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| 1 | Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats显示文摘Objective:To assess the effect of quercetin(flavonoid) against lindane induced alterations in lipid profile of wistar rats.Methods:Rats were administered orally with lindane(100 mg/kg body weight) and quercetin(10 mg/kg body weight) for 30 days.After the end of treatment period lipid profile was estimated in serum and tissue.Results:Elevated levels of serum cholesterol, triglycerides,low density lipoprotein(LDL),very Low Density Lipoprotein(VLDL) and tissue triglycerides,cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.Conclusions:Our study suggests that quercetin has hypolipidemic effect and offers protection against lindane induced toxicity in liver by restoring the altered levels of lipids.The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane. | Viswanadha Vijaya Padma Gurusamy Lalitha Nichokon Puthanveedu Shirony Rathinasamy Baskaran | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 9 |
| 2 | Current protective strategies in liver surgery显示文摘During liver resection surgery for cancer or liver transplantation,the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow),which results in liver injury [ischemiareperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia,ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response),ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion),pharmacological agents to decrease IR injury,genetic modulation of IR injury,and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC,ischaemic postconditioning,various pharma-cological agents,gene therapy,and machine perfusion decrease IR injury,none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning,gene therapy,and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection. | Kurinchi S Gurusamy Hector D Gonzalez Brian R Davidson | 2010 | World Journal of Gastroenterology2010，16，48： | 7 |
| 3 | Plasticized Polymer Electrolyte Membranes Based on PEO/PVdF-HFP for Use as an Effective Electrolyte in Lithium-ion Batteries显示文摘Plasticized polymer electrolytes were prepared using poly(ethylene oxide)(PEO)/poly(vinylidene fluoridehexafluoro propylene)(PVd F-HFP) with lithium perchlorate(Li Cl O4) and different plasticizers. XRD and FTIR spectroscopic techniques were used to characterize the structure and the complexation of plasticizer with the host polymer matrix. The role of interaction between polymer hosts and plasticizer on conductivity is discussed using the results of alternating current(a.c.) impedance studies. TG-DTA and SEM were used for thermal and physical characterizations. Maximum ionic conductivity(3.26 × 10^(-4) S·cm^(-1)) has been observed for ethylene carbonate(EC)-based polymer electrolytes. Electrochemical performance of the plasticized polymer electrolyte is evaluated in LiFePO_4/plasticized polymer electrolytes(PPEs)/Li coin cell. Good performance with low capacity fading on charge discharge cycling is demonstrated. | pradeepa prabakaran ramesh prabhu manimuthu sowmya gurusamy edwinraj sebasthiyan | 2017 | Chinese Journal of Polymer Science2017，35，3： | 7 |
| 4 | Elastography for the diagnosis of severity of fibrosis in chronic liver disease: A meta-analysis of diagnostic accuracy显示文摘 | E.A. Tsochatzis K.S. Gurusamy S. Ntaoula E. Cholongitas B.R. Davidson A.K. Burroughs | 2010 | Journal of Hepatology2010，，4： | 5 |
| 5 | Physical chemical and biological characterization of a new bacteriocin produced by Bacillus cereus NS02显示文摘Objective:To screen the bacteriocinogenic isolate from buffalo milk and to characterize it on physical,chemical and biological aspects for the application in biopreservation.Methods:Bacillus cereus(B.cereus)was isolated and assessed for its baceteriocinogenic activity.Bacteriocin was produced and purified by ammonium sulphate precipitation,dialysis and gel filtration chromatography.Purified bacteriocin was used to clieck its antimicrobial activity against food borne bacteria.Effect and stability of bacteripcin was determined with the respect to temperature,pH,enzymes,organic solvents and chemicals.Bacteriocin was also subjected to SDS PAGE analysis to determine its molecular weight.In addition,functional groups exist in the bacteriocin was determined by FTIR analysis.Results:B.cereus was identified by 16S rRNA sequence analysis.Bacteriocin showed increased activity against all the bacteria used and its activity unit was found to be 51,200 AU/mL.It was stable to high temperature(100℃)and wide range of pH(3-10),sensitive to proteolytic enzymes and resistant to nonprotcolytic enzymes.It was low molecular weight(3.5-6 kDa)protein and FTIR study revealed the presence of amide group and NH stretching,Conclusions:Bacteriocin produced in this study possesses the highest antimicrobial activity against both gram positive and gram negative bacteria thereby it has immense application as biopreservative agent.FTIR proved its peptide nature. | Senbagam D Gurusamy R Senthilkumar B | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，12： | 4 |
| 6 | Use of cellulose-based wastes for adsorption of dyes from aqueous solutions显示文摘 | Gurusamy Annadurai Ruey-Shin Juang Duu-Jong Lee | 2002 | Journal of Hazardous Materials2002，，3： | 2 |
| 7 | Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar carcinoma: A meta-analysis显示文摘 | Giacomo Germani Maria Pleguezuelo Kurinchi Gurusamy Tim Meyer Graziella Isgrò Andrew Kenneth Burroughs | 2010 | Journal of Hepatology2010，，3： | 2 |
| 8 | Meta‐analysis of randomized clinical trials on safety and efficacy of biliary drainage before surgery for obstructive jaundice显示文摘 | Y. Fang K. S. Gurusamy Q. Wang B. R. Davidson H. Lin X. Xie C. Wang | 2013 | Br J Surg2013，，12： | 2 |
| 9 | Long term properties under marine exposure of steel fiber reinforced concrete containing PFA 显示文摘 | MANGAT D S GURUSAMY K | 1988 | Materials and Structures1988，21，125： | 1 |
| 10 | Resveratrol in cardiovascular health and disease 显示文摘 | Petrovski G Gurusamy N Das DK | 2011 | Ann N Y Acad Sci2011，1215，1： | 1 |
| 11 | Genome-wide transcriptomic analysis of cotton under drought stress reveal significant down-regulation of genes and pathways involved in fibre elongation and up-regulation of defense responsive genes显示文摘 | Kethireddy Venkata Padmalatha Gurusamy Dhandapani Mogilicherla Kanakachari Saravanan Kumar Abhishek Dass Deepak Prabhakar Patil Vijayalakshmi Rajamani Krishan Kumar Ranjana Pathak Bhupendra Rawat Sadhu Leelavathi Palakolanu Sudhakar Reddy Neha Jain Kasu N | 2012 | Plant Molecular Biology2012，，3： | 1 |
| 12 | Trace element concentration in primary liver cancers-- a systematic review显示文摘 | Gurusamy K | 2007 | Biol Trace Elem Res2007，118，： | 1 |
| 13 | Targeted delivery of low moleculardrugs using chitosan and its derivatives显示文摘 | Jae H P Gurusamy S Kwangmeyung K | 2010 | Advanced Drug Delivery Revie-ws2010，62，： | 1 |
| 14 | Chloride diffusion in steelfiber reinforced marine concrete显示文摘 | MANGAT D S GURUSAMY K | 1988 | Cement and Concrete Research1988，18，3： | 1 |
| 15 | Differentiated sur- vivability with improved fairness in IP/GMPLS-over WDM optical networks 显示文摘 | Ratnam K Gurusamy M Zhou L Y | 2009 | Computer Networks2009，53，5： | 1 |
| 16 | Routine abdominal drainage versus no abdominal drainage for uncomplicated laparoscopic cholecystectomy显示文摘 | Gurusamy KS Koti R Davidson BR | 2013 | Cochrane Database Syst Rev2013，9，00： | 1 |
| 17 | Resveratrol in car- diovascular health and disease 显示文摘 | Petrovski G Gurusamy N Das DK | 2011 | Ann N Y Acad Sci2011，1215，： | 1 |
| 18 | Use of cellulose-based wastes for adsorption of dyes from aqueous solution 显示文摘 | Gurusamy Annadurai Ruey-Shin Juang Duu-Jong Lee | 2002 | Journal of Hazardous Materials2002，92，3： | 1 |
| 19 | Routime abdominal drainage for uncomplicated liver resection显示文摘 | Gurusamy KS Samraj K Davidson BR | 2007 | Coehrane Database Syst Rev2007，18，3： | 1 |
| 20 | Routine abdominal drainage for uncomplicated open cholecystectomy 显示文摘 | Gurusamy KS Samraj K | 2007 | Cochrane Database Syst Rev2007，18，00： | 1 |
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