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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Randomised con-trolled trial of recombinant tissue plasminogen activator versus uro-kinase in the tretment of acute pulmonary embolism显示文摘 | Goldhaber SZ Kessler CM Heit J | 1988 | Lancet1988，2，3： | 1 |
| 3 | An automated p- nitrophengy lphosphate serum alkaline phosphatase procedure for the Auto - Analyzerz显示文摘 | Morgenstem S Kessler G Auerbach J | 1995 | Clin Chem1995，11，： | 1 |
| 4 | Differential capacity of left and fight hemispheric areas for compensation of poststroke aphasia显示文摘 | Heiss WD Kessler J Thiel A | 1999 | Ann Neurol1999，45，4： | 1 |
| 5 | Disruption of matrix metallo- proteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiugenesis and tumor growth in vivo显示文摘 | Silletti S Kessler T Goldberg J | 2001 | Proc Nat Acad Sci USA2001，98，1： | 1 |
| 6 | The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions 显示文摘 | KESSLER L G BARNHART H X BUCKLER A J | 2014 | Stat Methods Med Res2014，24，1： | 1 |
| 7 | Randomized controlled trial of recombinant tissue plasminogen activator versus urokinase in the treatment of acute pulmonary embolism显示文摘 | Kessler CM Heit J | 1988 | Lancet1988，2，8606： | 1 |
| 8 | Highly Efficient Cu ( In, Ga) Se2 Mini-Modules 显示文摘 | KESSLER J WENNERBERG J BODEGARD M | 2003 | Solar Energy Materials & Solar Ceils2003，75，12： | 1 |
| 9 | Double-shouldered tool joints increase tortional strength显示文摘 | Kessler F Smith J | 1996 | Journal of Petroleum Technology1996，48，6： | 1 |
| 10 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 11 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 12 | Language activation in ischemic stroke and brain tumor: a PET study显示文摘 | HEISS WD THIEL A KESSLER J | 2002 | Zentralbl Neurochir2002，63，： | 1 |
| 13 | Interface study of CuInSe2/ZnO and Cu (In, Ga) Se2/ZnO devices using ALD ZnO buffer layers显示文摘 | Platzer-Bjorkman C Lu J Kessler J | 2003 | Thin Solid Films2003，，： | 1 |
| 14 | A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L显示文摘 | Hemelaar J Lelyveld VS Kessler BM | 2003 | J Biol Chem2003，278，51： | 1 |
| 15 | Clinical emergency medical casebook 显示文摘 | Kessler CS Brown J | 2010 | Jour- nal of the American Medical Association2010，303，2： | 1 |
| 16 | Proteglycans on bone marrow endothelial cells bind and present SDF-1 towards hematopoietic progenitor cells 显示文摘 | Netelenbos T van den Born J Kessler FL Zweeqman S Merle PA van Oostveen JW | 2003 | Leukemia2003，17，1： | 1 |
| 17 | Multicentre evaluation of the diagnostic value of cardiac troponin-T,CK-MB mass,and myoglobin for assessing patients with suspected acute coronary syndromes in routine clinical practice显示文摘 | COLLINSON P O STUBBS P J KESSLER AC | 2003 | Heart2003，89，3： | 1 |
| 18 | Influencing Social Workers to Use Research Evidence in Practice: Lessons from Medicine and the Allied Health Professions显示文摘 | Gira EC Kessler ML Poertner J | 2004 | Social Work Practice2004，14，2： | 1 |
| 19 | Peripheral regional an- aesthesia and outcome: lessons learned from the last 10 years显示文摘 | Kessler J Marhofer P Hopkins PM | 2015 | Br J Anaesth2015，114，5： | 1 |
| 20 | Manufacture and Development of Multilayer Diffraction Gratings 显示文摘 | KECK J OLIVER J B KESSLER T J | 2005 | Proc SPIE2005，5991，： | 1 |
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