIU Da-sheng WANG Yan-ping LU Ai-ping | 2018 | Chinese Journal of Integrative Medicine2018，24，7： | 8 |
| 10 | Consensus by Chinese Expert Panel on Chlamydia trachomatis-Resistant and Chlamydia trachomatis-Persistent Infection显示文摘 | Man-Li Qi Yuan-Li Guo Qian-Qiu Wang Xiang-Sheng Chen Jian-De Han Xiao-Hong Su Wen-Hui Lun Hao Cheng Jin-Hua Xu Hong-Qing Tian Li Che Zhi-Yuan Ya Wen-Li Feng Juan Jiang Ping-Yu Zhou Xian-Biao Zo Hong-Hui Xu Wei-Min Shi Jun Liu Lin Zhu Quan-Zhong Liu | 2017 | Chinese Medical Journal2017，，23： | 7 |
| 11 | Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography显示文摘Background The correlation among the ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol(LDL-C/HDL-C), total cholesterol/high-density lipoprotein cholesterol(TC/HDL-C) and thin-cap fibroatheroma has not yet been established. Methods It was a single center, retrospective observational study. In total, we recruited 421 patients(82.4% men;mean age 65.73 ± 10.44 years) with one culprit vessel which determined by intravascular optical coherence tomography(OCT). The thinnest-capped fibroatheroma(TCFA) group was defined as lipid contents in > 2 quadrants, with the thinnest fibrous cap measuring less than 65 μm. Univariate and multivariate logistic regression were carried out to explore the relationship between lipoprotein ratios, TCFA and other characteristics of plaque. To compare different ratios, the area under curve(AUC) of receiver-operating characteristic(ROC) curve was assessed. Results OCT was performed in 421 patients(TCFA group(n = 109), non-TCFA group(n = 312)). LDL-C/HDL-C in the TCFA group was significantly higher than in the non-TCFA group(2.95 ± 1.20 vs. 2.43 ± 0.92, P < 0.05), as was TC/LDL in TCFA and non-TCFA group(4.57 ± 1.58 vs. 4.04 ± 1.13, P < 0.05). Both LDL-C/HDL-C(OR: 1.002(1.002-1.003), P < 0.05) and TC/HDL-C(OR: 1.001(1.001-1.004), P < 0.05) were considered independent factors for the prediction of TCFA according to the logistic regression. Based on the AUC comparison, LDL-C/HDL-C and TC/HDL-C had no significant difference statistically(LDL-C/HDL-C AUC: 0.63;TC/HDL-C AUC: 0.61;P = 0.10) for the prediction of TCFA. Conclusions LDL-C/HDL-C and TC/HDL-C could be the independent factors for predicting the presence of TCFA, indicating coronary plaque vulnerability in CAD patients. Moreover, TC/HDL-C also showed a comparative performance for the prediction of TCFA as LDL-C/HDL-C. | Yao WANG Si-Si ZHANG Qing-Bo LV Ya LI Jin ZHAO Jia HAN Guo-Sheng FU Wen-Bin ZHANG | 2020 | Journal of Geriatric Cardiology2020，17，11： | 7 |
| 12 | Ursodeoxycholic acid induces apoptosis in hepatocellular carcinoma xenografts in mice显示文摘AIM: To evaluate the efficacy of ursodeoxycholic acid(UDCA) as a chemotherapeutic agent for the treatment of hepatocellular carcinoma(HCC).METHODS: BALB/c nude mice were randomized into four groups 24 h before subcutaneous injection of hepatocarcinoma BEL7402 cells suspended in phosphate buffered saline(PBS) into the right flank. The control group(n = 10) was fed a standard diet while treatment groups(n = 10 each) were fed a standard daily diet supplemented with different concentrations of UDCA(30,50 and 70 mg/kg per day) for 21 d. Tumor growth was measured once each week,and tumor volume(V) was calculated with the following equation: V =(L × W2) × 0.52,where L is the length and W is the width of the xenograft. After 21 d,mice were killed under ether anesthesia,and tumors were excised and weighed. Apoptosis was evaluated through detection of DNA fragmentation with gel electrophoresis and the terminaldeoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) assay. Western blot analysis was performed to determine the expression of apoptosisrelated proteins BAX,BCL2,APAF1,cleaved caspase-9,and cleaved caspase-3.RESULTS: UDCA suppressed tumor growth relative to controls. The mean tumor volumes were the following: control,1090 ± 89 mm3; 30 mg/kg per day,612 ± 46 mm3; 50 mg/kg per day,563 ± 38 mm3; and 70 mg/kg per day,221 ± 26 mm3. Decreased tumor volumes reached statistical significance relative to control xenografts(30 mg/kg per day,P < 0.05; 50 mg/kg per day,P < 0.05; 70 mg/kg per day,P < 0.01). Increasing concentrations of UDCA led to increased DNA fragmentation observed on gel electrophoresis and in the TUNEL assay(control,1.6% ± 0.3%; 30 mg/kg per day,2.9% ± 0.5%; 50 mg/kg per day,3.15% ± 0.7%,and 70 mg/kg per day,4.86% ± 0.9%). Western blot analysis revealed increased expression of BAX,APAF1,cleaved-caspase-9 and cleaved-caspase-3 proteins,which induce apoptosis,but decreased expression of BCL2 protein,which is an inhibitor of apoptosis,following administration of UDCA. CONCLUSION: UDCA suppresses growth of BEL7402 hepatocellular carcinoma cells in vivo,in part through apoptosis induction,and is thus a candidate for therapeutic treatment of HCC. | Hui Liu Hong-Wei Xu Yu-Zhen Zhang Ya Huang Guo-Qing Han Tie-Jun Liang Li-Li Wei Cheng-Yong Qin Cheng-Kun Qin | 2015 | World Journal of Gastroenterology2015，21，36： | 7 |
| 13 | Synthesis of magnetically modified palygorskite composite for immobilization of Candida sp. 99–125 lipase via adsorption显示文摘Magnetically modified palygorskite composites were synthesized with γ-Fe2O3 dispersing on the external surface of clay mineral. The magnetic clay was characterized with Fourier transform infrared, X-ray diffraction, transmission electron microscopy, and vibrating sample magnetometer. Candida sp. 99–125 lipase was immobilized on magnetic palygorskite composites by physical adsorption with enzyme loading of41.5 mg·g-1support and enzyme activity of 2631.6 U·(g support)-1. The immobilized lipase exhibit better thermal and broader p H stability and excellent reusability compared with free lipase. | Ya Li Jicheng Hu Pingfang Han | 2015 | Chinese Journal of Chemical Engineering2015，23，5： | 6 |
| 14 | The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST显示文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. | Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
| 15 | New contributions to Goodyerinae and Dendrobiinae(Orchidaceae)in the flora of China显示文摘Eight new species from China,Cheirostylis chuxiongensis,C.yei,Myrmechis lingulata,M.longii,Bulbophyllum ximaense,B.xizangense,B.retusum and B.pulcherissimum,are described and illustrated.Cheirostylis chuxiongensis differs from C.thailandica by having 5-9 irregular and papillae-like calli on each side in the sac of the lip,epichile with entire lobes,petals narrowly obliquely obovate and an apex that is not recurved.Cheirostylis yei is easily distinguished from its relatives similar by having a long stem,pubescent ovary and sepals,epichile lobes with irregular and undulate margins,a subquadrate callus without teeth in the saccate hypochile.Myrmechis lingulata differs from M.chinensis by having a simple and lanceolate to ligulate lip,glabrous bracts and ovary,oblique and narrowly ovate petals.Myrmechis longii differs from M.pumila by having white-veined leaves,oblong-lanceolate epichile lobes,and viscidium attached to the middle of the caudicle.Bulbophyllum ximaense is easily distinguished from its relatives similar by having distant pseudobulbs,shorter scape,an inflorescence with 9-16 orange-red flowers,shorter lateral sepals with a long acuminate apex,incurved and tubular apical margins,a papillate lip disk and triangular-subulate stelidia.Bulbophyllum xizangense is easily distinguished from its relatives similar by having narrow lanceolate leaves,shorter inflorescence with 1-3 greenish-yellow flowers,falcate-ovoid lateral sepals,a lip with small lateral lobes and 3 keels at the base.Bulbophyllum retusum differs from B.spathulatum by having shorter inflorescence,peduncles with 2 tubular sheaths,dorsal sepals with a retuse apex,lateral sepals with lower edges that are connate to each other and free and divergent toward the apex,obovate petals with an acute or slightly retuse apex.Bulbophyllum pulcherissimum differs from B.lopalanthum by its 5-veined dorsal sepal,ovate-lanceolate lateral sepals,obliquely ovate-oblong petal,erose-toothed margins and obovate lip with a large,oblong basal callus,and an obtuse base.In addition,three species(Bulbophyllum frostii,B.raskotii and B.nematocaulon)are reported for the first time in China. | Ji-Dong Ya Ting Zhang Tirtha Raj Pandey Cheng Liu Zhou-Dong Han De-Ping Ye De-Ming He Qiang Liu Lan Yang Li Huang Rong-Zhen Zhang Hong Jiang Jie Cai | 2021 | Plant Diversity2021，43，5： | 5 |
| 16 | Estimating biological reference points for Largehead hairtail(Trichiurus lepturus) fishery in the Yellow Sea and Bohai Sea显示文摘It is important to find a reliable method to estimate maximum sustainable yield(MSY)or total allowable catch(TAC)for fishery management,especially when the data availability is limited which is a case in China.A recently developed method(CMSY)is a data-poor method,which requires only catch data,resilience and exploitation history at the first and final years of the catch data.CMSY was used in this study to estimate the biological reference points for Largehead hairtail(Trichiurus lepturus,Temminck and Schlegel)in the Yellow Sea and Bohai Sea,based on the fishery data from China Fishery Statistical Year Books during 1986 to 2012.Additionally,Bayesian state-space Schaefer surplus production model(BSM)and the classical surplus production models(Schaefer and Fox)performed by software CEDA and ASPIC,were also projected in this study to compare with the performance of CMSY.The estimated MSYs from all models are about 19.7×104–27.0×104 t,while CMSY and BSM yielded more reasonable population parameter estimates(the intrinsic population growth rate and the carrying capacity).The biological reference points of B/BMSY smaller than 1.0,while F/FMSY higher than 1.0 revealed an over-exploitation of the fishery,indicating that more conservative management strategies are required for Largehead hairtail fishery. | Yupeng Ji Qun Liu Baochao Liao Qingqing Zhang Ya’nan Han | 2019 | Acta Oceanologica Sinica2019，38，10： | 5 |
| 17 | Di(2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats显示文摘Objective Previous studies have indicated that the plasticizer di(2-ethylhexyl) phthalate(DEHP) affects lipid accumulation;however, its underlying mechanism remains unclear. We aim to clarify the effect of DEHP on lipid metabolism and the role of TYK2/STAT1 and autophagy. Methods In total, 160 Wistar rats were exposed to DEHP [0, 5, 50, 500 mg/(kg·d)] for 8 weeks. Lipid levels, as well as mRNA and protein levels of TYK2, STAT1, PPARγ, AOX, FAS, LPL, and LC3 were detected. Results The results indicate that DEHP exposure may lead to increased weight gain and altered serum lipids. We observed that DEHP exposure affected liver parenchyma and increased the volume or number of fat cells. In adipose tissue, decreased TYK2 and STAT1 promoted the expression of PPARγ and FAS. The mRNA and protein expression of LC3 in 50 and 500 mg/(kg·d) groups was increased significantly. In the liver, TYK2 and STAT1 increased compensatorily;however, the expression of FAS and AOX increased, while LPL expression decreased. Joint exposure to both a high-fat diet and DEHP led to complete disorder of lipid metabolism. Conclusion It is suggested that DEHP induces lipid metabolism disorder by regulating TYK2/STAT1. Autophagy may play a potential role in this process as well. High-fat diet, in combination with DEHP exposure, may jointly have an effect on lipid metabolism disorder. | ZHANG Yue Zhu ZHANG Zhao Ming ZHOU Li Ting ZHU Jian ZHANG Xiao Han QI Wen DING Shuang XU Qi HAN Xu ZHAO Ya Ming SONG Xin Yue ZHAO Tian Yang YE Lin | 2019 | Biomedical and Environmental Sciences2019，32，6： | 4 |
| 18 | Three new species of Liparis s.l.(Orchidaceae:Malaxideae)from Southwest China based on morphological characters and phylogenetic evidence显示文摘Liparis aureolabella and L mengziensis,two new species from the karst region of southwestern China,and L bingzhongluoensis,a new species from montane region in Yunnan,are described and illustrated.L aureolabella is easily distinguished from its relatives by having abaxially purple leave with purple reticulate veins prominent adaxially,a lip auriculate at base,and falcate-lanceolate pollinia.Liparis mengziensis is closely related to L.petiolata and L.auriculata,but differs from them by having an ovate to broadly ovate leaf,purple lip and apex connate along the margins.Liparis bingzhongluoensis is similar to Liparis nanlingensis,but the new species is characterized by having a lip with two transparent ridges on its disc,longitudinally concave basal callus and triangular column wings.Phylogenetic analyses based on nuclear ribosomal ITS and plastid matK sequences showed that L aureolabella and L mengziensis are nested with L petiolata or L auriculata in a monophyletic clade.L bingzhongluoensis is sister to a clade formed by L.nanlingensis,L.tsii,L sasakii and L.krameri.Moreover,morphological comparisons strongly support that the three species as separated species newly to science. | Ji-Dong Ya Dong-Liang Lin Zhou-Dong Han Lei Cai Zhi-Rong Zhang De-Ming He Xiao-Hua Jin Wen-Bin Yu | 2021 | Plant Diversity2021，43，5： | 4 |
| 19 | Room-temperature-densified H_(3)BO_(3) microwave dielectric ceramics with ultra-low permittivity and ultra-high Qf value显示文摘With the rapid development of mobile communication technology towards 5G and 6G,the microwave dielectric materials with ultra-low permittivity and ultra-high Qf value are urgently demanded.Here,the excellent microwave dielectric properties are reported in H3BO3 ceramics with the molecular crystal structure,whose permittivity(2.84)and density(1.46 g/cm^(3))are record-low among the low-loss ceramics.The ultra-high Qf value of 146,000 GHz(or the ultra-low dielectric loss of 1.03×10^(-4) at 15 GHz)is also distinguished.Besides,the H_(3)BO_(3) ceramics can be densified at room temperature by a simple cold sintering process in a short time of 10 min,and this brings many advantages for the integration with microwave circuits.The large molecule volume originating from the molecular crystal structure and the low dielectric polarizabilities of H^(+) and B^(3+) are responsible for the ultra-low permittivity of H_(3)BO_(3) ceramics,and more microwave dielectric materials with ultra-low permittivity and ultra-high Qf value are expected to be explored in the molecular crystals. | Wen Bin Hong Lei Li Han Yan Shu Ya Wu Hang Sheng Yang Xiang Ming Chen | 2020 | Journal of Materiomics2020，6，2： | 3 |
| 20 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
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