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| 1 | Biofilms and Helicobacter pylori: Dissemination and persistence within the environment and host显示文摘The presence of viable Helicobacter pylori(H. pylori) in the environment is considered to contribute to the levels of H. pylori found in the human population, which also aids to increase its genetic variability and its environment adaptability and persistence. H. pylori form biofilms both within the in vitro and in vivo envi-ronment. This represents an important attribute that assists the survival of this bacterium within environ-ments that are both hostile and adverse to prolifera-tion. It is the aim of this paper to review the ability of H. pylori to form biofilms in vivo and in vitro and to address the inherent mechanisms considered to sig-nificantly enhance its persistence within the host and in external environments. Furthermore, the dissemi-nation of H. pylori in the external environment and within in the human body and its impact upon infec-tion control shall be discussed. | Steven L Percival Louise Suleman | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 6 |
| 2 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 3 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 4 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 5 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 6 | Targeting the AMPK Pathway for the Treatment of Type2Diabetes显示文摘 | Benot V Louise L Jocelyne DL | 2009 | Front Biosci2009，14，： | 1 |
| 7 | Immigrant and refugee preschool ers sandplay representations of the tsunami 显示文摘 | Louise L | 2006 | Art Psychother2006，34，2： | 1 |
| 8 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 9 | Polymorphism in the α1-antichymotrypsin (ACT) gen promoter effect on expression in transfected glial and liver cell line and plasma ACT concentrations显示文摘 | Kevin M Federico L Louise T | 2001 | Hum Genet2001，109，： | 1 |
| 10 | A critical evaluation of the three-stage BCR sequential extraction procedure to assess the potential mobility and toxicity of heavy metals in industrially-contaminated land显示文摘 | Christine M Davidson Ailsa L Duncan David Littlejohn Allan M Ure Louise M Garden | 1998 | Analytica Chimica Acta1998，，1： | 1 |
| 11 | Comprehensive modeling of mat density effect on duckweed (Lenma minor) growth under controlled eutrophication 显示文摘 | FREDERIC M SAMIR L LOUISE M | 2006 | Water Research2006，40，15： | 1 |
| 12 | The Ten-year Single-center Experience With 6-Mercaptopurine in the Treatment of Inflammatory Bowel Disease显示文摘 | Kenneth D Glazier Adam L Palance Louis H Griffel Kiron M Das | 2005 | Journal of Clinical Gastroenterology2005，，1： | 1 |
| 13 | Fetus papyraceus:congenital pulmonary anomalies associated with congenital aplasia cutis on the surviving twin显示文摘 | Louise L Annabel M Hubert L | 2013 | Pediatr Dermatol2013，30，6： | 1 |
| 14 | Sedation for endoscopy:the safe use of propofol by general practitioner sedationists显示文摘 | Anthony C Louise L Hillman C | 2002 | Med J Aust2002，1764，： | 1 |
| 15 | Nephrotic syndrome in children显示文摘 | Rachel L Louise W Nicholas JAW | 2010 | Paediatrics and Child Health2010，20，1： | 1 |
| 16 | Sedation for endoscopy: The safe use of propofol by general practitioner sedationists显示文摘 | CLARKE A C LOUISE C HILLMAN L C | 2002 | Medical Journal of Australia2002，176，4： | 1 |
| 17 | Challenges to effective cancer control in China, India, and Russia显示文摘 | Paul E Goss Kathrin Strasser-Weippl Brittany L Lee-Bychkovsky Lei Fan Junjie Li Yanin Chavarri-Guerra Pedro E R Liedke C S Pramesh Tanja Badovinac-Crnjevic Yuri Sheikine Zhu Chen You-lin Qiao Zhiming Shao Yi-Long Wu Daiming Fan Louis W C Chow Jun Wang Qio | 2014 | Lancet Oncology2014，，5： | 1 |
| 18 | lronuptake and metabolism in the new millennium 显示文摘 | Louise L Dunn Yohan Suryo Rahmanto Des R Richardson | 2006 | Trends in Cell Biology2006，17，2： | 1 |
| 19 | Effects of qua- ternary-ammonium-based formulations on bacterial community dynamics and antimicrobial susceptibility 显示文摘 | ANDREW J M RUTH G L LOUISE E M | 2004 | Appl Environ Mi- crobiol2004，70，6： | 1 |
| 20 | Nursing students ’ knowledge and attitudesregarding pain显示文摘 | Louise P Cynthia L | 2006 | Pain Management Nursing2006，17，4： | 1 |
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