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| 1 | Using old liver grafts for liver transplantation: Where are the limits?显示文摘The scarcity of ideal liver grafts for orthotopic liver transplantation(OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts. | Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero Iago Justo Alonso Cristina Alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González | 2014 | World Journal of Gastroenterology2014，20，31： | 11 |
| 2 | The importance of avoiding unnecessary right ventricular pacing in clinical practice显示文摘Symptomatic bradycardia is effectively treated with the implantation of a cardiac pacemaker. Although a highly successful therapy, during recent years there has been a focus on the negative effects associated with longterm pacing of the apex of the right ventricle(RV). It has been shown in both experimental and clinical studies that RV pacing leads to ventricular dyssynchrony, similar to that of left bundle branch block, with subsequent detrimental effects on cardiac structure and function, and in some cases adverse clinical outcomes such as atrial fibrillation, heart failure and death. There is substantial evidence that patients with reduced left ventricular function(LVEF) are at particular high risk of suffering the detrimental clinical effects of long-term RV pacing. The evidence is, however, incomplete, coming largely from subanalyses of pacemaker and implantable cardiac defibrillator studies. In this group of patients with reduced LVEF and an expected high amount of RV pacing, biventricular pacing(cardiac resynchronization therapy) devices can prevent the negative effects of RV pacing and reduce ventricular dyssynchrony. Therefore, cardiac resynchronization therapy has emerged as an attractive option with promising results and more clinical studies are underway. Furthermore, specific pacemaker algorithms, which minimize RV pacing, can also reduce the negative effects of RV stimulation on cardiac function and may prevent clinical deterioration. | Finn Akerstrm Miguel A Arias Marta Pachón Jesús Jiménez-López Alberto Puchol Justo Juliá-Calvo | 2013 | World Journal of Cardiology2013，5，11： | 3 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Field Cancerization in the Intestinal Epithelium of Patients With Crohn’s Ileocolitis显示文摘 | Susan Galandiuk Manuel Rodriguez–Justo Rosemary Jeffery Anna M. Nicholson Yong Cheng Dahmane Oukrif George Elia Simon J. Leedham Stuart A.C. McDonald Nicholas A. Wright Trevor A. Graham | 2012 | Gastroenterology2012，，4： | 2 |
| 5 | Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia显示文摘 | Simon J. Leedham Trevor A. Graham Dahmane Oukrif Stuart A.C. McDonald Manuel Rodriguez–Justo Rebecca F. Harrison Neil A. Shepherd Marco R. Novelli Janusz A.Z. Jankowski Nicholas A. Wright | 2009 | Gastroenterology2009，，2： | 2 |
| 6 | Long‐term oncological outcomes after laparoscopic radical prostatectomy显示文摘 | Marcel Hruza Justo Lorenzo Bermejo Bettina Flinspach Michael Schulze Dogu Teber Hans Joachim Rumpelt Jens Jochen Rassweiler | 2012 | BJU Int2012，，： | 2 |
| 7 | 坦桑尼亚推广中国水稻种植技术进展及建议显示文摘坦桑尼亚大部分地区属于热带草原气候,适合各类作物生长,农作物种类丰富。水稻是该国第二大粮食作物,以雨养种植为主,占72%,旱稻种植占22%,大规模灌溉种植占6%左右。根据气候、降雨和河流分布等特性,水源有保障的地方全年可种植水稻一季或二季半。大多数农户以常规品种直播种植为主,草害严重,肥水管理粗放,产量较低。建设中国援坦桑尼亚农业技术示范中心以来,推广中国水稻种植技术取得了一定进展。建议继续推广育苗移栽技术,强化肥水管理,减少养分流失,采用化学除草控制草害,引进或培育新品种,以促进坦桑尼亚水稻生产发展,更好地实现水稻增产增收。 | 王骞 王楚桃 Sophia Kashenge Killenga Barnaas Justo Sitta 黄乾龙 管玉圣 | 2021 | 南方农业2021，15，34： | 2 |
| 8 | Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation显示文摘 | Jose A. Rodríguez-Navarro Laura Rodríguez María J. Casarejos Rosa M. Solano Ana Gómez Juan Perucho Ana María Cuervo Justo García de Yébenes María A. Mena | 2010 | Neurobiology of Disease2010，，3： | 2 |
| 9 | Automatically maintaining wrappers for semi-structured web sources 显示文摘 | Juan Raposo Alberto Pan Manuel Alvarez Justo Hidalgo | 2007 | Data & Knowledge Engineering2007，61，： | 1 |
| 10 | First Report of a Closterovirus-Like Particle Associated with Pineapple Plants显示文摘 | Eduviges G B Mayra Cintra Justo Gonzalez | 1998 | Plant Disease1998，82，2： | 1 |
| 11 | Hybrid technique for high resolution imaging of the eye fundus显示文摘 | Justo Arines Salvador Bara | 2003 | Optics Express2003，11，7： | 1 |
| 12 | Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors显示文摘 | Zelter D Justo D Halkin A | 2003 | Medicine (Baltimore)2003，82，： | 1 |
| 13 | Long-term blood pressure control prevents oxidative renal injury显示文摘 | Lazaro A Gallego-Delgado J Justo P | 2005 | Antioxid Redox Signal2005，7，910： | 1 |
| 14 | Preparation of Transparent and Conductive Al-doped ZnO Thin Films by ECR Plasma Enhanced CVD显示文摘 | Martin A Espinos J P Justo A | 2002 | Surface and Coatings Technology2002，，： | 1 |
| 15 | Determination of Tryptophan by High-performance Liquid Chromatography of Alkaline Hydrolysates With Spectrophotometric Detection 显示文摘 | Maria M Y Justo P Julio G C etal | 2004 | Food Chemistry(S0308-8146)2004，85，2： | 1 |
| 16 | Drug-induced atrioventricular block: prognosis after discontinuation of the culprit drug显示文摘 | David Zeltser Dan Justo Amir Halkin Raphael Rosso Maya Ish-Shalom Mordechai Hochenberg Sami Viskin | 2004 | Journal of the American College of Cardiology2004，，1： | 1 |
| 17 | Torsades de pointes induced by antibiotics显示文摘 | Justo D Zeltser D | 2006 | EurJ Intern Med2006，17，4： | 1 |
| 18 | <ce:link locator='fx1'/> Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells显示文摘 | Stuart A.C. McDonald Laura C. Greaves Lydia Gutierrez–Gonzalez Manuel Rodriguez–Justo Maesha Deheragoda Simon J. Leedham Robert W. Taylor Chung Yin Lee Sean L. Preston Matthew Lovell Toby Hunt George Elia Dahmane Oukrif Rebecca Harrison Marco R. Novelli I | 2008 | Gastroenterology2008，，2： | 1 |
| 19 | AC-microgrids versus DC-microgrids with distributed energy resources:a review显示文摘 | Jackson John Justo Francis Mwasilu Lee Ju | 2013 | Renewable and Sustainable Energy Reviews2013，24，： | 1 |
| 20 | Affinity purification of copper chelating peptides from chickpea protein hydrolysates显示文摘 | Cristina Megías Justo Pedroche Maria M Yust | 2007 | Journal of Agricultural and Food Chemistry2007，50，10： | 1 |
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