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| 1 | All-silicon carrier accumulation modulator based on a lateral metal-oxide-semiconductor capacitor显示文摘In silicon photonics, the carrier depletion scheme has been the most commonly used mechanism for demonstrating high-speed electro-optic modulation. However, in terms of phase modulation efficiency, carrieraccumulation-based devices potentially offer almost an order of magnitude improvement over those based on carrier depletion. Previously reported accumulation modulator designs only considered vertical metal-oxidesemiconductor(MOS) capacitors, which imposes serious restrictions on the design flexibility and integratability with other photonic components. In this work, for the first time to our knowledge, we report experimental demonstration of an all-silicon accumulation phase modulator based on a lateral MOS capacitor. Using a Mach–Zehnder interferometer modulator with a 500-μm-long phase shifter, we demonstrate high-speed modulation up to 25 Gbit∕s with a modulation efficiency(V_πL_π) of 1.53 V·cm. | KAPIL DEBNATH DAVID J.THOMSON WEIWEI ZHANG ALI Z.KHOKHAR CALLUM LITTLEJOHNS JAMES BYERS LORENZO MASTRONARDI MUHAMMAD K.HUSAIN KOUTA IBUKURO FREOERIC Y.GARDES GRAHAM T,REED SHINICHI SAITO | 2018 | Photonics Research2018，6，5： | 6 |
| 2 | Genome-wide association studies of lactation yields of milk, fat, protein and somatic cell score in New Zealand dairy goats显示文摘Background: Identifying associations between genetic markers and traits of economic importance will provide practical benefits for the dairy goat industry, enabling genomic prediction of the breeding value of individuals, and facilitating discovery of the underlying genes and mutations. Genome-wide association studies were implemented to detect genetic regions that are significantly associated with effects on lactation yields of milk(MY), fat(FY),protein(PY) and somatic cell score(SCS) in New Zealand dairy goats.Methods: A total of 4,840 goats were genotyped with the Caprine 50 K SNP chip(Illumina Inc., San Diego, CA).After quality filtering, 3,732 animals and 41,989 SNPs were analysed assuming an additive linear model. Four GWAS models were performed, a single-SNP additive linear model and three multi-SNP Bayes C models. For the single-SNP GWAS, SNPs were fitted individually as fixed covariates, while the Bayes C models fit all SNPs simultaneously as random effects. A cluster of significant SNPs were used to define a haplotype block whose alleles were fitted as covariates in a Bayesian model. The corresponding diplotypes of the haplotype block were then fit as class variables in another Bayesian model.Results: Across all four traits, a total of 43 genome-wide significant SNPs were detected from the SNP GWAS. At a genome-wide significance level, the single-SNP analysis identified a cluster of variants on chromosome 19 associated with MY, FY, PY, and another cluster on chromosome 29 associated with SCS. Significant SNPs mapped in introns of candidate genes(45%), in intergenic regions(36%), were 0–5 kb upstream or downstream of the closest gene(14%) or were synonymous substitutions(5%). The most significant genomic window was located on chromosome 19 explaining up to 9.6% of the phenotypic variation for MY, 8.1% for FY, 9.1% for PY and 1% for SCS.Conclusions: The quantitative trait loci for yield traits on chromosome 19 confirms reported findings in other dairy goat populations. There is benefit to be gained from using these results for genomic selection to improve milk production in New Zealand dairy goats. | Megan Scholtens Andrew Jiang Ashley Smith Mathew Littlejohn Klaus Lehnert Russell Snell Nicolas Lopez-Villalobos Dorian Garrick Hugh Blair | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 2 |
| 3 | Continuation of long term treatment with hydroxychoroquine in systemic lupus erythematosus and rheumatoid arthritis显示文摘 | McCloud P Littlejohn G | 1992 | Ann Rheum Dis,1992，51，： | 1 |
| 4 | Electrical stimulation of red deer ( Cervus elaphus ) carcasses — effects on rate of pH-decline, meat tenderness, colour stability and water-holding capacity显示文摘 | E Wiklund J.M Stevenson-Barry S.J Duncan R.P Littlejohn | 2001 | Meat Science2001，，2： | 1 |
| 5 | Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study 显示文摘 | Ettinger MP Littlejohn TW Schwartz SL | 2003 | J American Med Associ2003，289，14： | 1 |
| 6 | Transurethral resection of the prostate: the new old standard显示文摘 | Joe O. Littlejohn Mohamed A. Ghafar Young M. Kang Steven A. Kaplan | 2002 | Current Opinion in Urology2002，，： | 1 |
| 7 | Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients显示文摘 | Daniel Bloomfield Gary L. Carlson Aditi Sapre Diane Tribble James M. McKenney Thomas W. Littlejohn Christine McCrary Sisk Yale Mitchel Richard C. Pasternak | 2009 | American Heart Journal2009，，2： | 1 |
| 8 | A diffusion tube sampler for the determination of acetic acid and formic acid vapours in museum cabinets显示文摘 | GIBSON L T COOKSEY B G LITTLEJOHN D | 1997 | Analytica Chimica Acta1997，341，： | 1 |
| 9 | The use of DNA markers in deciding conservation priorities in sheep and other livestock显示文摘 | Crawford A M Littlejohn R P | 1998 | Anim Genet Res Inform1998，23，： | 1 |
| 10 | Long-term algal control in a reservoir using barley straw显示文摘 | Barrett P R F Littlejohn J W Curnow J | 1999 | Hydrobiologia1999，415，： | 1 |
| 11 | Kinetics and interactions of BTEX compounds during degradation by a bacterial consortium 显示文摘 | Littlejohns J V Daugulis A J | 2008 | Process Biochem2008，43，： | 1 |
| 12 | Comparative efficacy of two angiotension Ⅱ receptor antagonists, irbesartan and losartan, in mild-to-moderate hypertension显示文摘 | Kassler TK Littlejohn T Elliott W | 1998 | Am J Hypertens1998，11，： | 1 |
| 13 | Comparative efficacy of two angiotensin Ⅱ receptor antagonists,irbesartan and losartan, in mild-to-moderate hypertension 显示文摘 | Kassler-Taub K Littlejohn T Elliott W | 1998 | Am J Hypertens1998，11，4： | 1 |
| 14 | Kinetics of NO absorption in aqueous iron(Ⅱ) bis(2,3-dimercapto-1-propanesulfonate) solutions using a stirred reactor显示文摘 | SHI Y LITTLEJOHN D CHANG S G | 1996 | Industrial and Engineering Chemistry Research1996，35，5： | 1 |
| 15 | A critical evaluation of the three-stage BCR sequential extraction procedure to assess the potential mobility and toxicity of heavy metals in industrially-contaminated land显示文摘 | Christine M Davidson Ailsa L Duncan David Littlejohn Allan M Ure Louise M Garden | 1998 | Analytica Chimica Acta1998，，1： | 1 |
| 16 | Telmisartan/hydrochlorothiazide in comparison with losartan/ hydrochlorothiazide ill managing patients with mild-to-moderate hypertension显示文摘 | NEUTEL JM LITTLEJOHN TW CHRYSANT SG | 2005 | Hypertens Res2005，28，7： | 1 |
| 17 | Ultrasonication Extraction and Solid Phase Extraction Clean-up for Determination of US EPA 16 Priority Pollutant Polycyclic Aromatic Hydrocarbons in Soils by Reversed-phase Liquid Chromatography with Ultraviolet Absorption Detection显示文摘 | Fusheng Sun David Littlejohn Mark David Gibson | 1998 | Analytica Chimica Acta1998，364，： | 1 |
| 18 | A review of the management of dysphagia:a South African perspective显示文摘 | Blackwell Z Littlejohns P | | 0，，02： | 1 |
| 19 | Blunted sleep-related lute- inizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index 显示文摘 | Bordini B Littlejohn E Rosenfield RL | 2009 | J Clin Endocrinol Metab2009，94，4： | 1 |
| 20 | Expression and purification of recombinant human indoleamine 2,3-dioxygenase 显示文摘 | LITTLEJOHN T K TAKI KAWA O SKYLAS D | 2000 | Protein Expre Purif2000，19，1： | 1 |
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