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| 1 | Translational pain research: Evaluating analgesic effect in experimental visceral pain models显示文摘Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood. One way to optimize treatment of visceral pain is to improve knowledge of the mechanisms behind the pain and the mode of action of analgesic substances. This can be achieved through stand-ardized experimental human pain models. Experimental pain models in healthy volunteers are advantageous for evaluation of analgesic action, as this is often diff icult to assess in the clinic because of confounding factors such as sedation, nausea and general malaise. These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining experimental pain studies and pharmacokinetic stud- ies can improve understanding of the pharmacokinetic-pharmacodynamic relationship of analgesics and, thus, provide valuable insight into optimal clinical treatment of visceral pain. To improve treatment of visceral pain, it is important to study the underlying mechanisms of pain and the action of analgesics used for its treatment. An experimental pain model activates different modalities and can be used to investigate the mechanism of action of different analgesics in detail. In combination with pharmacokinetic studies and objective assessment such as electroencephalography, new information re-garding a given drug substance and its effects can be obtained. Results from experimental human visceral pain research can bridge the gap in knowledge between animal studies and clinical condition in patients suffering from visceral pain, and thus constitute the missing link in translational pain research. | Anne Estrup Olesen Trine Andresen Lona Louring Christrup Richard N Upton | 2009 | World Journal of Gastroenterology2009，15，2： | 3 |
| 2 | A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated experimental pain model显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，123，12： | 1 |
| 3 | The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy:a randomized controlled trial显示文摘 | Ame Christensen Lona Louring Christrup Paul Erik Fabricius | 2010 | Journal of Hypertension2010，，28： | 1 |
| 4 | Neuropsycho-logical assessment of chronic non-malignant pain patientstreated in a multidisciplinary pain centre显示文摘 | Sj0gren P Christrup LL Petersen MA | 2005 | European Jour-nal of Pain2005，9，4： | 1 |
| 5 | A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated,experimental pain model显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，2，6： | 1 |
| 6 | Single-dose and steady-state pharmaeokinetics of diltiazem administered in two different tablet formulations显示文摘 | Bonde J Rasmussen SN | 1992 | Pharmacol Toxicol1992，71，： | 1 |
| 7 | Pharmacokinetics,efficacy,and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction:a randomized,double-blind,double-dummy,two-way,crossover study显示文摘 | Christrup LL Foster D Popper ED | 2008 | Clin Ther2008，30，3： | 1 |
| 8 | Role of activemetabolites in the use of opioids 显示文摘 | COLLER J CHRISTRUP L SOMOGYI A | 2009 | Eur J Clin Pharmacol2009，65，2： | 1 |
| 9 | A comparativestuy of oxycodone and morphine in a multl-modal, tissue-differ- entiated experimental pain model显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，123，12： | 1 |
| 10 | Neuropsychologicalassessment of chronic nonmalignant pain patients treated in a muit-idisciplinary pain centre 显示文摘 | Sjogren P Christrup LL Petersen MA | 2005 | Eur J Pain2005，9，4： | 1 |
| 11 | A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated experimental pain model显示文摘 | CAMILLA S CHRISTRUP L L ANDERSEN S D | 2006 | Pain2006，123，1： | 1 |
| 12 | Gentamicin dosing in critically ill patients 显示文摘 | Hansen M Christrup LL JarlCv JO | 2011 | Acta Anaesthesiol Scand2011，45，6： | 1 |
| 13 | The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial 显示文摘 | Arne Christensen Lona Louring Christrup Paul Erik Fabrlcius | 2010 | Journal of Hypertension2010，28，： | 1 |
| 14 | A comparative study of oxycodone and morphine in a multi - modal, tissue - differentiated experimental pain model显示文摘 | Camilla S Lona L Christrup | 2006 | Pain2006，123，： | 1 |
| 15 | A comparative study of oxycodone and morphine in a multi-modal,tissue differentiated experimental pain model显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，123，12： | 1 |
| 16 | A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated experimental pain model显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，123，12： | 1 |
| 17 | A comparativestudy of oxycodone and morphine in a multi - modal, tissue - dif-ferentiated ,experimental pain model 显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，2，6： | 1 |
| 18 | Differences between opioids: pharmacological, experimental, clinical and economical perspectives显示文摘 | Asbj?rn M. Drewes Rasmus D. Jensen Lecia M. Nielsen Joanne Droney Lona L. Christrup Lars Arendt‐Nielsen Julia Riley Albert Dahan | 2012 | British Journal of Clinical Pharmacology2012，，1： | 1 |
| 19 | The Impact of an Electronic Monitoring and Reminder Device on Patient Compliance with Antihypertensive Therapy: A Randomized Controlled Trial显示文摘 | Christensen A Christrup L L Fabricius P E | 2010 | J Hypertens2010，28，1： | 1 |
| 20 | A comparative study of oxycodone and morphine in a multi modal, tissue-dif- ferentiated experimental pain model 显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，123，12： | 1 |
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