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| 1 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 2 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 3 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 4 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 5 | 肛门电刺激治疗大便失禁的随机、对照试验显示文摘PURPOSE: Anal electric stimulation has been described as effective for fecal incontinence in several case series, but no study has addressed possible mechanism of benefit. We wished to examine whether anal electric stimulation, using an anal probe electrode, used on a daily basis at home for eight weeks, in the Absence of any adjunctive exercises or advice, would improve symptoms of fecal incontinence and anal sphincter pressures when compared with “ sham” electric stimulation. METHODS: Ninety patients (9 males, 81 females), with median age of 55 (range, 30- 77) years were randomized, 47 to active anal stimulation at 35 Hz and 43 to “ sham' stimulation at 1 Hz. Outcome measures included a one-week bowel diary, symptom questionnaire, manometry, and patients evaluation of outcome. RESULTS: Seventy patients completed the study. On an intention-to-treat analysis, there was no difference between the two groups on any of the outcome measures after eight weeks. Of those who completed stimulation, 44 (63 percent) felt the stimulation had improved their continence. Those with intact anal sphincters were not likely to rate their change more positively than those with sphincter disruption (P = 0.71). Median patient rating of bowel control increased from 3 of 10 before stimulation to 5 of 10 after stimulation (P = 0.001). CONCLUSIONS: Eight weeks of anal electric stimulation was rated by patients as having improved their bowel control to a modest extent. There was no statistically significant difference detected between the groups, suggesting that 1 Hz was as effective as 35 Hz. This raises the possibility that the main effect is not sphincter contraction but sensitization of the patient to the anal area,or simply the effect of intervening per se. Home electric stimulation is a relatively cheap and generally well-tolerated therapy in the conservative treatment of fecal incontinence. | Norton C. Gibbs A. Kamm M.A. 纪泛扑(译) 史敏(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 2 |
| 6 | Oral Bisacodyl Is Effective and Well-Tolerated in Patients With Chronic Constipation显示文摘 | Michael A. Kamm Stefan Mueller–Lissner Arnold Wald Erika Richter Ros Swallow Ulrika Gessner | 2011 | Clinical Gastroenterology and Hepatology2011，，7： | 2 |
| 7 | Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome显示文摘 | Charles D.R. Murray Joanna Flynn Laura Ratcliffe Meron R. Jacyna Michael A. Kamm Anton V. Emmanuel | 2004 | Gastroenterology2004，，6： | 2 |
| 8 | Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis显示文摘 | Matthew Rutter Brian Saunders Kay Wilkinson Steve Rumbles Gillian Schofield Michael Kamm Christopher Williams Ashley Price Ian Talbot Alastair Forbes | 2004 | Gastroenterology2004，，： | 2 |
| 9 | Thirty-Year Analysis of a Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis显示文摘 | Matthew D. Rutter Brian P. Saunders Kay H. Wilkinson Steve Rumbles Gillian Schofield Michael A. Kamm Christopher B. Williams Ashley B. Price Ian C. Talbot Alastair Forbes | 2006 | Gastroenterology2006，，： | 2 |
| 10 | Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation显示文摘 | Emmanuel AV Kamm MA | 2001 | Gut2001，49，2： | 1 |
| 11 | Vasoactive in testinal Polypepatide Levels diseasein sigm oid idiopation and diverticular显示文摘 | Milner P Crowe R Kamm M A | 1990 | Gastroenterology1990，99，3： | 1 |
| 12 | The burden of constipation on quality of life:Results of a multinational survey显示文摘 | Wald A Scarpignato C Kamm MA | 2007 | Aliment Pharmacol Ther2007，1526，2： | 1 |
| 13 | Clinical pharmacokinetics of mycophenolate mofetil显示文摘 | Bullingham RE Nicholls AJ Kamm BR | 1998 | Clin Pharmacokinet1998，34，6： | 1 |
| 14 | Studies of image quality and dose in digital subtraction angiography显示文摘 | Heckmann H Kamm KF Vetter S | 1997 | Aktuelle Radiol1997，7，4： | 1 |
| 15 | Pharmacoligical treatment of irritable bowel syndrome - from concept to sales显示文摘 | Kamm MA | 2002 | Eur J Stag Suppl2002，587，： | 1 |
| 16 | Mechanotransduction in cardiac myocytes显示文摘 | Lammerding J Kamm R D Lee R T | 2004 | Ann N Y Acad Sci2004，1015，： | 1 |
| 17 | Lamellar-to-hexagonaⅢ phase transitions in the plasma membrane of isolated protoplasts after freeze-induced dehydration 显示文摘 | Gordon - Kamm W J Steponkus P L | 1984 | Proceedings of the National Academy of Sciences of the United States of America1984，81，20： | 1 |
| 18 | Cytokine and catabolic enzyme expression in synovium,synovial fluid and articular cartilage of naturally osteoarthritic equine carpi显示文摘 | Kamm JL Nixon AJ Witte TH | | 0，，： | 1 |
| 19 | Entrepreneuri al teams in new venture creation:a research agenda显示文摘 | Kamm J B Shuman J C Seeger J A Nurick A J | | 0，，04： | 1 |
| 20 | Impact of the physical micro- environment on tumor progression and metastasis显示文摘 | Spill F Reynolds DS Kamm RD | | Curt Opin Biotechnol0，40，： | 1 |
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