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| 1 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 2 | Assessment of quadriceps muscle thickness using bedside ultrasonography by nurses and physicians in the intensive care unit:Intra- and inter-operator agreement显示文摘BACKGROUND Data regarding the agreement among multiple operators for measurement of quadriceps muscle thickness by bedside ultrasonography(USG)are sparse.AIM To statistically assess the agreement among 5 operators for measurement of quadriceps muscle thickness on bedside USG.METHODS This was a cross-sectional observational study.The 5 operators of varied experience(comprised of 1 critical care consultant,2 fellows,and 2 nurses)independently measured quadriceps muscle thickness in triplicate for 45 critically ill patients each,using USG.Intra-and interrater agreement rates among the 5 operators were assessed using intraclass correlation coefficient(ICC)and expressed with 95%confidence interval(CI).RESULTS The 5 operators produced a total of 135 readings and 675 observations for ICC calculations to determine the intraoperator and interoperator variations respectively.For intraoperator agreement,the overall ICC(95%CI)was 0.998(0.997,0.999)for operator 1,0.998(0.997,0.999)for operator 2,0.997(0.995,0.999)for operator 3,0.999(0.998,0.999)for operator 4,and 0.998(0.997,0.999)for operator 5.For interoperator agreement,the overall ICC(95%CI)was 0.977(0.965,0.986;P<0.001)for reading 1,0.974(0.960,0.984;P<0.001)for reading 2,and 0.975(0.961,0.985;P<0.001)for reading 3.CONCLUSION USG measurement of quadriceps muscle thickness was not dependent on clinical experience,supporting training for nurses in it. | Rohit Kumar Tajamul Hussain Shah Vijay Hadda Pawan Tiwari Saurabh Mittal Karan Madan Maroof Ahmad Khan Anant Mohan | 2019 | World Journal of Critical Care Medicine2019，8，7： | 2 |
| 3 | Simplex and duplex PCR assays for species specific identification of cattle and buffalo milk and cheese显示文摘 | Sachinandan De Biswajit Brahma Shamik Polley Ayan Mukherjee Deepak Banerjee Moloya Gohaina Karan Pratap Singh Rameswar Singh Tirtha Kumar Datta Surender Lal Goswami | 2010 | Food Control2010，，5： | 1 |
| 4 | EfFect of acute andchronic administration of Larginine on morphineinduced inhibition of gastrointestinal motility 显示文摘 | Karan RS Kumar R Pandhi P | 2000 | Indian J Physiol Pharmacol2000，44，3： | 1 |
| 5 | Structural and electrochemical characterization of pure LiFePO4 and Nanocomposite C-LiFePO4 cathodes for lithium ion rechargeable batteries显示文摘 | KUMAR A THOMAS R KARAN N K | 2009 | Journal of Nanotechnology2009，，1： | 1 |
| 6 | Influence of sea buckthorn (Hippophae rhamnoides L) flavone on dermal wound healing in rats显示文摘 | Asheesh Gupta Ratan Kumar Karan Pal | 2006 | Molecular and Cellular Biochemistry2006，290，： | 1 |
| 7 | 'Diesel siphoner′s lung': Exogenous lipoid pneumonia following hydrocarbon aspiration显示文摘 | Kavitha Venkatnarayan Karan Madan Ritika Walia Jaya Kumar Deepali Jain Randeep Guleria | 2014 | Lung India2014，，： | 1 |
| 8 | Effect of leaf extract of Seabuckthorn on lipopolysaccharide induced inflammatory response in murine macrophages显示文摘 | Yogendra Padwad Lilly Ganju Monika Jain Sudipta Chanda Dev Karan Pratul Kumar Banerjee Ramesh Chand Sawhney | 2005 | International Immunopharmacology2005，，1： | 1 |
| 9 | Preparation, Characterization, Dielectric, Piezoelectric and Ferroelectric Properties of Yttrium and Praseodymium Doped Lead Titanate Ceramics显示文摘 | Karan Singh Vishal Singh Rashmi Gupta Krishen Kumar Bamzai | 2014 | 材料科学与工程(中英文B版)2014，4，10： | 0 |
| 10 | Diabetes more than retinopathy,it’s effect on the anterior segment of eye显示文摘Diabetes mellitus(DM)is one of the chronic metabolic noncommunicable diseases that has attained worldwide epidemics.It threatens healthy life around the globe,with mild-to-severe secondary complications and leads to significant illness including nephropathy,neuropathy,retinopathy,and macrovascular abnormalities including peripheral vasculopathy,and ischaemic heart disease.Research into diabetic retinopathy(DR),which affects one-third of persons with diabetes,has made considerable strides in recent years.In addition,it can lead to several anterior segment complications such as glaucoma,cataract,cornea,conjunctiva,lacrimal glands and other ocular surface diseases.Uncontrolled DM also caused gradual damage to corneal nerves and epithelial cells,which raises the likelihood of anterior segment diseases including corneal ulcers,dry eye disease,and chronic epithelial abnormalities.Although DR and other associated ocular complications are well-known,the complexity of its aetiology and diagnosis makes therapeutic intervention challenging.Strict glycaemic control,early detection and regular screening,and meticulous management is the key to halting the progression of the disease.In this review manuscript,we aim to provide an in-depth understanding of the broad spectrum of diabetic complications in the anterior segment of the ocular tissues and illustrate the progression of diabetes and its pathophysiology,epidemiology,and prospective therapeutic targets.This first such review article will highlight the role of diagnosing and treating patients with a plethora of anterior segment diseases associated with diabetes,which are often neglected. | Arvind Kumar Morya Prasanna Venkatesh Ramesh Kirandeep Kaur Bharat Gurnani Aarti Heda Karan Bhatia Aprajita Sinha | 2023 | World Journal of Clinical Cases2023，11，16： | 0 |
| 11 | Nonselective beta‐blockers reduce mortality in patients with acute‐on‐chronic liver failure显示文摘Aim:Nonselective beta‐blockers(NSBBs)can reduce the incidence of complications in patients with cirrhosis and prolong survival.The safety and efficacy of NSBBs in real‐world settings in patients with acute‐on‐chronic liver failure(ACLF)identified by the Asian Pacific Association for the Study of Liver criteria are unknown.This study aimed to assess the safety and efficacy of NSBBs in patients with Asian Pacific Association for the Study of Liver(APASL)‐defined ACLF Methods:In this retrospective,multicenter study,patients with ACLF with complete 30 days follow‐up from January 2019 to December 2021 were included.The primary objective was to compare 30‐day mortality among standard of care(SOC)and NSBB(+SOC)groups.The secondary objectives were to compare the incidence of infection,variceal bleed,and recompensation among both the groups.Results:A total of 346 patients were included.Only 26%(n=89)of them received NSBBs,while 74%(n=257)received only SOC.On Kaplan-Meier analysis,the incidence of mortality was 21%(95%confidence interval[CI]:16.20-26.50)in SOC group compared to only 8%(95%CI:3.22-15.53)in NSBB group at Day 30(p=0.005).Similarly,mortality in SOC group was 63%(95%CI:56.81-69.00)compared to 46%(95%CI:35.44-57.00)in NSBB group at 1 year(p=0.001).NSBB therapy could not reduce the incidence of infections or variceal bleed.Forty‐seven percent of patients in the SOC group and 73%of patients in the NSBB group(p<0.001)recompensated.Carvedilol was prescribed in 77.5%and propranolol in 22.5%of patients.Conclusions:NSBBs reduce mortality without any effect on infection or variceal bleed in patients with ACLF.However,only one in four ACLF patients are suitable for NSBB therapy. | Anand V.Kulkarni Madhumita Premkumar Karan Kumar Juned A.Khan Baqar A.Gora Sowmya Tirumalle Sameer Shaik Mithun Sharma Rajesh Gupta Nageshwar D.Reddy Padaki N.Rao | 2022 | Portal Hypertension & Cirrhosis2022，1，1： | 0 |
| 12 | The evolution of sinus surgery in England in the last decade - An observational study显示文摘Background and objective::Sinus surgery has seen significant changes over the years with advancements in instruments,endoscopes and imaging.This study aimed to use Hospital Episode Statistics(HES)data to review the total number of sinus related procedures performed in both adults and children across England and identify whether there were any trends across the study period.We predicted an increase in endoscopic sinus procedures with a decline in open approaches to the paranasal sinuses.Methods::Data from HES was extracted for the years 2010-2019.The operative(OPCS-4)codes relevant to all sinus procedures between E12.1 and E17.9 were analysed.After examination of overall sinus related procedures,further subgroup analysis was performed with regards to open or endoscopic techniques.Results::The total number of sinus procedures performed between 2010 and 2019 was 89,495.There was an increase in endoscopic surgeries by 21.1%and a decrease of open surgeries 35.3%during this time.There was an overall increase in maxillary,frontal and sphenoid sinus procedures,with a decrease in ethmoid sinus and lateral rhinotomy operations.There was an increase in the proportion of endoscopic cases overall by 5.7%and for all sinuses individually.Conclusion::Overall,we see an increase in sinus surgery over the last 9 years from 2010 to 2019.These findings are in keeping with our initial hypotheses.Although our data set is limited by coding,and lack of patient factors,it represents most,if not all,of the data in England over a large study period.It is therefore useful to add to previous studies when demonstrating the increasing popularity of endoscopic sinus surgery over open procedures. | Keshav Kumar Gupta Karan Jolly Navdeep Bhamra Max Sallis Osborne Shahzada Khuram Ahmed | 2021 | World Journal of Otorhinolaryngology-Head and Neck Surgery2021，7，3： | 0 |
| 13 | Cavitary lung lesion 6 years after renal transplantation显示文摘The differential diagnoses of a cavitary lung lesion in renal transplant recipients would include infection, malignancy and less commonly inflammatory diseases. Bacterial infection, Tuberculosis, Nocardiosis, fungal infections like Aspergillosis and Cryptococcosis need to be considered in these patients. Pulmonary cryptococcosis usually presents 16-21 mo after transplantation, more frequently in patients who have a high level of cumulative immunosuppression. Here we discuss an interesting patient who never received any induction/anti-rejection therapy but developed both BK virus nephropathy as well as severe pulmonary Cryptococcal infection after remaining stable for 6 years after transplantation. This case highlights the risk of serious opportunistic infections even in apparently low immunologic risk transplant recipients many years after transplantation. | Arun Kumar Subbiah Sudheer Arava Soumita Bagchi Karan Madan Chandan J Das Sanjay Kumar Agarwal | 2016 | World Journal of Transplantation2016，6，2： | 0 |
| 14 | Implantable photoelectronic charging(I-PEC)for medical implants显示文摘Medical implants with functionalities such as sensing,health monitoring,stimulation,diagnosis,and physiological treatment are rapidly growing.With the increasing functional sophistication and addition of modules such as data transmission,on-chip processing,and data storage,energy demand of the implantable system is also growing.Using implantable energy harvester either to recharge or ultimately replace hazardous battery is essential to provide a long-term sustainable solution.Energy harvesting techniques using piezoelectric,thermoelectric,radio frequency power transmission,biofuel,and photoelectronic(or sometimes termed as“photovoltaic”in terms of solar light harvesting,i.e.,PV)conversion,have been attempted for the implantable,but these methods are currently limited by insufficient power output,large footprint,and low efficiency.Nevertheless,the planar PV with potential of lighter weight,higher energy density,and higher efficiency,provides promising power solution for in-body medical implants.In this short review,we will discuss the potential opportunities and challenges associated with PV's for medical implants,covering materials,to devices,and to system level requirements. | Kai Wang Sumanta Kumar Karan Mohan Sanghadasa Congcong Wu Shashank Priya | 2022 | Energy Reviews2022，1，2： | 0 |
| 15 | Development of prosthetic arm using body actioned SEMG signals显示文摘People's working capability is badly affected when they sufer an amputated arm.Artifcial replacements with prosthetic devices to get a satisfactory level of performance for essential functions with the currently available prosthetic technology are very dificult.Myoelectric arm prostheses are becoming popular because they are operated by a natural contraction of intact muscles.Hence,SEMG based artifdal arm was fabricated.The system cousists of diferent electronic and mechanical assemblies for operation of hand utilizing microcontroller in order to have minimum signal loss during its processing.With the hep of relay switching connected to low power DC motor,system is capable of opening and closing of grip according to individual wish. | Karan Veer Tanu Sharma Amod Kumar | 2016 | Journal of Innovative Optical Health Sciences2016，9，6： | 0 |
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