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| 1 | Imatinib-induced fatal acute liver failure显示文摘Imatinib mesylate is a drug that has been approved for treatment of chronic myeloid leukemia (CML) in blast crisis, accelerated or chronic phase, and also for advanced gastrointestinal stromal tumors. Severe hepatic toxicity and three deaths from hepatic failure have been reported. We report the case of a 51-year-old woman who was admitted to our institution with severe acute hepatitis. She was diagnosed with CML and began treatment with imatinib mesylate at a dose of 400 mg/d. Five months after beginning treatment, she developed severe hepatitis associated with coagulopathy, and was admitted to our institution. She had been consuming acetaminophen 500-1000 mg/d after the onset of symptoms. She had a progressive increase in bilirubin level and a marked decrease of clotting factor Ⅴ. Five days after admission, grade Ⅱ encephalopathy developed and she was referred for liver transplantation. Her clinical condition progressively deteriorated, and 48 h after being referred for transplantation she suffered a cardiac arrest and died. This report adds concern about the possibility of imatinib-mesylate-induced hepatotoxicity and liver failure, particularly in the case of concomitant use with acetaminophen. Liver function tests should be carefully monitored during treatment and, with the appearance of any elevation of liver function tests, treatment should be discontinued. | Ezequiel Ridruejo Roberto Cacchione Alejandra G Villamil Sebastián Marciano Adrián C Gadano Oscar G Mandó | 2007 | World Journal of Gastroenterology2007，13，48： | 5 |
| 2 | Intraoperative laparoscopic complications for urological cancer procedures显示文摘AIM: To structure the rate of intraoperative complications that requires an intraoperative or perioperative resolution. METHODS: We perform a literature review of Medline database. The research was focused on intraoperative laparoscopic procedures inside the field of urological oncology. General rate of perioperative complications in laparoscopic urologic surgery is described to be around 12.4%. Most of the manuscripts published do not make differences between pure intraoperative, intraoperative with postoperative consequences and postoperative complications. RESULTS: We expose a narrative statement of complications, possible solutions and possible preventions for most frequent retroperitoneal and pelvic laparoscopic surgery. We expose the results with the following order: retroperitoneal laparoscopic surgery(radical nephrectomy, partial nephrectomy, nephroureterectomy and adrenalectomy) and pelvic laparoscopic surgery(radical prostatectomy and radical cystectomy).CONCLUSION: Intraoperative complications vary from different series. More scheduled reports should be done in order to better understand the real rates of complications. | Sergio Fernández-Pello Montes Ivan Gonzalez Rodríguez Rodrigo Gil Ugarteburu Luis Rodríguez Villamil Begoa Diaz Mendez Patricio Suarez Gil Javier Mosquera Madera | 2015 | World Journal of Clinical Cases2015，3，5： | 4 |
| 3 | 1413 SIMEPREVIR (TMC435) WITH PEGINTERFERON/RIBAVIRIN FOR TREATMENT OF CHRONIC HCV GENOTYPE-1 INFECTION IN TREATMENT-NA?VE PATIENTS: RESULTS FROM QUEST-2, A PHASE III TRIAL显示文摘 | M. Manns P. Marcellin F.P. Fred Poordad E. Stanislau Affonso de Araujo M. Buti Y. Horsmans E.J. Ewa Janczewska F. Villamil M. Peeters O. Lenz S. Ouwerkerk-Mahadevan R. Kalmeijer M. Beumont-Mauviel | 2013 | Journal of Hepatology2013，，： | 2 |
| 4 | Selective and Cell-Active Inhibitors of the USP1/ UAF1 Deubiquitinase Complex Reverse Cisplatin Resistance in Non-small Cell Lung Cancer Cells显示文摘 | Junjun Chen Thomas S. Dexheimer Yongxing Ai Qin Liang Mark A. Villamil James Inglese David J. Maloney Ajit Jadhav Anton Simeonov Zhihao Zhuang | 2011 | Chemistry & Biology2011，，11： | 2 |
| 5 | Ascitic fluid alpha 1-antitrypsin 显示文摘 | Villamil FG Sorroche PB Aziz HF etal | 1990 | Dig Dis Sci1990，35，9： | 1 |
| 6 | Report of the first International Liver Transplantation Society expert panel consensus conference on liver trans- plantation and hepatitis C显示文摘 | Wiesner RH Sorrell M Villamil F | 2003 | Liver Transpl2003，9，11： | 1 |
| 7 | Annual variation of airborne pollen in the city of Bahia,Argenting显示文摘 | Murray Maria G Sonaglioni Monica I Villamil Carlos B | 2002 | Grana2002，41，3： | 1 |
| 8 | Optimal contract when enforcement is a decision variable显示文摘 | KRASA S VILLAMIL A | 2000 | Econometrica2000，68，： | 1 |
| 9 | Effect of sodium dodecylsulfate and benzotriazole on the interracial behavior of Cu/Cu(Ⅱ), H2SO4显示文摘 | Villamil R F V Cordeiro G G O Matos J | 2002 | Materials Chemistry and Physics2002，，78： | 1 |
| 10 | Isoelectric Focusing of Esterases for Fine Fecue Identification显示文摘 | Villamil C B Duell R W | 1984 | Crop Science1984，，22： | 1 |
| 11 | Assessing the impact of peer revision on L2 writing显示文摘 | VILLAMIL O DE GUERRERO M | 1998 | Applied Linguistics1998，19，4： | 1 |
| 12 | Sodium dodecylsulfate-benzotriazole synergistic effect as an inhibitor of processes on copper chloridric acid interfaces显示文摘 | Villamil R F V Corio P Rubim J C | 2002 | Journal of Electroanalytical Chemistry2002，，535： | 1 |
| 13 | Renin inhibition aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide显示文摘 | Villamil A Chrysant SG Calhoun D | 2007 | J Hypertens2007，25，： | 1 |
| 14 | Assessing the impact of peer revision on L2 writing显示文摘 | Villamil O S Guerrero M | 1998 | Applied Linguistics1998，19，4： | 1 |
| 15 | Credit Rationing by Loan Size in Commercial Loan Markets 显示文摘 | Schreft S L Villamil A P | 1992 | Eco - nomic Review1992，78，2： | 1 |
| 16 | Control of Vibrio alginolyticus in Artemia culture by Treatment with bacterial probiotics显示文摘 | VILLAMIL L FIGUERAS A PIANAS M | 2003 | Aquaculture2003，219，： | 1 |
| 17 | Assessing the Impact of Peer Revision on L2 Writing显示文摘 | Guerrero MCMDE | 1998 | Applied Linguistics1998，19，4： | 1 |
| 18 | Metaphorical conceptuafizations of ESL teaching and learning显示文摘 | De Guerrero Maria C M VILLAMIL O S | 2002 | Language Teaching Research2002，6，2： | 1 |
| 19 | Isolation of Hbrio alginolyticus and Hbrio splendidus from aquacultured carpet shell clam (Ruditapes decussatus) larvae associated with mass mortalities 显示文摘 | Gomez-Loon J Villamil L Lemos M L | 2005 | Appl Environ Microbiol2005，71，1： | 1 |
| 20 | Report of the first international liver transplantation society expert panel consensus conference on liver transplantation and hepatitis C 显示文摘 | Wiesner RH Sorrell M Villamil F | 2003 | Liver Transpl2003，9，11： | 1 |
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