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| 1 | Torque teno virus:Its prevalence and isotypes in North India显示文摘AIM: To investigate the prevalence and genotype dis-tribution of Torque teno virus (TTV) in patients with different liver diseases and chronic renal failure treated at a referral hospital in North India. METHODS: Whereas prevalence of TTV was based on amplification of conserved region of ORF2 of TTV genome,the genotyping of TTV was carried out using restriction fragment length polymorphism (RFLP) procedure on the N22 region of ORF1. RESULTS: TTV-DNA was detected in 137 of 513 (26.7%) patients with liver diseases and 38 of 65 (58.5%) patients with chronic renal failure. TTV was also detected in 27% of healthy controls. The sequence analysis of the PCR product from 10 randomly selected cases failed to show a significant sequence divergence when compared with that of the TRM1 isolate of TTV genotype 1. The results of genotyping in 55 randomly selected patients showed the presence of genotype 1 (G1) in 53 (96.4%) and genotype 2 (G2) in 2 cases (3.6%),respectively. Other genotypes were not identified in this patient subgroup,suggesting that G1 is predominant in this area. The results of genotyping by RFLP were also supported by phylogenetic tree analysis,where G1 was found to be the major genotype. CONCLUSION: These results indicate that TTV is moderately present in Indian patients,with G1 to be the major genotype in North India. The pathogenicity and etiological role of TTV in different diseases is still a question mark and warrant further studies. | Mohammad Irshad Shiwani Singh Khushboo Irshad Sanjay Kumar Agarwal Yogendra Kumar Joshi | 2008 | World Journal of Gastroenterology2008，14，39： | 5 |
| 2 | Intestinal permeability and its association with the patient and disease characteristics in Crohn's disease显示文摘AIM:To assess the intestinal permeability (IP) in patients with Crohn's disease (CD) and study the association of IP with the patient and disease characteristics. METHODS: One hundred and twenty five consecutive patients of CD (Males: 66) were diagnosed on the basis of a combination of standard clinical, endoscopic, imaging and histological features. CD activity index (CDAI) was used to calculate the activity of the disease while the behavior of the disease was assessed by the modified Montreal classification. IP was measured by the ratio of the percentage excretion of ingested doses of lactulose and mannitol in urine (LMR). The upper limit of normality of LMR (0.037) was derived from 22 healthy controls. RESULTS: Thirty six percent of patients with CD had increased IP. There was no significant difference in mannitol excretion (patients vs controls = 12.5% vs 14.2%, P = 0.4652), but lactulose excretion was significantly higher in patients compared to healthy controls (patients vs controls = 0.326% vs 0.293%, P = 0.0391). The mean LMR was also significantly higher in the patients as compared to healthy controls [0.027 (0.0029-0.278) vs 0.0164 (0.0018-0.0548), P = 0.0044]. Male patients had a higher LMR compared to females [0.036 (95% CI 0.029, 0.046) vs 0.022 (95% CI 0.0178, 0.028) (P = 0.0024), though there was no difference in the number of patients with abnormal IP in boththe sexes. Patients with an ileo-colonic disease had a higher LMR than those with only colonic disease [0.045 (95% CI 0.033, 0.06) vs 0.021 (95% CI 0.017, 0.025) (P < 0.001)]. Of patients with ileo-colonic disease, 57.8% had an abnormal IP, compared to 26.7% with colonic and 15.6% with small intestinal disease. Patients with a stricturing disease had significantly higher LMR compared to non-fistulising non-stricturing disease [0.043 (95% CI 0.032, 0.058) vs 0.024 (95% CI 0.019, 0.029) (P = 0.0062)]. There was no correlation of IP with age, disease activity, duration of illness, D-xylose absorption, upper GI involvement, perianal disease, and extra- intestinal manifestations. On multiple regression analysis, male gender and ileo-colonic disease were independent factors associated with increased IP. Gender, location, behavior of the disease and upper GI involvement could explain up to 23% of variability in IP (R2 = 0.23). CONCLUSION: IP was increased in 36% of patients with CD. Male gender and an ileo-colonic disease were the independent factors associated with increased IP. | Jaya Benjamin Govind K Makharia Vineet Ahuja Mani Kalaivan Yogendra K Joshi | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 3 | Evaluation of cytotoxic and anti-tumor activity of partially purified serine protease isolate from the Indian earthworm Pheretima posthuma显示文摘Objective:To isolate,partially purify and evaluate the cytotoxic and antitumor activity of a serine protease from the chosen Indian earthworm Pheretima posthuma.Methods:Whole animal extract was prepared and purified its protein constituents by size and charge based chromatographic separation techniques using Sephadex G-50 and DEAE-Cellulose resin respectively.Average molecular weight of the protein isolate was determined and analyzed for its cytotoxic property against Vero cells in different dilutions(1:20 and 1:40)and anti-tumor activity by MTT assay(a colorimetric assay)using breast cancer cell line MCF-7,with tamoxifen as standard.Results:One of the protein constituents after purification was characterized as serine protease by Caseinolytic plate diffusion assay.Average molecular weight of this purified isolate was determined,by SDS-PAGE analysis with standard protein ladder,as of 15 kDa.The performed tests suggested that the 15kDa fraction has potent cytotoxic activity and satisfactory antitumor activity as well in vitro.Conclusions:Exact molecular mechanism of the cytotoxic and antitumor activities is yet to be explored and currently we are working on ultra-purification and biophysical characterization of this fraction.Further investigation into the mechanism(s)of cytotoxic and antitumor activities at molecular level would be useful in treatment of various classes of cancer and viral infections in future. | Mahendra Kumar Verma Francies Xavier Yogendra Kumar Verma Kota Sobha | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，11： | 3 |
| 4 | Early Enteral Nutrition in Severe Acute Pancreatitis: A Prospective Randomized Controlled Trial Comparing Nasojejunal and Nasogastric Routes显示文摘 | Ajay Kumar Namrata Singh Shyam Prakash Anoop Saraya Yogendra Kumar Joshi | 2006 | Journal of Clinical Gastroenterology2006，，5： | 2 |
| 5 | Lipid constituents from Stellaria media 显示文摘 | Archana PD Yogendra N Shukla | | Phytochemistry0，39，3： | 1 |
| 6 | Oligomerization of Anthrax Toxin Protective Antigen and Binding of Lethal Factor during Endocytic Uptake into Mammalian Cells显示文摘 | Yogendra S Kurt RK Seema G | 1999 | J Infection and Immunity1999，67，3： | 1 |
| 7 | Efficacy of polyvalent bacteriophage P-27/HP to control multidrug resistant Staphylococcus aureus associated with human infections 显示文摘 | Ragini Gupta Yogendra Prasad | 2011 | Current Microbiology2011，62，1： | 1 |
| 8 | Dietary Counseling Versus Dietary Supplements for Malnutrition in Chronic Pancreatitis: A Randomized Controlled Trial显示文摘 | Siddharth Singh Shallu Midha Namrata Singh Yogendra Kumar Joshi Pramod Kumar Garg | 2008 | Clinical Gastroenterology and Hepatology2008，，3： | 1 |
| 9 | Quantitative resistance in potato leaves to late blight associated with in duced hydroxycinnamie acid amides 显示文摘 | KALENAHALLI N YOGENDRA D P KAREEM A M | 2014 | Functional & Integrative Genomics2014，14，2： | 1 |
| 10 | Comparison of endoscopic variceal sclerotherapy with sequential endoscopic band ligation plus low-dose sclerotherapy for sencondary prophylaxis of variceal hemorrhage:a prospective randomized study显示文摘 | Pramod K G Yogendra K J Rakesh K T | 1999 | Gastrointestinal Endoscopy1999，50，： | 1 |
| 11 | Wireless Communication and Environ- ment Monitoring in Underground Coal Mines - Review显示文摘 | Yogendra S Dohare | 2015 | IETE Technical Review2015，32，2： | 1 |
| 12 | Annona muricata fruit extract protects against diethylnitrosamine-induced hepatocellular cancer in rats显示文摘Objective: To evaluate the anticancer potentials of Annona muricata fruit by in vitro and in vivo methods. Methods: The ethanolic extract of Annona muricata fruit was prepared by Soxhlet extraction method and further fractionated with petroleum ether, ethyl acetate and chloroform. The fractions were tested for cytotoxicity, apoptosis, scratch wound assay, and cell cycle analysis. IC50, apoptotic index and percentage cell migration were determined using HepG2 cells. For the in vivo studies, hepatocellular carcinoma was induced by administering 0.01% diethylnitrosamine(DEN) in drinking water in Wistar rats. In pre-treatment, rats were co-administered 200 mg/kg of fruit extract with DEN for 14 weeks. In post-treatment, the extract was co-administered after 8-weeks of DEN-induction for 14 weeks. Liver function test, haematological test, oxidative stress markers, relative liver weight, number of cancer nodules and histopathological parameters were determined.Results: Annona muricata fruit extract =significantly lowered cell proliferation counts. The chloroform-fraction possessed higher activity (IC50=(53.7±4.3) μg/mL)The chloroform fraction inhibited cell migration, which was significant compared to curcumin. Further investigations regarding the mode of anticancer activity revealed that the chloroform fraction induced apoptosis. The cell cycle analysis indicated that cells were being arrested at G0/G1. In the in vivo studies, the DEN-control group showed a significant decrease in body weights with increased mortality rate, hepatic nodules, and impairment of liver function compared to normal rats. The rats pre-treated and post-treated with the extract showed positive results with significant improvement in the parameters that were adversely affected by DEN. In addition, other adverse effects of DEN, such as blood dyscrasias and hepatic endogenous antioxidant, were significantly attenuated by Annona muricata fruit extract.Conclusions: The Annona muricata fruit extract has anticancer activity when tested by in vitro and in vivo hepatocellular cancer models. | Subin Varghese Thomas John Paul Akhila Hosur Shrungeswara Subhankar Biswas Aarti Abhishek Shah Chandrashekar Kodangala Subraya Yogendra Nayak | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，6： | 1 |
| 13 | CuCl2nanoparticles dispersed in activated carbon fibers for the oxygen production step of the Cu-Cl thermochemical water splitting cycle显示文摘 | BHASKAR BHADURI YOGENDRA NATH PRAJAPATI ASHUTOSH SHARMA | 2012 | Industrial&Engineering Chemistry Research2012，51，15： | 1 |
| 14 | Subcritical water extraction of antioxidant compounds from Seabuckthorn (Hippopkae rkamnoides) leaves for the comparative evaluation ofantioxidant activity显示文摘 | YOGENDRA KUMAR M S RUMA D DIPTI P | 2011 | Food Chem2011，，127： | 1 |
| 15 | Bazedoxifene acetate:a selective estrogen receptor modulator with im- proved selectivity 显示文摘 | Baryy SK Yogendra PK Peter VNB | 2005 | Endocrinology2005，146，9： | 1 |
| 16 | Generalized kernel regression estimator for dependent sized-biased data 显示文摘 | YOGENDRA C P JUN L | 2012 | Journal of Statistical Planning and Inference2012，142，： | 1 |
| 17 | Optimization of novel photobio- reactor design using computational fluid dynamics显示文摘 | Abhinav Soman Yogendra Shastri | 2015 | Applied En- ergy2015，，140： | 1 |
| 18 | Energy Efficient Thermal Management of Electronic Components Using Solid-Liquid Phase Change Materials显示文摘 | Dong won Yoo Joshi Yogendra K | 2004 | IEEE Transactions on Device and Materials Reliability2004，4，4： | 1 |
| 19 | Subcritical water extraction of antioxidant compounds from Seabuckthorn (Hippopkae rkamnoides) leaves for the comparative evaluation ofantioxidant activity显示文摘 | YOGENDRA KUMAR M S RUMA D DIPTI P | 2011 | Food Chem2011，，127： | 1 |
| 20 | Dietary Counseling Versus Dietary Supplements for Malnutrition in Chronic Pancreatitis: A Randomized Controlled Trial显示文摘 | Siddharth Singh Shallu Midha Namrata Singh Yogendra Kumar Joshi Pramod Kumar Garg | 2008 | Clinical Gastroenterology and Hepatology2008，，3： | 1 |
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