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| 1 | Wheat powdery mildew resistance gene Pm64 derived from wild emmer (Triticum turgidum var.dicoccoides) is tightly linked in repulsion with stripe rust resistance gene Yr5显示文摘Stripe rust and powdery mildew are both devastating diseases for durum and common wheat.Pyramiding of genes conferring resistance to one or more diseases in a single cultivar is an important breeding approach to provide broader spectra of resistances in wheat improvement. A new powdery mildew resistance gene originating from wild emmer(Triticum turgidum var.dicoccoides) backcrossed into common wheat(T. aestivum) line WE35 was identified. It conferred an intermediate level of resistance to Blumeria graminis f. sp. tritici isolate E09 at the seedling stage and a high level of resistance at the adult plant stage. Genetic analysis showed that the powdery mildew resistance in WE35 was controlled by a dominant gene designated Pm64. Bulked segregant analysis(BSA) and molecular mapping indicated that Pm64 was located in chromosome bin 2 BL4-0.50–0.89. Polymorphic markers were developed from the corresponding genomic regions of Chinese Spring wheat and wild emmer accession Zavitan to delimit Pm64 to a 0.55 cM genetic interval between markers WGGBH1364 and WGGBH612, corresponding to a 15 Mb genomic region on Chinese Spring and Zavitan 2 BL, respectively. The genetic linkage map of Pm64 is critical for fine mapping and cloning. Pm64 was completely linked in repulsion with stripe rust resistance gene Yr5. Analysis of a larger segregating population might identify a recombinant line with both genes as a valuable resource in breeding for resistance to powdery mildew and stripe rust. | Deyun Zhang Keyu Zhu Lingli Dong Yong Liang Genqiao Li Tilin Fang Guanghao Guo Qiuhong Wu Jingzhong Xie Yongxing Chen Ping Lu Miaomiao Li Huaizhi Zhang Zhenzhong Wang Yan Zhang Qixin Sun Zhiyong Liu | 2019 | The Crop Journal2019，7，6： | 8 |
| 2 | Formation condition of deep gas reservoirs in tight sandstones in Kuqa Foreland Basin显示文摘Due to the high expense of deep oil and gas exploration,prediction of gas-bearing properties before drilling is crucial for deep gas reservoir of tight sandstone.Deep tight sandstone gas fields in Kuqa Foreland Basin are characterized by high abundance,high gas saturation,high pressure,high and stable yield,which belong to high-efficiency tight gas reservoir.Based on theoretical analysis of controlling factors and mechanisms of gas-bearing properties for tight sandstone gas reservoir,and taking tight sandstone gas fields with high effectiveness such as Dibei,Keshen and Dibei gas fields in Kuqa Foreland Basin as examples,formation condition and mechanism of high-efficiency tight sandstone gas reservoir in Kuqa area are studied through a comparative analysis of typical tight sandstone gas reservoir in Sichuan Basin and Ordos Basin.The results show that the formation condition of deep gas reservoir of tight sandstone in Kuqa foreland basin includes four factors:i.e.,overpressure gas charging,fracture development,“early-oil and late-gas”accumulation process and favorable preservation condition.The overpressure gas charging and fracture development are the most important factors for formation of high-efficiency tight gas reservoirs in Kuqa Foreland Basin.High-quality source rocks,high sourcereservoir pressure difference,and overpressure filling induced thereby are preconditions for formation of tight sandstone with high gas saturation.The fracture development controls gas migration,accumulation,and high yield of tight sandstone gas reservoir.The reservoir wettability changed by the early oil charging is beneficial to late natural gas charging,and the preservation condition of high-quality gypsum cap rocks is the key factor for gas reservoirs to maintain overpressure and high gas saturation.Matching of above four favorable factors leads to the tight sandstone gas reservoir with high abundance,high gas saturation and high gas production in Kuqa Foreland Basin,which is very different from other basins.Under the condition of little difference in physical property of tight sandstone reservoir,excessive source-reservoir pressure difference,facture development,preservation condition and current formation overpressure are the most significant factors to be considered in exploration and evaluation of deep tight sandstone gas. | Xuesong Lu Mengjun Zhao Keyu Liu Qingong Zhuo Junjia Fan Zhichao Yu Yanjie Gong | 2018 | Petroleum Research2018，3，4： | 4 |
| 3 | Detection of Porcine Epidemic Diarrhea Virus in Guangxi Province from 2011 to 2014 and Sequence Analysis of Its M Gene显示文摘Detection of pigs epidemic diarrhea virus( PEDV) was conducted on 331 piglets diarrhea fecal samples collected in Nanning,Yulin and other 12 areas of Guangxi Province from January of 2011 to April of 2014 by the method of reverse transcription-polymerase chain reaction( RT-PCR). The results showed that the positive samples of PEDV were 210 and the positive rate was 63. 44%. The clone and sequencing of M gene was carried out on 25 positive samples. PEDV reference strains were selected from Gene Bank to conduct the sequence homology alignment analysis and the phylogenetic tree of M gene. The M gene homology and amino acid sequence identity between 25 isolated strains and 51 reference strains were 96. 0%- 99. 6% and 94. 3%- 99. 6%,respectively. The genetic variation analysis of M gene showed that the genetic relationship of PEDV prevalent strains in Guangxi Province from 2013 to 2014 was close to that of the prevalent strains in Beijing,Anhui,Wuhan,Hebei and Guangdong from 2010 to 2013,and which were far from that of the Chinese early isolates CH / S( Gen Bank number: JN547228),vaccine strain CV777( Gen Bank number: AF353511) and Attenuated DR13( Gen Bank number: JQ023162). Indicating that the PEDV strains prevalent in Guangxi in recent years showed significant variation with the early isolates. | Lu Bingxia Qin Yibin He Ying Li Yingying Liang Jiaxing Li Keyu Li Bin Su Qianlian Zhou Yingning Jiang Dongfu Lu Jingzhuan Bi Bingfen Liang Baozhong Duan Qunpeng Zhao Wu | 2016 | Animal Husbandry and Feed Science2016，8，1： | 3 |
| 4 | Human health risk assessment of groundwater nitrate at a two geomorphic units transition zone in northern China显示文摘To assess groundwater nitrate contamination and its human health risks,489 unconfined groundwater samples were collected and analyzed from Zhangjiakou,northern China.The spatial distribution of principle hydrogeochemical results showed that the average concentrations of ions in descend order was HCO3-,SO42-,Na+,Ca2+,Cl-,NO3-,Mg2+and K+,among which the NO3-concentrations were between 0.25 and 536.73 mg/L with an average of 29.72 mg/L.In total,167 out of 489 samples(34%)exceeded the recommended concentration of 20 mg/L in Quality Standard for Groundwater of China.The high NO3-concentration groundwater mainly located in the northern part and near the boundary of the two geomorphic units.As revealed by statistical analysis,the groundwater chemistry was more significantly affected by anthropogenic sources than by the geogenic sources.Moreover,human health risks of groundwater nitrate through oral and dermal exposure pathways were assessed by model,the results showed that about 60%,50%,32%and 26%of the area exceeded the acceptable level(total health index>1)for infants,children,adult males and females,respectively.The health risks for different groups of people varied significantly,ranked:infants>children>adult males>adult females,suggesting that younger people are more susceptible to nitrate contamination,while females are more resistant to nitrate contamination than males.To ensure the drinking water safety in Zhangjiakou and its downstream areas,proper management and treatment of groundwater will be necessary to avoid the health risks associated with nitrate contamination. | Huiliang Wang Keyu Lu Chenyang Shen Xiaoguang Song Bin Hu Gang Liu | 2021 | Journal of Environmental Sciences2021，33，12： | 2 |
| 5 | Structure and digestibility of endosperm water-soluble α-glucans from different sugary maize mutants显示文摘 | Ming Miao Rong Li Bo Jiang Steve W. Cui Keyu Lu Tao Zhang | 2014 | Food Chemistry2014，，： | 1 |
| 6 | Effect of laser remelting on corrosion behavior of plasma-sprayed Ni-coated WC coatings显示文摘 | Xie Guozhi Zhang Jingxian Lu Yijun Wang Keyu Mo Xiangyin Lin Pinghua | 2007 | Materials Science & Engineering A2007，，： | 1 |
| 7 | Highly ordered iron oxide nanotube arrays as electrodes for electrochemical energy storage显示文摘 | Keyu Xie Jie Li Yanqing Lai Wei Lu Zhi’an Zhang Yexiang Liu Limin Zhou Haitao Huang | 2011 | Electrochemistry Communications2011，，6： | 1 |
| 8 | Innovative fluorescence spectroscopic techniques for rapidly characterising oil inclusions显示文摘 | Liu Keyu George SC Lu Xuesong Gong Se Tian Hua Gui Lili | 2014 | Organic Geochemistry2014，72，： | 1 |
| 9 | Rapid subsurface damage detection of SiC using inductivity coupled plasma显示文摘This paper proposes a method for the rapid detection of subsurface damage(SSD)of Si C using atmospheric inductivity coupled plasma.As a plasma etching method operated at ambient pressure with no bias voltage,this method does not introduce any new SSD to the substrate.Plasma diagnosis and simulation are used to optimize the detection operation.Assisted by an Si C cover,a taper can be etched on the substrate with a high material removal rate.Confocal laser scanning microscopy and scanning electron microscope are used to analyze the etching results,and scanning transmission electron microscope(STEM)is adopted to confirm the accuracy of this method.The STEM result also indicates that etching does not introduce any SSD,and the thoroughly etched surface is a perfectly single crystal.A rapid SSD screening ability is also demonstrated,showing that this method is a promising approach for the rapid detection of SSD. | Yi Zhang Linfeng Zhang Keyu Chen Dianzi Liu Dong Lu Hui Deng | 2021 | International Journal of Extreme Manufacturing2021，3，3： | 1 |
| 10 | Specific Index System of Ecological Balanced Fertilization for Maize显示文摘This paper studied the index system of ecological balanced fertilization for maize by data mining method based on data of'3414 fertilizer field trials'of maize by published papers from national soil testing and recommendation since 2005.The results and conclusions were as follows.①Soil nutrient content could not be used as indicator of fertilizer application of maize.②The conceptual model of N conversion rate of maize for plot was Y N≈a+b×optimum production-c×optimum fertilizer amount of N-d×optimum phosphorus application amount-e×optimum potassium application amount-f×temperature in growth season-g×rainfall in growth season.The conceptual model of P conversion rate of maize for plot was Y P≈a+b×optimum phosphorus application amount-c×optimum nitrogen application amount-d×optimum potassium application amount.The conceptual model of K conversion rate of maize for plot was Y K≈a+b×optimum yield-c×optimum nitrogen application amount-d×optimum phosphorus application amount-e×optimum potassium application amount-f×temperature in growth season-g×rainfall in growth season.③The conceptual model of the optimum fertilizer amount of N of maize for plot was Y N≈a+b×optimum phosphorus application amount+c×optimum potassium application amount+d×temperature in growing season+e×rainfall in growing season,and the conceptual model of the optimum fertilizer amount of P was Y P≈a+b×optimum nitrogen application amount,and the conceptual model of the optimum fertilizer amount of K was Y K≈a+b×optimum nitrogen application amount+c×temperature in growth season+d×rainfall in growth season-e×optimum yield.④The conceptual model of relative abundance-deficiency value of soil N of maize for plot was that Y N≈a,and the conceptual model of relative abundance-deficiency value of soil P was Y P≈a,and the conceptual model of relative abundance-deficiency value of soil K was Y K≈a+b×optimum nitrogen application amount+c×optimum phosphorus application amount. | Keyu LIN Hongyan ZHENG Zhiping HUANG Jian DING Changhong MI Shutian LIU Xianda HOU Shuojin WANG Ling LU Yanlin HOU | 2020 | Meteorological and Environmental Research2020，11，5： | 0 |
| 11 | Unveiling mitophagy-mediated molecular heterogeneity and development of a risk signature model for colorectal cancer by integrated scRNA-seq and bulk RNA-seq analysis显示文摘Background:Accumulating researchers have recognized mitophagy as a key player in tumors,but few studies have investigated its role in the tumor microenvironment(TME).Advances in the technology of single-cell RNA sequencing(scRNA-seq)have allowed unveiling the concealed features of the TME at cellular resolution.This study aimed to elucidate the role of mitophagy within the TME of colorectal cancer(CRC)and to establish a mitophagy-mediated risk model.Methods:We assessed mitophagy-related pathway activities at both single-cell and tissue levels.Subsequently,an unsupervised clustering algorithm was employed to identify mitophagy-mediated subtypes.Furthermore,we developed a mitophagy-mediated risk signature(MMRS)using least absolute shrinkage and selection operator(LASSO)Cox analysis and constructed a MMRS model incorporating the risk score and clinical variables.Subsequently,we used quantitative reverse transcription polymerase chain reaction analysis to verify the expression of the screened genes.Results:We retrieved and annotated a total of 14,719 cells from eight samples in the scRNA-seq GSE132465 data set.The activities of mitophagy-related pathways were uniformly upregulated in cancer cells.Integrating with bulk RNA-seq data,we identified two mitophagy-mediated clusters(C1 and C2)with distinct characteristics and prognoses.C2 was identified as a mitophagy-high cluster.Then,we developed a five-gene MMRS via LASSO Cox analysis in The Cancer Genome Atlas(TCGA)cohort.We utilized the GSE39582 cohort to validate the efficacy of our model.The expression of CX3CL1 and INHBB was upregulated in CRC tissues.Conclusions:The present study identified two mitophagy-mediated CRC subtypes with distinct features.Our MMRS may provide potential therapeutic strategies for CRC.The findings of our work offer novel insights into the involvement of mitophagy in CRC. | Han Gao Qi Zou Linyun Ma Keyu Cai Yi Sun Li Lu Donglin Ren Bang Hu | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 12 | Extended pancreatoduodenectomy with portal vein and inferior vena cava resection and reconstruction combined with sorafenib for hepatoid carcinoma of the pancreas:a strategy of superextended surgery combined with targeted therapy显示文摘Hepatoid carcinoma of the pancreas(HCP)is an extremely rare pancreatic cancer resembling hepatocellular carcinoma,a type of liver cancer(1).Most reports have shown that it has an aggressive behavior and is associated with early metastasis.There is no standardized treatment for HCP due to its rarity,and the limited number of cases reported in the literature(2,3).However,treatment options for this type of rare cancer include surgery,chemotherapy,and radiation therapy,depending on the stage of the cancer.Nevertheless,the prognosis of HCP is poor. | Deling Wei Banghao Xu Hai Zhu Jilong Wang Zongrui Jin Weitao Chen Jianyong Zhang Zhujing Lan Keyu Huang Ling Zhang Tingting Lu Ni Fang Ya Guo Tao Peng Minhao Peng Zhang Wen | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
| 13 | Isolation of Swine Corynebacteria and Analysis of 16S rDNA Gene显示文摘A strain of gram-positive bacillus was isolated from suppurative lung organs of nursery pigs in a pig farm,which was further characterized by morphological observation,cultivation test,biochemical test,drug sensitivity test,pathogenicity test and 16 S rDNA gene cloning and sequence analysis. The results showed that the isolate grew well in rabbit blood agar plate and horse serum tryptone soybean agar( TSA) plate under aerobic condition,which could lead to mortality of mice and were susceptible to cephalosporin antibiotics and fluoroquinolone antibiotics. Phylogenetic analysis showed that the isolate had close genetic evolutionary relationships with Corynebacterium bacteria,and the sequence of 16 S rRNA gene shared the homology of 91. 7%-98. 3% with the representative strain of corynebacteria,indicating the isolated strain was corynebacterium. | Qin Yibin He Pingping Lu Bingxia He Ying Li Bin Liang Jiaxing Duan Qunpeng Chen Zhongwei Bi Bingfen Zhou Yingning Su Qianlian Jiang Dongfu Li Keyu Lu Jingzhuan Zhao Wu | 2016 | Animal Husbandry and Feed Science2016，8，6： | 0 |
| 14 | External rectal prolapse:abdominal or perineal repair for men?A retrospective cohort study显示文摘Background:External rectal prolapse is a relatively rare disease,in which male patients account for a minority.The selection of abdominal repair or perineal repair for male patients has rarely been investigated.Methods:Fifty-one male patients receiving abdominal repair(laparoscopic ventral rectopexy)or perineal repair(Delorme or Altemeier procedures)at the Sixth Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between March 2013 and September 2019 were retrospectively analysed.We compared the recurrence,complication rate,post-operative defecation disorder,length of stay,and quality of life between the abdominal and perineal groups.Results:Of the 51 patients,45 had a complete follow-up,with a median of 48.5 months(range,22.8–101.8 months).A total of 35 patients were under age 40 years.The complication rate associated with abdominal repair was less than that associated with perineal repair(0%vs 20.7%,P=0.031)and the recurrence rate was also lower(9.5%vs 41.7%,P=0.018).Multivariate analysis showed that perineal repair(odds ratio,9.827;95%confidence interval,1.296–74.50;P=0.027)might be a risk factor for recurrence.Moreover,only perineal repair significantly improved post-operative constipation status(preoperative vs post-operative,72.4%vs 25.0%,P=0.001).There was no reported mortality in either of the groups.No patient’s sexual function was affected by the surgery.Conclusions:Both surgical approaches were safe in men.Compared with perineal repair,the complication rate and recurrence rate for abdominal repair were lower.However,perineal repair was better able to correct constipation. | Bang Hu Qi Zou Zhenyu Xian Dan Su Chao Liu Li Lu Minyi Luo Zixu Chen Keyu Cai Han Gao Hui Peng Wuteng Cao Donglin Ren | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 15 | Advances in the Application of Perovskite Materials显示文摘Nowadays, the soar of photovoltaic performance of perovskite solar cells has set off a fever in the study of metal halide perovskite materials. The excellent optoelectronic properties and defect tolerance feature allow metal halide perovskite to be employed in a wide variety of applications. This article provides a holistic review over the current progress and future prospects of metal halide perovskite materials in representative promising applications, including traditional optoelectronic devices(solar cells, light-emitting diodes, photodetectors, lasers), and cutting-edge technologies in terms of neuromorphic devices(artificial synapses and memristors) and pressure-induced emission. This review highlights the fundamentals, the current progress and the remaining challenges for each application, aiming to provide a comprehensive overview of the development status and a navigation of future research for metal halide perovskite materials and devices. | Lixiu Zhang Luyao Mei Kaiyang Wang Yinhua Lv Shuai Zhang Yaxiao Lian Xiaoke Liu Zhiwei Ma Guanjun Xiao Qiang Liu Shuaibo Zhai Shengli Zhang Gengling Liu Ligang Yuan Bingbing Guo Ziming Chen Keyu Wei Aqiang Liu Shizhong Yue Guangda Niu Xiyan Pan Jie Sun Yong Hua Wu‑Qiang Wu Dawei Di Baodan Zhao Jianjun Tian Zhijie Wang Yang Yang Liang Chu Mingjian Yuan Haibo Zeng Hin‑Lap Yip Keyou Yan Wentao Xu Lu Zhu Wenhua Zhang Guichuan Xing Feng Gao Liming Ding | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 16 | Functional characterization of powdery mildew resistance gene MIIW172,a new Pm60 allele and its allelic variation in wild emmer wheat显示文摘Wild emmer wheat(Triticum dicoccoides,WEW)is an immediate progenitor of both the cultivated tetraploid and hexaploid wheats and it harbors rich genetic diversity against powdery mildew caused by Blumeria graminis f.sp.tritici(Bgt).A powdery mildew resistance gene Ml I^(W172)originated from WEW accession I^(W172)(G-797-M)is fine mapped in a 0.048 centimorgan(c M)genetic interval on 7 AL,corresponding to a genomic region spanning 233 kb,1 Mb and 800 kb in Chinese Spring,WEW Zavitan,and T.urartu G1812,respectively.Ml I^(W172)encodes a typical NLR protein NLRI^(W172)and physically locates in an NBS-LRR gene cluster.NLRI^(W172)is subsequently identified as a new allele of Pm60,and its function is validated by EMS mutagenesis and transgenic complementation.Haplotype analysis of the Pm60 alleles reveals diversifications in sequence variation in the locus and presence and absence variations(PAV)in WEW populations.Four common single nucleotide variations(SNV)are detected between the Pm60 alleles from WEW and T.urartu,indicative of speciation divergence between the two different wheat progenitors.The newly identified Pm60 alleles and haplotypes in WEW are anticipated to be valuable for breeding powdery mildew resistance wheat cultivars via marker-assisted selection. | Qiuhong Wu Yongxing Chen Beibei Li Jing Li Panpan Zhang Jingzhong Xie Huaizhi Zhang Guanghao Guo Ping Lu Miaomiao Li Keyu Zhu Wenling Li Tzion Fahima Eviatar Nevo Hongjie Li Lingli Dong Zhiyong Liu | 2022 | Journal of Genetics and Genomics2022，49，8： | 0 |
| 17 | Full experimental determination of tunneling time with attosecond-scale streaking method显示文摘Tunneling is one of the most fundamental and ubiquitous processes in the quantum world.The question of how long a particle takes to tunnel through a potential barrier has sparked a long-standing debate since the early days of quantum mechanics.Here,we propose and demonstrate a novel scheme to accurately determine the tunneling time of an electron.In this scheme,a weak laser field is used to streak the tunneling current produced by a strong elliptically polarized laser field in an attoclock configuration,allowing us to retrieve the tunneling ionization time relative to the field maximum with a precision of a few attoseconds.This overcomes the difficulties in previous attoclock measurements wherein the Coulomb effect on the photoelectron momentum distribution has to be removed with theoretical models and it requires accurate information of the driving laser fields.We demonstrate that the tunneling time of an electron from an atom is close to zero within our experimental accuracy.Our study represents a straightforward approach toward attosecond time-resolved imaging of electron motion in atoms and molecules. | Miao Yu Kun Liu Min Li Jiaqing Yan Chuanpeng Cao Jia Tan Jintai Liang Keyu Guo Wei Cao Pengfei Lan Qingbin Zhang Yueming Zhou Peixiang Lu | 2022 | Light(Science & Applications)2022，11，8： | 0 |
| 18 | Feature extraction of gear-localized defect using adaptive lifting scheme and local gradient maps显示文摘In this paper,the adaptive lifting scheme (ALS) and local gradient maps (LGM) are proposed to isolate the transient feature components from the gearbox vibration signals. Based on entropy minimization rule,the ALS is employed to change properties of an initial wavelet and design adaptive wavelet. Then LGM is applied to characterize the transient feature components in detail signal of decomposition results using ALS. In the present studies, the orthogonal Daubechies 4 (Db 4) wavelet is used as the initial wavelet. The proposed method is applied to both simulated signals and vibration signals acquired from a gearbox for periodic impulses detection. The two conventional methods (cepstrum analysis and Hilbert envelope analysis) and the orthogonal Db4 wavelet are also used to analyze the same signals for comparison. The results demonstrate that the proposed method is more effective in extracting transient components from noisy signals. | Zhang Lu Zhao Hong Li Zhen Qi Keyu Li Zongyao Yao Nianling | 2013 | Engineering Sciences2013，11，1： | 0 |
| 19 | Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome显示文摘The treatment of non-small cell lung cancer(NSCLC)remains a challenge due to tumor evolution during anti-angiogenesis therapies,in which the mechanism of vascular mimicry(VM)is believed to result in ineffective treatment[1].To conquer this challenge,substantial effort has recently been devoted to seeking out natural compounds on account of their multitarget actions.As a traditional herbal medicine,platycodin D(PD)is the major bioactive monomer derived from Platycodon grandiflorum(P.grandiflorum)and is used as an expectorant for pulmonary disease in Asia[2]. | Shuyu Zheng Yanlin Xin Jiamin Lin Zejuan Xie Keyu Cheng Shanshan Wang Wenli Lu Hao Yang Tianming Lu Jun Li Ruogu Qi Yuanyuan Guo | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
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