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| 1 | Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells显示文摘Artemisinin 对药抵抗的疟疾的寄生虫是高度有效的,它将近影响全球人口和杀死的一半 > 500 000 个人每年。artemisinin 的主要费用是过去常从 Artemisia annua 提取并且净化这药的昂贵的过程。这显然不必要的步的消除将在地方性的区域使这有势力抗疟药药买得起到全球人口生活。这里,我们报导了非蛋白质药 artemisinin biosynthesized 的口头的交货(0.8 mg/g 干燥重量) 在在由设计二的烟草的临床上有意义的层次,新陈代谢的小径指向了到三不同细胞的分隔空间(叶绿体,原子核,和线粒体) 。二倍地转基因的线显示出 isopentenyl 焦磷酸盐的三方面的改进,并且指向 AACPR, DBR2,和 CYP71AV1 到叶绿体导致了更高的表示和 dihydroartemisinic 酸的有效相片氧化到 artemisinin。从转基因的烟草植物的叶子的部分净化的摘录在变形体感染 falciparum 的红血房间的 vitro 生长前进禁止了。artemisinin 减少了的整个未经触动的植物房间 bioencapsulating 的口头的喂在与商业药比较的质问老鼠的 parasitemia 层次。如此的新奇 synergistic 途径应该通过可食的植物的新陈代谢的工程便于 artemisinin 和另外的药的便宜生产和交货。 | Karan Malhotra Mayavan Subramaniyan Khushboo Rawat Md. Kalamuddin M. Irfan Qureshi Pawan Malhotra Asif Mohmmed Katrina Cornish Henry Daniell Shashi Kumar1 | 2016 | Molecular Plant2016，9，11： | 14 |
| 2 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 3 | Defining the advantages and exposing the limitations of endoscopic variceal ligation in controlling acute bleeding and achieving complete variceal eradication显示文摘BACKGROUND Bleeding esophageal varices(BEV)is a potentially life-threatening complication in patients with portal hypertension with mortality rates as high as 25%within six weeks of the index variceal bleed.After control of the initial bleeding episode patients should enter a long-term surveillance program with endoscopic intervention combined with non-selectiveβ-blockers to prevent further bleeding and eradicate EV.AIM To assess the efficacy of endoscopic variceal ligation(EVL)in controlling acute variceal bleeding,preventing variceal recurrence and rebleeding and achieving complete eradication of esophageal varices(EV)in patients who present with BEV.METHODS A prospectively documented single-center database was used to retrospectively identify all patients with BEV who were treated with EVL between 2000 and 2018.Control of acute bleeding,variceal recurrence,rebleeding,eradication and survival were analyzed using Baveno assessment criteria.RESULTS One hundred and forty patients(100 men,40 women;mean age 50 years;range,21-84 years;Child-Pugh grade A=32;B=48;C=60)underwent 160 emergency and 298 elective EVL interventions during a total of 928 endoscopy sessions.One hundred and fourteen(81%)of the 140 patients had variceal bleeding that was effectively controlled during the index banding procedure and never bled again from EV,while 26(19%)patients had complicated and refractory variceal bleeding.EVL controlled the acute sentinel variceal bleed during the first endoscopic intervention in 134 of 140 patients(95.7%).Six patients required balloon tamponade for control and 4 other patients rebled in hospital.Overall 5-d endoscopic failure to control variceal bleeding was 7.1%(n=10)and four patients required a salvage transjugular intrahepatic portosystemic shunt.Index admission mortality was 14.2%(n=20).EV were completely eradicated in 50 of 111 patients(45%)who survived>3 mo of whom 31 recurred and 3 rebled.Sixteen(13.3%)of 120 surviving patients subsequently had 21 EV rebleeding episodes and 10 patients bled from other sources after discharge from hospital.Overall rebleeding from all sources after 2 years was 21.7%(n=26).Sixty-nine(49.3%)of the 140 patients died,mainly due to liver failure(n=46)during follow-up.Cumulative survival for the 140 patients was 71.4%at 1 year,65%at 3 years,60%at 5 years and 52.1%at 10 years.CONCLUSION EVL was highly effective in controlling the sentinel variceal bleed with an overall 5-day failure to control bleeding of 7.1%.Although repeated EVL achieved complete variceal eradication in less than half of patients with BEV,of whom 62%recurred,there was a significant reduction in subsequent rebleeding. | Jake Krige Eduard Jonas Urda Kotze Christo Kloppers Karan Gandhi Hisham Allam Marc Bernon Sean Burmeister Mashiko Setshedi | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，10： | 10 |
| 4 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 5 | PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis显示文摘Prostaglandin E2(PGE2), a major cyclooxygenase-2(COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis(OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of novel drug targets of PGE2 signaling in OA progression is urgently needed. Osteoclasts play a critical role in subchondral bone homeostasis and OA-related pain. However, the mechanisms by which PGE2 regulates osteoclast function and subsequently subchondral bone homeostasis are largely unknown. Here, we show that PGE2 acts via EP4 receptors on osteoclasts during the progression of OA and OA-related pain. Our data show that while PGE2 mediates migration and osteoclastogenesis via its EP2 and EP4 receptors, tissue-specific knockout of only the EP4 receptor in osteoclasts(EP4 Lys M) reduced disease progression and osteophyte formation in a murine model of OA. Furthermore, OA-related pain was alleviated in the EP4 Lys M mice, with reduced Netrin-1 secretion and CGRP-positive sensory innervation of the subchondral bone. The expression of plateletderived growth factor-BB(PDGF-BB) was also lower in the EP4 Lys Mmice, which resulted in reduced type H blood vessel formation in subchondral bone. Importantly, we identified a novel potent EP4 antagonist, HL-43, which showed in vitro and in vivo effects consistent with those observed in the EP4 Lys Mmice. Finally, we showed that the Gαs/PI3 K/AKT/MAPK signaling pathway is downstream of EP4 activation via PGE2 in osteoclasts. Together, our data demonstrate that PGE2/EP4 signaling in osteoclasts mediates angiogenesis and sensory neuron innervation in subchondral bone, promoting OA progression and pain, and that inhibition of EP4 with HL-43 has therapeutic potential in OA. | Wenhao Jiang Yunyun Jin Shiwei Zhang Yi Ding Konglin Huo Junjie Yang Lei Zhao Baoning Nian Tao PZhong Weiqiang Lu Hankun Zhang Xu Cao Karan Mehul Shah Ning Wang Mingyao Liu Jian Luo | 2022 | Bone Research2022，10，2： | 7 |
| 6 | Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated: a prospective study using patient-reported outcome measures显示文摘我们试图在有一般麻药 transperineal (TP ) 的男人决定短期的报导病人的结果前列腺活体检视。未来的队研究在有诊断 TP 活体检视的男人被执行。这用立即活体检视以后的一张验证并且适应的问询表并且在后续被做在越过三个第三级的工作分派的 7 和 14 天之间,有回答的医院 51.6% 评价。立即,在活体检视以后,人的 43/201 (21.4%) 感觉到头昏眼花, syncopal,或承受中略。百分之 53 个人在活体检视以后感到了不快(与 95% 得分 < 5 在 0-10 规模) 。12 在过程以后立即从 196 个人(6.1%) 感到了疼痛。尽管有症状的高发生(例如直到 75% 有的一些血尿症, 47% 得了一些疼痛) ,它不是为大多数的一个中等或严重的问题,除了 31 个人承受了的 hemoejaculate。十一个人需要 catheterization (5.5%) 。由于复杂并发症没有住院病人录取(血尿症,败血) 。在重复在一个以后的时间点询问以后,仅仅人的 25/199 (12.6%) 说尽管有重要、显著的减小,重复活体检视将是一个重要问题。从这研究,我们断定那 TP 活体检视很好与类似的副作用侧面和人的态度被容忍重复活体检视到有 TRUS 活体检视的人。这些数据给予与局部麻醉 TP 活体检视为 tolerability 在 TP 活体检视和一个基准以前人建议通知为临床的使用正在被开发。 | Karan Wadhwa Lina Carmona-Echeveria Timur Kuru Gabriele Gaziev Eva Serrao Deepak Parasha Julia Frey Ivailo Dimov Jonas Seidenader Pete Acher Gordon Muir Andrew Doble Vincent Gnanapragasam Boris Hadaschik Christof Kastner | 2017 | Asian Journal of Andrology2017，19，1： | 5 |
| 7 | Weed Recognition Using Image-Processing Technique Based on Leaf Parameters显示文摘 | Kamal N. Agrawal Karan Singh Ganesh C. Bora Dongqing Lin | 2012 | Journal of Agricultural Science and Technology(B)2012，2，8： | 5 |
| 8 | Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway显示文摘Alzheimer’s disease(AD),the predominant form of dementia,is a chronic,incurable neurodegenerative disorder presenting with symptoms includ-ing progressive memory loss and disturbed emotional state.It has been estimated that dementia affects over 47 million people worldwide(Prince et al.,2015),and with 60–80%of cases attributable to AD.The primary pathological hallmarks of AD are neuronal death,the deposition of insolu-ble amyloid-beta(Aβ)plaques,the accumulation of hyperphosphorylated tau neurofibrillary tangles(NFTs),and the widespread dysregulation | Andrea Kwakowsky Beatriz Calvo-Flores Guzman Karan Govindpani Henry J. Waldvogel Richard L. Faull | 2018 | Neural Regeneration Research2018，13，8： | 4 |
| 9 | Toward point-of-care assessment of patient response:a portable tool for rapidly assessing cancer drug efficacy using multifrequency impedance cytometry and supervised machine learning显示文摘We present a novel method to rapidly assess drug efficacy in targeted cancer therapy,where antineoplastic agents are conjugated to antibodies targeting surface markers on tumor cells.We have fabricated and characterized a device capable of rapidly assessing tumor cell sensitivity to drugs using multifrequency impedance spectroscopy in combination with supervised machine learning for enhanced classification accuracy.Currently commercially available devices for the automated analysis of cell viability are based on staining,which fundamentally limits the subsequent characterization of these cells as well as downstream molecular analysis.Our approach requires as little as 20μL of volume and avoids staining allowing for further downstream molecular analysis.To the best of our knowledge,this manuscript presents the first comprehensive attempt to using high-dimensional data and supervised machine learning,particularly phase change spectra obtained from multi-frequency impedance cytometry as features for the support vector machine classifier,to assess viability of cells without staining or labelling. | Karan Ahuja Gulam M.Rather Zhongtian Lin Jianye Sui Pengfei Xie Tuan Le Joseph R.Bertino Mehdi Javanmard | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 10 | 2006年碳市场发展状况与趋势分析(第1~3季度)显示文摘执行总结
碳市场总价值在2006年前三季度增长到215亿美元。比上年上涨一倍有余(见表格一)。全球碳市场主要以欧盟排放交易体系(EUETS)为主,且成功摆脱了由于2006年5月核证减排量数据公布而引起的交易价格下滑、市场疲软的局面。同时,基于项目的市场总值也在今年的前九个月增至24亿1000万美元。 | Karan Capoor Philippe Ambrosi | 2006 | 世界环境2006，，6： | 4 |
| 11 | Vascular dysfunction in Alzheimer’s disease: a biomarker of disease progression and a potential therapeutic target显示文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the predominant form of dementia.Since its initial description by Alois Alzheimer in 1906,several advances have been made in our understanding of the progression of the disease and its clinical consequences,yet the underlying etiology remains contentious.Given the stereotyped patterns of cortical and hippocampal neuronal loss and the progressive degeneration of key neurotransmitter pathways,research has traditionally been focused on factors affecting neuronal viability,including the contribution of glial dysfunction to neuronal degeneration.From a clinical perspective,the fruits of this work have been underwhelming.Key pathological markers of the disease,includingβ-amyloid(Aβ)plaque formation and tau hyperphosphorylation,have yielded no effective therapies,highlighted by the recent discontinuations of several high profile Aβimmunotherapy trials.The few current symptomatic therapies for AD are predicated on the amelioration of cholinergic or glutamatergic dysfunction.Aside from underscoring the inadequacy of current therapeutic approaches,this also points to the importance of alternative contributors to AD pathogenesis.In recent years,there has been a growing appreciation for the multimodal and multifactorial nature of the condition;the case for combinatorial therapies is thus strong. | Karan Govindpani Chitra Vinnakota Henry J.waldvogel Richard L.Faull Andrea Kwakowsky | 2020 | Neural Regeneration Research2020，15，6： | 3 |
| 12 | 有机小分子发光材料与聚合物发光材料在大气存放条件下的稳定性对比研究显示文摘分别采用紫外光电子能谱 (UPS)、X光电子能谱 (XPS)、原子力显微镜 (AFM )、以及光致发光光谱(PL)等方法对在大气存放条件下的 8 羟基喹啉铝 (Alq)薄膜和聚 ( 9,9 二辛烷基芴 ) (PFO)薄膜的电子结构、表面形貌以及发光特性进行了对比研究。研究结果表明 ,PFO的电子结构、表面形貌以及发光特性受外界气氛影响极小 ,是一种非常稳定的聚合物发光材料。这为聚合物发光器件的稳定性提供了有利的条件。 | 徐正 廖良生 李振声 李述汤 Inbase karan M Woo E P Wu W W | 2000 | 发光学报2000，21，3： | 3 |
| 13 | A rapid solid-state synthesis of electrochemically active Chevrel phases (Mo6T8; T = S, Se) for rechargeable magnesium batteries显示文摘 | Partha Saha Prashanth H. Jampani Moni K. Datta Daeho Hong Bharat Gattu Prasad Patel Karan S. Kadakia Ayyakkannu Manivannan Prashant N. Kumta | 2017 | Nano Research2017，10，12： | 2 |
| 14 | Performance characteristics of retrograde single-balloon endoscopy: A single center experience显示文摘AIM: To evaluate the technical success, diagnostic yield(DY) and therapeutic potential of retrograde single balloon enteroscopy(rS BE). METHODS: A retrospective review of 136 rS BE procedures performed at a tertiary academic referral center from January 2006 and September 2013 was completed. Patient characteristics including age, gender and inpatient status were collected. The indication for the procedure was categorized into one of three groups: Obscure gastrointestinal bleeding(GIB), evaluation for Crohn's disease and abnormal imaging. Procedural characteristics including insertion depth(ID), procedure time, concordance with pre-procedural imaging and complications were also recorded. Lastly, DY, defined as the percentage of cases producing either a definitive diagnosis or findings that could explain clinical symptoms and therapeutic yield(TY), defined as the percentage of cases in which a definitive intervention was performed, were determined. Mucosal tattooing and biopsy alone were not included in the TY. RESULTS: A total of 136 rS BE procedures were identified. Mean patient age was 57.5(± 16.2) years, 67(49.2%) were male, and 110(80.9%) procedures were performed on an outpatient basis. Indications for rS BE included GIB in 55(40.4%), evaluation of inflammatory bowel disease(IBD) in 29(21.3%), and imaging suggestive of pathology other than GIB or IBD in 43(31.6%). Nine(6.6%) rS BEs were performed for other indications. Mean ID was 68.3(± 39.3) cm proximal to the ileocecal valve and mean time to completion was 41.7(± 15.5) min. Overall, 73(53.7%) cases were diagnostic and 25(18.4%) cases were therapeutic in which interventions(argon plasma coagulation, stricture dilatation, polypectomy, etc.) were performed. Pre-procedural imaging was performed in 88(64.7%) patients. Endoscopic concordance of positive imaging findings was seen in 31(35.2%) cases. Follow up data was available in 93(68.4%) patients; 2(2.2%) reported post-procedural abdominal pain within 30 d following rS BE. There were no other reported complications. CONCLUSION: rS BE exhibits an acceptable diagnostic and TY, rendering it a safe and effective procedure for the evaluation and treatment of small bowel diseases. | Kaci E Christian Karan Kapoor Eric M Goldberg | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，15： | 2 |
| 15 | Effect of Six-Food Elimination Diet on Clinical and Histologic Outcomes in Eosinophilic Esophagitis显示文摘 | Amir F. Kagalwalla Timothy A. Sentongo Sally Ritz Therese Hess Suzanne P. Nelson Karan M. Emerick Hector Melin–Aldana B.U.K. Li | 2006 | Clinical Gastroenterology and Hepatology2006，，： | 2 |
| 16 | The Prognostic Value of MicroRNAs Varies with Patient Race/Ethnicity and Stage of Colorectal Cancer显示文摘 | Liselle C. Bovell Chandrakumar Shanmugam Balananda-Dhurjati K. Putcha Venkat R. Katkoori Bin Zhang Sejong Bae Karan P. Singh William E. Grizzle Upender Manne | 2013 | Clinical Cancer Research2013，，14： | 2 |
| 17 | "Malignant" right coronary artery presenting as an ST-segment elevation myocardial infarction -a case report显示文摘 | Cherisse Baldeo Karan Seegobin Dmitry Yaranov Fabiana Rollini | 2018 | Journal of Geriatric Cardiology2018，15，6： | 2 |
| 18 | Advancing dental implants:Bioactive and therapeutic modifications of zirconia显示文摘Zirconium-based implants have gained popularity in the dental implant field owing to their corrosion resistance and biocompatibility,attributed to the formation of a native zirconia(ZrO_(2))film.However,enhanced bioactivity and local therapy from such implants are desirable to enable the earlier establishment and improved long-term maintenance of implant integration,especially in compromised patient conditions.As a result,surface modification of zirconium-based implants have been performed using various physical,chemical and biological techniques at the macro-,micro-,and nano-scales.In this extensive review,we discuss and detail the development of Zr implants covering the spectrum from past and present advancements to future perspectives,arriving at the next generation of highly bioactive and therapeutic nano-engineered Zr-based implants.The review provides in-depth knowledge of the bioactive/therapeutic value of surface modification of Zr implants in dental implant applications focusing on clinical translation. | Divya Chopra Anjana Jayasree Tianqi Guo Karan Gulati Saso Ivanovski | 2022 | Bioactive Materials2022，7，7： | 2 |
| 19 | Plasma Pulse Technology: An uprising EOR technique显示文摘Conventionally oil recovery factor is too low,which leaves great prospects for the application of enhanced oil recovery(EOR)methods to increase recovery factor.EOR methods are capital intensive and few are environmentally hazardous.So the paper discusses on the alternate enhanced oil recovery technique which has tremendous potential to curb the challenges of conventional EOR methods.Plasma pulse technology(PPT)aided EOR treatment is administered with an electric wireline conveyed plasma pulse generator tool that is run in the well and positioned alongside the perforations.Using energy stored in the generator's capacitors,a plasma arc is created that emits a tremendous amount of heat and pressure for a fraction of a second.This in turn creates a broad band of hydraulic impulse acoustic waves that are powerful enough to clean perforations and near wellbore damage.These waves continue to resonate deep into the reservoir,exciting the fluid molecules and increasing the reservoirs natural resonance to the degree that it can break larger hydrocarbon molecules to smaller one and simultaneously reducing adhesion tension which results in increased mobility of hydrocarbons.The plasma pulse technology has been successfully used on production as well as injection wells.It has been used often as a remedial procedure to increase well's productivity that has been on production for a period of time.This paper throws light on fundamentals of this advancing plasma pulse technology,contrasting it with recent EOR techniques.Effectiveness of treatment in increasing oil recovery,it's applicability to different reservoir types and results achieved so far are also covered in the paper. | Karan Patel Manan Shah Anirbid Sircar | 2018 | Petroleum Research2018，3，2： | 2 |
| 20 | Assessment of quadriceps muscle thickness using bedside ultrasonography by nurses and physicians in the intensive care unit:Intra- and inter-operator agreement显示文摘BACKGROUND Data regarding the agreement among multiple operators for measurement of quadriceps muscle thickness by bedside ultrasonography(USG)are sparse.AIM To statistically assess the agreement among 5 operators for measurement of quadriceps muscle thickness on bedside USG.METHODS This was a cross-sectional observational study.The 5 operators of varied experience(comprised of 1 critical care consultant,2 fellows,and 2 nurses)independently measured quadriceps muscle thickness in triplicate for 45 critically ill patients each,using USG.Intra-and interrater agreement rates among the 5 operators were assessed using intraclass correlation coefficient(ICC)and expressed with 95%confidence interval(CI).RESULTS The 5 operators produced a total of 135 readings and 675 observations for ICC calculations to determine the intraoperator and interoperator variations respectively.For intraoperator agreement,the overall ICC(95%CI)was 0.998(0.997,0.999)for operator 1,0.998(0.997,0.999)for operator 2,0.997(0.995,0.999)for operator 3,0.999(0.998,0.999)for operator 4,and 0.998(0.997,0.999)for operator 5.For interoperator agreement,the overall ICC(95%CI)was 0.977(0.965,0.986;P<0.001)for reading 1,0.974(0.960,0.984;P<0.001)for reading 2,and 0.975(0.961,0.985;P<0.001)for reading 3.CONCLUSION USG measurement of quadriceps muscle thickness was not dependent on clinical experience,supporting training for nurses in it. | Rohit Kumar Tajamul Hussain Shah Vijay Hadda Pawan Tiwari Saurabh Mittal Karan Madan Maroof Ahmad Khan Anant Mohan | 2019 | World Journal of Critical Care Medicine2019，8，7： | 2 |
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