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| 1 | ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome显示文摘OBJECTIVES:Anti-citrullinated protein antibodies(ACPAs)are a group of autoantibodies targeted against citrullinated proteins/peptides and are informative rheumatoid arthritis(RA)biomarkers.ACPAs also play a crucial role in RA pathogenesis,and their underlying mechanism merits investigation.METHODS:Immunohistochemical(IHC)assays were carried out to determine IL-1βlevels in ACPA+and ACPA−RA patients.PBMCderived monocytes were differentiated into macrophages before stimulation with ACPAs purified from RA patients.The localization and interaction of molecules were analyzed by confocal microscopy,co-IP,and surface plasmon resonance.RESULTS:In our study,we found that IL-1βlevels were elevated in ACPA+RA patients and that ACPAs promoted IL-1βproduction by PBMC-derived macrophages.ACPAs interacted with CD147 to enhance the interaction between CD147 and integrinβ1 and,in turn,activate the Akt/NF-κB signaling pathway.The nuclear localization of p65 promoted the expression of NLRP3 and pro-IL-1β,resulting in priming.Moreover,ACPA stimulation activated pannexin channels,leading to ATP release.The accumulated ATP bound to the P2X7 receptor,leading to NLRP3 inflammasome activation.CONCLUSIONS:Our study suggests a new hypothesis regarding IL-1βproduction in RA involving ACPAs,which may be a potential therapeutic target in RA treatment. | Xiwen Dong Zhaohui Zheng Peng Lin Xianghui Fu Fanni Li Jianli Jiang Ping Zhu | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 2 | Design of Nichols PID Controller for Load Frequency Control显示文摘为解决互联水电系统负荷频率控制(load frequencycontrol,LFC)问题,及保持互联电网系统频率、联络线功率及区域控制误差(area control error,ACE)的稳定,根据闭环系统谐振峰值与系统响应最大峰值之间的关系,构建一个与系统参数及控制器参数都相关的优化问题,通过该问题的求解获得控制器参数与系统参数之间的数学关系,针对水轮发电系统非最小相位特性,通过串加比例–微分(proportional-derivative,PD)控制方式降低系统阶次,设计尼科尔斯(Nichols)曲线的比例–积分–微分(proportional-integral-derivative,PID)控制器。基于模型参数扰动和负荷干扰的仿真结果表明:尼科尔斯PID控制器能快速调整系统频率偏差、联络线功率偏差及ACE为0,具有良好的鲁棒性能和抗负荷干扰性能,系统过渡过程性能明显优于传统PID调节器结果。 | KONG Fannie LI Xiaocong WU Jiekang GUO Zhuangzhi | 2012 | 中国电机工程学报2012，32，22： | 10 |
| 3 | Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway显示文摘 | Zhijian Lu Na Lu Chenglin Li Fanni Li Kai Zhao Biqi Lin Qinglong Guo | 2012 | Toxicology Letters2012，，3： | 2 |
| 4 | VI-14, a novel flavonoid derivative, inhibits migration and invasion of human breast cancer cells显示文摘 | Fanni Li Chenglin Li Haiwei Zhang Zhijian Lu Zhiyu Li Qidong You Na Lu Qinglong Guo | 2012 | Toxicology and Applied Pharmacology2012，，： | 1 |
| 5 | Early results of endoscopic lung volume reduction for emphysema显示文摘 | Anthony P.C Yim Thomas M.T Hwong Tak Wai Lee Wilson W.L Li Shirley Lam Tai Kong Yeung David S.C Hui Fanny W.S Ko Alan D.L Sihoe Kin Hoi Thung Ahmed A Arifi | 2004 | The Journal of Thoracic and Cardiovascular Surgery2004，，6： | 1 |
| 6 | Autonomous Chemistry Enabling Environment-Adaptive Electrochemical Energy Storage Devices显示文摘Next-generation electronics that are fused into the human body can play a key role in future intelligent communication,smart healthcare,and human enhancement applications.As a promising energy supply component for smart biointegrated electronics,environment-adaptive electrochemical energy storage(EES)devices with complementary adaptability and functions have garnered huge interest in the past decade.Owing to the advancements in autonomous chemistry,which regulate the constitutional dynamic networks in materials,EES devices have witnessed higher freedom of autonomous adaptability in terms of mechano-adaptable,biocompatibility,and stimuli-response properties for biointegrated and smart applications.In this mini-review,we summarize the recent progress in emerging environmentadaptive EES devices enabled by the constitutional dynamic network of mechanical adaptable materials,biocompatible materials,and stimuli-responsive supramolecular polymer materials.Finally,the challenges and perspectives of autonomous chemistry on the environment-adaptive EES devices are discussed. | Zhisheng Lv Wenlong Li Jiaqi Wei Fanny Ho Jie Cao Xiaodong Chen | 2023 | CCS Chemistry2023，5，1： | 0 |
| 7 | Switching the coordination geometry to enhance erbium(Ⅲ)single-molecule magnets显示文摘Two erbium(Ⅲ)complexes[ErCl(OAr^(Ad))_(3)][Na(THF)_(6)](1)and Er(OAr^(Ad))_(3)(2)are successfully prepared by using one variety of'hard'base ligand with large steric hindrance.The coordination geometry around the Er(Ⅲ)site changes from distorted tetrahedral to flat trigonal pyramid geometry in different solvent environment due to the removal of the coordinated chloride.Such an alternation significantly enhances the single-molecule magnet(SMM)behavior and makes the field-induced effective energy barrier(Ueff)arrive at 43(1)cm-1for the latter.Together with theoretical calculations,this study shows that strong equatorial ligand field and high local symmetry are critical to suppress the quantum tunneling of the magnetization(QTM)and achieve high-performance erbium(Ⅲ)based SMMs. | Qian-Cheng Luo Ning Ge Yuan-Qi Zhai Tengbo Wang Lin Sun Qi Sun Fanni Li Zhendong Fu Yan-Zhen Zheng | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
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