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| 1 | Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells显示文摘砷三氧化物(ATO ) 能在肿瘤房间作为反肿瘤药导致区别和 apoptosis。间充质的干细胞(MSC ) 在骨头髓的造血作用起重要作用。许多报告证明了 MSC adipogenic 和 osteogenic 区别的混乱发生在一些疾病。然而,关于 MSC 上的 ATO 的效果的报告是有限的。在这研究,我们发现 1 M ATO 主要通过 p21 支持了 MSC 老朽,尽管它没在这剂量在 apoptosis 上有效果。而且, ATO 支持了 adipogenic 区别,但是在 MSC 禁止了 osteogenic 区别。我们的学习也显示出那 CCAAT/enhancer-binding 蛋白质 alpha C/EBP 和 peroxisome 激活 proliferator 的受体 gamma PPAR 可能涉及 ATO 导致的 adipogenic 和 osteogenic 区别的规定。我们的结果显示 ATO 可以由影响骨头髓微型环境施加反肿瘤效果。而且,它可以调整 MSC 的 adipogenic 和 osteogenic 区别。 | Huanchen Cheng Lin Qiu Hao Zhang Mei Cheng Wei Li Xuefei Zhao Keyu Liu Lei Lei Jun Ma | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 8 |
| 2 | Tunable and scalable broadband metamaterial absorber involving VO2-based phase transition显示文摘Optical absorbers with dynamic tuning features are able to flexibly control the absorption performance, which offers a good platform for realizing optical switching, filtering, modulating, etc. Here, we propose a thermally tunable broadband absorber applying a patterned plasmonic metasurface with thermo-chromic vanadium dioxide (VO2) spacers. An actively tunable absorption bandwidth and peak resonant wavelength in the region from the near-to mid-infrared (NMIR) are simultaneously achieved with the insulating.metallic phase transition ofVO2·Moreover, the scalable unit cell,which is composed of multi-width sub-cells, provides a new freedom to further manipulate (i.e., broaden or narrow) the absorption bandwidth while maintaining a high relative absorption bandwidth and efficient absorbance at the same time. For both transverse-electric and transverse-magnetic polarizations, the proposed nanostructure exhibits a high absorption over a wide angular range up to 60°.This method holds a promising potential for versatile utilizations in optical integrated devices,NMIR photodetection, thermal emitters, smart temperature control systems,and so fbrth. | Lei Lei Fei Lou Keyu Tao Haixuan Huang Xin Cheng Ping Xu | 2019 | Photonics Research2019，7，7： | 8 |
| 3 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 4 | Identification of long non-coding RNA p34822 as a potential plasma biomarker for the diagnosis of hepatocellular carcinoma显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide(Li and Satomura,2015).Early diagnosis and treatment are vital for reducing mortality.Currently,biomarkers such as serum alpha fetoprotein(AFP),AFP-L2,and carcinoembryonic antigen are widely used tumor markers for managing HCC in patients(Shi et al.,2016).However,because of their low diagnostic sensitivity and specificity,novel biomarkers with high sensitivity and specificity for early HCC diagnosis are needed. | Cheng Wang Tianyu Ren Keyu Wang Shaogeng Zhang Shubin Liu Hu Chen Penghui Yang | 2017 | Science China(Life Sciences)2017，60，9： | 2 |
| 5 | Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice显示文摘呼吸 syncytial 病毒(RSV ) 是在婴儿和孩子的更低的呼吸感染的一个领先的原因,但是仍然没有可得到的准许的疫苗。在这份报告,我们基于 Bac-to-Bac baculovirus 表达式系统开发了像病毒的粒子(VLP ) 疫苗,由一个流行性感冒病毒矩阵(M1 ) 组成蛋白质和 RSV 熔化蛋白质(F) 或 glycoprotein (G) 。这些 RSV VLP 被西方的污点分析和电子显微镜学识别。有 RSV-F VLP, RSV-G VLP,或两个的 intranasally 使免疫的女 BALB/c 老鼠(i.n ) 对 RSV 显示出病毒特定的抗体回答。全部的 IgG, IgG1, IgG2a,和 mucosal IgA 与 RSV-F 正 RSV-G VLP 在老鼠被检测,揭示细胞的有势力和 mucosal 免疫者回答。而且,我们发现这些混合 RSV VLP 对实时 RSV 挑战授与提高的保护,在病毒的复制和组织病理学说的变化的明显的变细与病毒的感染联系了的肺的出现重要减少。这些结果证明由 intranasal 种痘的 RSV-F 正 RSV-G VLP 是保证使用棉花老鼠和首领模型的进一步的评估的一个有希望的疫苗的候选人。 | Mengying Cai Cheng Wang Yufeng Li Hongjing Gu Sujing Sun Yueqiang Duan Chengcai Lai Keyu Wang Xiaolan Yang Li Xing Peirui Zhang Zhaohai Wang Shaogeng Zhang Xiaodong Guo Shubing Liu Yigang Tong Xiliang Wang Penghui Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 1 |
| 6 | Three-Phase Boost-Type Grid-Connected inverter 显示文摘 | YANG CHENG KEYUE SMEDLEY | 2008 | IEEE Trans on Power Electronics2008，23，5： | 1 |
| 7 | Rapid and sensitive detection of urinary KIM-1 using fully printed photonic crystal microarrays显示文摘Urinary kidney injury molecule 1(uKIM-1)serves as a reliable marker for the early diagnosis of acute kidney injury(AKI).The rapid and facile detection of changes in uKIM-1 is essential for early AKI diagnosis,ultimately improving the prognosis of patients.In this study,we developed a fully printed photonic crystal-integrated microarray with photonic crystal-enhanced fluorescence properties,which can detect uKIM-1 levels at the point-of-care.We confirmed its efficacy in the early diagnosis of AKI using clinical urine specimens.Direct quantitative detection of uKIM-1 was achieved within 10 min.The lowest limit of detection is 8.75 pg·mL^(-1) with an accuracy of 94.2%.The diagnostic efficacy was validated using 86 clinical urine samples,highlighting the high sensitivity and stability of the photonic crystal microarray.Consequently,a facile and reliable immunoassay was designed and prepared for the rapid quantitative detection of uKIM-1,which is crucial for the early identification and convenient detection of AKI in hospital or community settings.Rapid,convenient,cost-effective,and long-term monitoring of changes in uKIM-1 levels can assist clinicians in making timely adjustments to treatment regimens,preventing the transition from AKI to chronic kidney disease(CKD),improving the quality of life of patients with AKI,and reducing healthcare costs.It highlights the advantages of utilizing urine samples as a noninvasive and easily accessible medium for early detection and monitoring of kidney-related conditions. | Yang Liu Xuwei He Zewei Lian Qian Guo Jimei Chi Xiaoxue Lin Liyue Zhang Zheng Liu Yingyuan Liu Meng Su Keyu Wang Qiangguo Ao Qingli Cheng | 2024 | Nano Research2024，17，5： | 0 |
| 8 | Platycodin D inhibits angiogenic vascular mimicry in NSCLC by regulating the eIF4E-mediated RNA methylome显示文摘The treatment of non-small cell lung cancer(NSCLC)remains a challenge due to tumor evolution during anti-angiogenesis therapies,in which the mechanism of vascular mimicry(VM)is believed to result in ineffective treatment[1].To conquer this challenge,substantial effort has recently been devoted to seeking out natural compounds on account of their multitarget actions.As a traditional herbal medicine,platycodin D(PD)is the major bioactive monomer derived from Platycodon grandiflorum(P.grandiflorum)and is used as an expectorant for pulmonary disease in Asia[2]. | Shuyu Zheng Yanlin Xin Jiamin Lin Zejuan Xie Keyu Cheng Shanshan Wang Wenli Lu Hao Yang Tianming Lu Jun Li Ruogu Qi Yuanyuan Guo | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
| 9 | Gadolinium-doped mesoporous tungsten oxides:Rational synthesis,gas sensing performance,and mechanism investigation显示文摘As a typical family of volatile toxic compounds,benzene derivatives are massive emission in industrial production and the automobile field,causing serious threat to human and environment.The reliable and convenient detection of low concentration benzene derivatives based on intelligent gas sensor is urgent and of great significance for environmental protection.Herein,through heteroatomic doping engineering,rare-earth gadolinium(Gd)doped mesoporous WO_(3)with uniform mesopores(15.7–18.1 nm),tunable high specific surface area(52–55 m^(2)·g^(−1)),customized crystalline pore walls,was designed and utilized to fabricate highly sensitive gas sensors toward benzene derivatives,such as ethylbenzene.Thanks to the high-density oxygen vacancies(OV)and significantly increased defects(W^(5+))produced by Gd atoms doping into the lattice of WO_(3)octahedron,Gd-doped mesoporous WO_(3)exhibited excellent ethylbenzene sensing performance,including high response(237 vs.50 ppm),rapid response–recovery dynamic(13 s/25 s vs.50 ppm),extremely low theoretical detection limit of 24 ppb.The in-situ diffuse reflectance infrared Fourier transform and gas chromatograph-mass spectrometry results revealed the gas sensing process underwent a catalytic oxidation conversion of ethylbenzene into alcohol species,benzaldehyde,acetophenone,and carboxylate species along with the resistance change of the Gd-doped mesoporous WO_(3)based sensor.Moreover,a portable smart gas sensing module was fabricated and demonstrated for real-time detecting ethylbenzene,which provided new ideas to design heteroatom doped mesoporous materials for intelligent sensors. | Yanyan Li Keyu Chen Yan Liu Junhao Ma Yaozu Liao Haitao Yang Jinsheng Cheng Qin Yue Kaiping Yuan Yuan Ren Yidong Zou Yonghui Deng | 2023 | Nano Research2023，16，5： | 0 |
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