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| 1 | Clp Protease and OR Directly Control the Proteostasis of Phytoene Synthase, the Crucial Enzyme for Carotenoid Biosynthesis in Arabidopsis显示文摘Phytoene synthase (PSY ) 是在类胡萝卜素 biosynthetic 小径的关键 plastidial 酶。然而,它的 translational 以后规定留下逃犯。同样, Clp 朊酶组成质体朊酶网络的中央部分,但是它为降级的底层不是众所周知的。在这研究,我们报导 PSY 是 Clp 朊酶的底层。PSY 被揭开身体上与各种各样的 Clp 朊酶子单元交往(即, ClpS1, ClpC1,和 ClpD ) 。在 clpc1, clpp4,和 clpr1-2 异种的 PSY 和几另外的 carotenogenic 酶蛋白质 overaccumulate 高级。overaccumulated PSY 被发现部分酶地活跃。在 clpc1 的 Clp 活动的缺陷导致 PSY 蛋白质周转的减少的率,进一步在降级的 PSY 支持 Clp 朊酶的角色蛋白质。在另一方面, ORANGE (或) 蛋白质,有 holdase 女伴活动的 PSY 的一个主要 translational 以后管理者,提高 PSY 蛋白质稳定性并且在 clpc1 增加 PSY 的酶地活跃的比例, counterbalancing 在维持 PSY 蛋白质动态平衡的调停 Clp 的解朊作用。一起,这些调查结果提供新奇卓见进质体局部性的蛋白质的质量控制并且建立迄今未辩别出的 translational 以后在在植物的 modulating 类胡萝卜素生合成的 carotenogenic 酶的规章的机制。 | Ralf Welsch Xiangjun Zhou Hui Yuan Daniel Alvarez Tianhu Sun Dennis Schlossarek Yong Yang Guoxin Shen Hong Zhang Manuel Rodriguez-Concepcion Theodore W. Thannhauser Li Li | 2018 | Molecular Plant2018，11，1： | 10 |
| 2 | Effect of climate and altitude on plant community composition and richness in Brazilian inselbergs显示文摘Plant communities are shaped by multiple factors along environmental gradients;however,studies are limited on how environmental filtering drives community composition and species richness on tropical inselbergs.We evaluate the influence of altitude and climatic variables related to temperature and precipitation on plant community composition and species richness on Brazilian inselbergs.We assume as a premise that both climate and altitude would induce changes on plant community composition and species richness at the local level.We used plant inventory data from 370 sampling units across four inselberg sites in the Atlantic Forest of Espírito Santo State,south-eastern Brazil.We tested the univariate and multivariate effects of altitude and climate variables on community composition and species richness with multiple models.Differences in species richness between inselbergs were evaluated using sample-based data to estimate rarefaction and extrapolation curves.In addition,differences in species composition and taxonomic beta diversity were examined via novel frequency-based metrics.A contrasting climate pattern was observed between the inselberg sites,with south sites being wet compared to the dry conditions found in northern sites.Species richness by rarefaction showed a similar pattern within regional sites;however,there were marked differences between regions.Species richness and beta diversity showed significant differences among sites,with higher values in southern sites than in northern sites.In a multi-model comparison between inselberg sites,altitude significantly influenced community composition and species richness and explained more variance than climate models.This finding suggested that climate could act to some extent on these tropical inselbergs;however,altitude was a better predictor of plant community composition and species richness at the local level. | Herval Vieira PINTO-JUNIOR Pedro Manuel VILLA Luis Fernando Tavares de MENEZES Miriam Cristina Alvarez PEREIRA | 2020 | Journal of Mountain Science2020，17，8： | 2 |
| 3 | Automatically maintaining wrappers for semi-structured web sources 显示文摘 | Juan Raposo Alberto Pan Manuel Alvarez Justo Hidalgo | 2007 | Data & Knowledge Engineering2007，61，： | 1 |
| 4 | Automatically maintaining wrappers for semi-structured Web sources 显示文摘 | Juan Raposo Alberto Pan Manuel Alvarez | 2007 | Data & Knowledge Engineering2007，61，： | 1 |
| 5 | Healthcare staff as promoters of parental presence at anesthetic induction:Net Promoter Score survey显示文摘BACKGROUND Surgical intervention is usually a traumatic event that causes stress and anxiety in the pediatric patient and the family environment.To reduce the harmful effects of presurgical anxiety,parental presence during induction of anesthesia(PPIA)is one of the more notable interventions used in medical centers.However,data on this measure are difficult to evaluate and often face resistance from healthcare staff.AIM To analyze the perception of the healthcare workers after the implementation of a PPIA program.METHODS A survey was developed and sent by email to all the healthcare staff working in the children’s area of a tertiary hospital.It consisted of 14 items divided into positive aspects of PPIA and negative aspects of PPIA evaluated with the use of a Likert scale(1 to 5).The demographics of the respondents were included in the data collected.The answers to the questions were interpreted through the Net Promoter Score(NPS).The statistical analysis compared the differences in the responses to each question of the survey made by the different groups of health personnel included.RESULTS A total of 141 surveys were sent out,with a response rate of 69%.Of the total number of responses,68%were from women and 32%from men.The average age of the participants was 42.3±10.6 years.As for the positive questions about the PPIA,83%had an NPS>50,and only one had a score between 0 and 50,which means that the quality of the service was rated as excellent or good by 100%of the respondents.On the other hand,100%of the negative questions about the PPIA had a negative NPS.Responses to the question“PPIA increases patient safety”were significantly different(P=0.037),with a lower percentage of pediatric surgeons(70%)thinking that PPIA increased patient safety,compared with anesthesiologists(90%),nursing(92%),and other medical personnel(96%).CONCLUSION The personnel who participated in the PPIA program at our center were in favor of implementation.There were no validated arguments to support worker resistance to the development of the PPIA. | María Velayos Karla Estefanía María Alvarez María C Sarmiento Lucas Moratilla Pascual Sanabria Francisco Hernández Manuel V López Santamaría | 2021 | World Journal of Clinical Pediatrics2021，10，6： | 1 |
| 6 | Fenton Reagent Advanced Oxidation of Polynuclear Aromatic Hydrocarbons in Water显示文摘 | Fernando J. Beltrán Manuel González Francisco J. Ribas Pedro Alvarez | 1998 | Water Air and Soil Pollution (-)1998，，3： | 1 |
| 7 | Automatically maintaining wrappers for semi-structured Web sources 显示文摘 | Juan Raposo Alberto Pan Manuel Alvarez | 2007 | Data & Knowledge Engineering2007，61，： | 1 |
| 8 | Preterm delivery after selective termination in twin pregnancies显示文摘 | Lauren Lynch Richard L. Berkowitz Joanne Stone Manuel Alvarez Robert Lapinski | 1996 | Obstetrics & Gynecology1996，，3： | 1 |
| 9 | Use of liquid nitrogen during storage in a cell and tissue bank: Contamination risk and effect on the detectability of potential viral contaminants显示文摘 | Vicente Mirabet Manuel Alvarez Pilar Solves Dolores Ocete Concepción Gimeno | 2011 | Cryobiology2011，，2： | 1 |
| 10 | Fusion of bone marrow derived cells with Purkinje neurons, cardiomyocytes and hepatocytes显示文摘 | Manuel Alvarez Doladol Ricardo Pardal Jose M Garcla-Verdugo | 2003 | Nature2003，425，6961： | 1 |
| 11 | Evolution of methicillin-resistant Staphylococcus aureus clones in Latin America显示文摘 | Eduardo Rodríguez-Noriega Carlos Seas Manuel Guzmán-Blanco Carlos Mejía Carlos Alvarez Luis Bavestrello Jeannete Zurita Jaime Labarca Carlos M. Luna Mauro J.C. Salles Eduardo Gotuzzo | 2009 | International Journal of Infectious Diseases2009，，7： | 1 |
| 12 | Incidence of childhood cancer among Mexican children registered under a public medical insurance program显示文摘 | Roberto Rivera‐Luna Cecilia Correa‐González Eduardo Altamirano‐Alvarez Fernando Sánchez‐Zubieta Rocio Cárdenas‐Cardós Gabriela Escamilla‐Asian Alberto Olaya‐Vargas Aurora Bautista‐Marquez Manuel Aguilar‐Romo | 2012 | Int. J. Cancer2012，，： | 1 |
| 13 | High-sensitivity C-reactive protein in high-grade carotid stenosis: risk marker for unstable carotid plaque显示文摘 | Beatriz Alvarez Garcia Carmen Ruiz Pilar Chacon Jose Alvarez Sabin Manuel Matas | 2003 | Journal of Vascular Surgery2003，，5： | 1 |
| 14 | Labat法坐骨神经阻滞下局部麻醉药低容量高浓度较高容量低浓度更有效:一项前瞻性随机对照研究显示文摘背景有很多因素可以明显影响外周神经阻滞的起效时间和成功率,本项前瞻、随机、双盲研究比较了Labat后路法行坐骨神经阻滞时,单剂量的甲哌卡因300mg分别稀释至20和30ml注射后的阻滞效果差异。方法90例行足部手术的患者,随机分为2组接受坐骨神经阻滞,一组给予1.5%甲哌卡因20m1(45例),另一组给予1%甲哌卡因30m1(45例),所有阻滞均在神经刺激仪定位下进行(参数为刺激频率2Hz;刺激电流为1.5~0.5mA)。两组中,神经刺激反应在〈0.5mA时引出,亦可以定向诱发足部肌肉向跖侧屈曲,分别记录胫神经和腓总神经的运动感觉功能被阻滞的起效时间。而坐骨神经支配区域的针刺感觉消失,同时足部跖曲及背曲运动消失为阻滞成功的标准。结果用20ml的1.5%甲哌卡因组阻滞成功率(96.6%)显著高于30ml的1%甲哌卡因组(68.9%,P〈0.05)。而前者达到感觉与运动完全阻滞所需要的时间(11±6分钟,13±7分钟)也短于后者(17±8分钟,19±8分钟,P〈0.05)。结论Labat法行坐骨神经阻滞时,与高容量低浓度的局部麻醉药(1%甲哌卡因)比较,使用低容量高浓度的局部麻醉药(1.5%甲哌卡因)能够获得更高的阻滞成功率及更短的起效时间。 | Manuel Taboada Muniz, MD, PhD Jaime Rodriguez, MD, PhD Maria Bermudez, MD Cristina Valino, MD Noemi Blanco, MD Marcos Amor, MD Pilar, Aguirre, MD Ana Masid, MD Joaquin Cortes, MD, Ph Julian Alvarez, MD, PhD Peter G. Atanassoff, MD 杨光(译) 崔苏扬(校) | 2010 | 麻醉与镇痛2010，，2： | 1 |
| 15 | Using clustering and edit distance techniques for automat- ic web data extraction 显示文摘 | Manuel Alvarez Alberto Pan Juan Raposo | 2007 | Web Information Systems Engineering2007，4831，： | 1 |
| 16 | Impact of Recipient HLA-C in Liver Transplant: A Protective Effect of HLA-Cw*07 on Acute Rejection显示文摘 | Maria R. Moya-Quiles Ruben Alvarez Manuel Miras Jorge Gomez-Mateo Maria R. Lopez-Alvarez Isabel Marin-Moreno Enrique Martínez-Barba Maria P.S. Sanchez-Mozo Manuel Gomez Francisco Arnal Francisco Sanchez-Bueno Luis A. Marin Ana M. Garcia-Alonso Alfredo Min | 2007 | Human Immunology2007，，1： | 1 |
| 17 | Increased Orocecal Transit Time in Patients with Nonalcoholic Fatty Liver Disease显示文摘 | Alejandro Soza MD Arnoldo Riquelme MD Robinson González MD Manuel Alvarez MD Rosa María Pérez-ayuso MD Juan Carlos Glasinovic MD Marco Arrese MD | 2005 | Digestive Diseases and Sciences2005，，6： | 1 |
| 18 | Analysis of 35 priority semivolatile compounds in water by stir bar sorptive extraction-thermal desorption-gas chromatography-mass spectrometry: Part II: Method validation显示文摘 | VICTOR MANUEL LEON B ALVAREZ M A COBOLLO | 2006 | Analytica Chimica Acta2006，，558： | 1 |
| 19 | Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis显示文摘 | Philippe Lehert Gérard Chéron Guillermo Alvarez Calatayud Jean-Pierre Cézard Pedro Gutierrez Castrellón José-Manuel Meléndez Garcia Mar Santos M.R. Savitha | 2011 | Digestive and Liver Disease2011，，9： | 1 |
| 20 | Liver transplantation from Maastricht category 2 non-heart-beating donors显示文摘 | Alejandra Otero Manuel Gómez-Gutiérrez Francisco Suárez Francisco Arnal Antón Fernández-García Javier Aguirrezabalaga José García-Buitrón Joaquín Alvarez Rafael Má?ez | 2003 | Transplantation2003，，7： | 1 |
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