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| 1 | Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis显示文摘AIM: To evaluate the effect of pyrrolidine dithio- carbamate (PDTC; an NF-κB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis. METHODS: Mice were divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+PDTC-treated groupⅠ(low-dose group), and DSS+PDTC-treated groupⅡ (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue were measured. RESULTS: The DSS+PDTC-treated groupⅡ exhibited suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels were significantly lower in DSS+PDTC- treated groupⅡ. CONCLUSION: These findings suggest that PDTC is useful for the treatment of ulcerative colitis. | Ichiro Hirata Shingo Yasumoto Ken Toshina Takuya Inoue Takashi Nishikawa Naoko Murano Mitsuyuki Murano Fang-Yu Wang Ken-ichi Katsu | 2007 | World Journal of Gastroenterology2007，13，11： | 20 |
| 2 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 3 | Endoscopic transgastric drainage of a gastric wall abscess after endoscopic submucosal dissection显示文摘A 63-year-old woman was referred to our hospital for further examination because of an incidental finding of early gastric cancer.Endoscopic submucosal dissection(ESD)was successfully performed for complete resection of the tumor.On the first post-ESD day,the patient suddenly complained of abdominal pain after an episode of vomiting.Abdominal computed tomography(CT)showed delayed perforation after ESD.The patient was conservatively treated with an intravenous proton pump inhibitor and antibiotics.On the fifth post-ESD day,CT revealed a gastric wall abscess in the gastric body.Gastroscopy revealed a gastric fistula at the edge of the post-ESD ulcer,and pus was found flowing into the stomach.An intradrainage stent and an extradrainage nasocystic catheter were successfully inserted into the abscess for endoscopic transgastric drainage.After the procedure,the clinical symptoms and laboratory test results improved quickly.Two months later,a follow-up CT scan showed no collection of pus.Consequently,the intradrainage stent was removed.Although the gastric wall abscess recurred 2 wk after stent removal,it recovered soon after endoscopic transgastric drainage.Finally,after stent removal and oral antibiotic treatment for 1 mo,no recurrence of the gastric wall abscess was found. | Osamu Dohi Moyu Dohi Ken Inoue Yasuyuki Gen Masayasu Jo Kazuhiko Tokita | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 4 | Efficient hemostatic method for endoscopic submucosal dissection of colorectal tumors显示文摘AIM:To evaluate a new hemostatic method using hemostatic forceps to prevent perforation and perioperative hemorrhage during colonic endoscopic submucosal dissection(ESD).METHODS:We studied 250 cases,in which ESD for colorectal tumors was performed at the Kyoto Prefectural University of Medicine or Nara City Hospital between 2005 and 2010.We developed a new hemostatic method using hemostatic forceps in December 2008 for the efficient treatment of submucosal thick vessels.ESD was performed on 126 cases after adoption of the new method(the adopted group)and the new method was performed on 102 of these cases.ESD was performed on 124 cases before the adoption of the new method (the unadopted group).The details of the new method are as follows:firstly,a vessel was coagulated using the hemostatic forceps in the soft coagulation mode according to the standard procedure,and the coagulated vessel was removed using the forceps in the'endocut' mode without perioperative hemorrhage.Secondly,the partial surrounding submucosa was dissected using the forceps in the endocut mode.In the current study,we evaluated the efficacy of this method.RESULTS:Coagulated vessels were successfully removed using the hemostatic forceps in all 102 cases without severe perioperative hemorrhage.Moderate perioperative hemorrhage occurred in five cases(4.9%);however,it was stopped by immediately reuse of the hemostatic forceps.The partial surrounding submucosa was dissected using the forceps in all 102 cases.In the adopted group,the median operation time was 105 min.The proportion of endoscopic en bloc resection was 92.8%(P<0.01)compared to 80.6%in the unadopted group.The postoperative hemorrhage and perforation rates were 2.3%and 2.3%.The rate of perforation was significantly lower than that in the unadopted group (9.6%,P<0.01).We evaluated the ease of use of this method by allowing our three trainees to performed ESD on 46 cases,which were accomplished without any severe hemorrhage.CONCLUSION:The new method effectively treated submucosal thick vessels and shows promise for the prevention of perforation and perioperative hemorrhage in colonic ESD. | Naohisa Yoshida Yuji Naito Munehiro Kugai Ken Inoue Naoki Wakabayashi Nobuaki Yagi Akio Yanagisawa Toshikazu Yoshikawa | 2010 | World Journal of Gastroenterology2010，16，33： | 4 |
| 5 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 6 | Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease显示文摘AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction score.RESULTS: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD. | Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata Masafumi Inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita | 2016 | World Journal of Gastroenterology2016，22，23： | 2 |
| 7 | Laparoscopic splenectomy for histiocytic sarcoma of the spleen显示文摘Primary histiocytic sarcoma of the spleen is a rare but potentially lethal condition. It can remain asymptomatic or only mildly symptomatic for a long time. An 81-year-old woman presented with an extremely enlarged spleen. She suffered from progressive anemia and required a red blood cell transfusion once a month. Although computed tomography, ultrasonography, and magnetic resonance imaging were performed for diagnosis, a confirmed diagnosis was not obtained. Her enlarged spleen compressed her stomach, and she suffered from gastritis and a sense of gastric fullness just after meals. She underwent laparoscopic splenectomy for therapeutic and diagnostic purposes. Her postoperative course was uneventful. After surgery, her red blood cell and platelet counts increased markedly. The tumor was diagnosed as splenic histiocytic sarcoma. Post-surgical chemotherapy was not performed, and the patient died of liver failure due to liver metastasis 5 mo after surgery. Laparoscopic splenectomy is minimally invasive and useful for the relief of symptoms related to hematological disorders. However, in cases of an enlarged spleen, optimal views and working space are limited. In such cases, splenic artery ligation can markedly reduce the size of the spleen, thus facilitating the procedure. The case reported herein suggests that laparoscopic splenectomy may be useful for the treatment of splenic malignancy. | Satoshi Yamamoto Tadashi Tsukamoto Akishige Kanazawa Sadatoshi Shimizu Keiichiro Morimura Takahiro Toyokawa Zhang Xiang Katsunobu Sakurai Tatsunari Fukuoka Kayo Yoshida Mamiko Takii Ken Inoue | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 2 |
| 8 | 铁路道口事故中汽车司机的因素显示文摘通过对曾驶越过带栏木铁路道口的汽车司机的调查了解,归纳了铁路道口事故中存在的问题,并对常见的问题进行分析,得出发生事故的过程和原因,进而探讨了防范事故的措施。 | Takafumi INOUE Ken KUSUKAMI Sachiko KON-NO 张未 | 1998 | 中国铁路1998，，5： | 2 |
| 9 | H. pylori eradication did not improve dysregulation of specific oncogenic miRNAs in intestinal metaplastic glands显示文摘 | Akiko Shiotani Noriya Uedo Hiroyasu Iishi Takahisa Murao Tomoko Kanzaki Yoshiki Kimura Tomoari Kamada Hiroaki Kusunoki Kazuhiko Inoue Ken Haruma | 2012 | Journal of Gastroenterology2012，，9： | 2 |
| 10 | Protective role of urinary tryp sin-inhibitor in acute lung injury induced by lipopolysaecharide显示文摘 | Ken - Ichiro Inoue Hirohisa Takano Rie Yanagisawa | 2005 | Exp Biol Med2005，230，4： | 1 |
| 11 | Dynamic analysis of motion of crawler-type remotely operated vehicles显示文摘 | Tomoya Inoue Takuya Shiosawa Ken Takagi | 2013 | IEEE Journal of Oceanic Engineering2013，38，2： | 1 |
| 12 | Evaluation of Humoral Immunity to Mycobacterium tuberculosis -Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development显示文摘 | Mamiko Niki Maho Suzukawa Shunsuke Akashi Hideaki Nagai Ken Ohta Manabu Inoue Makoto Niki Yukihiro Kaneko Kozo Morimoto Atsuyuki Kurashima Seigo Kitada Sohkichi Matsumoto Koichi Suzuki Yoshihiko Hoshino Pedro A. Reche | 2015 | Journal of Immunology Research2015，，： | 1 |
| 13 | Potential Use of Beards for Single-Follicle Micrografts: Convenient Follicle-Harvesting Technique Using an Injection Needle 显示文摘 | Takashi Hirai Naoko Inoue Ken Nagamoto | 2001 | Ann Plast Surg2001，47，7： | 1 |
| 14 | Preparation and properties of nanostructured TiO 2 electrode by a polymer organic-medium screen-printing technique显示文摘 | Tingli Ma Tetsuya Kida Morito Akiyama Kozo Inoue Shuji Tsunematsu Ken Yao Hiroaki Noma Eiichi Abe | 2003 | Electrochemistry Communications2003，，4： | 1 |
| 15 | Flowering Phenology, Pollination, and Fruit Set of Cypripedium macranthos var. rebunense, a Threatened Lady’s Slipper (Orchidaceae)显示文摘 | Naoto Sugiura Taketoshi Fujie Ken Inoue Kenji Kitamura | 2001 | Journal of Plant Research2001，，2： | 1 |
| 16 | Treatment for autoimmune pancreatitis: consensus on the treatment for patients with autoimmune pancreatitis in Japan显示文摘 | Tetsuhide Ito Isao Nishimori Naoko Inoue Ken Kawabe Junya Gibo Yoshiyuki Arita Kazuichi Okazaki Ryoichi Takayanagi Makoto Otsuki | 2007 | Journal of Gastroenterology2007，，18： | 1 |
| 17 | Protective role of urinary trypsininhibitor in acute lung injury induced by lipopolysaceharide 显示文摘 | Ken - Ichiro Inoue Hirohisa Takano Rie Yanagisawa | 2005 | Experimental Biology and Medicine2005，230，4： | 1 |
| 18 | Refractory ulcerative colitis accompanied with cytomegalovirus colitis and multiple liver abscesses: A case report显示文摘Various hepato-biliary complications are an increased incidence in patients with inflammatory bowel disease,and portal bacteremia is well documented in patients with ulcerative colitis (UC). However, few reports mention UC in association with liver abscesses. Recently, there are several reports describing cytomegalovirus (CMV) infection in association with disease exacerbation and steroid refractoriness in patients with UC. Here we present a case of refractory UC accompanied with multiple liver abscesses and CMV colitis. The patient, a 72-year-old male, with a five-year history of repeated admissions to our hospital for UC, presented with an exacerbation of his UC.Sigmoidoscopy performed on admission suggested that his UC was exacerbated, then he was given prednisolone and mesalazine orally, and betamethasone enemas.However, he had exacerbated symptoms. Repeat sigmoidoscopy revealed multiple longitudinal ulcers and pseudopolyps in the rectosigmoid colon. Although immunohistochemical staining of biopsy specimens and the serum testing for antigenemia were negative on admission and after the repeat sigmoidoscopy, they became histologically positive for CMV. Nonetheless, the patient developed spiking fevers, soon after ganciclovir was administered. Laboratory studies revealed an increased white cell count with left shift, and Enterococcus fecalis grew in blood cultures. An abdominal computed tomography (CT) scan was obtained and the diagnosis of liver abscesses associated with UC was made, based on CT results. The hepatic abscesses were successfully treated with intravenous meropenem for 6 wk, without further percutaneous drainage. To our knowledge, this is the first reported case of multiple liver abscesses that develop during UC exacerbation complicated by CMV colitis. | Takuya Inoue Ichiro Hirata Yutaro Egashira Kumi Ishida Ken Kawakami Eijiro Morita Naoko Murano Shingo Yasumoto Mitsuyuki Murano Ken Toshina Takashi Nishikawa Norihiro Hamamoto Ken Nakagawa Ken-Ichi Katsu | 2005 | World Journal of Gastroenterology2005，11，33： | 1 |
| 19 | Facilitation by 5-hydroxytryptamine of ATP-activated current in rat pheochromocytoma cells显示文摘 | Ken Nakazawa Kaori Inoue Shuichi Koizumi Kazuhide Inoue | 1994 | Pflügers Archiv European Journal of Physiology (-)1994，，5： | 1 |
| 20 | Peroral endoscopic myotomy for esophageal achalasia: C linical impact of 28 cases显示文摘 | Hitomi Minami Hajime Isomoto Naoyuki Yamaguchi Kayoko Matsushima Yuko Akazawa Ken Ohnita Fuminao Takeshima Haruhiro Inoue Kazuhiko Nakao | 2014 | Digestive Endoscopy2014，，1： | 1 |
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