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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Effect of double platinum agents, combination of miriplatintransarterial oily chemoembolization and cisplatinhepatic arterial infusion chemotherapy, in patients with hepatocellular carcinoma: Report of two cases显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers and the third highest cause of cancerassociated mortality worldwide. The treatment of HCC is complicated by its variable biological behavior and the frequent coexistence of chronic liver disease, particularly cirrhosis. To date, multiple treatment modalities have been developed according to the stage of the tumor and the hepatic functional reserve, including transarterial treatments such as transarterial chemoembolization, transarterial oily chemoembolization(TOCE), and hepatic arterial infusion chemotherapy(HAIC). We conducted a phase I and II study of the combination therapy with double platinum agents, miriplatin and cisplatin, and confirmed its safety and efficacy. Here, we describe two cases of unresectable HCC who were successfully treated by miriplatin-TOCE/cisplatin-HAIC combination therapy, resulting in complete responses with no significant adverse events. This report will provide that the combination therapy can be the therapeutic option for HCC patients in the advanced stage. | Kohei Ogawa Kenya Kamimura Yukari Watanabe Yosuke Motai Daisuke Kumaki Ryoya Seki Akira Sakamaki Satoshi Abe Hirokazu Kawai Takeshi Suda Satoshi Yamagiwa Shuji Terai | 2017 | World Journal of Clinical Cases2017，5，6： | 4 |
| 3 | Liver-targeted hydrodynamic gene therapy: Recent advances in the technique显示文摘One of the major research focuses in the field of gene therapy is the development of clinically applicable, safe, and effective gene-delivery methods. Since the first case of human gene therapy was performed in 1990, a number of gene-delivery methods have been developed, evaluated for efficacy and safety, and modified for human application. To date, viral-vectormediated deliveries have shown effective therapeutic results. However, the risk of lethal immune response and carcinogenesis have been reported, and it is still controversial to be applied as a standard therapeutic option. On the other hand, delivery methods for nonviral vector systems have been developed, extensively studied, and utilized in in vivo gene-transfer studies. Compared to viral-vector mediated gene transfer, nonviral systems have less risk of biological reactions. However, the lower gene-transfer efficiency was a critical hurdle for applying them to human gene therapy. Among a number of nonviral vector systems, our studies focus on hydrodynamic gene delivery to utilize physical force to deliver naked DNA into the cells in the living animals. This method achieves a high gene-transfer level by DNA solution injections into the tail vein of rodents, especially in the liver. With the development of genome editing methods, in vivo gene-transfer therapy using this method is currently the focus in this research field. This review explains the method principle, efficiency, safety, and procedural modifications to achieve a high level of reproducibility in large-animal models. | Takeshi Yokoo Kenya Kamimura Hiroyuki Abe Yuji Kobayashi Tsutomu Kanefuji Kohei Ogawa Ryo Goto Masafumi Oda Takeshi Suda Shuji Terai | 2016 | World Journal of Gastroenterology2016，22，40： | 3 |
| 4 | Usefulness of Kyoto criteria as expanded selection criteria for liver transplantation for hepatocellular carcinoma显示文摘 | Toshimi Kaido Kohei Ogawa Akira Mori Yasuhiro Fujimoto Takashi Ito Koji Tomiyama Yasutsugu Takada Shinji Uemoto | 2013 | Surgery2013，，： | 3 |
| 5 | Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis显示文摘 | Shujiro Yazumi Takanobu Yoshimoto Hiroshi Hisatsune Kazunori Hasegawa Masaya Kida Shinsuke Tada Yoshito Uenoyama Junichi Yamauchi Seiji Shio Mureo Kasahara Kohei Ogawa Hiroto Egawa Koichi Tanaka Tsutomu Chiba | 2006 | Journal of Hepato-Biliary-Pancreatic Surgery2006，，6： | 2 |
| 6 | Diagnosis and management of fibromuscular dysplasia and segmental arterial mediolysis in gastroenterology field: A mini-review显示文摘The vascular diseases including aneurysm, occlusion, and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients. With the development and improvement of imaging modalities, diagnostic frequency of these vascular diseases in abdominal lesions is increasing even with the small changes in the vasculatures. Among various vascular diseases, fibromuscular dysplasia(FMD) and segmental arterial mediolysis(SAM) are noninflammatory, nonatherosclerotic arterial diseases which need to be diagnosed urgently because these diseases could affect various organs and be lethal if the appropriate management is not provided. However, because FMD and SAM are rare, the cause, prevalence, clinical characteristics including the symptoms, findings in the imaging studies, pathological findings, management, and prognoses have not been systematically summarized. Therefore, there have been neither standard diagnostic criteria nor therapeutic methodologies established, to date. To systematically summarize the information and to compare these disease entities, we have summarized the characteristics of FMD and SAM in the gastroenterological regions by reviewing the cases reported thus far. The information summarized will be helpful for physicians treating these patients in an emergency care unit and for the differential diagnosis of other diseases showing severe abdominal pain. | Masayoshi Ko Kenya Kamimura Kohei Ogawa Kentaro Tominaga Akira Sakamaki Hiroteru Kamimura Satoshi Abe Kenichi Mizuno Shuji Terai | 2018 | World Journal of Gastroenterology2018，24，32： | 2 |
| 7 | Toward Seamless Indoor-Outdoor Applications:Developing Stakeholder-Oriented Location-Based Services显示文摘Location-Based Services (LBS),an emerging new business based on smartphone and mobile networks,are becoming more and more popular.Most of these LBSs,however,only offer non-seamless indoor/outdoor applications and simple applications without giving stakeholders the chance to play an active role.Our specific aim is to solve these issues.This paper presents concepts to solve these issues by expanding the Open Location Services Interface Standard (OpenLS) to allow seamless indoor/outdoor positioning and to extend the content of the services to include information recommended by stakeholders. | Kohei OGAWA Edward VERBREE Sisi ZLATANOVA Naohiko KOHTAKE Yoshiaki OHKAMI | 2011 | Geo-Spatial Information Science2011，14，2： | 2 |
| 8 | How transplant surgeons can overcome the inevitable insufficiency of allograft size during adult living‐donor liver transplantation: strategy for donor safety with a smaller‐size graft and excellent recipient results显示文摘 | Tomohide Hori Yasuhiro Ogura Kohei Ogawa Toshimi Kaido Hajime Segawa Hideaki Okajima Takayuki Kogure Shinji Uemoto | 2012 | Clin Transplant2012，，3： | 2 |
| 9 | Vascular reconstruction and complications in living donor liver transplantation in infants weighing less than 6 kilograms: The Kyoto experience显示文摘 | Yasumasa Shirouzu Mureo Kasahara Daisuke Morioka Seisuke Sakamoto Kaoru Taira Kenji Uryuhara Kohei Ogawa Yasutsugu Takada Hiroto Egawa Koichi Tanaka | 2006 | Liver Transpl2006，，8： | 1 |
| 10 | Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation显示文摘 | Takashi Ito Yasutsugu Takada Mikiko Ueda Hironori Haga Yoji Maetani Fumitaka Oike Kohei Ogawa Seisuke Sakamoto Yasuhiro Ogura Hiroto Egawa Koichi Tanaka Shinji Uemoto | 2007 | Liver Transpl2007，，12： | 1 |
| 11 | How transplant surgeons can overcome the inevitable insufficiency of allograft size during adult living‐donor liver transplantation: strategy for donor safety with a smaller‐size graft and excellent recipient results显示文摘 | Tomohide Hori Yasuhiro Ogura Kohei Ogawa Toshimi Kaido Hajime Segawa Hideaki Okajima Takayuki Kogure Shinji Uemoto | 2012 | Clin Transplant2012，，3： | 1 |
| 12 | Comparison of Lafutidine and Rabeprazole in 7‐day Second‐line Amoxicillin‐ and Metronidazole‐Containing Triple Therapy for Helicobacter pylori: A Pilot Study显示文摘 | Takahiko Kudo Haruka Fujinami Takayuki Ando Jun Nishikawa Kohei Ogawa Ayumu Hosokawa Tadahiro Orihara Jun Murakami Terumi Takahara Toshiro Sugiyama | 2012 | Helicobacter2012，，4： | 1 |
| 13 | Immunohistochemical expression of geminin in colorectal cancer: Implicationof prognostic significance显示文摘 | Keisuke Nishihara Kohei Shomori Takayuki Tamura Shinji Fujioka Toshihide Ogawa Hisao Ito | 2009 | Oncology Reports2009，，5： | 1 |
| 14 | Thrombotic microangiopathy-like disorder after living-donor liver transplantation:A single-center experience in Japan显示文摘AIM:To investigate thrombotic microangiopathy (TMA)in liver transplantion,because TMA is an infrequent but life-threatening complication in the transplantation field. METHODS:A total of 206 patients who underwent living-donor liver transplantation (LDLT) were evaluated,and the TMA-like disorder (TMALD) occurred in seven recipients. RESULTS:These TMALD recipients showed poor outcomes in comparison with other 199 recipients. Although two TMALD recipients successfully recovered,the other five recipients finally died despite intensive treatments including repeated plasma exchange (PE) and re-transplantation. Histopathological analysis of liver biopsies after LDLT revealed obvious differences according to the outcomes. Qualitative analysis of antibodies against a disintegrin-like domain and metalloproteinase with thrombospondin type 1 motifs (ADAMTS-13) were negative in all patients. The fragmentation of red cells,the microhemorrhagic macules and the platelet counts were early markers for the suspicion of TMALD after LDLT. Although the absolute values of von Willebrand factor (vWF) and ADAMTS-13 did not necessarily reflect TMALD,the vWF/ADAMTS-13 ratio had a clear diagnostic value in all cases. The establishment of adequate treatments for TMALD,such as PE for ADAMTS-13 replenishment or treatments against inhibitory antibodies,must be decided according to each case. CONCLUSION:The optimal induction of adequate therapies based on early recognition of TMALD by the reliable markers may confer a large advantage for TMALD after LDLT. | Tomohide Hori Toshimi Kaido Fumitaka Oike Yasuhiro Ogura Kohei Ogawa Yukihide Yonekawa Koichiro Hata Yoshiya Kawaguchi Mikiko Ueda Akira Mori Yasutsugu Takada Hiroto Egawa Atsushi Yoshizawa Shinji Uemoto Hajime Segawa Kimiko Yurugi Takuma Kato Kanako Saito Linan Wan Mie Torii Feng Chen Ann-Marie T Baine Lindsay B Gardner | 2011 | World Journal of Gastroenterology2011，17，14： | 1 |
| 15 | Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis显示文摘 | Shujiro Yazumi Takanobu Yoshimoto Hiroshi Hisatsune Kazunori Hasegawa Masaya Kida Shinsuke Tada Yoshito Uenoyama Junichi Yamauchi Seiji Shio Mureo Kasahara Kohei Ogawa Hiroto Egawa Koichi Tanaka Tsutomu Chiba | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，6： | 1 |
| 16 | Does a positive lymphocyte cross-match contraindicate living-donor liver transplantation?显示文摘 | Tomohide Hori Shinji Uemoto Yasutsugu Takada Fumitaka Oike Yasuhiro Ogura Kohei Ogawa Aya Miyagawa-Hayashino Kimiko Yurugi Justin H. Nguyen Yukinobu Hori Feng Chen Hiroto Egawa | 2010 | Surgery2010，，6： | 1 |
| 17 | Living-donor liver transplantation with monosegments显示文摘 | Mureo Kasahara Satoshi Kaihara Fumitaka Oike Takashi Ito Yasuhiro Fujimoto Yasuhiro Ogura Kohei Ogawa Mikiko Ueda Mohamed Rela Nigel D Heaton Koichi Tanaka | 2003 | Transplantation2003，，4： | 1 |
| 18 | Perioperative changes in nutritional parameters and impact of graft size in patients undergoing adult living donor liver transplantation显示文摘 | Ahmed Hammad Toshimi Kaido Kohei Ogawa Yasuhiro Fujimoto Koji Tomiyama Akira Mori Tadahiro Uemura Shinji Uemoto | 2014 | Liver Transpl2014，，12： | 1 |
| 19 | How far can we lower graft-to-recipient weight ratio (GRWR) for LDLT under modulation of portal venous pressure?显示文摘 | Tadahiro Uemura Seidai Wada Toshimi Kaido Akira Mori Yasuhiro Ogura Shintaro Yagi Yasuhiro Fujimoto Kohei Ogawa Koichiro Hata Atsushi Yoshizawa Hideaki Okajima Shinji Uemoto | 2016 | Surgery2016，，： | 1 |
| 20 | Standard hepatic vein reconstruction with patch plasty using the native portal vein in adult living donor liver transplantation显示文摘 | Akira Mori Toshimi Kaido Yasuhiro Ogura Kohei Ogawa Koichiro Hata Shintaro Yagi Atsushi Yoshizawa Hiroyoshi Isoda Toshiya Shibata Shinji Uemoto | 2012 | Liver Transpl2012，，5： | 1 |
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