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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Wheat powdery mildew resistance gene Pm64 derived from wild emmer (Triticum turgidum var.dicoccoides) is tightly linked in repulsion with stripe rust resistance gene Yr5显示文摘Stripe rust and powdery mildew are both devastating diseases for durum and common wheat.Pyramiding of genes conferring resistance to one or more diseases in a single cultivar is an important breeding approach to provide broader spectra of resistances in wheat improvement. A new powdery mildew resistance gene originating from wild emmer(Triticum turgidum var.dicoccoides) backcrossed into common wheat(T. aestivum) line WE35 was identified. It conferred an intermediate level of resistance to Blumeria graminis f. sp. tritici isolate E09 at the seedling stage and a high level of resistance at the adult plant stage. Genetic analysis showed that the powdery mildew resistance in WE35 was controlled by a dominant gene designated Pm64. Bulked segregant analysis(BSA) and molecular mapping indicated that Pm64 was located in chromosome bin 2 BL4-0.50–0.89. Polymorphic markers were developed from the corresponding genomic regions of Chinese Spring wheat and wild emmer accession Zavitan to delimit Pm64 to a 0.55 cM genetic interval between markers WGGBH1364 and WGGBH612, corresponding to a 15 Mb genomic region on Chinese Spring and Zavitan 2 BL, respectively. The genetic linkage map of Pm64 is critical for fine mapping and cloning. Pm64 was completely linked in repulsion with stripe rust resistance gene Yr5. Analysis of a larger segregating population might identify a recombinant line with both genes as a valuable resource in breeding for resistance to powdery mildew and stripe rust. | Deyun Zhang Keyu Zhu Lingli Dong Yong Liang Genqiao Li Tilin Fang Guanghao Guo Qiuhong Wu Jingzhong Xie Yongxing Chen Ping Lu Miaomiao Li Huaizhi Zhang Zhenzhong Wang Yan Zhang Qixin Sun Zhiyong Liu | 2019 | The Crop Journal2019，7，6： | 8 |
| 3 | Construction of a small-caliber tissue-engineered blood vessel using icariin-loaded β-cyclodextrin sulfate for in situ anticoagulation and endothelialization显示文摘The rapid endothelialization of tissue-engineered blood vessels(TEBVs) can effectively prevent thrombosis and inhibit intimal hyperplasia. The traditional Chinese medicine ingredient icariin is highly promising for the treatment of cardiovascular diseases.β-cyclodextrin sulfate is a type of hollow molecule that has good biocompatibility and anticoagulation properties and exhibits a sustained release of icariin. We studied whether icariin-loaded β-cyclodextrin sulfate can promote the endothelialization of TEBVs. The experimental results showed that icariin could significantly promote the proliferation and migration of endothelial progenitor cells; at the same time, icariin could promote the migration of rat vascular endothelial cells(RAVECs). Subsequently,we used an electrostatic force to modify the surface of the TEBVs with icariin-loaded β-cyclodextrin sulfate, and these vessels were implanted into the rat common carotid artery. After 3 months, micro-CT results showed that the TEBVs modified using icariin-loaded β-cyclodextrin sulfate had a greater patency rate. Scanning electron microscopy(SEM) and CD31 immunofluorescence results showed a better degree of endothelialization. Taken together, icariin-loaded β-cyclodextrin sulfate can achieve anticoagulation and rapid endothelialization of TEBVs to ensure their long-term patency. | Jingyuan Yang Keyu Wei Yeqin Wang Yanzhao Li Ning Ding Da Huo Tianran Wang Guanyuan Yang Mingcan Yang Tan Ju Wen Zeng Chuhong Zhu | 2018 | Science China(Life Sciences)2018，61，10： | 5 |
| 4 | Geochemistry of Palaeozoic marine petroleum from the Tarim Basin, NW China: Part 3. Thermal cracking of liquid hydrocarbons and gas washing as the major mechanisms for deep gas condensate accumulations显示文摘 | Shuichang Zhang Jin Su Xiaomei Wang Guangyou Zhu Haijun Yang Keyu Liu Zhenxi Li | 2011 | Organic Geochemistry2011，，： | 2 |
| 5 | Implications from Subseasonal Prediction Skills of the Prolonged Heavy Snow Event over Southern China in Early 2008显示文摘An exceptionally prolonged heavy snow event(PHSE)occurred in southern China from 10 January to 3 February 2008,which caused considerable economic losses and many casualties.To what extent any dynamical model can predict such an extreme event is crucial for disaster prevention and mitigation.Here,we found the three S2S models(ECMWF,CMA1.0 and CMA2.0)can predict the distribution and intensity of precipitation and surface air temperature(SAT)associated with the PHSE at 10-day lead and 10−15-day lead,respectively.The success is attributed to the models’capability in forecasting the evolution of two important low-frequency systems in the tropics and mid-latitudes[the persistent Siberian High and the suppressed phase of the Madden−Julian Oscillation(MJO)],especially in the ECMWF model.However,beyond the 15-day lead,the three models show almost no skill in forecasting this PHSE.The bias in capturing the two critical circulation systems is responsible for the low skill in forecasting the 2008 PHSE beyond the 15-day lead.On one hand,the models cannot reproduce the persistence of the Siberian High,which results in the underestimation of negative SAT anomalies over southern China.On the other hand,the models cannot accurately capture the suppressed convection of the MJO,leading to weak anomalous southerly and moisture transport,and therefore the underestimation of precipitation over southern China.The Singular Value Decomposition(SVD)analyses between the critical circulation systems and SAT/precipitation over southern China shows a robust historical relation,indicating the fidelity of the predictability sources for both regular events and extreme events(e.g.,the 2008 PHSE). | Keyue ZHANG Juan LI Zhiwei ZHU Tim LI | 2021 | Advances in Atmospheric Sciences2021，38，11： | 2 |
| 6 | Effects of lead and cadmium co-exposure on bone mineral density in a Chinese population显示文摘 | Xiao Chen Keyue Wang Zhongqiu Wang Caohui Gan Ping He Yihuai Liang Taiyi Jin Guoying Zhu | 2014 | Bone2014，，： | 1 |
| 7 | Tight gas sandstone reservoirs in China: characteristics and recognition criteria显示文摘 | Caineng Zou Rukai Zhu Keyu Liu Ling Su Bin Bai Xiangxiang Zhang Xuejian Yuan Jinhong Wang | 2012 | Journal of Petroleum Science and Engineering2012，，： | 1 |
| 8 | Evaluation of individualized treatment of nonproliferative diabetic retinopathy:a multicenter,randomized,parallel-controlled study显示文摘OBJECTIVE:To evaluate the differences in the efficacy of stationary treatment and individualized treatment for patients with nonproliferative diabetic retinopathy(NPDR).METHODS:This study was a randomized,controlled,multicenter clinical trial.Participants with NPDR were randomized into the stationary treatment group or the individualized treatment group.The stationary treatment group was given the basic treatment and Qiming granules,and the individualized treatment group was given the basic treatment,Qiming granules,and individualized Chinese herbal medicines over a 12-week period.The individualized therapeutic formula was also changed over time to adjust to the changes in the clinical presentation of the patient.We conducted observations of fundus retinal exudation and hemorrhage,visual acuity,Traditional Chinese Medicine symptom scores and other indicators.RESULTS:A total of 140 participants with NPDR were randomized into the stationary treatment group or the individualized treatment group,and 132 participants completed this study.Following the 12-week treatment,significant improvements in both primary and secondary outcomes were observed in the stationary and individualized treatment groups.No remarkable difference in the primary outcomes between the two groups was observed.However,there was a significant difference in the Traditional Chinese Medicine symptom scores(18±7 vs 15±6;P<0.05).There were no severe adverse effects.CONCLUSION:Compared with stationary treatment,individualized treatment is more effective at relieving the Traditional Chinese Medicine symptoms and improving vision and fundus lesions at 12 weeks post treatment. | HUO Jian DUAN Junguo LIU Lisha ZHANG Fuwen ZHU Keyu SUI Jiaqing JIAN Wenyuan | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 1 |
| 9 | Tight gas sand- stone reservoirs in China: characteristics and recognition criteria显示文摘 | Zou Caineng Zhu Rukai Liu Keyu | 2012 | Journal of Petroleum Science and Engineering2012，8889，： | 1 |
| 10 | Tight gas sandstone reservoirs in China :Characteristics and recognition criteria显示文摘 | Zou Caineng Zhu Rukai Liu Keyu? Su Ling Bai Bin Zhang Xiangxiang | 2012 | Journal of Petro-leum Science and Engineering2012，8889，： | 1 |
| 11 | Tight gas sandstone reservoirs in China: characteristics and recognition criteria显示文摘 | ZOU Caineng ZHU Rukai LIU Keyu | 2012 | Journal of Petroleum Science and Engineering2012，8889，： | 1 |
| 12 | A sequence stratigraph- ic model for reservoir sand-body distribution in the lower Permian Shanxi Formation in the Ordos Basin, northern China显示文摘 | Zhu Hongtao Chen Kaiyuan Liu Keyu | 2008 | Marine and Petroleum Geology2008，，25： | 1 |
| 13 | A well-preserved 250million-year-old oil accumulation in the Tarim Basin, westernChina: Implication for hydrocarbon exploration in old anddeep basins 显示文摘 | Zhu Guangyou Zhang Shuichang Liu Keyu Yang Haijun Zhang Bin Su Jin Zhang Yaguang | 2013 | Mar Pet Geol2013，43，47： | 1 |
| 14 | Extended pancreatoduodenectomy with portal vein and inferior vena cava resection and reconstruction combined with sorafenib for hepatoid carcinoma of the pancreas:a strategy of superextended surgery combined with targeted therapy显示文摘Hepatoid carcinoma of the pancreas(HCP)is an extremely rare pancreatic cancer resembling hepatocellular carcinoma,a type of liver cancer(1).Most reports have shown that it has an aggressive behavior and is associated with early metastasis.There is no standardized treatment for HCP due to its rarity,and the limited number of cases reported in the literature(2,3).However,treatment options for this type of rare cancer include surgery,chemotherapy,and radiation therapy,depending on the stage of the cancer.Nevertheless,the prognosis of HCP is poor. | Deling Wei Banghao Xu Hai Zhu Jilong Wang Zongrui Jin Weitao Chen Jianyong Zhang Zhujing Lan Keyu Huang Ling Zhang Tingting Lu Ni Fang Ya Guo Tao Peng Minhao Peng Zhang Wen | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
| 15 | Differential interformational velocity analysis as an effective direct hydrocarbon indicator under velocity reversal conditions,an example from the anomalously high temperature and over-pressured DF1-1 Gas Field in the Yinggehai Basin,South China Sea显示文摘In the DF1-1 Gas Field in the Yinggehai Basin,South China Sea,the velocity-depth plot and velocity spectra show significant variations from a linear trend,exhibiting a distinct reversal phenomenon.Velocity parameters derived from velocity spectral analysis of the seismic data and sonic logs indicate that the interval velocity reverses below 2,100 m(2.2 s two-way time(TWT)) in the DF1-1 Gas Field.Some direct hydrocarbon indicators(DHIs) models developed for the shallow strata cannot be simply applied to the moderately to deeply buried strata for direct exploration target recognition because the velocity reversal has caused the middle-deep gas reservoirs to exhibit a moderate or weak seismic amplitude.The hydrocarbon indicator method of 'Differential Interformational Velocity Analysis(DIVA)' with the aid of other hydrocarbon indicating techniques was employed to effectively identify DHIs in the middle-deep strata under velocity inversion.The result has shown that the DIVA technique can be effectively used as a DHI in both the shallow and the middle-deep strata in the study area with the shallow strata characterized by Type I DIVA anomaly and the middle-deep strata characterized by the Type II DIVA anomaly. | Zhu Hongtao Liu Keyu Chen Kaiyuan Li Min Huang Shengbing | 2009 | Petroleum Science2009，6，4： | 0 |
| 16 | Advances in the Application of Perovskite Materials显示文摘Nowadays, the soar of photovoltaic performance of perovskite solar cells has set off a fever in the study of metal halide perovskite materials. The excellent optoelectronic properties and defect tolerance feature allow metal halide perovskite to be employed in a wide variety of applications. This article provides a holistic review over the current progress and future prospects of metal halide perovskite materials in representative promising applications, including traditional optoelectronic devices(solar cells, light-emitting diodes, photodetectors, lasers), and cutting-edge technologies in terms of neuromorphic devices(artificial synapses and memristors) and pressure-induced emission. This review highlights the fundamentals, the current progress and the remaining challenges for each application, aiming to provide a comprehensive overview of the development status and a navigation of future research for metal halide perovskite materials and devices. | Lixiu Zhang Luyao Mei Kaiyang Wang Yinhua Lv Shuai Zhang Yaxiao Lian Xiaoke Liu Zhiwei Ma Guanjun Xiao Qiang Liu Shuaibo Zhai Shengli Zhang Gengling Liu Ligang Yuan Bingbing Guo Ziming Chen Keyu Wei Aqiang Liu Shizhong Yue Guangda Niu Xiyan Pan Jie Sun Yong Hua Wu‑Qiang Wu Dawei Di Baodan Zhao Jianjun Tian Zhijie Wang Yang Yang Liang Chu Mingjian Yuan Haibo Zeng Hin‑Lap Yip Keyou Yan Wentao Xu Lu Zhu Wenhua Zhang Guichuan Xing Feng Gao Liming Ding | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 17 | Functional characterization of powdery mildew resistance gene MIIW172,a new Pm60 allele and its allelic variation in wild emmer wheat显示文摘Wild emmer wheat(Triticum dicoccoides,WEW)is an immediate progenitor of both the cultivated tetraploid and hexaploid wheats and it harbors rich genetic diversity against powdery mildew caused by Blumeria graminis f.sp.tritici(Bgt).A powdery mildew resistance gene Ml I^(W172)originated from WEW accession I^(W172)(G-797-M)is fine mapped in a 0.048 centimorgan(c M)genetic interval on 7 AL,corresponding to a genomic region spanning 233 kb,1 Mb and 800 kb in Chinese Spring,WEW Zavitan,and T.urartu G1812,respectively.Ml I^(W172)encodes a typical NLR protein NLRI^(W172)and physically locates in an NBS-LRR gene cluster.NLRI^(W172)is subsequently identified as a new allele of Pm60,and its function is validated by EMS mutagenesis and transgenic complementation.Haplotype analysis of the Pm60 alleles reveals diversifications in sequence variation in the locus and presence and absence variations(PAV)in WEW populations.Four common single nucleotide variations(SNV)are detected between the Pm60 alleles from WEW and T.urartu,indicative of speciation divergence between the two different wheat progenitors.The newly identified Pm60 alleles and haplotypes in WEW are anticipated to be valuable for breeding powdery mildew resistance wheat cultivars via marker-assisted selection. | Qiuhong Wu Yongxing Chen Beibei Li Jing Li Panpan Zhang Jingzhong Xie Huaizhi Zhang Guanghao Guo Ping Lu Miaomiao Li Keyu Zhu Wenling Li Tzion Fahima Eviatar Nevo Hongjie Li Lingli Dong Zhiyong Liu | 2022 | Journal of Genetics and Genomics2022，49，8： | 0 |
| 18 | AN IMPROVED LP MODEL FOR ENERGY OPTIMIZATION OF THE INTEGRATED IRON AND STEEL PLANT WITH A COGENERATION SYSTEM IN CHINA显示文摘在有一个 cogeneration 系统的一个综合熨斗和钢植物,再循环精力连续地被搬运进 cogeneration 系统和电连续地被产生,并且他们俩不能很长时间被存储。而且,电的产生和消费是不规则的,它可以引起更意外的不平衡。因此,由优化精力利用的操作安排全部精力系统是一个关键问题,它在这二个系统在生产系统,在 cogeneration 系统的产生电和再循环的精力包括未加工的精力。在这份报纸,为在有一个 cogeneration 系统的综合的铁和钢植物的精力优化的一个改进线性编程模型被建立。改进模型集中于控制整个精力流动并且通过与一个 cogeneration 系统在一个综合熨斗和钢植物优化各种精力分发和利用在在生产系统之间的全部精力系统和 cogeneration 系统安排整个精力消费。改进模型在更高的精力利用,更低的精力费用和更低的污染排出物为最佳的操作条件提供的案例研究表演。 | Zhanglin Peng Chao Fu Keyu Zhu Qiang Zhang Dawei Ni Shanlin Yang | 2016 | Journal of Systems Science and Systems Engineering2016，25，4： | 0 |
| 19 | Erratum to: Implications from Subseasonal Prediction Skills of the Prolonged Heavy Snow Event over Southern China in Early 2008显示文摘In the original publication of this article,the blue lines(PCC skill of 500-hPa geopotential height over mid-high latit-udes between the observation and ECWMF)in Fig.8a was misplaced.The correct Fig.8 is shown below.The associated description of“other than in P2−P3”should be“other than in P2”in section 3.3.Neither the abstract nor the conclusions are impacted. | Keyue ZHANG Juan LI Zhiwei ZHU Tim LI | 2022 | Advances in Atmospheric Sciences2022，39，1： | 0 |
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