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| 1 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 2 | Oct4 links multiple epigenetic pathways to the pluripotency network显示文摘Oct4 是在干细胞自强, pluripotency,和体的房间 reprogramming 起基本作用的一个著名抄写因素。然而,有限信息在联系 Oct4 的蛋白质建筑群和他们支配 Oct4 的批评规章的活动的内在的蛋白质蛋白质相互作用上是可得到的。这里,我们采用了与集体 spectrometry 相结合在老鼠净化 Oct4 蛋白质建筑群的一条改进亲密关系纯化途径胚胎的干细胞(mESCs ) ,并且发现了为 mESCs 的自强和 pluripotency 重要的许多新奇 Oct4 搭挡。尤其是,我们发现那 Oct4 与多重修改染色质的建筑群被联系与记录以及最新在干细胞维护和体的房间 reprogramming 证明意义功能。我们的学习建立一个稳固的生物化学的基础为基因并且干细胞 pluripotency 的 epigenetic 规定并且为探索其他的基于因素的 reprogramming 策略提供一个框架。 | Junjun Ding HuileiXu Francesco Faiola Avi Ma'ayan Jianlong Wang | 2012 | Cell Research2012，22，1： | 6 |
| 3 | 我国贸易扩张的源泉:外延边际与内延边际——多样性的度量与经济增长的贡献率显示文摘基于Feenstra等人的理论方法,本文利用2000-2007年相关年份数据度量我国省份国际贸易增长的两个源泉——外延边际和内延边际,体现贸易多样性的外延边际成为我国出口贸易的显著因素,略高于内延边际;实证发现新兴工业国逐渐成为我国贸易多样性拉动增长的重要新市场。在多样性增长的影响变量方面,贸易显性或掩性壁垒成为限制因素,中小企业的贡献显著,外资进入和市场化改革则成为其拉动力量。贸易多样性对经济增长率的贡献成为传统要素(资本和劳动力)后的第三大因素。 | 赵永亮 Ayan | 2010 | 国际贸易问题2010，，9： | 6 |
| 4 | Islet cell dysfunction in patients with chronic pancreatitis显示文摘Chronic pancreatitis(CP)is characterized by progressive inflammation and fibrosis of the pancreas that eventually leads to pancreatic exocrine and endocrine insufficiency.Diabetes in the background of CP is very difficult to manage due to high glycemic variability and concomitant malabsorption.Progressive beta cell loss leading to insulin deficiency is the cardinal mechanism underlying diabetes development in CP.Alpha cell dysfunction leading to deranged glucagon secretion has been described in different studies using a variety of stimuli in CP.However,the emerging evidence is varied probably because of dependence on the study procedure,the study population as well as on the stage of the disease.The mechanism behind islet cell dysfunction in CP is multifactorial.The intra-islet alpha and beta cell regulation of each other is often lost.Moreover,secretion of the incretin hormones such as glucagon like peptide-1 and glucose-dependent insulinotropic polypeptide is dysregulated.This significantly contributes to islet cell disturbances.Persistent and progressive inflammation with changes in the function of other cells such as islet delta cells and pancreatic polypeptide cells are also implicated in CP.In addition,the different surgical procedures performed in patients with CP and antihyperglycemic drugs used to treat diabetes associated with CP also affect islet cell function.Hence,different factors such as chronic inflammation,dysregulated incretin axis,surgical interventions and anti-diabetic drugs all affect islet cell function in patients with CP.Newer therapies targeting alpha cell function and beta cell regeneration would be useful in the management of pancreatic diabetes in the near future. | Ayan Roy Jayaprakash Sahoo Sadishkumar Kamalanathan Dukhabandhu Naik Pazhanivel Mohan Biju Pottakkat | 2020 | World Journal of Diabetes2020，11，7： | 5 |
| 5 | Diabetes and pancreatic cancer:Exploring the two-way traffic显示文摘Pancreatic cancer(PC)is often associated with a poor prognosis.Long-standing diabetes mellitus is considered as an important risk factor for its development.This risk can be modified by the use of certain antidiabetic medications.On the other hand,new-onset diabetes can signal towards an underlying PC in the elderly population.Recently,several attempts have been made to develop an effective clinical tool for PC screening using a combination of history of new-onset diabetes and several other clinical and biochemical markers.On the contrary,diabetes affects the survival after treatment for PC.We describe this intimate and complex two-way relationship of diabetes and PC in this review by exploring the underlying pathogenesis. | Ayan Roy Jayaprakash Sahoo Sadishkumar Kamalanathan Dukhabandhu Naik Pazhanivel Mohan Raja Kalayarasan | 2021 | World Journal of Gastroenterology2021，27，30： | 3 |
| 6 | Absolute copy number differences of Y chromosomal genes between crossbred (Bos taurus×Bos indicus) and Indicine bulls显示文摘Background: The Y chromosome in mammal is paternally inherited and harbors genes related to male fertility and spermatogenesis. The unique intra-chromosomal recombination pattern of Y chromosome and morphological difference of this chromosome between Bos taurus and Bos indicus make it an ideal model for studying structural variation, especially in crossbred(Bos taurus × Bos indicus) bulls. Copy Number Variation(CNV) is a type of genomic structural variation that gives information complementary to SNP data. The purpose of this study was to find out copy number differences of four Y chromosomal spermatogenesis-related candidate genes in genomic DNA of crossbred and purebred Indicine bulls. Result: Four Y chromosomal candidate genes of spermatogenesis namely, sex determining gene on Y chromosome(SRY), DEAD box polypeptide 3-Y chromosome(DDX3Y), Ubiquitin specific peptidase 9, Y-linked(USP9Y), testis-specific protein on Y chromosome(TSPY) were evaluated. Absolute copy numbers of Y chromosomal genes were determined by standard curve-based quantitative real time PCR. Copy numbers of SRY and TSPY genes per unit amount of genomic DNA are higher in crossbred than Indicine bulls. However, no difference was observed in DDX3Y and USP9Y gene copy numbers between two groups. Conclusion: The present study demonstrates that the structural organization of Y chromosomes differs between crossbred and Indicine bulls which are reproductively healthy as observed from analysis of semen attributes. The absolute copy numbers of SRY and TSPY genes in unit mass of genomic DNA of crossbred bulls are significantly higher than Indicine bulls. No alteration in absolute copies of DDX3Y and USP9Y gene was found between the genome of crossbred and Indicine bulls. This study suggests that the DDX3Y and USP9Y are likely to be single copy genes in the genome of crossbred and Indicine bulls and variation in Y chromosome length between crossbred and Indicine bulls may be due to the copy number variation of SRY gene and TSPY array. | Ayan Mukherjee Gulshan Dass Jagan Mohanarao G Moloya Gohain Biswajit Brahma Tirtha Kumar Datta Sachinandan De | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 7 | Analysis of an outbrak due to Chryseobacterium meningosepticum in a neonatal intensive care unit显示文摘 | TEKEREKOGLU M S DURMAZ R AYAN M | 2003 | New Microbiol2003，26，1： | 1 |
| 8 | Treatment of type Ⅲ A open fractures of tibial shaft with Ilizamv external fixator versus unreamed tibial nailing显示文摘 | Inan M Halici M Ayan I | 2007 | Arch Orthop Trauma Surg2007，8，： | 1 |
| 9 | Simple scanning semiconductor diode laser source and its application in wavelength modulation spectroscopy around 825nm显示文摘 | Ayan Ray Amitava Bandyopadhyay Sanka De | 2005 | Optics & Laser Technology2005，，： | 1 |
| 10 | Bacteriological, ctinicad and epidemi- ological characteristics of hospital acquired Acinetobacter baumannii infec- tion in a teaching hospita显示文摘 | Ayan M Durmaz R Aktas E d | 2003 | J Hosp Infect2003，54，1： | 1 |
| 11 | FPGA Realization of a CORDIC-based FFT Processor for Biomedical Signal Processing显示文摘 | Banerjee Ayan Sundar Dhar Anindya | 2001 | Microprocessors and Microsystems2001，25，3： | 1 |
| 12 | Effects of two different exercise programs on gait parameters in individuals with Parkinson's disease: a pilot study显示文摘 | Ayan C Cancela JM Gutierrez-Santiago A | 2014 | Gait Posture2014，39，1： | 1 |
| 13 | FPGA realization of a CORDIC based FFT processor for biomedical signal processing显示文摘 | Banerjee Ayan Sundar Dhar Anindya | 2001 | Microprocessors and Microsystems2001，25，3： | 1 |
| 14 | The effects of longterm oral administration of L-arginine on the erectile response of rabbits with alloxan induced diabetes显示文摘 | Yildirim S Ayan S Sarioglu Y | 1999 | BJU Int1999，83，6： | 1 |
| 15 | Parameter optimization on compressive strength of steel fiber reinforced high strength concrete 显示文摘 | Ayan E Saatciolu 0 Turanli L | 2011 | Construction and Building Materials2011，，25： | 1 |
| 16 | Simplex and duplex PCR assays for species specific identification of cattle and buffalo milk and cheese显示文摘 | Sachinandan De Biswajit Brahma Shamik Polley Ayan Mukherjee Deepak Banerjee Moloya Gohaina Karan Pratap Singh Rameswar Singh Tirtha Kumar Datta Surender Lal Goswami | 2010 | Food Control2010，，5： | 1 |
| 17 | The effect of N-acetyl cysteine on serum glutathione,TNF-alpha and tissue malondialde- hyde levels in the treatment of sepsis显示文摘 | GUL M AYAN M SEYDANOGLU A | 2011 | Ulus Travma Acil Cerrahi Derg2011，17，4： | 1 |
| 18 | Imaging of Extranodal Lymphoma With PET/CT显示文摘 | Ahmet Turan Ilica Kenan Kocacelebi Recep Savas Asli Ayan | 2011 | Clinical Nuclear Medicine2011，，10： | 1 |
| 19 | Effects of tirofiban main-tenance duration on myocardial perfusion defect severity in ante- riormyocardial infarction显示文摘 | TAS MH SIMSEK Z AYAN A | 2013 | Adv Ther2013，30，9： | 1 |
| 20 | Initial experience of 3 tesla appar-ent diffusion coefficient values in differentiating benign and malig-nant thyroid nodules显示文摘 | Ilica AT Artas H Ayan A | 2013 | J Magn Reson Imaging2013，37，： | 1 |
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