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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018,63,23: | 54 |
| 2 | Comparison of the effect and safety of Kuntai capsule and hormone replacement therapy in patients with perimenopausal syndrome:a systematic review and Meta-analysis显示文摘OBJECTIVE: To assess the effectiveness and safety of Kuntai capsule and hormone replacement therapy in treatment of perimenopausal syndrome.METHODS: Articles were retrieved from the databases Cochrane Database of Systematic Reviews,Pub Med, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Only randomized controlled trials were included; 15 trials involving1243 patients were identified from January 2005 to April 2015. A systemic review and Meta-analysis of publications was performed. The review was limit-ed to randomized controlled trials that compared Kuntai capsule and hormone replacement therapy to treat perimenopausal syndrome for at least 3months. The primary outcome assessed was the treatment efficacy at 3 months, including effective rate of Kupperman menopausal scores, Kupperman menopausal scores, and blood estradiol(E2) or blood follicle stimulating hormone(FSH) levels.Other outcomes assessed were safety or adverse events, such as gastrointestinal complaints, breast distending pain, or vaginal bleeding.RESULTS: Kupperman menopausal scores showed no significant difference in effective rate [odds ratio(OR): 1.05, 95% confidence intervals(CI): 0.71 to1.55] and changes in FSH level [mean difference(MD): 2.14, 95% CI:-2.36 to 6.65]. There was a significant statistical difference in Kupperman menopausal scores(MD:-1.14, 95% CI:-2.03 to-0.25)and changes in E2level(MD:-16.41, 95% CI:-18.83to-13.69). There were fewer adverse events in the Kuntai capsule group than in the hormone replacement therapy group(OR: = 0.35, 95% CI: 0.25 to0.48, P < 0.01).CONCLUSION: Compared with hormone replacement therapy, Kuntai capsule can improve perimenopausal symptoms and blood E2 levels, and reduce the incidence of adverse events. | Du Xiaoqin Xu Lin Wang Lijun Heng Mingli Bu Huaien Hao Yu Tian Jinhui | 2017 | Journal of Traditional Chinese Medicine2017,37,3: | 28 |
| 3 | Urban expansion in China and its effect on cultivated land before and after initiating'Reform and Open Policy'显示文摘Urbanization in China has expanded at an unprecedented speed since the declaration of 'Reform and Open Policy'and presented many challenges. Unbalanced regional development, appearance of super megacities and concomitant problems,and conflicts between urbanization and cultivated land protection are three critical problems that Chinese urbanization has to face. To develop new plans for foreseeable future urbanization in China, it is critical to understand the evolving history of cities across China. This study maps urban expansion of 60 typical Chinese cities based on large amount of remote sensing data and the labor-intensive image interpretation method, in order to understand the history of urban expansion from the 1970 s to 2013.Results showed that area of cities expanded 5.23 times compared to their area in the 1970 s. Urban expansion in China accelerated three times(1988–1996, 1999–2006, and 2009–2011) and decelerated three times(1997–1998, 2007–2008, and 2012–2013) over the 40 years. The urban area of South China expanded most significantly 9.42 times, while the urban area in Northeast China expanded only 2.37 times. The disparity among different administrative ranks of cities was even greater than(3.81 times) the differences among different regions. Super megacities have been continuously expanding at a fast rate(8.60-fold), and have not shown obvious signs of slowing down. The proportion of cultivated land among the land sources for urban expansion decreased to a small extent in the 1990 s, but cultivated land continues to be the major land source for urban expansion. Effective future urbanization needs controlling the expansion scale of large cities and reasonably developing medium and small cities, as well as balancing regional development. | ZHANG ZengXiang WEN QingKe LIU Fang ZHAO XiaoLi LIU Bin XU JinYong YI Ling HU ShunGuang WANG Xiao ZUO LiJun LI Na LI MinMin SHI LiFeng ZENG Tian JU HongRun | 2016 | Science China Earth Sciences2016,59,10: | 12 |
| 4 | Detection of dynamic brain networks modulated by acupuncture using a graph theory model显示文摘Neuroimaging studies involving acute acupuncture manipulation have already demonstrated significant modulatory effects on wide limbic/paralimbic nuclei, subcortical gray structures and the neocortical system of the brain. Due to the sustained effect of acupuncture, however, knowledge on the organization of such large-scale cortical networks behind the active needle stimulation phase is lacking. In this study, we originally adopted a network model analysis from graph theory to evaluate the functional connectivity among multiple brain regions during the post-stimulus phase. Evidence from our findings clearly supported the existence of a large organized functional connectivity network related to acupuncture function in the resting brain. More importantly, acupuncture can change such a network into a functional state underlying both pain perception and modulation, which is exhibited by significant changes in the functional connectivity of some brain regions. This analysis may help us to better understand the long-lasting effects of acupuncture on brain function, as well as the potential benefits of clinical treatments. | Lijun Bai Wei Qin Jie Tian Jianping Dai Wanhai Yang | 2009 | Progress in Natural Science:Materials International2009,19,7: | 11 |
| 5 | Hydroisomerization performance of platinum supported on ZSM-22/ZSM-23 intergrowth zeolite catalyst显示文摘Hydroisomerization catalysts Pt/ZSM-22,Pt/ZSM-23,and Pt/ZSM-22/ZSM-23 were prepared by supporting Pt on ZSM-22,ZSM-23,and intergrowth zeolite ZSM-22/ZSM-23,respectively.The typical physicochemical properties of these catalysts were characterized by X-Ray Diffraction(XRD),N2 absorption-desorption,Pyridine-Fourier Transform Infrared(Py-FTIR),Transmission Electron Microscopy(TEM),X-Ray Fluorescence(XRF),Scanning Electron Microscopy(SEM) and NH3-Temperature Programmed Desorption(NH3-TPD),and the performance of these catalysts in n-dodecane hydroisomerization was evaluated in a continuous down-flow fixed bed with a stainless steel tubular reactor.The characterization results indicated that the intergrowth zeolite ZSM-22/ZSM-23 possessed the dual structure of ZSM-22 and ZSM-23,and the catalyst Pt/ZSM-22/ZSM-23 had similar pores and weak acidity to Pt/ZSM-22 and Pt/ZSM-23 catalysts.Moreover,Pt/ZSM-22/ZSM-23 catalyst showed a high selectivity in hydroisomerization of long chain n-alkanes to mono-branched isomers.The evaluation results for n-dodecane hydroisomerization indicated that the activity of Pt/ZSM-22/ZSM-23 was the lowest,while the hydroisomerization selectivity was the highest among the three catalysts.The maximum yield of i-dodecane product was 68.3% over Pt/ZSM-22/ZSM-23 at 320 oC. | Chi Kebin Zhao Zhen Tian Zhijian Hu Sheng Yan Lijun Li Tianshu Wang Bingchun Meng Xiangbin Gao Shanbin Tan Mingwei Liu Yanfeng | 2013 | Petroleum Science2013,10,2: | 8 |
| 6 | The Smart Road: Practice and Concept显示文摘 | Lijun Sun Hongduo Zhao Huizhao Tu Yu Tian | 2018 | Engineering2018,4,4: | 8 |
| 7 | Intergrowth texture in Au-Ag-Te minerals from Sandaowanzi gold deposit,Heilongjiang Province:Implications for ore-forming environment显示文摘Sandaowanzi gold deposit,Heilongjiang Province,is the only single telluride type gold deposit so far documented in the world,in which 90% of gold is hosted in gold-silver telluride minerals.Optical microscope observation,scanning electron microscope,electron probe and X-ray diffraction analysis identified abundant intergrowth textures in the Au-Ag-Te minerals,typified by sylvanite-hosting hessite crystals and hessite-hosting petzite crystals.The intergrown minerals and their chemistry are consistent,and the hosted minerals are mostly worm-like or as oriented stripes,evenly distributed in the hosting minerals,with clear and smooth interfaces.These suggest an exsolution origin for the intergrowth texture.With reference to the phase-transformation temperature derived from synthesis experiments of tellurides,the exsolution texture of Au-Ag-Te minerals implies that the veined tellurides formed at 150-220℃.The early stage disseminated tellurides formed at log f(Te 2) from 13.6 to 7.8,log f(S 2) from 11.7 to 7.6,whereas the late stage veined tellurides formed at log f(Te 2) ranging from 11.2 to 9.7 and log f(S 2) from 16.8 to 12.2. | XU Hong YU YuXing WU XiangKe YANG LiJun TIAN Zhu GAO Shen WANG QiuShu | 2012 | Chinese Science Bulletin2012,57,21: | 6 |
| 8 | Reprogrammed mouse astrocytes retain a“memory”of tissue origin and possess more tendencies for neuronal differentiation than reprogrammed mouse embryonic fibroblasts显示文摘Direct reprogramming of a variety of somatic cells with the transcription factors Oct4(also called Pou5f1),Sox2 with either Klf4 and Myc or Lin28 and Nanog generates the induced pluripotent stem cells(iPSCs)with marker similarity to embryonic stem cells.However,the difference between iPSCs derived from different origins is unclear.In this study,we hypothesized that reprogrammed cells retain a“memory”of their origins and possess additional potential of related tissue differentiation.We reprogrammed primary mouse astrocytes via ectopic retroviral expression of OCT3/4,Sox2,Klf4 and Myc and found the iPSCs from mouse astrocytes expressed stem cell markers and formed teratomas in SCID mice containing derivatives of all three germ layers similar to mouse embryonic stem cells besides semblable morphologies.To test our hypothesis,we compared embryonic bodies(EBs)formation and neuronal differentiation between iPSCs from mouse embryonic fibroblasts(MEFsiPSCs)and iPSCs from mouse astrocytes(mAsiPSCs).We found that mAsiPSCs grew slower and possessed more potential for neuronal differentiation compared to MEFsiPSCs.Our results suggest that mAsiPSCs retain a“memory”of the central nervous system,which confers additional potential upon neuronal differentiation. | Changhai Tian Yongxiang Wang Lijun Sun Kangmu Ma Jialin C.Zheng | 2011 | Protein & Cell2011,2,2: | 6 |
| 9 | Synthesis of TiO_2 nanoparticles by propane/air turbulent flame CVD process显示文摘Synthesis of TiO2 nanoparticles by the oxidation of titanium tetrachloride (TiCl4) in high-strength propane/air turbulent flame is investigated tentatively for mass production of TiO2 nanoparticles. Effects of reactor heat flux varying from 247 to 627 kJ/m2 s, initial TiO2 number density from 2×1020 to 1×1021 m-3, and apparent residence time of TiO2 nanoparticles in reactor from 0.06 to 0.9 s, on particle morphology, phase composition, UV absorption and photoluminescence (PL) spectra are studied. The TiO2 nanoparti- cles synthesized, with mean size of 30-80 nm and rutile mass fraction from 0.155 up to 0.575, exhibited a strong PL signal at the wavelength of 370-450 nm, with a wide peak signal at 400-420 nm, reflecting significant oxygen vacancies on the surface of the TiO2 nanoparticles. | Hongyong Xie Guilan Gao Zhen Tian Naici Bing Lijun Wang | 2009 | Particuology2009,7,3: | 6 |
| 10 | Computational functionality-driven design of semiconductors for optoelectronic applications显示文摘The rapid development of the semiconductor industry has motivated researchers passion for accelerating the discovery of advanced optoelectronic materials.Computational functionality-driven design is an emerging branch of material science that has become effective at making material predictions.By combining advanced solid-state knowledge and high-throughput firstprinciples computational approaches with intelligent algorithms plus database development,experts can now efficiently explore many novel materials by taking advantage of the power of supercomputer architectures.Here,we discuss a set of typical design strategies that can be used to accelerate inorganic optoelectronic materials discovery from computer simulations:In silico computational screening;knowledge-based inverse design;and algorithm-based searching.A few representative examples in optoelectronic materials design are discussed to illustrate these computational functionality-driven modalities.Challenges and prospects for the computational functionality-driven design of materials are further highlighted at the end of the review. | Zhun Liu Guangren Na Fuyu Tian Liping Yu Jingbo Li Lijun Zhang | 2020 | InfoMat2020,2,5: | 4 |
| 11 | Bidirectional turbo equalization for underwater acoustic communications显示文摘A direct-adaptation based bidirectional turbo equalizer for underwater acoustic communications is proposed.Abandoning the channel estimation process,the direct-adaptation based turbo equalizer embedded with digital phase-locked loop is adopted to track time-varying channel.The fast self-optimized algorithm is used to adjust the step size,thus a good tradeoff between the convergence speed and performance has been made.Furthermore,by minimizing the mean squared error,an optimal weighting factor is derived to exploit bidirectional diversity gain.The forward turbo equalizer is combined with the backward turbo equalizer to eliminate error propagation effect.Simulated and experimental results demonstrate that the bidirectional turbo equalizer outperforms the single directional one.It can be seen from the experimental results that,compared with the channel estimation based algorithm,the direct-adaptation based algorithm is less sensitive to the time-varying channel and has a lower bit error rate. | XI Junyi YAN Shefeng XU Lijun TIAN Jing | 2016 | Chinese Journal of Acoustics2016,35,4: | 4 |
| 12 | Interactions between bubble and particles of key minerals of diasporic bauxite through the extended DLVO theory显示文摘The flotation of diasporic bauxite is to separate diaspore(valuable mineral)from aluminosilicate minerals(gangue minerals,mainly including kaolinite,illite and pyrophyllite),and the microscopic interaction force between the two types of minerals and air bubbles determines the separation efficiency.In this paper,based on the extended Derjaguin-Landau-Verwey-Overbeek(DLVO)theory,the van der Waals,electrostatic and hydrophobic interaction between particles of the four minerals mentioned above and air bubbles in collectorless solution were calculated first,and then diaspore and kaolinite were taken as examples to analyze the influence of various factors such as electrolyte concentration,mineral particle size,air bubble size,collector type(dodecylamine hydrochloride(DAH)and sodium oleate(NaOL))and concentration,and pulp pH on the interactions between the particles of valuable mineral and gangue minerals and air bubbles.The results showed that the total extended DLVO interactions between the four minerals and air bubbles were repulsive in most cases in collectorless solution.The increase in electrolyte concentration reduced the interaction force or even changed the direction of the force under certain circumstances.The addition of DAH and NaOL can reduce the adhesion energy barrier of kaolinitebubble and diaspore-bubble respectively.Each type of minerals exhibited a specific interface interaction response with air bubbles in each collector with different pH values.The research results have theoretical guiding significance for the optimization and directional control of diasporic bauxite flotation conditions. | Ningning Zhang Tian Pang Rui Han Songjiang Chen Zhen Li Yuexian Yu Zhongyu Shi Lijun Liu Jinzhou Qu Anning Zhou | 2022 | International Journal of Mining Science and Technology2022,32,1: | 3 |
| 13 | Scalable and fast fabrication of graphene integrated micro-supercapacitors with remarkable volumetric capacitance and flexibility through continuous centrifugal coating显示文摘Microscale electrochemical energy storage devices,e.g., micro-supercapacitors(MSCs),possessing tailored performance and diversified form factors of lightweight,miniaturization,flexibility and exceptional integration are highly necessary for the smart power sources-unitized electronics.Despite the great progress,the fabrication of MSCs combining high integration with high volumetric performance remains largely unsolved.Herein,we develop a simple,fast and scalable strategy to fabricate graphene based highly integrated MSCs by a new effective continuous centrifugal coating technique.Notably,the resulting highly conductive graphene films can act as not only patterned microelectrodes but also metal-free current collectors and interconnects,endowing modular MSCs with high integrity,remarkable flexibility,tailored voltage and capacitance output,and outstanding performance uniformity.More importantly,the strong centrifugal force and shear force generated in continuous centrifugal coating process lead to graphene films with high alignment,compactness and packing density,contributing to excellent volumetric capacitance of ~31.8 F cm^(-3) and volumetric energy density of ~2.8 mWh cm^(-3),exceeding most reported integrated MSCs.Therefore,our work paves a novel way for simple and scalable fabrication of integrated MSCs and offers promising opportunities as standalone microscale power sources for new-generation electronics. | Xiaoyu Shi Lijun Tian Sen Wang Pengchao Wen Ming Su Han Xiao Pratteek Das Feng Zhou Zhaoping Liu Chenglin Sun Zhong-Shuai Wu Xinhe Bao | 2021 | Journal of Energy Chemistry2021,30,1: | 3 |
| 14 | Hardware Design and Test of a Gear-Shifting Control System of a Multi-gear Transmission for Electric Vehicles显示文摘The performance of electric vehicles is affected by the shift quality of multi-gear transmission.The realization of dual-target tracking control requires the transmission control unit(TCU)to accurately measure and process the input signals of the gear-shifting control system and precisely control the drive motor torque and the position of shift motors.An electric-vehicle-dedicated TCU was designed to meet the above design requirements.Its function modules included a single-chip control circuit,shift position signal sampling circuit,signal conditioning circuit of the rotational speed and angle,controller area network communication circuit,and shift motor drive circuit.A hardware-in-the-loop simulation test system showed that the TCU design scheme met measurement accuracy requirements and coordinated the actions of the shift actuator and motor control unit to achieve fast and smooth shifting before the road test.The power interruption time of the shifting process was within 350 ms.The reliability of the TCU design was further verified in a 150,000-km vehicle road test. | Feng Tian Liqi Sui Yuanfan Zeng Bo Li Xingyue Zhou Lijun Wang Hongxu Chen | 2019 | Automotive Innovation2019,2,3: | 3 |
| 15 | Recent Progress on Smart Fiber and Textile Based Wearable Strain Sensors:Materials,Fabrications and Applications显示文摘With the rapid development of smart products,fexible and stretchable smart wearable electronic devices gradually play an important role,and they are considered as the pioneers of the new generation of fexible electronic devices.Among these intelligent devices,fexible and stretchable strain sensors have been widely studied for their good fexibility,high sensitivity,high repeatability and huge potential for application in personal healthcare and motion detection.Moreover,unlike traditional rigid bulky sensors,the high-performance fexible strain sensors are lightweight portable devices with excellent mechanical and electrical performance,which can meet personalized needs and become more popular.Herein,the research progress of fexible strain sensors in recent years are reviewed,which mainly introducing the sensing principles and key parameters of strain sensors,commonly used conductive materials and fexible substrates and common preparation methods,and fnally proposes the future application and prospects of strain sensors. | Xuhua Liu Jinlei Miao Qiang Fan Wenxiao Zhang Xingwei Zuo Mingwei Tian Shifeng Zhu Xueji Zhang Lijun Qu | 2022 | Advanced Fiber Materials2022,4,3: | 3 |
| 16 | The Progress of CDIO Engineering Education Reform in Several China Universities: A Review显示文摘 | Bai Jianfeng Lei Hu Yanfen Li Zhen Tian Lili Xie Lijun Wang Mingyuan Zhou Jie Guan Huaqing Xie | 2013 | Procedia - Social and Behavioral Sciences2013,,: | 3 |
| 17 | Soft Direct-Adaptation Based Bidirectional Turbo Equalization for MIMO Underwater Acoustic Communications显示文摘This paper proposes a soft direct-adaptation based bidirectional turbo equalizer for multiple-input multiple-output underwater acoustic communication systems. Soft, rather than hard, direct-adaptation based equalizer combined with the fast self-optimized least mean square algorithm is employed to achieve a faster convergence rate, and the second-order phase-locked loop is embedded into the equalizer to track the time-varying channel. Meanwhile, by utilizing a weighted linear combining scheme, the conventional soft direct-adaptation based equalizer is combined with the time-reversed soft direct-adaptation based equalizer to exploit bidirectional diversity and mitigate error propagation. Both the simulation and experimental results demonstrate that the soft direct-adaptation based bidirectional turbo equalizer outperforms the single-direction soft direct-adaptation based turbo equalizer, and achieves a faster convergence rate than the hard direct-adaptation based bidirectional turbo equalizer. | Junyi Xi Shefeng Yan Lijun Xu Jing Tian | 2017 | China Communications2017,14,7: | 3 |
| 18 | Below-Cloud Aerosol Scavenging by Different-Intensity Rains in Beijing City显示文摘Below-cloud aerosol scavenging process by precipitation is important for cleaning the polluted aerosols in the atmosphere, and is also a main process for acid rain formation. However, the related physical mechanism has not been well documented and clarified yet. In this paper, we investigated the below-cloud PM_(2.5)(particulate matter with aerodynamic diameter being 2.5 μm or less) scavenging by different-intensity rains under polluted conditions characterized by high PM_(2.5) concentrations, based on in-situ measurements from March 2014 to July 2016 in Beijing city. It was found that relatively more intense rainfall events were more efficient in removing the polluted aerosols in the atmosphere. The mean PM_(2.5) scavenging ratio and its standard deviation(SD) were 5.1% ± 25.7%, 38.5% ± 29.0%,and 50.6% ± 21.2% for light, moderate, and heavy rain events, respectively. We further found that the key impact factors on below-cloud PM_(2.5) scavenging ratio for light rain events were rain duration and wind speed rather than raindrop size distribution. However, the impacts of rain duration and wind speed on scavenging ratio were not important for moderate and heavy rain events. To our knowledge, this is the first statistical result about the effects of rain intensity, rain duration, and raindrop size distribution on below-cloud scavenging in China. | Tian LUAN Xueliang GUO Tianhang ZHANG Lijun GUO | 2019 | Journal of Meteorological Research2019,33,1: | 3 |
| 19 | InAs-based interband cascade lasers at 4.0 μm operating at room temperature显示文摘InAs-based interband cascade lasers(ICLs) with InAs plasmon waveguides or InAs/AlSb superlattice(SL) waveguides were demonstrated at emission wavelengths below 4.1 μm. The threshold current densities of the lasers with SL waveguides were 37 A/cm^2 at 77 K in continuous wave mode. The operation temperature of these lasers reached room temperature in pulsed mode. Compared with the thick InAs n++ plasmon cladding layer, the InAs/AlSb superlattice cladding layers have greater advantages for ICLs with wavelengths less than 4 μm even in InAs based ICLs because in the short-wavelength region they have a higher confinement factor than InAs plasmon waveguides. | Tian Yu Shuman Liu Jinchuan Zhang Bo Xu Lijun Wang Junqi Liu Ning Zhuo Shenqiang Zhai Xiaoling Ye Yonghai Chen Fengqi Liu Zhanguo Wang | 2018 | Journal of Semiconductors2018,39,11: | 3 |
| 20 | Recruited CD68^(+)CD206^(+)macrophages orchestrate graft immune tolerance to prompt xenogeneic-dentin matrix-based tooth root regeneration显示文摘Successful regenerative medicine strategies of xenogeneic extracellular matrix need a synergistic balance among inflammation,fibrosis,and remodeling process.Adaptive macrophage subsets have been identified to modulate inflammation and orchestrate the repair of neighboring parenchymal tissues.This study fabricated PPARγ-primed CD68+CD206+M2 phenotype(M2γ),and firstly verified their anti-inflammatory and tissue-regenerating roles in xenogeneic bioengineered organ regeneration.Our results showed that Th1-type CD3^(+)CD8^(+)T cell response to xenogeneic-dentin matrix-based bioengineered root complex(xeno-complex)was significantly inhibited by M2γmacrophage in vitro.PPARγactivation also timely recruited CD68^(+)CD206^(+)tissue macrophage polarization to xeno-complex in vivo.These subsets alleviated proinflammatory cytokines(TNF-α,IFN-γ)at the inflammation site and decreased CD3^(+)CD8^(+)T lymphocytes in the periphery system.When translated to an orthotopic nonhuman primate model,PPARγ-primed M2 macrophages immunosuppressed IL-1β,IL-6,TNF-α,MMPs to enable xeno-complex to effectively escape immune-mediated rejection and initiate graft-host synergistic integrity.These collective activities promoted the differentiation of odontoblast-like and periodontal-like cells to guide pulp-dentin and cementum-PDLs-bone regeneration and rescued partially injured odontogenesis such as DSPP and periostin expression.Finally,the regenerated root showed structure-biomechanical and functional equivalency to the native tooth.The timely conversion of M1-to-M2 macrophage mainly orchestrated odontogenesis,fibrogenesis,and osteogenesis,which represents a potential modulator for intact parenchymal-stromal tissue regeneration of targeted organs. | Hui Li Jingjing Sun Hefeng Yang Xue Han Xiangyou Luo LiJun Liao Bo Yang Tian Zhu Fangjun Huo Weihua Guo Weidong Tian | 2021 | Bioactive Materials2021,6,4: | 2 |