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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Huangqi Guizhi Wuwu Decoction for treating diabetic peripheral neuropathy:a meta-analysis of 16 randomized controlled trials显示文摘OBJECTIVE:This meta-analysis was performed to systematically assess the efficacy and safety of the Chinese herbal medicine Huangqi Guizhi Wuwu Decoction(HGWWD) for treating diabetic peripheral neuropathy.DATA SOURCES:Six electronic databases,including the Cochrane Library,MEDLINE database,Chinese Biomedical Database,Chinese National Knowledge Infrastructure Database,Chinese Science and Technique Journals Database,and the Wanfang Database,were search ed on the internet for randomized controlled trials published up until 1 December 2015.The search terms included 'Chinese herbal medicine','diabetic peripheral neuropathy' and 'randomized controlled trials' in Chinese and in English.DATA SELECTION:We included randomized controlled trials using HGWWD/modified HGWWD for the treatment group,without restriction for the control group.We assessed literature quality in accordance with the Cochrane Review Handbook.A random or a fixed effects model was used to analyze outcomes using Rev Man 5.2 software.OUTCOME MEASURES:The primary outcomes were changes in symptoms and nerve conduction velocities.The secondary outcomeswere fasting blood glucose and hemorheological indexes.RESULTS:Sixteen randomized controlled trials,with a total of 1,173 patients,were included.Meta-analysis revealed that the efficacy of HGWWD for diabetic peripheral neuropathy was significantly superior compared with the control treatment(i.e.,control group)(risk ratio = 0.36,95% confidence interval(CI):0.29–0.46,Z =8.33,P < 0.00001) Compared with the control group,there was an increase in median motor nerve conduction velocity(mean difference(MD) = 3.46,95%CI:1.88–5.04,Z = 4.30,P < 0.01) and median sensory nerve conduction velocity(MD = 3.30,95%CI:2.04–4.56,Z = 5.14,P < 0.01).There was also an increase in peroneal motor nerve conduction velocity(MD = 3.22,95%CI:2.45–3.98,Z = 8.21,P < 0.01) and peroneal sensory nerve conduction velocity(MD = 3.05,95%CI:2.01–4.09,Z = 5.75,P < 0.01) in the treatment groups.No significant difference in fasting blood glucose was found between the treatment groups and the control groups(MD =-0.12,95%CI:-0.42–0.19,Z = 0.76,P = 0.45).Plasma viscosity was significantly decreased after treatment(MD =-0.11,95%CI:-0.21 to-0.02,Z = 2.30,P = 0.02).No significant difference in fibrinogen was detectable(MD =-0.53,95%CI:-1.28–0.22,Z = 1.38,P = 0.17).Four trials reported that treatment groups experienced no adverse reactions.Adverse events were not mentioned in the other 12 trials.No trial reported the incidence of complications,quality of life outcomes,or health economics.CONCLUSION:HGWWD treatment improves diabetic neurologic symptoms and ameliorates nerve conduction velocities.Our study suggests that HGWWD may have significant therapeutic efficacy for the treatment of diabetic peripheral neuropathy.However,the methodological quality of the randomized controlled trials was generally low.Larger and better-designed randomized controlled trials are required to more reliably assess the clinical effectiveness of HGWWD. | Bing Pang Tian-yu Zhao Lin-hua Zhao Fang Wan Ru Ye Qiang Zhou Feng Tian Xiao-lin Tong | 2016 | Neural Regeneration Research2016，11，8： | 32 |
| 3 | Deformation mechanism of roadways in deep soft rock at Hegang Xing’an Coal Mine显示文摘Engineering geomechanics characteristics of roadways in deep soft rock at Hegang Xing'an Coal Mine were studied and the nature of clay minerals of roadway surrounding rock was analyzed. This paper is to solve the technical problems of high stress and the difficulty in supporting the coal mine, and provide a rule for the support design. Results show that mechanical deformation mechanisms of deep soft rock roadway at Xing'an Coal Mine is of ⅠABⅡABCⅢABCD type, consisting of molecular water absorption (the ⅠAB -type), the tectonic stress type + gravity deformation type + hydraulic type (the ⅡABC -type), and the ⅢABCD -type with fault, weak intercalation and bedding formation. According to the compound mechanical deformation mechanisms, the corresponding mechanical control measures and conversion technologies were proposed, and these technologies have been successfully applied in roadway supporting practice in deep soft rock at Xing'an Coal Mine with good effect. Xing'an Coal Mine has the deepest burial depth in China, with its overburden ranging from Mesozoic Jurassic coal-forming to now. The results of the research can be used as guidance in the design of roadway support in soft rock. | Yang Xiaojie Pang Jiewen Liu Dongming Liu Yang Tian Yihong Ma Jiao Li Shaohua | 2013 | International Journal of Mining Science and Technology2013，23，2： | 21 |
| 4 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 5 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 6 | Geothermal data analysis at the high-temperature hydrothermal area in Western Sichuan显示文摘The western Sichuan hydrothermal area is located at the northeastern margin of the eastern syntaxis of the Qinghai-Tibet Plateau, which is also the eastern end of the Mediterranean-Himalayan geothermal activity zone. There are 248 warm or hot springs in this area, and 11 have temperatures beyond the local boiling temperature. Most of these hot springs are distributed along the Jinshajiang, Dege-Xiangcheng, Ganzi-Litang, and Xianshuihe faults, forming a NW-SE hydrothermal belt. A geothermal analysis of this high-temperature hydrothermal area is an important basis for understanding the deep geodynamic process of the eastern syntaxis of the Qinghai-Tibet Plateau. In addition, this study offers an a priori view to utilize geothermal resources, which is important in both scientific research and application. We use gravity, magnetic, seismic, and helium isotope data to analyze the crust-mantle heat flow ratio and deep geothermal structure. The results show that the background terrestrial heat flow descends from southwest to northeast. The crustal heat ratio is not more than 60%. The high temperature hydrothermal active is related to crustal dynamics processes. Along the Batang-Litang-Kangding line, the Moho depth increases eastward, which is consistent with the changing Qc/Qm(crustal/mantle heat flow) ratio trend. The geoid in the hydrothermal zone is 4–6 km higher than the surroundings, forming a local 'platform'. The NW-SE striking local tensile stress zone and uplift structure in the upper and middle crust corresponds with the surface hydrothermal active zone. There is an average Curie Point Depth(CPD) of 19.5–22.5 km in Batang, Litang, and Kangding. The local shear-wave(S-wave) velocity is relatively low in the middle and lower crust. The S-wave shows a low velocity trap(Vs<3.2 km s.1) at 15–30 km, which is considered a high-temperature partial melting magma, the crustal source of the hydrothermal active zone. We conclude that the hydrothermal system in this area can be divided into Batang-type and Kangding-type, both of which rely on a crustal heating cycle of atmospheric precipitation and surface water along the fracture zone. The heat is derived from the middle and lower crust: groundwater penetrates the deep faults bringing geothermal energy back to the surface and forming high-temperature springs. | ZHANG Jian LI WuYang TANG XianChun TIAN Jiao WANG YingChun GUO Qi PANG ZhongHe | 2017 | Science China Earth Sciences2017，60，8： | 17 |
| 7 | Clinical Observation of Transepithelial Corneal Collagen Cross-linking by Iontophoresis of Riboflavin in Treatment of Keratoconus显示文摘Purpose: To evaluate the efficacy and safety of transepithelial collagen cross-linking by iontophoretic delivery of riboflavin in treatment of progressive keratoconus.Methods:.Eleven patients(15 eyes) with progressive keratoconus were enrolled. After 0.1% riboflavin-distilled water solution was deliveried via transepithelial iontophpresis for 5 min with 1 m A current, and ultraviolet radiation(370 nm,.3 m W /cm2) was performed at a 1.5 cm distance for 30 min. The follow up were 6 months in all eyes. The uncorrected visual acuity, corrected visual acuity,endothelial cell counting, corneal thickness,.intraocular pressure, corneal curvature, corneal topography,.OCT and corneal opacity before and 6-month after surgery were analyzed.Results: At 6 month postoperatively, mean uncorrected visual acuity and corrected visual acuity changed from 0.36 to 0.30 and from 0.42 to 0.57 without statistical significance..The mean value of each index of corneal curvature declined without statistical significance.Kmax value dereased from 60.91 to59.91, and the astigmatism declined from 3.86 to 3.19. Central corneal thickness decreased from 460.93 μm to 455.40μm,.and thinnest corneal thickness declined from 450.87 μm to 440.60 μm with no statistical significance..Intraocular pressure was significantly elevated from 10.85 mm Hg to 12.62 mm Hg. Endothelial cell count did not change significantly. No corneal haze occurred. Mean depth of corneal demarcation line was 288.46 μm at 1 month postoperatively..Conclusion:.Transepithelial corneal collagen cross-linking by iontophoresis is effective and safe in the treatment of progressive keratoconus, and yields stable clinical outcomes during 6-month follow up..However,.long-term follow up is urgently required. | Na Li Zhengjun Fan Xiujun Peng Xu Pang Chunyu Tian | 2014 | Eye Science2014，29，3： | 15 |
| 8 | Combination of symptoms, syndrome and disease: Treatment of refractory diabetic gastroparesis显示文摘AIM:To assess effect of combination of symptoms,syndrome and disease on treatment of diabetic gastroparesis with severe nausea and vomiting.METHODS:Professor Tong Xiaolin’s clinical electronic medical records of patients who were treated between January 1,2006 and October 1,2012 were used as a database.Patients who met the inclusion criteria were enrolled.General information(name,sex and age),symptoms and blood glucose levels were obtained from the clinic electronic medical record,which was supplemented by a telephone interview.The patient-rated Gastroparesis Cardinal Symptom Index(GCSI)was used to evaluate the severity of the symptoms of gastroparesis.The effects of the treatment were assessed by the change in the severity of the symptoms of gastroparesis and the change in blood glucose between the baseline levels and the post-treatment levels at 1,2,4,8 and 12 wk.RESULTS:Forty-five patients had a mean GCSI nausea and vomiting severity score of 4.21±0.67 and a total GCSI score of 2.77±0.63 before treatment.There was a significant improvement in the nausea and vomiting score at every return visit compared with the baseline score(1 wk:3.02±1.04 vs 4.18±0.71,P<0.001;2wk:2.32±1.25 vs 4.16±0.73,P<0.001;4 wk:2.12±1.26 vs 4.12±0.73,P<0.001;8 wk:1.79±1.09vs 4.24±0.77,P<0.001;12 wk:0.69±0.92 vs 4.25±0.70,P<0.001).Twenty-five of the 45 patients had complete resolution of vomiting during the observation period(mean time to resolution was 37.9±27.3 d).The postprandial fullness and early satiety subscale,bloating subscale and total GCSI scores were also improved.Finally,the blood glucose levels improved after treatment,although the change was not significant.CONCLUSION:Use of the combination of symptoms,syndrome and disease to treat diabetic gastroparesis with refractory nausea and vomiting may be a new treatment option. | Jun-Ling Li Min Li Bing Pang Qiang Zhou Jia-Xing Tian Hong-Xing Liu Xi-Yan Zhao Xiao-Lin Tong | 2014 | World Journal of Gastroenterology2014，20，26： | 13 |
| 9 | Value of early diagnosis of sepsis complicated with acute kidney injury by renal contrast-enhanced ultrasound显示文摘BACKGROUND The incidence of acute kidney injury(AKI)in patients with sepsis is high,and the prognosis of patients with septic AKI is poor.The early diagnosis and treatment of septic AKI is of great significance in improving the prognosis of patients with sepsis.AIM To explore the value of contrast-enhanced ultrasound(CEUS),serum creatinine(Scr),and other indicators in the early diagnosis of septic AKI.METHODS Ninety patients with sepsis during hospitalization at Tongji Hospital of Tongji University were recruited as subjects.Each patient was recorded with relevant basic data,clinical indicators,and CEUS results.The patients were divided into AKI group and non-AKI group according to the results of renal function diagnosis after 48 h.On the 7th day,the renal function of the non-AKI group was re-evaluated and the patients were further divided into AKI subgroup and non-AKI subgroup.The differences of the indicators in different groups were compared,and the diagnostic value of each indicator and their combination for septic AKI was analyzed.RESULTS Systemic inflammatory response score(2.58±0.75),blood lactic acid(3.01±1.33 mmol/L),Scr(141.82±27.19μmol/L),blood urea nitrogen(4.41±0.81mmol/L),and rise time(10.23±2.63 s)in the AKI group were higher than those in the non-AKI group.Peak intensity(PI)(10.78±3.98 dB)and wash in slope(WIS)(1.07±0.53 dB/s)were lower than those in the non-AKI group.The differences were statistically significant(P<0.05).The PI(12.83±3.77 dB)and WIS(1.22±0.68 dB/s)in the AKI subgroup were lower than those in the non-AKI subgroup,and the differences were statistically significant(P<0.05).The area under curve(AUC)of Scr for the diagnosis of septic AKI was 0.825 with a sensitivity of 56.76% and a specificity of 100%.The AUCs of WIS and PI(0.928 and 0.912)were higher than those of Scr.Their sensitivities were 100%,but the specificities were 71.70% and 75.47%.The AUC of the combination of three indicators for the diagnosis of septic AKI was 0.943,which was significantly higher than the AUC diagnosed by each single indicator.The sensitivity was 94.59%,and the specificity was 81.13%.CONCLUSION The combination of Scr,PI,and WIS can improve the diagnostic accuracy of septic AKI.PI and WIS are expected to predict the occurrence of early septic AKI. | Xiu-Yan Wang Yan-Ping Pang Tian Jiang Shuo Wang Jiang-Tao Li Bao-Min Shi Chen Yu | 2019 | World Journal of Clinical Cases2019，7，23： | 10 |
| 10 | Main progress and problems in research on Ordovician hydrocarbon accumulation in the Tarim Basin显示文摘The Tarim Basin is the largest petroliferous basin in the northwest of China, and is composed of a Paleozoic marine craton basin and a Meso-Cenozoic continental foreland basin. It is of great significance in exploration of Ordovician. In over 50 years of exploration, oil and gas totaling over 1.6 billion tonnes oil-equivalent has been discovered in the Ordovician carbonate formation. The accumulation mechanisms and distribution rules are quite complicated because of the burial depth more than 3,500 m, multi-source, and multi-stage accumulation, adjustment, reconstruction and re-enrichment in Ordovician. In this paper, we summarized four major advances in the hydrocarbon accumulation mechanisms of Ordovician carbonate reservoirs. First, oil came from Cambrian and Ordovician source rocks separately and as a mixture, while natural gas was mainly cracked gas generated from the Cambrian-Lower Ordovician crude oil. Second, most hydrocarbon migrated along unconformities and faults, with different directions in different regions. Third, hydrocarbon migration and accumulation had four periods: Caledonian, early Hercynian, late Hercynian and Himalayan, and the latter two were the most important for oil and gas exploration. Fourth, hydrocarbon accumulation and evolution can be generally divided into four stages: Caledonian (the period of hydrocarbon accumulation), early Hercynian (the period of destruction), late Hercynian (the period of hydrocarbon reconstruction and re-accumulation), and Himalayan (the period of hydrocarbon adjustment and re-accumulation). Source rocks (S), combinations of reservoir-seal (C), paleo-uplifts (M), structure balance belt (B) matched in the same time (T) control the hydrocarbon accumulation and distribution in the Ordovician formations. Reservoir adjustment and reconstruction can be classified into two modes of physical adjustment and variation of chemical compositions and five mechanisms. These mechanisms are occurrence displacement, biodegradation, multi-source mixing, high-temperature cracking and late gas invasion. Late hydrocarbon accumulation effects controlled the distribution of current hydrocarbon. The T-BCMS model is a basic geological model to help understanding the control of reservoirs. At present, the main problems of hydrocarbon accumulation focus on two aspects, dynamic mechanisms of hydrocarbon accumulation and the quantitative models of oil-bearing in traps, which need further systemic research. | Pang Xiongqi Tian Jun Pang Hong Xiang Caifu Jiang Zhenxue Li Sumei | 2010 | Petroleum Science2010，7，2： | 10 |
| 11 | Control of Formation of Lithological Reservoirs by Surrounding Mudstone显示文摘Taking the Jiyang depression as an example, this paper discusses the control of the formation of lithological reservoir by surrounding rocks by integrated application of geological analysis, physical simulation, and the analysis of oil & gas accumulation mechanism. Geological statistical shows that the major burial depth and interval of lithological reservoirs in the Jiyang depression are related to the hydrocarbon generation in and expulsion from the Lower Tertiary source rocks and the time of the formation of most lithological reservoirs coincides with the peak of hydrocarbon generation and expulsion. The lithological traps located in the center of effective source rocks are propitious to high oil saturation than those located on the margin of effective source rocks. The hydrocarbon charge degree of the lithological reservoir has a positive correlation with the intensity of hydrocarbon expulsion from surrounding source rocks. Geological analyses and NMR experiments also show that the oil saturation of surrounding source rocks control the hydrocarbon potential of lithological traps, and a critical value for oil saturation of surrounding mudstone is required, that is, when the oil saturation of surrounding mudstone is lower than this critical value, no oil and gas accumulate in the lithological trap. The control of surrounding mudstone on the oil-bearing properties of lithological reservoirs is also analyzed by the mechanisms of hydrocarbon generation and expulsion as well as accumulation. | Jiang Zhenxue Chen Dongxia Pang Xiongqi Zhang Jun Tian Fenghua | 2006 | Petroleum Science2006，3，2： | 7 |
| 12 | Development and Preliminary Evaluation of a Double-cell Ozonesonde显示文摘Ozonesondes are widely used to obtain ozone concentration profiles from the surface to the upper atmosphere. A kind of double-cell ozonesonde has been developed at the Institute of Atmospheric Physics(IAP), Chinese Academy of Sciences(named the 'IAP ozonesonde') based on previous experience over the past 20 years of developing the singlecell GPSO3 ozonesonde. The IAP ozonesonde is of the Electrochemical Concentration Cell(ECC) type. A detailed description of the IAP ozonesonde is firstly provided in the present paper, followed by a presentation of results from a series of launches carried out to evaluate its performance. The analysis involved comparing its observations with measurements from the GPSO3 and ECC ozonesondes(Model type ENSCI-Z) as well as a Brewer spectrophotometer. The results showed that the IAP ozonesonde is a vast improvement over the GPSO3 ozonesonde, able to capture vertical ozone structures very well and in good agreement with ECC ozonesonde measurements. The average difference in the ozone partial pressure between the IAP and ECC ozonesondes was 0.3 mPa from the surface to 2.5 km, close to zero from 2.5 to 9 km and generally less than 1 mPa for layers higher than 9 km. The apparent deviation is likely caused by a decreasing pump flow rate in the IAP ozonesonde which needs further improvement. The total ozone amounts measured by the IAP ozonesonde profiles were highly comparable with the Brewer data with a relative difference of 6%. The development of the IAP ozonesonde and its strong performance will surely accelerate the process of conventional observations of ozone profiles over China in the near future as well as provide more data for ozone research in general. | ZHANG Jinqiang XUAN Yuejian YAN Xiaolu LIU Mingyuan TIAN Hongmin XIA Xiang'ao PANG Li ZHENG Xiangdong | 2014 | Advances in Atmospheric Sciences2014，31，4： | 7 |
| 13 | Signaling pathways involved in ischemic stroke:molecular mechanisms and therapeutic interventions显示文摘Ischemic stroke is caused primarily by an interruption in cerebral blood flow,which induces severe neural injuries,and is one of the leading causes of death and disability worldwide.Thus,it is of great necessity to further detailly elucidate the mechanisms of ischemic stroke and find out new therapies against the disease.In recent years,efforts have been made to understand the pathophysiology of ischemic stroke,including cellular excitotoxicity,oxidative stress,cell death processes,and neuroinflammation.In the meantime,a plethora of signaling pathways,either detrimental or neuroprotective,are also highly involved in the forementioned pathophysiology.These pathways are closely intertwined and form a complex signaling network.Also,these signaling pathways reveal therapeutic potential,as targeting these signaling pathways could possibly serve as therapeutic approaches against ischemic stroke.In this review,we describe the signaling pathways involved in ischemic stroke and categorize them based on the pathophysiological processes they participate in.Therapeutic approaches targeting these signaling pathways,which are associated with the pathophysiology mentioned above,are also discussed.Meanwhile,clinical trials regarding ischemic stroke,which potentially target the pathophysiology and the signaling pathways involved,are summarized in details.Conclusively,this review elucidated potential molecular mechanisms and related signaling pathways underlying ischemic stroke,and summarize the therapeutic approaches targeted various pathophysiology,with particular reference to clinical trials and future prospects for treating ischemic stroke. | Chuan Qin Sheng Yang Yun-Hui Chu Hang Zhang Xiao-Wei Pang Lian Chen Luo-Qi Zhou Man Chen Dai-Shi Tian Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 7 |
| 14 | In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells显示文摘Circulating tumor cells(CTCs)is an established biomarker of cancer metastasis.The circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell dissemination.Although studies have revealed that the circadian rhythm may disrupt the growth of tumors,it is generally unclear whether the circadian rhythm controls the release of CTCs.In clinical examinations,the current in vitro methods for detecting CTCs in blood samples are based on a fundamental assumption that CTC counts in the peripheral blood do not change significantly over time,which is being challenged by recent studies.Since it is not practical to draw blood from patients repeatedly,a feasible strategy to investigate the circadian rhythm of CTCs is to monitor them by in vivo detection methods.Fluoresce nee in vivo flow cytometry(IVFC)is a powerful optical technique that is able to detect fluoresce nt circulating cells directly in living animals in a noninvasive manner over a long period of time.In this study,we applied fluorescence IVFC to monitor CTCs noninvasively in an orthotopic mouse model of human prostate cancer.We observed that CTCs exhibited stochastic bursts over cancer progression.The probability of the bursting activity was higher at early stages than at late stages.We longitudinally monitored CTCs over a 24-h period,and our results revealed striking daily oscillations in CTC counts that peaked at the onset of the night(active phase for rodents),suggesting that the release of CTCs might be regulated by the circadian rhythm. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，6： | 6 |
| 15 | Comparison of the Surface and Underground Natural Gas Occurrences in the Tazhong Uplift of the Tarim Basin显示文摘体积由探索的井的生产率揭示了的油,气体和水不反映实际地下的状况。在地质的条件下面,溶解天然气的某个数量在油或水被存储。在 Tazhong 基于探索的井的生产测试数据 Tarim 盆高举,这篇论文详细在在表面和地下的天然气之间的出现和分发 featrues 讨论差别;在不同温度,压力和中等条件下面根据天然气的可溶性介绍表面气体出现的恢复给实际地下的地质的条件;并且分类天然气进三个状态,即 oversaturated,浸透并且 undersaturated,根据它的相对内容地下。通过在表面和天然气的地下的出现的差别的比较分析,它讨论烃水库形成机制和分发规则,从而在学习区域为潜在的天然气水库分发的预言作为新方法和技术提供指导。 | TIAN Jun CHEN Junqing JIAO Jiao PANG Xiongqi | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 6 |
| 16 | Feature analysis of LIDAR waveforms from forest canopies显示文摘Airborne light detection and ranging (LIDAR) can detect the three-dimensional structure of forest canopies by transmitting laser pulses and receiving returned waveforms which contain backscatter from branches and leaves at different heights.We established a solid scatterer model to explain the widened durations found in analyzing the relationship between laser pulses and forest canopies,and obtained the corresponding rule between laser pulse duration and scatterer depth.Based on returned waveform characteristics,scatterers were classified into three types:simple,solid and complex.We developed single-peak derivative and multiple-peak derivative analysis methods to retrieve waveform features and discriminate between scatterer types.Solid scatterer simulations showed that the returned waveforms were widened as scatterer depth increased,and as space between sub-scatterers increased the returned waveforms developed two peaks which subsequently developed into two separate sub-waveforms.There were slight differences between the durations of simulated and measured waveforms.LIDAR waveform data are able to describe the backscatter characteristics of forest canopies,and have potential to improve the estimation accuracy of forest parameters. | LIU QingWang LI ZengYuan CHEN ErXue PANG Yong LI ShiMing TIAN Xin | 2011 | Science China Earth Sciences2011，54，8： | 6 |
| 17 | Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers显示文摘Background: Upon binding luteinizing hormone in the ovary, the luteinizing hormone/choriogonadotropin receptor (LHCGR) is necessary for follicular maturation and ovulation, as well as luteal function. We detected mutations in the LHCGR gene and evaluated their association with superovulation. Methods: Using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing, we examined polymorphisms in LHCGR and the genotypes associated with superovulation traits in 127 Chinese Holstein heifers. Results: A G/T polymorphism (ss52050737) in exon 11 was significantly associated with the total number of ova and the number of transferable embryos. Conclusions: LHCGR may be a new predictor for superovulation in Chinese Holstein heifers. | Yong Yu Yunwei Pang Haichao Zhao Xiaoling Xu Zhonghong Wu Lei An Jianhui Tian | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 6 |
| 18 | Million-year-old groundwater revealed by krypton-81 dating in Guanzhong Basin,China显示文摘Groundwater age,defined as the mean subsurface residence time spent isolated from the atmosphere,is of crucial significance for managing water resources and industrial waste.It is also very useful for understanding subsurface contaminant transport,and for paleoclimate reconstruction.It is an important parameter | Jie Li Zhonghe Pang Guo-Min Yang Jiao Tian Amin L.Tong Xiang-Yang Zhang Shui-Ming Hu | 2017 | Science Bulletin2017，62，17： | 6 |
| 19 | Arahidopsis CHLOROPHYLLASE 1 protects young leaves from long-term photodamage by facilitating FtsH-mediated D1 degradation in photosystemⅡrepair显示文摘The proteolytic degradation of the photodamaged D1 core subunit during the photosystemⅡ(PSⅡ)repair cycle is well understood,but chlorophyll turnover during D1 degradation remains unclear.Here,we report that Arabidopsis thaliana CHLOROPHYLLASE 1(CLH1)plays important roles in the PSII repair process.The abundance of CLH1 and CLH2 peaks in young leaves and is induced by high-light exposure.Seedlings of clh1 single and clh1-1/2-2 double mutants display increased photoinhibition after long-term high-light exposure,whereas seedlings overexpressing CLH1 have enhanced light tolerance compared with the wild type.CLH1 is localized in the developing chloroplasts of young leaves and associates with the PSⅡ-dismantling complexes RCC1 and RC47,with a preference for the latter upon exposure to high light.Furthermore,degradation of damaged D1 protein is retarded in young clh1-1/2-2 leaves after 18-h highlight exposure but is rescued by the addition of recombinant CLH1 in vitro.Moreover,overexpression of CLH1 in a variegated mutant(var2~2)that lacks thylakoid protease FtsH2,with which CLH1 interacts,suppresses the variegation and restores D1 degradation.A var2-2 clh1-1/2-2triple mutant shows more severe variegation and seedling death.Taken together,these results establish CLH1 as a long-sought chlorophyll dephytylation enzyme that is involved in PSⅡrepair and functions in long-term adaptation of young leaves to high-light exposure by facilitating FtsH-mediated D1 degradation. | Ya-nan Tian Rui-hao Zhong Jun-bin Wei Hong-hui Luo Yoram Eyal Hong-lei Jin La-jie Wu Ke-ying Liang Ying-man Li Shu-zhen Chen Zhao-qi Zhang Xue-qun Pang | 2021 | Molecular Plant2021，14，7： | 6 |
| 20 | Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque (Macaca leonina)显示文摘The northern pig-tailed macaque(Macaca leonina) has been identified as an independent species of Old World monkey, and we previously found that PBMCs from M. leonina were susceptible to human immunodeficiency virus type 1(HIV-1), which may be due to the absence of a TRIM5 protein restricting HIV-1 replication. Here we investigated the infection potentials of six laboratory adapted HIV-1 strains and three primary HIV-1 isolates in PBMCs from M. leonina. The results indicate that these strains are characterized by various but low replication levels, and among which, HIV-1NL4-3 shows the highest replication ability. Based on the abundant evidence of species-specific interactions between restriction factors APOBEC3 and HIV/SIV-derived Vif protein, we subsequently examined the replication potentials of vif-substituted HIV-1(HSIV) in M. leonina PBMCs. Notably, HSIV-vifmac and stHIV-1SV chimeras, two HIV-1NL4-3-derived viruses encoding the viral infectivity factor(Vif) protein from SIVmac239, replicated robustly in cells from M. leonina, which suggests that HSIV could effectively antagonize the antiviral activity of APOBEC3 proteins expressed in cells of M. leonina. Therefore, our data demonstrate that M. leonina has the potential to be developed into a promising animal model for human AIDS. | Ai-Hua LEI Gao-Hong ZHANG Ren-Rong TIAN Jia-Wu ZHU Hong-Yi ZHENG Wei PANG Yong-Tang ZHENG | 2014 | Zoological Research2014，35，3： | 5 |
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