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| 1 | Retrospective study of mycophenolate mofetil treatment in IgA nephropathy with proliferative pathological phenotype显示文摘 | Liang Yan Zhang Junjun Liu Dongwei Quan Songxia Xing Guolan Liu Zhangsuo | 2014 | Chinese Medical Journal2014，，1： | 7 |
| 2 | Integrated histopathological,lipidomic,and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is transmitted on mink farms between minks and humans in many countries.However,the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown.Here,we demonstrated that minks were largely permissive to SARS-CoV-2,characterized by severe and diffuse alveolar damage,and lasted at least 14 days post inoculation(dpi).We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular,hepatobiliary,urinary,endocrine,digestive,and immune systems.The viral protein partially co-localized with activated Mac-2+macrophages throughout the body.Moreover,we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks,especially at 6 dpi,and were similar to that of patients with severe and fatal COVID-19.Particularly,altered metabolic pathways,abnormal digestion,and absorption of vitamins,lipids,cholesterol,steroids,amino acids,and proteins,consistent with hepatic dysfunction,highlight metabolic and immune dysregulation.Enriched kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage activation.Melatonin,which has significant anti-inflammatory and immunomodulating effects,was significantly downregulated at 6 dpi and displayed potential as a targeted medicine.Our data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients,delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies,vaccine research,and potential biomarkers. | Zhiqi Song Linlin Bao Wei Deng Jiangning Liu Erjun Ren Qi Lv Mingya Liu Feifei Qi Ting Chen Ran Deng Fengdi Li Yunpeng Liu Qiang Wei Hong Gao Pin Yu Yunlin Han Wenjie Zhao Junjun Zheng Xujian Liang Fuhe Yang Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 3 | Effect of Intermittent Aeration on the Treatment Performance in a Submerged Membrane Bioreactor显示文摘In order to improve removal for nitrogen in a pilot-scale submerged membrane bioreactor(SMBR),intermittent aeration was conducted,and the effect on the treatment performance under four kinds of operation condition(run 1,continuous aeration;run 2,60/60 min aeration on/off time;run 3,60/90 min aeration on/off time;run 4,60/75 min aeration on/off time) was evaluated.The results showed that depending on the specific on/off of the aeration time ratio,removal efficiency of nitrogen could be improved significantly,and the removal rates of total nitrogen(TN) under different operation conditions were 28.0%,59.5%,66.8% and 70.7%,respectively.There were no obvious differences for removal rates for CODCr and ammonia among different operation conditions.In general,intermittent aeration could be used as a feasible way to improve treatment performance for nitrogen in the SMBR. | CHANG Junjun LIANG Wei XIAO Enrong WU Zhenbin | 2010 | Wuhan University Journal of Natural Sciences2010，15，5： | 2 |
| 4 | Devonian integrative stratigraphy and timescale of China显示文摘The Global Boundary Stratotype Sections and Points(GSSPs) for the bases of all seven international Devonian stages have been formally defined and ratified by IUGS till 1996, and nowadays, the main tasks for Devonian stratigraphers include further subdivision of these standard stages, strictly constrained absolute ages for the boundaries, and precise neritic-pelagic and marine-terrestrial correlations using multidisciplinary stratigraphy methods. Establishment of high-resolution Devonian integrative stratigraphy framework and timescale of China would play an important role in improving regional and international correlation, facilitating the recognition of important stratigraphic levels in different paleogeographic settings, and understanding the evolution pattern of biota, paleoclimate and paleoenvironment during this critical interval. Based on well-studied bio-and chronostratigraphy of Devonian in South China and adjacent areas, in combination with recent achievements in carbon isotope stratigraphy, event stratigraphy and radioactive isotope ages, this paper briefly summarize the research history and current status of Devonian chronostratigraphy of China, and for the first time introduce Devonian integrative stratigraphy framework of China.Up to date, few studies have been conducted on the astronomical cyclostratigraphy and high-resolution radioactive isotope dating in Devonian of China, which should be our main focuses in the near future. | Wenkun QIE Xueping MA Honghe XU Li QIAO Kun LIANG Wen GUO Junjun SONG Bo CHEN Jianfeng LU | 2019 | Science China Earth Sciences2019，62，1： | 2 |
| 5 | Selective and Cell-Active Inhibitors of the USP1/ UAF1 Deubiquitinase Complex Reverse Cisplatin Resistance in Non-small Cell Lung Cancer Cells显示文摘 | Junjun Chen Thomas S. Dexheimer Yongxing Ai Qin Liang Mark A. Villamil James Inglese David J. Maloney Ajit Jadhav Anton Simeonov Zhihao Zhuang | 2011 | Chemistry & Biology2011，，11： | 2 |
| 6 | Systematic analysis of clinical relevance and molecular characterization of m^(6)A in COVID-19 patients显示文摘N6-methyladenosine(m6A)is the most prevalent post-transcriptional RNA modification in mRNA and long non-coding RNAs of eukaryotes,and its biological functions are mediated by m6A writers,erasers and readers.1 A nuclear methyltransferase complex consisting of METTL3,METTL14,WTAP,VIRMA,ZC3H13,RBM15(or RBM15B),YWHAG,TRA2A and CAPRIN1 catalyzes the m6A modifications,acting as m6A writers.1 m6A demethylase ALKBH5 as well as m6A demethylase FTO mediate the demethylation of m6As,acting as the m6A erasers. | Sanqi An Zhouhua Xie Yanyan Liao Junjun Jiang Wenyi Dong Fuqiang Yin Wen-Xing Li Li Ye Jianyan Lin Hao Liang | 2022 | Genes & Diseases2022，9，5： | 1 |
| 7 | Preparation and mechanical properties of two nickel base alloy coatings achieved by electrospark deposition显示文摘Ni398 and Ni818 base alloy coatings were deposited on 1045 steel by electrospark deposition technique (ESD). Forming properties, thickness, microhardness and wear resistance of the coatings were investigated. The chemical composition and crosssection morphology were analyzed through energy dispersive spectrum (EDS) and metalloscope. The results show that the technological parameter window of Ni398 is larger than that of Ni818 electrode. However, other properties of the Ni818 coating, such as thickness and microhardness, were better than those of the Ni398 coating. Especially the wornout volume of Ni818 coating is only 1/6 of that for 1045 steel and 1/3 for Ni398 coating. Chemical composition analysis indicated that the addition of Mo promoted grain refinement of nickel alloy. Metallographic analysis shows that the molten droplets of Ni398 coatings have an average structure thickness of 20-40 μm while the microstructure of Ni818 coatings is flat with width of 5-20 μm. | Ping ZHANG Lin MA Zhijie LIANG Junjun ZHAO | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，4： | 1 |
| 8 | MDM2 SNP309 variation contributes to leukemia risk: meta-analyses based on 7259 subjects显示文摘 | Wenlei Zhuo Liang Zhang Junjun Ling Bo Zhu Zhengtang Chen | 2012 | Leukemia & Lymphoma2012，，： | 1 |
| 9 | Asymmetric Two-component Fermi gas in Two Dimensions显示文摘 | Du Jiajia Chen Cheng Liang Junjun | 2009 | Phys Rev A2009，80，02： | 1 |
| 10 | Expression and Significance of ILK in Renal Allograft with Non-Chronic Rejection CAN显示文摘 | Hequn Zou Guirong Liang Qiang Yan Weiguo Sui Hao Luo Huaizhou Chen Shenping Xie Junjun Guo | 2011 | 器官移植内科学杂志2011，6，3： | 1 |
| 11 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 12 | Variation and Correlation of Erucic Acid,Oleic Acid and Glucosinolate Contents in Brassica rapa Seeds显示文摘In order to screen and identify excellent breeding resources and provide basic materials for Brassica rapa breeding,the contents of erucic acid,oleic acid and glucosinolate in 84 kinds of B. rapa were determined by near-infrared spectroscopy,and the correlations among them were also analyzed. The results showed that the content of erucic acid and oleic acid were significantly negatively correlated,the contents of erucic acid and glucosinolate were significantly positively correlated,while the contents of oleic acid and glucosinolate were significantly negatively correlated; principal component analysis( PCA) were performed on the population materials,factors 1 and 2 were extracted for plotting,factor 1 and factor 2 could explain 73. 7% and 23. 2% of the phenotypic variation,respectively; through cluster analysis,79 materials aggregated to form group I,and five special variants deviated from the population. The variation of erucic acid,oleic acid and glucosinolates in B. rapa populations was rich and there was significant correlation. Through cluster analysis,five excellent B. rapa breeding materials( No. 32,No. 45,No. 46,No. 50,and No. 59) were screened. | Entang TIAN Hailun LIANG Junjun WANG Jun GUO Huilin CAO Shuchun LIN | 2018 | Asian Agricultural Research2018，10，6： | 0 |
| 13 | Heat Treatment of Centrifugally Cast High-Vanadium Alloy Steel for High-Pressure Grinding Roller显示文摘The roller is one of the main parts of a high-pressure grinding roller, which is a type of highly efficient ore crushing equipment. Its working life is strongly affected by the materials used. In this paper, a new kind of roller material,the high-vanadium alloy steel(HVAS), was investigated. The results showed that the as-cast microstructures of the HVAS roller contained martensite, residual austenite, and alloy carbides. The HVAS sample quenched at 1,080 °C had a high hardness, and it had much higher compressive strength and abrasive wear resistance after tempering at 560 °C for 30 min.The mechanical properties of the HVAS are more sufficient than the existing roller materials, which are feasible for larger machine design. | Haizhi Li Weiping Tong Junjun Cui Hui Zhang Liqing Chen Liang Zuo | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 0 |
| 14 | Metaverse virtual social center for elderly communication in time of social distancing显示文摘Background The lack of social activities among the elderly due to physical limitations can result in loneliness and depression. The spread of COVID-19 has made it difficult for the elderly to conduct stable social activities, increasing feelings of loneliness. The metaverse is a virtual world that mirrors reality. This allows the elderly to overcome the constraints of reality and perform social activities stably and continuously, providing new ideas for alleviating loneliness. Methods By analyzing their needs, a virtual social center framework for the elderly was proposed in this study. In addition, a prototype system was designed according to this framework. The elderly can socialize in virtual reality with metaverse-related technologies and human–computer interaction tools. Additionally, a test was conducted jointly with the chief physician of the geriatric rehabilitation department of a tertiary hospital. Results The results demonstrated that the mental state of the elderly who had used the virtual social center was significantly better than that of those who had not used it. Conclusions Thus, virtual social centers can help relieve loneliness and depression among the elderly with increasing global epidemics and an aging society. Hence,they have promotional value. | Hui LIANG Jiupeng LI Yi WANG Junjun PAN Yazhou ZHANG Xiaohang DONG | 2023 | Virtual Reality & Intelligent Hardware2023，5，1： | 0 |
| 15 | BaMBNet:A Blur-Aware Multi-Branch Network for Dual-Pixel Defocus Deblurring显示文摘Reducing the defocus blur that arises from the finite aperture size and short exposure time is an essential problem in computational photography.It is very challenging because the blur kernel is spatially varying and difficult to estimate by traditional methods.Due to its great breakthrough in low-level tasks,convolutional neural networks(CNNs)have been introdu-ced to the defocus deblurring problem and achieved significant progress.However,previous methods apply the same learned kernel for different regions of the defocus blurred images,thus it is difficult to handle nonuniform blurred images.To this end,this study designs a novel blur-aware multi-branch network(Ba-MBNet),in which different regions are treated differentially.In particular,we estimate the blur amounts of different regions by the internal geometric constraint of the dual-pixel(DP)data,which measures the defocus disparity between the left and right views.Based on the assumption that different image regions with different blur amounts have different deblurring difficulties,we leverage different networks with different capacities to treat different image regions.Moreover,we introduce a meta-learning defocus mask generation algorithm to assign each pixel to a proper branch.In this way,we can expect to maintain the information of the clear regions well while recovering the missing details of the blurred regions.Both quantitative and qualitative experiments demonstrate that our BaMBNet outperforms the state-of-the-art(SOTA)methods.For the dual-pixel defocus deblurring(DPD)-blur dataset,the proposed BaMBNet achieves 1.20 dB gain over the previous SOTA method in term of peak signal-to-noise ratio(PSNR)and reduces learnable parameters by 85%.The details of the code and dataset are available at http://gffzz188fe103f8f1460aswfukovnuoucn66q5.ffgz.tsg.suse.edu.cn/junjun-jiang/BaMBNet. | Pengwei Liang Junjun Jiang Xianming Liu Jiayi Ma | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，5： | 0 |
| 16 | Study of Quality Standards of Xiao’er Qingre Enema Preparation in Hospitals显示文摘Objective:To establish the quality standards for the preparation of Xiao’er Qingre enema in hospitals.Method:Thin-layer chromatography(TLC)was used to identify Radix Isatidis and Glycyrrhizae in the prescription.The content of(R,S)-Goitrin was determined by high-performance liquid chromatography(HPLC).Results:In TLC identification,there was no interference between the negative controls of Radix Isatidis and glycyrrhizae,and the spots were well-separated.The HPLC results of(R,S)-Goitrin showed a good linear relationship between the peak area and concentration within the range of 0.476-95.2μg·mL-1(r=0.9999).Conclusion:The TLC and HPLC methods established in this experiment are simple,reproducible,and specific,making them suitable for the quality control Xiao’er Qingre enema preparation in hospitals. | Ruizhong Wang Yurong Zhang Junjun Mao Shaoli Liang Yan Wu Lin Chen | 2024 | Journal of Clinical and Nursing Research2024，8，1： | 0 |
| 17 | Tet酶调控端粒和基因组稳定性的作用和机制显示文摘Tets家族催化5-甲基胞嘧啶转变为5-羟甲基胞嘧啶。在小鼠胚胎干细胞中单独干扰Tet1或/和Tet2,伴随着端粒重组下降,导致端粒长度缩短和基因组稳定性异常。 | Jiao Yang Renpeng Guo Hua Wang Xiaoying Ye Zhongcheng Zhou Jiameng Dan Haiying Wang Peng Gong Wei Deng Yu Yin Shi Qing Mao Lingbo Wang Junjun Ding Jinsong Li David L.Keefe Meelad M.Dawlaty Jianlong Wang Guo Liang Xu 刘林 | 2017 | 科学新闻2017，19，4： | 0 |
| 18 | Effects of paraprobiotics on bile acid metabolism and liver health in largemouth bass(Micropterus salmoides)fed a cottonseed protein concentrate-based diet显示文摘Cottonseed protein concentrate is a sustainable fishmeal alternative in aquafeed.A 10-week experiment was conducted to investigate the effects of a cottonseed protein concentrate-based diet with and without multi-strain yeast fractions(MsYF)on growth,bile acid metabolism,and health in largemouth bass.Four hundred fish(54.0±0.0 g)were casually distributed into 16 tanks(4 replicates/diet).Fish were fed with 4 iso-nitrogen and iso-energetic diets 3 times daily,including a fishmeal diet(FM),a soy protein concentrate-based diet(SPC;replacing 81%fishmeal protein),a cottonseed protein concentrate-based diet(CPC;replacing 81%fishmeal protein),and a CPC diet supplemented with 800 mg/kg MsYF(CPCY).Results showed that the survival of SPC was the lowest,i.e.,48%,with no apparent diet effect among other treatments;we omitted the SPC in additional analyses.Fish fed cottonseed protein concentrate-based diets showed lower growth than FM(P<0.05).Fish fed CPC showed the highest nuclear dense hepatic phenotypes ratio(50%),followed by CPCY(33%)and FM(17%).Further,dietary CPC increased hepatic total cholesterol and triglyceride levels with concurrently increased cholesterol syn-thesis but decreased triglyceride synthesis-associated transcription levels(P<0.05).Furthermore,di-etary CPC increased bile acid synthesis but decreased bile acid transport-associated transcription levels(P<0.05),and then induced an increment of plasma cholic acid and hepatic chenodeoxycholic acid content and the decrement of genus Romboustia(P<0.05).Regarding the effect of MsYF,fish fed CPCY reduced hepatic lipid accumulation and total plasma bile acid content(P<0.05)compared to CPC,suggesting an improvement in liver health.Also,dietary MsYF could reverse the microbiota community structure showing a similar gut microbial composition to FM.In conclusion,81%of fishmeal protein replaced by cottonseed protein concentrate suppressed growth and liver health,while dietary MsYF might mitigate the negative impact of a high cottonseed protein concentrate level diet on liver functions via gut microbiota regulation. | Xiaoze Xie Xiaofang Liang Hao Wang Qiang Zhu Junjun Wang Ying Chang Eric Leclercq Min Xue Jie Wang | 2023 | Animal Nutrition2023，，2： | 0 |
| 19 | The conclusion of reducing acute rejection after liver transplantation by machine perfusion should be extrapolated with caution显示文摘There is a theory that the unavoidable graft damage caused by ischemia-reperfusion injury(IRI)during liver transplantation(LT)can lead to severe IRI-related inflammation and trigger an early activation of the innate immune response mediated by T-cells,which potentially worsening the acute cellular rejection(ACR)cascade.As a result,machine perfusion(MP)has been placed great expectations for the potential to diminish post-LT ACR and other related immune responses by alleviating IRI through removing harmful substances and restoring cellular metabolism homeostasis(1,2).However,there has been much debate about MP’s benefits on ACR as relative data is limited. | Aijun Liang Linya Zhang Junjun Jia Kebo Zhong Yu Nie | 2023 | Hepatobiliary Surgery and Nutrition2023，12，5： | 0 |
| 20 | Devonian integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas显示文摘The Devonian System in the Qinghai-Tibetan Plateau and its surrounding areas is widely distributed,diverse in lithotypes and rich in fossils.It records the crucial processes of continuous subduction and reduction of the Paleo-Asian Ocean in the northern hemisphere and the transformation of the Proto-Tethys Ocean into the Paleo-Tethys Ocean in the southern hemisphere.Thus,it is of great significance for explaining the global paleogeographic evolution,tectonic activities and biodiversity changes during this critical period.The blocks on both sides of the southern Tienshan suture zone and the Longmu Co-ShuanghuChangning-Menglian suture zone belong to different sedimentary systems and paleobiogeographic realms and regions,showing important tectonic paleogeographic partitioning significance.The two suture zones represent the main branches of the PaleoAsian Ocean and the Paleo-Tethys Ocean,respectively,and on this basis the Devonian System can be subdivided into three types:the Tienshan type,the Tethys type and the Gondwana type.Based on recent research progress on the Devonian stratigraphy and paleontology in combining provenance analysis and biotic characteristics in the Qinghai-Tibetan Plateau and surrounding areas,this paper aims to establish the latest integrative stratigraphic framework and conduct paleogeographic reconstruction,providing foundation for exploring the geological evolution and dynamic mechanisms of various terranes and blocks in the northern margin of Gondwana.The results indicate that the North Qiangtang,South Qiangtang,Simao,Baoshan and Tengchong terranes,as well as the Himalaya Tethys Zone and the South China Block have affinities with the Indian Block,while the Lhasa Terrane has affinities with the Australian Block,and may be located between the South China and Australian blocks.In the Emsian(Early Devonian),the South China Block separated from the northern margin of Gondwana,a process that was accompanied by the opening of the Jinshajiang-Ailaoshan Ocean.In the Middle Devonian,the mid-oceanic ridge of the Paleo-Tethys Ocean expanded rapidly,corresponding with a global sea-level rise,the widespread development of carbonate platforms and nadir values of Devonian seawater strontium isotopes.By the Late Devonian,the Paleo-Tethys Ocean had reached a considerable size,leading to abundant occurrences of Upper Devonian radiolarian cherts in the Paleo-Tethys suture zones. | Wenkun QIE Kun LIANG Wen GUO Biao GAO Junjun SONG Bo CHEN Pu HUANG Li QIAO Honghe XU Jitao CHEN Yucong SUN Yichun ZHANG | 2024 | Science China Earth Sciences2024，67，4： | 0 |
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