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| 1 | Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis显示文摘Acute obstructive suppurative cholangitis(AOSC) due to biliary lithiasis is a life-threatening condition that requires urgent biliary decompression. Although endoscopic retrograde cholangiopancreatography(ERCP) with stent placement is the current gold standard for biliary decompression, it can sometimes be difficult because of failed biliary cannulation. In this retrospective case series, we describe three cases of successful biliary drainage with recovery from septic shock after urgent endoscopic ultrasound-guided choledochoduodenostomy(EUS-CDS) was performed for AOSC due to biliary lithiasis. In all three cases, technical success in inserting the stents was achieved and the patients completely recovered from AOSC with sepsis in a few days after EUS-CDS. There were no procedure-related complications. When initial ERCP fails, EUS-CDS can be an effective life-saving endoscopic biliary decompression procedure that shortens the procedure time and prevents post-ERCP pancreatitis, particularly in patients with AOSC-induced sepsis. | Kosuke Minaga Masayuki Kitano Hajime Imai Kentaro Yamao Ken Kamata Takeshi Miyata Shunsuke Omoto Kumpei Kadosaka Tomoe Yoshikawa Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，16： | 18 |
| 2 | Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease显示文摘Solitary organ autoimmune disorders,formerly known as autoimmune pancreatitis(AIP),autoimmune sialadenitis,and autoimmune sclerosing cholangitis,are now considered organ-specific manifestations of systemic immunoglobulin G4-related disease(IgG4-RD).AIP and IgG4-RD are characterized by elevated serum concentration of IgG4 antibody(Ab),accumulation of IgG4-expressing plasmacytes in the affected organs,and involvement of multiple organs.It is well established that enhanced IgG4 Ab responses are a hallmark of AIP and IgG4-RD for diagnosis and monitoring disease activity.However,a significant fraction of patients with AIP and IgG4-RD who develop chronic fibroinflammatory responses have normal serum concentrations of this IgG subtype.In addition,disease flare-up is sometimes seen even in the presence of normalized serum concentrations of IgG4 Ab after successful induction of remission by prednisolone.Therefore,it is necessary to identify new biomarkers based on the understanding of the pathophysiology of AIP and IgG4-RD.Recently,we found that activation of plasmacytoid dendritic cells producing both interferon-α(IFN-α)and interleukin-33(IL-33)mediate murine AIP and human IgG4-RD.More importantly,we provided evidence that serum concentrations of IFN-αand IL-33 could be useful biomarkers for the diagnosis and monitoring of AIP and IgG4-RD activity after induction of remission in these autoimmune disorders.In this Frontier article,we have summarized and discussed biomarkers of AIP and IgG4-RD,including Igs,autoAbs,and cytokines to provide useful information not only for clinicians but also for researchers. | Akane Hara Tomohiro Watanabe Kosuke Minaga Tomoe Yoshikawa Ken Kamata Masatoshi Kudo | 2021 | World Journal of Gastroenterology2021，27，19： | 8 |
| 3 | Efficient hemostatic method for endoscopic submucosal dissection of colorectal tumors显示文摘AIM:To evaluate a new hemostatic method using hemostatic forceps to prevent perforation and perioperative hemorrhage during colonic endoscopic submucosal dissection(ESD).METHODS:We studied 250 cases,in which ESD for colorectal tumors was performed at the Kyoto Prefectural University of Medicine or Nara City Hospital between 2005 and 2010.We developed a new hemostatic method using hemostatic forceps in December 2008 for the efficient treatment of submucosal thick vessels.ESD was performed on 126 cases after adoption of the new method(the adopted group)and the new method was performed on 102 of these cases.ESD was performed on 124 cases before the adoption of the new method (the unadopted group).The details of the new method are as follows:firstly,a vessel was coagulated using the hemostatic forceps in the soft coagulation mode according to the standard procedure,and the coagulated vessel was removed using the forceps in the'endocut' mode without perioperative hemorrhage.Secondly,the partial surrounding submucosa was dissected using the forceps in the endocut mode.In the current study,we evaluated the efficacy of this method.RESULTS:Coagulated vessels were successfully removed using the hemostatic forceps in all 102 cases without severe perioperative hemorrhage.Moderate perioperative hemorrhage occurred in five cases(4.9%);however,it was stopped by immediately reuse of the hemostatic forceps.The partial surrounding submucosa was dissected using the forceps in all 102 cases.In the adopted group,the median operation time was 105 min.The proportion of endoscopic en bloc resection was 92.8%(P<0.01)compared to 80.6%in the unadopted group.The postoperative hemorrhage and perforation rates were 2.3%and 2.3%.The rate of perforation was significantly lower than that in the unadopted group (9.6%,P<0.01).We evaluated the ease of use of this method by allowing our three trainees to performed ESD on 46 cases,which were accomplished without any severe hemorrhage.CONCLUSION:The new method effectively treated submucosal thick vessels and shows promise for the prevention of perforation and perioperative hemorrhage in colonic ESD. | Naohisa Yoshida Yuji Naito Munehiro Kugai Ken Inoue Naoki Wakabayashi Nobuaki Yagi Akio Yanagisawa Toshikazu Yoshikawa | 2010 | World Journal of Gastroenterology2010，16，33： | 4 |
| 4 | Dendritic cell-based vaccination in metastatic melanoma patients: PhaseII clinical trial显示文摘 | Chie Oshita Masako Takikawa Akiko Kume Haruo Miyata Tadashi Ashizawa Akira Iizuka Yoshio Kiyohara Shusuke Yoshikawa Ryuji Tanosaki Naoya Yamazaki Akifumi Yamamoto Kazutoh Takesako Ken Yamaguchi Yasuto Akiyama | 2012 | Oncology Reports2012，，4： | 2 |
| 5 | Modified single transluminal gateway transcystic multiple drainage technique for a huge infected walled-off pancreatic necrosis: A case report显示文摘We report a successful endoscopic ultrasonographyguided drainage of a huge infected multilocular walledoff necrosis(WON) that was treated by a modified single transluminal gateway transcystic multiple drainage(SGTMD) technique. After placing a widecaliber fully covered metal stent, follow-up computed tomography revealed an undrained subcavity of WON. A large fistula that was created by the wide-caliber metal stent enabled the insertion of a forward-viewing upper endoscope directly into the main cavity, and the narrow connection route within the main cavity to the subcavity was identified with a direct view, leading to the successful drainage of the subcavity. This modified SGTMD technique appears to be useful for seeking connection routes between subcavities of WON in some cases. | Kosuke Minaga Masayuki Kitano Hajime Imai Kentaro Yamao Ken Kamata Takeshi Miyata Tomohiko Matsuda Shunsuke Omoto Kumpei Kadosaka Tomoe Yoshikawa Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，21： | 2 |
| 6 | Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial显示文摘 | Akira Terano Tetsuo Arakawa Toshiro Sugiyama Hidekazu Suzuki Takashi Joh Toshikazu Yoshikawa Kazuhide Higuchi Ken Haruma Kazunari Murakami Kenzo Kobayashi | 2007 | Journal of Gastroenterology2007，，8： | 1 |
| 7 | Contribution of Adventitious Roots to Water Use Strategy of Juniperus sabina in a Semiarid Area of China显示文摘 | Lingli Yang Naoko H. Miki Naoko Matsuo Guosheng Zhang Linhe Wang Ken Yoshikawa | 2014 | Journal of Agricultural Science and Technology(A)2014，4，3： | 1 |
| 8 | Second-look arthroscopy of anterior cruciate ligament grafts with multistranded hamstring tendons显示文摘 | Yukiyoshi Toritsuka Konsei Shino Shuji Horibe Tomoki Mitsuoka Masayuki Hamada Ken Nakata Norimasa Nakamura Hideki Yoshikawa | 2004 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2004，，： | 1 |
| 9 | Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells显示文摘 | Wataru Ando Kosuke Tateishi David A. Hart Daisuke Katakai Yoshinari Tanaka Ken Nakata Jun Hashimoto Hiromichi Fujie Konsei Shino Hideki Yoshikawa Norimasa Nakamura | 2007 | Biomaterials2007，，36： | 1 |
| 10 | Whole-Genome Profiling of a Novel Mutagenesis Technique Using Proofreading-Deficient DNA Polymerase δ显示文摘 | Yuh Shiwa Sanae Fukushima-Tanaka Ken Kasahara Takayuki Horiuchi Hirofumi Yoshikawa Hiromi Nishida | 2012 | International Journal of Evolutionary Biology2012，，： | 1 |
| 11 | Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial显示文摘 | Akira Terano Tetsuo Arakawa Toshiro Sugiyama Hidekazu Suzuki Takashi Joh Toshikazu Yoshikawa Kazuhide Higuchi Ken Haruma Kazunari Murakami Kenzo Kobayashi | 2007 | Journal of Gastroenterology2007，，8： | 1 |
| 12 | Myoepithelioma of the lung: Report of two cases and review of the literature显示文摘 | Masahiko Higashiyama Ken Kodama Hideoki Yokouchi Koji Takami Toshiyuki Kabuto Naoko Tsuji Masayuki Mano Shingo Ishiguro Takafumi Ueda Hideki Yoshikawa Masayuki Tatsuta | 1998 | Lung Cancer1998，，1： | 1 |
| 13 | The detection of surface patterns by flexible spectral imaging color enhancement without magnification for diagnosis of colorectal polyps显示文摘 | Naohisa Yoshida Yuji Naito Yutaka Inada Munehiro Kugai Ken Inoue Kazuhiko Uchiyama Osamu Handa Tomohisa Takagi Hideyuki Konishi Nobuaki Yagi Yasutaka Morimoto Naoki Wakabayashi Akio Yanagisawa Toshikazu Yoshikawa | 2012 | International Journal of Colorectal Disease2012，，5： | 1 |
| 14 | Outcome of endoscopic submucosal dissection for colorectal tumors in elderly people显示文摘 | Naohisa Yoshida Yuji Naito Kyoko Sakai Yoshio Sumida Kazuyuki Kanemasa Ken Inoue Yasutaka Morimoto Hideyuki Konishi Naoki Wakabayashi Satoshi Kokura Nobuaki Yagi Akio Yanagisawa Toshikazu Yoshikawa | 2010 | International Journal of Colorectal Disease2010，，4： | 1 |
| 15 | Outcome of endoscopic submucosal dissection for colorectal tumors in elderly people显示文摘 | Naohisa Yoshida Yuji Naito Kyoko Sakai Yoshio Sumida Kazuyuki Kanemasa Ken Inoue Yasutaka Morimoto Hideyuki Konishi Naoki Wakabayashi Satoshi Kokura Nobuaki Yagi Akio Yanagisawa Toshikazu Yoshikawa | 2010 | International Journal of Colorectal Disease2010，，4： | 1 |
| 16 | ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells显示文摘AIM: To investigate the effects of nicotine and nicotine plus angiotensin Ⅱ receptor blocker(ARB) on the gene expression profile of human coronary artery endothelial cells(HCAECs).METHODS: The changes in gene expression profiles in HCAECs treated with nicotine and nicotine plus ARB olmesartan were analyzed by DNA microarray. In nicotine-treated HCAECs, 432 genes selected by P < 0.01 were greater than 1.5-fold compared with the untreated cells. Data were analyzed using IPA(Ingenuity? Systems, www.ingenuity.com).RESULTS: The gene expression levels of tumor necrosis factor-α, collagen type 1, matrix metalloproteinase-10, and disintegrin and metalloprotease domain 8, which are related to 'cardiovascular function and disease', were significantly increased. In canonical pathway analyses using IPA, 'atherosclerosis signaling' was strongly affected by nicotine treatment and this effect was reduced by co-incubation with ARB olmesartan. These data indicate that the deleterious cardiovascular consequences of cigarette smoking may, at least in part, be due to the nicotine-induced gene expression profile related to 'atherosclerosis signaling'.CONCLUSION: The inhibitory effect of ARB against the nicotine-induced gene expression profile may possibly induce anti-atherosclerotic effects that are independent of those from lowering the blood pressure. | Masataka Kudo Ken Matsuda Kaori Sugawara Yuko Iki Naotaka Kogure Takako Saito-Ito Kyoko Shimizu Ikuko Sato Takeo Yoshikawa Akira Uruno Ryo Ito Atsushi Yokoyama Akiko Saito-Hakoda Sadayoshi Ito Akira Sugawara | 2014 | World Journal of Hypertension2014，4，1： | 0 |
| 17 | Late-onset non-islet cell tumor hypoglycemia: A case report显示文摘BACKGROUND Hypoglycemia due to non-insulin-producing tumors is referred to as non-islet cell tumor hypoglycemia(NICTH).As NICTH is a rare lesion,the natural course of NICTH is not well understood.We report a case of NICTH that was observed 30 years before the onset of hypoglycemia.CASE SUMMARY A 50-year-old man was diagnosed with an abnormal right chest shadow during a routine X-ray examination,but no further examination was undertaken because the lesion appeared benign.Thirty years after the tumor discovery,the patient was admitted to the hospital with symptoms of severe hypoglycemia,which was diagnosed as NICTH based on a complete examination.The tumor was resected and found to be a solitary fibrous mass(15.6 cm×13.7 cm×10.4 cm);thereafter,the patient’s blood glucose levels normalized and he completely recovered.CONCLUSION NICTH can have an acute onset,even if the tumor has been present and asymptomatic over a long time period. | Shunichi Matsumoto Eijiro Yamada Yasuyo Nakajima Naoki Yamaguchi Takashi Okamura Toshiki Yajima Satoshi Yoshino Kazuhiko Horiguchi Emi Ishida Masashi Yoshikawa Jun Nagaoka Sho Sekiguchi Mai Sue Shuichi Okada Izumi Fukuda Ken Shirabe Masanobu Yamada | 2021 | World Journal of Clinical Cases2021，9，1： | 0 |
| 18 | Clinical utility of treatment method conversion during single-session endoscopic ultrasound-guided biliary drainage显示文摘BACKGROUND Although several techniques for endoscopic ultrasound-guided biliary drainage(EUS-BD)are available at present,an optimal treatment algorithm of EUS-BD has not yet been established.AIM To evaluate the clinical utility of treatment method conversion during single endoscopic sessions for difficult cases in initially planned EUS-BD.METHODS This was a single-center retrospective analysis using a prospectively accumulated database.Patients with biliary obstruction undergoing EUS-BD between May 2008 and April 2016 were included.The primary outcome was to evaluate the improvement in EUS-BD success rates by converting the treatment methods during a single endoscopic session.Secondary outcomes were clarification of the factors leading to the conversion from the initial EUS-BD and the assessment of efficacy and safety of the conversion as judged by technical success,clinical success,and adverse events(AEs).RESULTS A total of 208 patients underwent EUS-BD during the study period.For 18.8%(39/208)of the patients,the treatment methods were converted to another EUSBD technique from the initial plan.Biliary obstruction was caused by pancreatobiliary malignancies,other malignant lesions,biliary stones,and other benign lesions in 22,11,4,and 2 patients,respectively.The reasons for the difficulty with the initial EUS-BD were classified into the following 3 procedures:Target puncture(n=13),guidewire manipulation(n=18),and puncture tract dilation(n=8).Technical success was achieved in 97.4%(38/39)of the cases and clinical success was achieved in 89.5%of patients(34/38).AEs occurred in 10.3%of patients,including bile leakage(n=2),bleeding(n=1),and cholecystitis(n=1).The puncture target and drainage technique were altered in subsequent EUSBD procedures in 25 and 14 patients,respectively.The final technical success rate with 95%CI for all 208 cases was 97.1%(95%CI:93.8%-98.9%),while that of the initially planned EUS-BD was 78.8%(95%CI:72.6%-84.2%).CONCLUSION Among multi-step procedures in EUS-BD,guidewire manipulation appeared to be the most technically challenging.When initially planned EUS-BD is technically difficult,treatment method conversion in a single endoscopic session may result in successful EUS-BD without leading to severe AEs. | Kosuke Minaga Mamoru Takenaka Kentaro Yamao Ken Kamata Shunsuke Omoto Atsushi Nakai Tomohiro Yamazaki Ayana Okamoto Rei Ishikawa Tomoe Yoshikawa Yasutaka Chiba Tomohiro Watanabe Masatoshi Kudo | 2020 | World Journal of Gastroenterology2020，26，9： | 0 |
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