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| 1 | 利用测井资料识别层序地层单元技术与方法进展及趋势显示文摘测井曲线包含丰富的地质信息,测井曲线的形态、幅度可以反映出岩性和沉积旋回韵律等地层特征。在综述国内外研究成果的基础上,认为基于测井资料进行层序地层单元划分的方法可以分为定性和定量识别两种,其中,定性方法有自然电位和自然电位镜像法、声波时差与电阻率曲线重叠法、声波时差法、自然电位和视电阻率组合法以及累计地层倾角测井法等;定量识别方法有时频分析技术、INPEFA技术、多尺度小波分析技术、经验模态分解法、测井曲线分形分析和测井多尺度数据融合方法等。人工神经网络、人工智能技术和多尺度数据融合方法将是测井识别层序地层单元研究的趋势。结合INPEFA定量识别方法对西湖凹陷钻井层序地层单元定量识别进行实例分析,效果良好。 | 朱红涛 黄众 刘浩冉 Keyu Liu 刘强虎 | 2011 | 地质科技情报2011，30，4： | 25 |
| 2 | 塔中Ⅰ号带奥陶系烃包裹体荧光特征与成藏期显示文摘根据显微镜下烃包裹体的荧光特征、与方解石脉的穿插关系以及均一温度等特征,将塔中Ⅰ号坡折带奥陶系储层中发育的烃包裹体划分为4个期次;结合塔中地区区域构造演化特点,研究区四期烃包裹体分别对应着4个油气成藏期次,即志留纪末低成熟油形成时期,海西晚期生油期,早喜马拉雅期凝析油-湿气形成期,喜马拉雅期后期干气阶段。这4期烃包裹体在塔中Ⅰ号带奥陶系储层中具有明显的分带性,由东南浅埋藏油区向西北深埋油区将塔中Ⅰ号带奥陶系储层包裹体分布情况分成4个区域,其中第Ⅲ,Ⅳ期烃包裹体古油对现在油气藏起决定作用。 | 张鼐 赵瑞华 张蒂嘉 Liu Keyu 陈延贵 邢永亮 | 2010 | 石油与天然气地质2010，31，1： | 23 |
| 3 | A Combination of N2 and CO2 Adsorption to Characterize Nanopore Structure of Organic-Rich Lower Silurian Shale in the Upper Yangtze Platform, South China: Implications for Shale Gas Sorption Capacity显示文摘The pores in shales are mainly of nanometer-scale,and their pore size distribution is very important for the preservation and exploitation of shale gas.This study focused on the organic-rich Lower Silurian black shale from four wells in the Upper Yangtze Platform,and their TOC,mineralogical composition and pore characterization were investigated.Low pressure N_2 and CO_2 adsorption were conducted at 77.35 K and 273.15 K,respectively,and the pore structures were characterized by modified Brunauer-Emmett-Teller(BET),Dubinin-Radushkevich(DR),t-plot,BarrettJoyner-Halenda(BJH) and density functional theory(DFT) methods and then the relationship between pore structure and shale gas sorption capacity was discussed.The results indicate that(1) The Lower Silurian shale has high TOC content of 0.92%-4.96%,high quartz content of 30.6%-69.5%,and high clays content of 24.1%-51.2%.The total specific surface area varies from 7.56 m^2/g to 25.86 m^2/g.Both the total specific surface area and quartz content are positively associated with the TOC content.(2)Shale samples with higher TOC content have more micropores,which results in more complex nanopore structure.Micropore volumes/surface areas and non-micropore surface areas all increase with the increasing TOC content.(3) A combination of N_2 and CO_2 adsorption provides the most suitable detection range(~0.3-60 nm) and has high reliability and accuracy for nanopore structure characterization.(4) The TOC content is the key factor to control the gas sorption capacity of the Lower Silurian shale in the Upper Yangtze Platform. | CHEN Lei JIANG Zhenxue LIU Keyu GAO Fenglin WANG Pengfei | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 21 |
| 4 | 鄂尔多斯盆地东北部山西组河流相沉积证据显示文摘对于鄂尔多斯盆地东北部主力含层段二叠系山西组尤其是山2段的沉积相研究众说纷纭,不同的观点导致对各个沉积体系内部的砂岩展布解释与砂层对比产生了很大差异,进而加大了高效砂体分布预测和勘探部署的难度。为此,在前人研究的基础上,结合测井、地震、岩心、露头等资料,对该区山西组沉积相进行了综合研究。结果指出,河流冲积作用是控制鄂尔多斯盆东部高效储层形成与分布的基本因素,进而提出湿地—强侵蚀限制性河道下切谷充填沉积体系的新观点,并提出了相应的沉积模式和勘探思路。 | 朱红涛 陈开远 Liu Keyu 何生 | 2007 | 天然气工业2007，27，12： | 17 |
| 5 | 陆相湖盆层序构型及其岩性预测意义:以珠江口盆地惠州凹陷为例显示文摘地层岩相组合有规律地分布于层序的不同体系域。为了有效地进行储层发育、烃源岩分布的预测,文中提出层序构型的明确概念、类型、识别标志及其意义。层序构型是指三级层序内不同体系域地层单元时间-空间组成配置关系,其类型可分为L型、T型、TH型、H型(E-H型和L-H型)4种,其中,L型层序主要为富砂层序,储层相对发育;T型层序为富泥层序,烃源岩最为发育;TH型层序为富泥层序,烃源岩相对发育;E-H型层序为富泥层序,烃源岩发育程度次于TH型层序;L-H型层序主要为富砂层序,储层相对发育。珠江口盆地富烃的惠州凹陷文昌组层序构型实例分析表明,惠州凹陷南缘主要为T型层序,烃源岩相对发育,北缘主要为H型层序,储层相对发育。 | 朱红涛 Keyu Liu 杨香华 舒誉 吴静 李敏 | 2012 | 地学前缘2012，19，1： | 15 |
| 6 | Dynamic Field Division of Hydrocarbon Migration,Accumulation and Hydrocarbon Enrichment Rules in Sedimentary Basins显示文摘Hydrocarbon distribution rules in the deep and shallow parts of sedimentary basins are considerably different, particularly in the following four aspects. First, the critical porosity for hydrocarbon migration is much lower in the deep parts of basins: at a depth of 7000 m, hydrocarbons can accumulate only in rocks with porosity less than 5%. However, in the shallow parts of basins (i.e., depths of around 1000 m), hydrocarbon can accumulate in rocks only when porosity is over 20%. Second, hydrocarbon reservoirs tend to exhibit negative pressures after hydrocarbon accumulation at depth, with a pressure coefficient less than 0.7. However, hydrocarbon reservoirs at shallow depths tend to exhibit high pressure after hydrocarbon accumulation. Third, deep reservoirs tend to exhibit characteristics of oil (-gas)-water inversion, indicating that the oil (gas) accumulated under the water. However, the oil (gas) tends to accumulate over water in shallow reservoirs. Fourth, continuous unconventional tight hydrocarbon reservoirs are distributed widely in deep reservoirs, where the buoyancy force is not the primary dynamic force and the caprock is not involved during the process of hydrocarbon accumulation. Conversely, the majority of hydrocarbons in shallow regions accumulate in traps with complex structures. The results of this study indicate that two dynamic boundary conditions are primarily responsible for the above phenomena: a lower limit to the buoyancy force and the lower limit of hydrocarbon accumulation overall, corresponding to about 10%-12% porosity and irreducible water saturation of 100%, respectively. These two dynamic boundary conditions were used to divide sedimentary basins into three different dynamic fields of hydrocarbon accumulation: the free fluid dynamic field, limit fluid dynamic field, and restrain fluid dynamic field. The free fluid dynamic field is located between the surface and the lower limit of the buoyancy force, such that hydrocarbons in this field migrate and accumulate under the influence of, for example, the buoyancy force, pressure, hydrodynamic force, and capillary force. The hydrocarbon reservoirs formed are characterized as 'four high,' indicating that they accumulate in high structures, are sealed in high locations, migrate into areas of high porosity, and are stored in reservoirs at high pressure. The basic features of distribution and accumulation in this case include hydrocarbon migration as a result of the buoyancy force and formation of a reservoir by a caprock. The limit fluid dynamic field is located between the lower limit of the buoyancy force and the lower limit of hydrocarbon accumulation overall; the hydrocarbon migrates and accumulates as a result of, for example, the molecular expansion force and the capillary force. The hydrocarbon reservoirs formed are characterized as 'four low,' indicating that hydrocarbons accumulate in low structures, migrate into areas of low porosity, and accumulate in reservoirs with low pressure, and that oil(-gas)-water inversion occurs at low locations. Continuous hydrocarbon accumulation over a large area is a basic feature of this field. The restrain fluid dynamic field is located under the bottom of hydrocarbon accumulation, such that the entire pore space is filled with water. Hydrocarbons migrate as a result of the molecular diffusion force only. This field lacks many of the basic conditions required for formation of hydrocarbon reservoirs: there is no effective porosity, movable fluid, or hydrocarbon accumulation, and potential for hydrocarbon exploration is low. Many conventional hydrocarbon resources have been discovered and exploited in the free fluid dynamic field of shallow reservoirs, where exploration potential was previously considered to be low. Continuous unconventional tight hydrocarbon resources have been discovered in the limit fluid dynamic field of deep reservoirs; the exploration potential of this setting is thought to be tremendous, indicating that future exploration should be focused primarily in this direction. | PANG Xiongqi LIU Keyu MA Zhongzhen JIANG Zhenxue XIANG Caifu HUO Zhipeng PANG Hong CHEN Junqing | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 13 |
| 7 | A unified model for the formation and distribution of both conventional and unconventional hydrocarbon reservoirs显示文摘The discovery and large-scale exploration of unconventional oil/gas resources since 1980s have been considered as the most important advancement in the history of petroleum geology;that has not only changed the balance of supply and demand in the global energy market,but also improved our understanding of the formation mechanisms and distribution characteristics of oil/gas reservoirs.However,what is the difference of conventional and unconventional resources and why they always related to each other in petroliferous basins is not clear.As the differences and correlations between unconventional and conventional resources are complex challenging issues and very critical for resources assessment and hydrocarbon exploration,this paper focused on studying the relationship of formations and distributions among different oil/gas reservoirs.Drilling results of 12,237 exploratory wells in 6 representative petroliferous basins of China and distribution characteristics for 52,926 oil/gas accumulations over the world were applied to clarify the formation conditions and genetic relations of different oil/gas reservoirs in a petroliferous basin,and then to establish a unified model to address the differences and correlations of conventional and unconventional reservoirs.In this model,conventional reservoirs formed in free hydrocarbon dynamic field with high porosity and permeability located above the boundary of hydrocarbon buoyancy-driven accumulation depth limit.Unconventional tight reservoirs formed in confined hydrocarbon dynamic field with low porosity and permeability located between hydrocarbon buoyancy-driven accumulation depth limit and hydrocarbon accumulation depth limit.Shale oil/gas reservoirs formed in the bound hydrocarbon dynamic field with low porosity and ultra-low permeability within the source rock layers.More than 75%of proved reserves around the world are discovered in the free hydrocarbon dynamic field,which is estimated to contain only 10%of originally generated hydrocarbons.Most of undiscovered resources distributed in the confined hydrocarbon dynamic field and the bound hydrocarbon dynamic field,which contains 90%of original generated hydrocarbons,implying a reasonable and promising area for future hydrocarbon explorations.The buried depths of hydrocarbon dynamic fields become shallow with the increase of heat flow,and the remaining oil/gas resources mainly exist in the deep area of“cold basin”with low geothermal gradient.Lithology changing in the hydrocarbon dynamic field causes local anomalies in the oil/gas dynamic mechanism,leading to the local formation of unconventional hydrocarbon reservoirs in the free hydrocarbon dynamic field or the occurrence of oil/gas enrichment sweet points with high porosity and permeability in the confined hydrocarbon dynamic field.The tectonic movements destroy the medium conditions and oil/gas components,which leads to the transformation of conventional oil/gas reservoirs formed in free hydrocarbon dynamic field to unconventional ones or unconventional ones formed in confined and bound hydrocarbon dynamic fields to conventional ones. | Xiongqi Pang Chengzao Jia Junqing Chen Maowen Li Wenyang Wang Qinhong Hu Yingchun Guo Zhangxin Chen Junwen Peng Keyu Liu Keliu Wu | 2021 | Geoscience Frontiers2021，12，2： | 8 |
| 8 | Wheat powdery mildew resistance gene Pm64 derived from wild emmer (Triticum turgidum var.dicoccoides) is tightly linked in repulsion with stripe rust resistance gene Yr5显示文摘Stripe rust and powdery mildew are both devastating diseases for durum and common wheat.Pyramiding of genes conferring resistance to one or more diseases in a single cultivar is an important breeding approach to provide broader spectra of resistances in wheat improvement. A new powdery mildew resistance gene originating from wild emmer(Triticum turgidum var.dicoccoides) backcrossed into common wheat(T. aestivum) line WE35 was identified. It conferred an intermediate level of resistance to Blumeria graminis f. sp. tritici isolate E09 at the seedling stage and a high level of resistance at the adult plant stage. Genetic analysis showed that the powdery mildew resistance in WE35 was controlled by a dominant gene designated Pm64. Bulked segregant analysis(BSA) and molecular mapping indicated that Pm64 was located in chromosome bin 2 BL4-0.50–0.89. Polymorphic markers were developed from the corresponding genomic regions of Chinese Spring wheat and wild emmer accession Zavitan to delimit Pm64 to a 0.55 cM genetic interval between markers WGGBH1364 and WGGBH612, corresponding to a 15 Mb genomic region on Chinese Spring and Zavitan 2 BL, respectively. The genetic linkage map of Pm64 is critical for fine mapping and cloning. Pm64 was completely linked in repulsion with stripe rust resistance gene Yr5. Analysis of a larger segregating population might identify a recombinant line with both genes as a valuable resource in breeding for resistance to powdery mildew and stripe rust. | Deyun Zhang Keyu Zhu Lingli Dong Yong Liang Genqiao Li Tilin Fang Guanghao Guo Qiuhong Wu Jingzhong Xie Yongxing Chen Ping Lu Miaomiao Li Huaizhi Zhang Zhenzhong Wang Yan Zhang Qixin Sun Zhiyong Liu | 2019 | The Crop Journal2019，7，6： | 8 |
| 9 | Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells显示文摘砷三氧化物(ATO ) 能在肿瘤房间作为反肿瘤药导致区别和 apoptosis。间充质的干细胞(MSC ) 在骨头髓的造血作用起重要作用。许多报告证明了 MSC adipogenic 和 osteogenic 区别的混乱发生在一些疾病。然而,关于 MSC 上的 ATO 的效果的报告是有限的。在这研究,我们发现 1 M ATO 主要通过 p21 支持了 MSC 老朽,尽管它没在这剂量在 apoptosis 上有效果。而且, ATO 支持了 adipogenic 区别,但是在 MSC 禁止了 osteogenic 区别。我们的学习也显示出那 CCAAT/enhancer-binding 蛋白质 alpha C/EBP 和 peroxisome 激活 proliferator 的受体 gamma PPAR 可能涉及 ATO 导致的 adipogenic 和 osteogenic 区别的规定。我们的结果显示 ATO 可以由影响骨头髓微型环境施加反肿瘤效果。而且,它可以调整 MSC 的 adipogenic 和 osteogenic 区别。 | Huanchen Cheng Lin Qiu Hao Zhang Mei Cheng Wei Li Xuefei Zhao Keyu Liu Lei Lei Jun Ma | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 8 |
| 10 | 陆内克拉通盆地层序地层构型及其控制因素显示文摘通过总结我国鄂尔多斯盆地和澳大利亚Surat basin这两个典型的陆内克拉通盆地的层序充填序列,认为该类盆地具有典型的层序地层充填模式:(1)典型的正粒序岩性组合特征;(2)基准面旋回为上升半旋回为主的不对称旋回,具有长期持续水进、短期水退旋回特征;(3)层序主要以LST为主,发育相互切割叠置的复合砂体,为最有利储层;TST和HST相对不发育,发育孤立状的单砂体,为中-差储层.陆内克拉通盆地层序地层及其控制的砂体具有'溯源退积'的时空展布模式,该模式主要受到盆地边缘构造、沉积物供给、湖平面变化、古地形、'盆地充填'和气候等因素的单独或综合控制. | 朱红涛 李敏 Liu Keyu 刘强虎 黄众 杜文波 | 2010 | 地球科学(中国地质大学学报)2010，35，6： | 8 |
| 11 | A new type of dehydration unit of natural gas and its design considerations显示文摘A new type of dehydration unit for natural gas is described and its basic structure and working principles are presented.The key factors affecting the performance and dehydration efficiency of the unit such as nucleation rate, droplet growth rate, the strength of the swirl, and the position at which the shock wave occurs are discussed. And accordingly the design considerations of each component of the unit are provided. Experimental investigations on the working performance of the unit justified the design considerations. | LIU Hengwei LIU Zhongliang ZHANG Jian GU Keyu YAN Tingmin | 2005 | Progress in Natural Science:Materials International2005，15，12： | 7 |
| 12 | 陆内克拉通盆地“溯源退积”层序构型构建:以鄂尔多斯盆地山西组为例显示文摘陆内克拉通盆地是我国重要的含油气盆地类型之一,其层序地层学研究相对薄弱.以我国典型的陆内克拉通盆地-鄂尔多斯盆地山西组的层序地层学研究为例,提出陆内克拉通盆地长期持续退积、短期进积'溯源退积'层序构型的模式.其涵义是指陆内克拉通盆地所形成的三级层序的层序构型均以LST为主,TST和HST相对不发育,对应的基准面旋回具有长期持续退积(水进)、短期进积(水退)旋回特征;不同级别层序地层格架控制下的砂体,自下而上(从老到新),具有向北部物源区依次退积叠置的'溯源退积'特征. | 朱红涛 刘依梦 Liu Keyu 刘强虎 | 2013 | 地球科学(中国地质大学学报)2013，38，4： | 6 |
| 13 | 层序地层控制因素的多变量系统显示文摘层序充填和层序发育受一系列相互作用地质变量的控制。提出了层序地层控制因素多变量系统的观点,指出该系统具有层序控制因素的多变性、不确定性和层序发育过程的复杂性特征。层序地层控制因素分为综合变量和独立变量,假设综合变量为独立变量,可以简化层序模拟,假设越多,模拟越简单,但模拟结果越粗略。目前研究层序控制因素的手段主要依靠计算机模拟技术、沉积充填物理模拟技术以及多场景技术。借助SEDPAK二维地层模拟软件,模拟了断层活动对层序展布的影响。 | 朱红涛 史军 Keyu Liu 陈开远 | 2008 | 油气地质与采收率2008，15，4： | 6 |
| 14 | 定量模拟层序叠加模式对断陷盆地非均一构造沉降活动的响应显示文摘利用SEDPAK二维层序模拟软件,通过考虑控制层序沉积过程的不同参数,探讨层序叠加模式对断陷盆地非均一性构造沉降活动的响应。结果表明,在非均一构造沉降活动作用下,盆地两侧同期层序显示出同步和非同步的叠加模式。同步叠加模式即盆地两侧同期层序同为退积或进积特征,非同步叠加模式即盆地两侧层序叠加模式相反(一侧退积,另一侧则进积)。同期层序非同步叠加模式的形成机理是盆地一侧可容纳空间的增量(△A)小于沉积物供应(△S)(△A<△S),而另一侧盆地一侧可容纳空间的增量大于或等于沉积物供应(△A≥△S)。此外,二者可以控制非同步叠加模式的持续时间。同期层序非同步叠加模式的识别,对陆相层序地层研究提出新的认识,尤其是对我国东部新生代断陷盆地的层序研究,具有一定的参考价值。 | 朱红涛 Keyu Liu 杜远生 何生 陈令 | 2008 | 沉积学报2008，26，5： | 5 |
| 15 | Key factors controlling hydrocarbon accumulations in Ordovician carbonate reservoirs in the Tazhong area, Tarim basin, western China显示文摘 | Hong Pang Junqing Chen Xiongqi Pang Luofu Liu Keyu Liu Caifu Xiang | 2013 | Marine and Petroleum Geology2013，，： | 4 |
| 16 | 可容纳空间转换系统的定量模拟显示文摘为探讨盆地两侧可容纳空间和层序叠加模式的非一致性变化,利用SEDPAK二维层序模拟软件,通过考虑控制层序沉积过程的不同参数,对可容纳空间转换系统进行定量模拟并提出新的认识.模拟结果表明,盆地两侧同期层序叠加模式可以分为'同步'和'非同步'两种,同步叠加模式多出现在层序的低位体系域及高位体系域后期,非同步叠加模式多出现在层序的水进体系域及高位体系域初期.多种地质参数的合理组合,盆地两侧同期层序均可形成非同步叠加模式.非同步叠加模式对体系域界面的识别、层序对比具有一定的参考价值. | 朱红涛 Keyu Liu 杜远生 李敏 王继立 | 2009 | 地球科学(中国地质大学学报)2009，34，5： | 4 |
| 17 | Formation condition of deep gas reservoirs in tight sandstones in Kuqa Foreland Basin显示文摘Due to the high expense of deep oil and gas exploration,prediction of gas-bearing properties before drilling is crucial for deep gas reservoir of tight sandstone.Deep tight sandstone gas fields in Kuqa Foreland Basin are characterized by high abundance,high gas saturation,high pressure,high and stable yield,which belong to high-efficiency tight gas reservoir.Based on theoretical analysis of controlling factors and mechanisms of gas-bearing properties for tight sandstone gas reservoir,and taking tight sandstone gas fields with high effectiveness such as Dibei,Keshen and Dibei gas fields in Kuqa Foreland Basin as examples,formation condition and mechanism of high-efficiency tight sandstone gas reservoir in Kuqa area are studied through a comparative analysis of typical tight sandstone gas reservoir in Sichuan Basin and Ordos Basin.The results show that the formation condition of deep gas reservoir of tight sandstone in Kuqa foreland basin includes four factors:i.e.,overpressure gas charging,fracture development,“early-oil and late-gas”accumulation process and favorable preservation condition.The overpressure gas charging and fracture development are the most important factors for formation of high-efficiency tight gas reservoirs in Kuqa Foreland Basin.High-quality source rocks,high sourcereservoir pressure difference,and overpressure filling induced thereby are preconditions for formation of tight sandstone with high gas saturation.The fracture development controls gas migration,accumulation,and high yield of tight sandstone gas reservoir.The reservoir wettability changed by the early oil charging is beneficial to late natural gas charging,and the preservation condition of high-quality gypsum cap rocks is the key factor for gas reservoirs to maintain overpressure and high gas saturation.Matching of above four favorable factors leads to the tight sandstone gas reservoir with high abundance,high gas saturation and high gas production in Kuqa Foreland Basin,which is very different from other basins.Under the condition of little difference in physical property of tight sandstone reservoir,excessive source-reservoir pressure difference,facture development,preservation condition and current formation overpressure are the most significant factors to be considered in exploration and evaluation of deep tight sandstone gas. | Xuesong Lu Mengjun Zhao Keyu Liu Qingong Zhuo Junjia Fan Zhichao Yu Yanjie Gong | 2018 | Petroleum Research2018，3，4： | 4 |
| 18 | Applications of Light Stable Isotopes(C, O, H) in the Study of Sandstone Diagenesis: A Review显示文摘This article reviews the applications of light stable isotope, including carbon, oxygen and hydrogen, in thestudies on origin and formation temperature of authigenic carbonate, quartz and clay minerals. Theoretical knowledge andanalytical methods for major light stable isotopes are introduced in detail. Negative and positive δ^(13)C values indicatesignificant differences on the origin of carbonate cements. The δ^(18)O value is an effective palaeotemperature scale forauthigenic minerals formation. Various fractionation equations between δ^(18)O and temperature are proposed for carbonatecements, quartz cements and clay minerals, whose merit and demerit, applicable conditions are clarified clearly. Clumpedisotope analysis can reconstruct the temperature of carbonate precipitation with no requirement on the δ^(18)O of initial waters,which makes temperature calculation of carbonate cements formation more convenient and accurate. Hydrogen and oxygenisotopes mainly reflect the origin of diagenetic fluid for clay mineral formation, providing reliable evidence for diageneticenvironment analysis. This work aims at helping researchers for better understanding the applications of light stable isotopein sandstone diagenesis. | XI Kelai CAO Yingchang LIN Miruo LIU Keyu WU Songtao YUAN Guanghui YANG Tian | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 4 |
| 19 | Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering显示文摘A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasis.The stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of PTP1B.However,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely unknown.Here,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.Based on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3.Moreover,152RM induced type H vessels formation by activating Notch signaling.Demineralized bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic adsorption.The DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in vivo.In conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects. | Yong Tang Keyu Luo Yin Chen Yueqi Chen Rui Zhou Can Chen Jiulin Tan Moyuan Deng Qijie Dai Xueke Yu Jian Liu Chengmin Zhang Wenjie Wu Jianzhong Xu Shiwu Dong Fei Luo | 2021 | Bioactive Materials2021，6，7： | 3 |
| 20 | Origin of Oils in“Subtle pools”in the Dongying Depression,Bohai Bay Basin, China显示文摘摘要:微妙的陷井或油水池在 Dongying 消沉成为了一出重要探索戏, Bohai 海湾盆,华东。尽管有在探索的最近的成功,微妙的陷井的形成机制仍然不好被理解。在 Dongying 消沉的微妙的油水池的多数与主要具有在 mudstones 包含的透镜的盆地板 turbidite 沙的微妙的陷井在 Paleogene Shahejie 形成的 Es3 成员的中间的间隔被开发。在微妙的陷井的油以前被认为从一样的形成(Es3 ) 的包围来源岩石直接移植了。从消沉的 41 油和 41 件岩石样品的详细 geochemical 调查现在显示从微妙的陷井的油不能与包围 Es3 来源岩石被相关很好,它被高 Pr/Ph 描绘(> 1 ) ,低 Gammacerane/C30hopane,代表淡水湖的背景。在对比油特征低 Pr/Ph (< 1 ) 并且相对高的 Gammacerane 内容,与内在的 Es4 来源一起显示出一种基因亲密关系摇,它也有一样的质量,显示一个略有盐味的湖的背景。在 Es3 微妙的陷井的油可能从支配的上面的 Es4 来源岩石与贡献从混合来源被导出。要调用解释从 Es4 来源岩石分享油的因此异乎寻常的油迁居和累积机制需要,它可能通过 Es3 来源的厚低间隔来了摇没有明显结构或 stratigraphic 小径。我们建议微妙的油迁居小径可能这里起一个重要作用。这发现可以在 Dongying 消沉为未来探索和留下的资源评估有重要含意。 | LI Sumei JIANG Zhengxue LIU Keyu QIU Guiqiang GAO Yongjin | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 3 |
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