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| 1 | Neogene eolian deposits within the West Qinling Mountains:Climatic and tectonic implications显示文摘The Qinling Mountains constitute a key climate barrier between southern and northern China.Our recent investigations revealed widely spread eolian deposits of Neogene age mantling the piedmont highlands of the intermountain basins within West Qinling.Micro-mammalian fossils dated a 150.2 m section (NL-VI) near Xihe for the late Miocene to Pliocene (~10-4 Ma).Soil micromorphology,grain-size and geochemical analysis consistently define typical loess-soil alternations for the upper (0-66 m) and lower (98-150.2 m) parts of the section,with the middle section (66-98 m) having been affected by episodic slope erosions.These results add important insights to the earlier studies about the widespread eolian deposition in northern China during the Miocene,prior to 8 Ma.They also suggest that the basic configuration of the ridges and inter-ridge basins of West Qinling has already formed by ~10 Ma.The well-preserved eolian deposits are unlikely to support intense substratum deformation and rapid uplift of West Qinling since the late Miocene. | GE JunYi 1,2 & GUO ZhengTang 3 1 State Key Laboratory of Loess and Quaternary Geology (SKLLQG),Institute of Earth Environment,Chinese Academy of Sciences,Xi’an 710075,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Key Laboratory of Cenozoic Geology and Environment,Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing 100029,China | 2010 | Chinese Science Bulletin2010，55，15： | 8 |
| 2 | Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells(MSCs)显示文摘Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes.Autologous stem cell-based therapies and transgene-enhanced cartilage tissue engineering may open new avenues for the treatment of cartilage injuries.Bone morphogenetic protein 2(BMP2)induces effective chondrogenesis of mesenchymal stem cells(MSCs)and can thus be explored as a potential therapeutic agent for cartilage defect repair.However,BMP2 also induces robust endochondral ossification.Although the precise mechanisms through which BMP2 governs the divergence of chondrogenesis and osteogenesis remain to be fully understood,blocking endochondral ossification during BMP2-induced cartilage formation may have practical significance for cartilage tissue engineering.Here,we investigate the role of Sox9-donwregulated Smad7 in BMP2-induced chondrogenic differentiation of MSCs.We find that overexpression of Sox9 leads to a decrease in BMP2-induced Smad7 expression in MSCs.Sox9 inhibits BMP2-induced expression of osteopontin while enhancing the expression of chondrogenic marker Col2a1 in MSCs.Forced expression of Sox9 in MSCs promotes BMP2-induced chondrogenesis and suppresses BMP2-induced endochondral ossification.Constitutive Smad7 expression inhibits BMP2-induced chondrogenesis in stem cell implantation assay.Mouse limb explant assay reveals that Sox9 expands BMP2-stimulated chondrocyte proliferating zone while Smad7 promotes BMP2-intitated hypertrophic zone of the growth plate.Cell cycle analysis indicates that Smad7 induces significant early apoptosis in BMP2-stimulated MSCs.Taken together,our results strongly suggest that Sox9 may facilitate BMP2-induced chondrogenesis by downregulating Smad7,which can be exploited for effective cartilage tissue engineering. | Chen Zhao Wei Jiang Nian Zhou Junyi Liao Mingming Yang Ning Hu Xi Liang Wei Xu Hong Chen Wei Liu Lewis L.Shi Leonardo Oliveira Jennifer Moriatis Wolf Sherwin Ho Aravind Athiviraham H.M.Tsai Tong-Chuan He Wei Huang | 2017 | Genes & Diseases2017，4，4： | 7 |
| 3 | Bidirectional turbo equalization for underwater acoustic communications显示文摘A direct-adaptation based bidirectional turbo equalizer for underwater acoustic communications is proposed.Abandoning the channel estimation process,the direct-adaptation based turbo equalizer embedded with digital phase-locked loop is adopted to track time-varying channel.The fast self-optimized algorithm is used to adjust the step size,thus a good tradeoff between the convergence speed and performance has been made.Furthermore,by minimizing the mean squared error,an optimal weighting factor is derived to exploit bidirectional diversity gain.The forward turbo equalizer is combined with the backward turbo equalizer to eliminate error propagation effect.Simulated and experimental results demonstrate that the bidirectional turbo equalizer outperforms the single directional one.It can be seen from the experimental results that,compared with the channel estimation based algorithm,the direct-adaptation based algorithm is less sensitive to the time-varying channel and has a lower bit error rate. | XI Junyi YAN Shefeng XU Lijun TIAN Jing | 2016 | Chinese Journal of Acoustics2016，35，4： | 4 |
| 4 | Soft Direct-Adaptation Based Bidirectional Turbo Equalization for MIMO Underwater Acoustic Communications显示文摘This paper proposes a soft direct-adaptation based bidirectional turbo equalizer for multiple-input multiple-output underwater acoustic communication systems. Soft, rather than hard, direct-adaptation based equalizer combined with the fast self-optimized least mean square algorithm is employed to achieve a faster convergence rate, and the second-order phase-locked loop is embedded into the equalizer to track the time-varying channel. Meanwhile, by utilizing a weighted linear combining scheme, the conventional soft direct-adaptation based equalizer is combined with the time-reversed soft direct-adaptation based equalizer to exploit bidirectional diversity and mitigate error propagation. Both the simulation and experimental results demonstrate that the soft direct-adaptation based bidirectional turbo equalizer outperforms the single-direction soft direct-adaptation based turbo equalizer, and achieves a faster convergence rate than the hard direct-adaptation based bidirectional turbo equalizer. | Junyi Xi Shefeng Yan Lijun Xu Jing Tian | 2017 | China Communications2017，14，7： | 3 |
| 5 | Atmospheric isoprene and monoterpenes in a typical urban area of Beijing: Pollution characterization, chemical reactivity and source identification显示文摘Continuous observation of isoprene, α-pinene and β-pinene was carried out in a typical urban area of Beijing from March 2014 to February 2015, using an AirmoV OC online analyzer. Based on the analysis of the ambient level and variation characteristics of isoprene, α-pinene and β-pinene, the chemical reactivity was studied, and their sources were identified. Results showed that the concentrations of isoprene, α-pinene and β-pinene in the urban area of Beijing were lower than those in richly vegetated areas; the concentrations of isoprene were at a moderate level compared with those of previous studies of Beijing. Concentrations of isoprene, α-pinene and β-pinene showed different seasonal, monthly, daily and diurnal variations, and all of the three species showed higher level at night than those in the daytime as a whole, the variations of isoprene, α-pinene and β-pinene mainly influenced by emission of sources, photochemical reaction, and meteorological parameters. Isoprene was the largest contributor to the total OFP values than α-pinene and β-pinene. α-Pinene was the largest contributor to the total SOAFP values than isoprene and β-pinene in autumn, while isoprene was the largest one in other seasons. Isoprene, α-pinene and β-pinene were derived mainly from biological sources; and α-pinene level were also affected by industrial sources. To reduce the concentrations of isoprene, α-pinene and β-pinene, it is necessary to scientifically select urban green plant species, and more strict control measures should be taken to reduce the emission of α-pinene from industrial sources, such as artificial flavors and resins synthesis processes. | Xi Cheng Hong Li Yujie Zhang Yuping Li Weiqi Zhang Xuezhong Wang Fang Bi Hao Zhang Jian Gao Fahe Chai Xiaoxiu Lun Yizhen Chen Junyi Lv | 2018 | Journal of Environmental Sciences2018，30，9： | 3 |
| 6 | Electromagnetic Confinement and Shaping for Plate-Form Part显示文摘The relationship between melt shape, electromagnetic pressure and magnetic field is studied for electromagnetic confinement and shaping of plate-form part. The results of experimental observation and theoretical inference can be summarized as follows. As the melt thickness a is large enough, causing the ratio of plate thickness to current theoretic skin depth α/δ larger than 2.2, the electromagnetic pressure acting on melt can be simply expressed as Pm =2μ\B2, and the melt shape would be known only by measuring the distribution of magnetic flux density. As α is small and makes the ratio α/δless than 2.2, the melt shape and electromagnetic pressure for confining and shaping are determined not only by magnetic flux density B but also by melt thickness a, electromagnetic parameter pry and current frequency f. In this paper, an equation used to calculate electromagnetic pressure acting on 'thin plate-form melt' is brought forward. The equation gives a precise relationship between electromagnetic pressure factor p and melt thickness α, electromagnetic parameter μγ and current frequency f. | Jun SHEN, Jianguo LI and Hengzhi FU (State Key Laboratory of Solidification Processing, Northwestern Polytechnic University, Xi’an 710072, China) Junyi SU (Xi’an Jiaotong University,Xi’an 710049, China) | 2000 | Journal of Materials Science & Technology2000，16，1： | 2 |
| 7 | Rapid velocity reduction and drift potential assessment of off-nozzle pesticide droplets显示文摘The droplet velocity and diameter significantly affect both the spatial drift loss and the interfacial deposition behaviors, thus determining the ultimate utilization efficiency during pesticide spraying.Investigating the spatial velocity and diameter evolutions can reveal the mechanism of drift loss and guide to design regulation strategy. Here, we explored the spatial velocity distribution of droplets after leaving the nozzle by particle image velocimetry technology and particle tracking model, considering that the effect of nozzle configuration and the air velocity. It shows that all droplets decelerate rapidly with the velocity attenuation ratio ranging from 50% to 80% within the region of 200 mm below the nozzle.The spatial velocity evolution differences between droplets in crossflow are determined by the competition of vertical drag force and net gravity, and the drag force sharply increases as the droplet diameter decreases, especially for that smaller than 150 μm. Based on the spatial evolution differences of the droplet velocity and diameter, a functional adjuvant was added to the liquid for improving the diameter distribution. And the drift loss was significantly reduced due to the reduction of the proportion of easily drifting droplets. | Shidong Xue Jingkun Han Xi Xi Junyi Zhao Zhong Lan Rongfu Wen Xuehu Ma | 2022 | Chinese Journal of Chemical Engineering2022，35，6： | 2 |
| 8 | Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy显示文摘Objective:This study aimed to evaluate the effects of mitochondrial pyruvate carrier(MPC)blockade on the sensitivity of detection and radiotherapy of prostate cancer(PCa).Methods:We investigated glycolysis reprogramming and MPC changes in patients with PCa by using metabolic profiling,RNASeq,and tissue microarrays.Transient blockade of pyruvate influx into mitochondria was observed in cellular studies to detect its different effects on prostate carcinoma cells and benign prostate cells.Xenograft mouse models were injected with an MPC inhibitor to evaluate the sensitivity of 18F-fluorodeoxyglucose positron emission tomography with computed tomography and radiotherapy of PCa.Furthermore,the molecular mechanism of this different effect of transient blockage towards benign prostate cells and prostate cancer cells was studied in vitro.Results:MPC was elevated in PCa tissue compared with benign prostate tissue,but decreased during cancer progression.The transient blockade increased PCa cell proliferation while decreasing benign prostate cell proliferation,thus increasing the sensitivity of PCa cells to 18F-PET/CT(SUVavg,P=0.016;SUVmax,P=0.03)and radiotherapy(P<0.01).This differential effect of MPC on PCa and benign prostate cells was dependent on regulation by a VDAC1-MPC-mitochondrial homeostasis-glycolysis pathway.Conclusions:Blockade of pyruvate influx into mitochondria increased glycolysis levels in PCa but not in non-carcinoma prostate tissue.This transient blockage sensitized PCa to both detection and radiotherapy,thus indicating that glycolytic potential is a novel mechanism underlying PCa progression.The change in the mitochondrial pyruvate influx caused by transient MPC blockade provides a critical target for PCa diagnosis and treatment. | Huan Xu Junyi Chen Zhi Cao Xi Chen Caihong Huang Jin Ji Yalong Xu Junfeng Jiang Yue Wang Guowang Xu Lina Zhou Jingyi He Xuedong Wei Jason Boyang Wu Zhong Wang Shancheng Ren Fubo Wang | 2022 | Cancer Biology & Medicine2022，19，9： | 1 |
| 9 | NUMERICAL SIMULATION ON SOLIDIFICATION OF HORIZONTALLY CONTINUOUSLY CAST IRON BARS显示文摘The solidification process of a horizontally continuously cast gray iron bar of 4.6cm in diame-ter was modelled.The function describing the distribution of heat flux at the internal surfaceof graphite sleeve,which was equal to that on the surface of the iron bar,was inversely derivedusing numerical calculation from the temperature distribution in the sleeve measured in realproduction.By using the distribution of heat flux as a boundary condition on the surface of theiron bar,the numerical simulation on solidification of the iron bar taking longitudinal heatconduction into account was made.The profile of solidification front obtained from the numer-ical simulation was approximately coincident with that in real production.In addition,thequantitative relationships of the thickness of solidified shell at the exit of the mold to the maintechnological parameters,including the temperature of liquid iron at the entrance of the mold,the moving speed of the bar and the intensity of water cooling,were obtained from the numeri-cal simulation. | ZHU Xianhua DONG Zengzhang SU Junyi Xi’an Jiaotong University,Xi’an,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，12： | 0 |
| 10 | High open-circuit voltage organic solar cells enabled by a difluorobenzoxadiazole-based conjugated polymer donor显示文摘A new polymer donor based on 3,3′-difluoro-2,2′-bithiophene(2F2T) and difluorobenzoxadiazole(ffBX), named 2F2T-ffBX, is designed and synthesized. The organic solar cell(OSC) based on 2F2T-ffBX donor and [6,6]-phenyl-C60-butyl acid methyl ester([60]PCBM) acceptor exhibits a high efficiency of 7.3% with a high open-circuit voltage(Voc) of 1.03 V. When blended with perylenediimide-based acceptor(PDI6), the corresponding OSC shows a higher Voc of 1.19 V with a low energy loss of 0.50 e V but a much lower efficiency of 2.0%. The detailed analyses including charge generation, transport, recombination properties, and morphology were performed to understand the performance of corresponding devices. | Ruiwen Zhang Junyi Wang Xi Liu Shuting Pang Chunhui Duan Fei Huang Yong Cao | 2019 | Science China Chemistry2019，62，7： | 0 |
| 11 | Service Function Chain Migration in LEO Satellite Networks显示文摘With the advancements of software defined network(SDN)and network function virtualization(NFV),service function chain(SFC)placement becomes a crucial enabler for flexible resource scheduling in low earth orbit(LEO)satellite networks.While due to the scarcity of bandwidth resources and dynamic topology of LEO satellites,the static SFC placement schemes may cause performance degradation,resource waste and even service failure.In this paper,we consider migration and establish an online migration model,especially considering the dynamic topology.Given the scarcity of bandwidth resources,the model aims to maximize the total number of accepted SFCs while incurring as little bandwidth cost of SFC transmission and migration as possible.Due to its NP-hardness,we propose a heuristic minimized dynamic SFC migration(MDSM)algorithm that only triggers the migration procedure when new SFCs are rejected.Simulation results demonstrate that MDSM achieves a performance close to the upper bound with lower complexity. | Geng Yuhui Wang Niwei Chen Xi Xu Xiaofan Zhou Changsheng Yang Junyi Xiao Zhenyu Cao Xianbin | 2024 | China Communications2024，21，3： | 0 |
| 12 | Corrigendum to “Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs)” [Genes & Diseases 4 (2017) 229–239]显示文摘The authors regret having image assembly errors in Figure 1A and Figure 3A.Specifically,in Figure 1A,the images for'C3H10T1/2',''BMP2'and'Sox9'were erroneously duplicated with the images from an irrelevant experiment that was conducted at the same time.In Figure 3A,the images for'Col2a1'and'β-actin'were erroneously duplicated with the images from an irrelevant experiment that was conducted at the same time. | Chen Zhao Wei Jiang Nian Zhou Junyi Liao Mingming Yang Ning Hu Xi Liang Wei Xu Hong Chen Wei Liu Lewis L. Shi Leonardo Oliveira Jennifer Moriatis Wolf Sherwin Ho Aravind Athiviraham H.M. Tsai Tong-Chuan He Wei Huang | 2023 | Genes & Diseases2023，10，2： | 0 |
| 13 | A Mathematical Model for Predicting Shrinkage Defect of Ductile Iron Castings显示文摘The shrinkage defect of a ductile iron casting is attributed to the volume variations occurring in solidification, which consist of liquid contraction, solidification shrinkage, graphitization expansion, and mold cavity enlargement. Based on this understanding, a mathematical model for predicting the shrinkage defect of the casting is developed, in which the volume variations of the casting in soli- dification are numerically simulated, especially, the mold cavity enlargement is quantitatively calculated. Moreover, the reliability of the model is verified in production and experiment. | ZhiqiangHan Junyi Su Kaike Cai Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China Xi’an Jiaotong University, Xi’an 710049, China | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，1： | 0 |
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