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| 1 | 脑缺氧是影响严重颅脑创伤患者短期预后的独立危险因素(英文)显示文摘Background:Brain hypoxia(BH)can aggravate outcome after severe traumatic brain injury(TBI).Whether BH or reduced brain oxygen(Pbto2)is an independent outcome predictor or a marker of disease severity is not fully elucidated.Objective To analyze the relationship between Pbto2,intracranial pressure(ICP),and cerebral perfusion pressure(CPP)and to examine whether BH correlates with worse outcome independently of ICP and CPP.Methods We studied103patients | Oddo M Levine JM Mackenzie L Frangos S Feihl F Kasner SE Katsnelson M Pukenas B Macmurtrie E Maloney-Wilensky E Kofke WA Leroux PD | 2011 | 中华神经外科疾病研究杂志2011，10，5： | 21 |
| 2 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 3 | Surgery for Peyronie's disease显示文摘Peyronie 的疾病(PD ) 最简单地被叫作 fibrotic tunica albuginea 的愈合创伤的混乱。它两个都是引起阴茎畸形的身体上并且心理上地破坏的混乱,弯曲,依赖,变窄并且弄短,它可以妥协性功能。尽管许多非外科的处理被建议了,注明日期提议阴茎畸形的可靠、有效的修正的没有。作为结果,外科仍然是标准答案治疗选择,提供将是这篇文章的焦点的最快速、可靠的治疗。我们考察外科手术前的评估,外科的算法,接枝材料和 PD 的手术后的管理。为弄短的 tunical 的结果, tunical 为阴茎弄直变长和阴茎修复术放置被考察。Tunica albuginea 折襞是与足够的刚硬为人弄直的比较喜欢的方法,更少的严重疾病把不到 70 ° 定义为弯曲;没有缩小 / 依赖。有更多的严重、复杂畸形,但是维持强壮的外科手术前的可勃起的功能的人应该为与匾切口或部分切除和 grafting 弄直被认为候选人。最后为有不适当的刚硬和 PD 的那些人,有弄直的阴茎修复术放置两个都是地址的最好的途径问题。 | Laurence A Levine Stephen M Larsen | 2013 | Asian Journal of Andrology2013，15，1： | 9 |
| 4 | 冠状动脉钙化的高血压患者左心室肥厚可预测心血管事件显示文摘冠状动脉钙化(coronary artery calcification,CAC)与心血管病风险增加有关。左心室肥厚(left ventricular hypertrophy,LVH)是心血管事件的独立危险因素。本研究目的是评估在CAC存在的情况下LVH的相对心血管病风险。 | Grossman C Levin M Koren-Morag N Bornstein G Lei-bowitz A Ben-Zvi I Shemesh J Grossman E 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，1： | 4 |
| 5 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 6 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 7 | Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines显示文摘Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an 'alternative' screening test that 'may be useful in select clinical circumstances',despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. | Barry M Berger Bernard Levin Robert J Hilsden | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 8 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 9 | Geometric primitive extraction using a genetic algorithm显示文摘 | Roth G Levin M D | 1994 | IEEE Trans on PAMI1994，16，9： | 2 |
| 10 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 11 | Modern treatment strategies for penile prosthetics in Peyronie’s disease:a contemporary clinical review显示文摘Peyronie's disease is a common condition resulting in penile deformity,psychological bother,and sexual dysfunction.Erectile dysfunction is one common comorbid condition seen in men with Peyronie’s disease,and its presence significantly impacts treatment considerations.In a man with Peyronie's disease and significant erectile dysfunction who desires the most reliable treatment,penile prosthesis placement should be strongly considered.In some instances,such as those patients with relatively mild curvature,prosthesis placement alone may result in adequate straightening.However,many patients will require additional straightening maneuvers such as manual modeling,penile plication,and tunica albuginea incision with or without grafting.For patients with severe penile shortening,penile length restoration techniques may also be considered.Herein,we provide a comprehensive clinical review of penile prosthesis placement in men with Peyronie's disease.Specifically,we discuss preoperative indications,intraoperative considerations,adjunctive straightening maneuvers,and postoperative outcomes. | Matthew J Ziegelmann M Ryan Farrell Laurence A Levine | 2020 | Asian Journal of Andrology2020，22，1： | 2 |
| 12 | Phenotypic plasticity in prostate cancer: role of ntrinsically disordered proteins显示文摘 | Steven M Mooney Mohit Kumar Jolly Herbert Levine Prakash Kulkarni | 2016 | Asian Journal of Andrology2016，18，5： | 2 |
| 13 | Resonse to placebo among bipolar 1 disorder patients experiencing their first manic episode显示文摘 | Chengappa KN Tohen M Levine J | 2000 | Bipolar Disord2000，2，4： | 1 |
| 14 | Activating mutation in the tyrosinc kinase JAK2 in polycythemia vent , essential thrombocythemia and myeloid metaplasia with myelofibrosis显示文摘 | Levine RL Wadleigh M | 2005 | Cancer Cell2005，7，4： | 1 |
| 15 | Comparison of the immu-nogenicity and safety of Cervarix and Gardasil human papilloma-virus(HPV)cervical cancer vaccines in health women aged 18-45 years显示文摘 | Einstein MH Baron M Levin MJ | 2009 | Hum Vaccin2009，5，10： | 1 |
| 16 | Changing Energy Intensity in Chinese Industry: The Relative Importance of Structural Shift and Intensity Change显示文摘 | Sinton J E Levine M D | 1994 | Energy Policy1994，22，3： | 1 |
| 17 | Partitioning and utilization of energy during the larval development of the xanthid crab,Rithropanopeus harrisii (Gould) 显示文摘 | Levine D M Sulkin S D | 1979 | J Exp Mar Biol Ecol1979，40，： | 1 |
| 18 | The management of traumatic spondylolisthesis of the axis 显示文摘 | Levine A M Edwards C C | 1985 | J Bone joint Surg (Am)1985，67，： | 1 |
| 19 | Two consecutive sets of transrectal ultrasound guided sextant biopsies of the prostate for the detection of prostate cancer显示文摘 | Levine MA Ittman M Melamed J | 1998 | J Urol1998，159，2： | 1 |
| 20 | Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer显示文摘 | Razandi M Pedram A Levin ER | 2000 | Mol Endocrinol2000，14，9： | 1 |
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