|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 3 | Breast cancer in China显示文摘 | Lei Fan Kathrin Strasser-Weippl Jun-Jie Li Jessica St Louis Dianne M Finkelstein Ke-Da Yu Wan-Qing Chen Zhi-Ming Shao Paul E Goss | 2014 | Lancet Oncology2014，，7： | 4 |
| 4 | Quality Improvement Guidelines for the Treatment of Lower Extremity Deep Vein Thrombosis with Use of Endovascular Thrombus Removal显示文摘 | Suresh Vedantham Patricia E. Thorpe John F. Cardella Clement J. Grassi Nilesh H. Patel Hector Ferral Lawrence V. Hofmann Bertrand M. Janne d’Othée Vittorio P. Antonaci Elias N. Brountzos Daniel B. Brown Louis G. Martin Alan H. Matsumoto Steven G. Meranze | 2006 | Journal of Vascular and Interventional Radiology2006，，3： | 3 |
| 5 | Myosin binding protein C:Structural abnormalities in familial hypertrophic cardiomyopathy显示文摘The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction, the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins, actin and titin, remain obscure. In additic n, several intra-domain interactions between adjacent MyBPC molecules have been identified. Although the basic structure of the molecule (a series of immunoglobulin and fibronectin domains) has been elucidated, the assembly of MyBPC in the sarcomere is a topic for debate. By analysing the MyBPC sequence with respect to FHC-causing mutations it is possible to identify individual residues or regions of each domain that may be important either for binding or regulation. This review looks at the current literature, in concert with alignments and the structural models of MyBPC, in an attempt to understand how FHC mutations may lead to the disease state. | Cecily E OAKLEY Brett D HAMBLY Paul MG CURMI Louise J BROWN | 2004 | Cell Research2004，14，2： | 2 |
| 6 | Is the negative prognostic impact of signet ring cell histology maintained in early gastric adenocarcinoma?显示文摘 | Caroline Gronnier Mathieu Messager William B. Robb Timothée Thiebot Damien Louis Guillaume Luc Guillaume Piessen Christophe Mariette | 2013 | Surgery2013，，： | 2 |
| 7 | A systematic review and meta-analysis of familial colorectal cancer risk显示文摘 | Louise E Johns Richard S Houlston | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 8 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 9 | Tumor necrosis factor gene polymorphism influences TNF alpha produc-tion in LPS-stimulated whole blood cell culture in healthy humans显示文摘 | Louis E Franchimont D Piron A | | 0，，3： | 1 |
| 10 | The developing cancer stem-cell model: clinical challenges and opportunities显示文摘 | Louis Vermeulen Felipe de Sousa e Melo Dick J Richel Jan Paul Medema | 2012 | Lancet Oncology2012，，： | 1 |
| 11 | Interrup- ting habitual car use: the importantce of car habit strength and moral motivation for personal car use reduction显示文摘 | LOUISE E JORGEN G ANNIKA M N | 2008 | Transportation Research Part F2008，，11： | 1 |
| 12 | Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor–Dependent Mechanism显示文摘 | Vijaya Karoor Masahiko Oka Sandra J. Walchak Louis B. Hersh York E Miller Edward C. Dempsey | 2013 | Hypertension2013，，4： | 1 |
| 13 | Quality Improvement Guidelines for the Treatment of Lower Extremity Deep Vein Thrombosis with Use of Endovascular Thrombus Removal显示文摘 | Suresh Vedantham Patricia E. Thorpe John F. Cardella Clement J. Grassi Nilesh H. Patel Hector Ferral Lawrence V. Hofmann Bertrand M. Janne d’Othée Vittorio P. Antonaci Elias N. Brountzos Daniel B. Brown Louis G. Martin Alan H. Matsumoto Steven G. Meranze | 2009 | Journal of Vascular and Interventional Radiology2009，，7： | 1 |
| 14 | Inhibition of the human two-pore domain potassium channel TREK-1 by flu-oxetine and its metabolite norfluoxetine 显示文摘 | Louise E Justin R Kishani M | 2005 | Briti J of Pharmacology2005，144，： | 1 |
| 15 | A new high-capacity cosmid vector and its use显示文摘 | Meyerowitz E M Gregory M G Louise S P | 1980 | Gene1980，11，： | 1 |
| 16 | Recent Advances in Synchronous-Clock One-Way-Travel-Time Acoustic Navigation显示文摘 | Ryan M E Louis LW | | 0，，： | 1 |
| 17 | Analysis of hyperspectral data for estimation of temperate forest canopy Nitrogen concentration:comparison between an airbome (AVIRIS) and a spaceborne (Hyperion) sensor显示文摘 | Smith Louise Marie Martin E Mary Ploourde Lucie | 2003 | IEEE Transactions on Geoscience and Remote sensing2003，41，6： | 1 |
| 18 | Challenges to effective cancer control in China, India, and Russia显示文摘 | Paul E Goss Kathrin Strasser-Weippl Brittany L Lee-Bychkovsky Lei Fan Junjie Li Yanin Chavarri-Guerra Pedro E R Liedke C S Pramesh Tanja Badovinac-Crnjevic Yuri Sheikine Zhu Chen You-lin Qiao Zhiming Shao Yi-Long Wu Daiming Fan Louis W C Chow Jun Wang Qio | 2014 | Lancet Oncology2014，，5： | 1 |
| 19 | Agro-forestry practice and policy in the United States of America显示文摘 | H E Gene Garrett Louise Buck | 1997 | Forest Ecology and Management1997，91，1： | 1 |
| 20 | Microbial response to simulated tillage in cultivated and uncultivated soils显示文摘 | Calderon J F Louise E J Scow K M | 2000 | Soil Biology and Biochemistry2000，32，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员