维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

1篇 您的检索式：作者名="Sameer Shaik"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Nonselective beta‐blockers reduce mortality in patients with acute‐on‐chronic liver failure显示文摘Aim:Nonselective beta‐blockers(NSBBs)can reduce the incidence of complications in patients with cirrhosis and prolong survival.The safety and efficacy of NSBBs in real‐world settings in patients with acute‐on‐chronic liver failure(ACLF)identified by the Asian Pacific Association for the Study of Liver criteria are unknown.This study aimed to assess the safety and efficacy of NSBBs in patients with Asian Pacific Association for the Study of Liver(APASL)‐defined ACLF Methods:In this retrospective,multicenter study,patients with ACLF with complete 30 days follow‐up from January 2019 to December 2021 were included.The primary objective was to compare 30‐day mortality among standard of care(SOC)and NSBB(+SOC)groups.The secondary objectives were to compare the incidence of infection,variceal bleed,and recompensation among both the groups.Results:A total of 346 patients were included.Only 26%(n=89)of them received NSBBs,while 74%(n=257)received only SOC.On Kaplan-Meier analysis,the incidence of mortality was 21%(95%confidence interval[CI]:16.20-26.50)in SOC group compared to only 8%(95%CI:3.22-15.53)in NSBB group at Day 30(p=0.005).Similarly,mortality in SOC group was 63%(95%CI:56.81-69.00)compared to 46%(95%CI:35.44-57.00)in NSBB group at 1 year(p=0.001).NSBB therapy could not reduce the incidence of infections or variceal bleed.Forty‐seven percent of patients in the SOC group and 73%of patients in the NSBB group(p<0.001)recompensated.Carvedilol was prescribed in 77.5%and propranolol in 22.5%of patients.Conclusions:NSBBs reduce mortality without any effect on infection or variceal bleed in patients with ACLF.However,only one in four ACLF patients are suitable for NSBB therapy.	Anand V.Kulkarni Madhumita Premkumar Karan Kumar Juned A.Khan Baqar A.Gora Sowmya Tirumalle Sameer Shaik Mithun Sharma Rajesh Gupta Nageshwar D.Reddy Padaki N.Rao	2022	Portal Hypertension & Cirrhosis2022，1，1：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费