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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | Metal-organic framework derived CoSe2 nanoparticles anchored on carbon fibers as bifunctional electrocatalysts for efficient overall water splitting显示文摘发展有效,便宜,稳定,为切开的水的 non-noble-metal electrocatalysts,特别地能两个都催化氢进化反应的那些(她的) 在在阳极的阴极和氧进化反应(OER ) ,是挑战。我们开发了一个灵巧的方法因为综合从从容容宽敞 2 nanoparticles 一致地在碳纤维纸上抛锚了(经由热分解和 selenization 的从从容容宽敞 2/CF) 在 situ 成年 zeolitic imidazolate framework-67 (ZIF-67 ) 。从从容容宽敞 2/CF 在碱的答案在 HER 和 OER 显示出高、稳定的催化活动。在一个低房间潜力,即, 1.63 V,与二个从从容容宽敞 2/CF 电极装备的水 electrolyzer 给了 10 mAen 的切开水的水流 2007 并且 2014 年 10 月 21 日。我们然后与一个低级术语并且通过临床的描述的一篇详细摘要识别了 PAOD 的盒子。结果我们识别了 POAD 的 25 个盒子。大多数病人比 60 老 ? 年(84 ?%) 或有象血胆脂醇过多那样的另一个心血管的风险因素,钰 ? 钰吗?? | Chencheng Sun Qiuchun Dong Jun Yang Ziyang Dai Jianjian Lin Peng Chen Wei Huang Xiaochen Dong | 2016 | Nano Research2016，9，8： | 16 |
| 3 | Community structure of macrobenthos in coastal water off Rushan, southern Shandong Peninsula, and the relationships with environmental factors显示文摘To understand the present actuality of the marine ecosystem in the southern coastal water region of the Shandong Peninsula and the impact of the global change and the human activities to the marine ecosystem of the region, the macrobenthic community structure was researched based on data from 26 sampling stations carried out on four seasonal cruises from December 2006 to November 2007. The data was analyzed using PRIMER 6.0 and SPSS 15.0 software packages. The results showed that 236 macrobenthic species in total were collected from the research region by the field works. Most of the species belong to Polychaeta (76 species), Mollusca (75) and Crustacea (60). Of which, 33 species were common species by the four cruises. The dominant species were different among the four seasons, however, the polychaete species Nephtys oligobranchia and Sternaspis scutata were always dominant in the four seasons. The abundances and biomasses of the macrobenthos from the research region were variable in the four seasons. The results of CLUSTER and MDS analysis showed that the similarities of macrobenthic structures among the stations were low, most of the similarities were at about 40% of similarity values, only that of two stations were up to 60%. In accordance with the similarity values of the macrobenthic structures, the 26 stations were clustered as six groups at arbitrary similarity level of 30%. The ABC curve indicated that the marcofauna communities in the research region had not been disturbed distinctly. The results of BIOENV and BVSTEP (Spearman) analysis implied that the concentrations of organic matter in bottom water and heavy metal copper in sediment, water depth and temperature of bottom were the most significant environmental factors to affect the macrobentic community. | LI Xinzheng LI Baoquan WANG Hongfa WANG Jinbao WANG Xiaochen ZHOU Jin HAN Qingxi MA Lin DONG Chao ZHANG Baolin | 2009 | Acta Oceanologica Sinica2009，28，5： | 14 |
| 4 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 5 | Precise temporal regulation of Dux is important for embryo development显示文摘Dear Editor,Zygotic genome activation(ZGA)following fertilization is accomplished through a process termed the maternal-to-zygotic transition,during which the maternal RNAs and proteins are degraded and zygotic genome is transcriptionally activated.In mice,minor ZGA occurs from S phase of the zygote to G1 phase of the two-cell(2C)embryo,while major ZGA takes place during the middle-to-late 2C stage with a burst of transcription of totipotent cleavage stage-specific genes and retrotransposons. | Mingyue Guo Yanping Zhang Jianfeng Zhou Yan Bi Junqin Xu Ce Xu Xiaochen Kou Yanhong Zhao Yanhe Li Zhifen Tu Kuisheng Liu Jiaming Lin Peng Yang Shaorong Gao Yixuan Wang | 2019 | Cell Research2019，29，11： | 5 |
| 6 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
| 7 | Nonlinear Prediction with Deep Recurrent Neural Networks for Non-Blind Audio Bandwidth Extension显示文摘Non-blind audio bandwidth extension is a standard technique within contemporary audio codecs to efficiently code audio signals at low bitrates. In existing methods, in most cases high frequencies signal is usually generated by a duplication of the corresponding low frequencies and some parameters of high frequencies. However, the perception quality of coding will significantly degrade if the correlation between high frequencies and low frequencies becomes weak. In this paper, we quantitatively analyse the correlation via computing mutual information value. The analysis results show the correlation also exists in low frequency signal of the context dependent frames besides the current frame. In order to improve the perception quality of coding, we propose a novel method of high frequency coarse spectrum generation to improve the conventional replication method. In the proposed method, the coarse high frequency spectrums are generated by a nonlinear mapping model using deep recurrent neural network. The experiments confirm that the proposed method shows better performance than the reference methods. | Lin Jiang Ruimin Hu Xiaochen Wang Weiping Tu Maosheng Zhang | 2018 | China Communications2018，15，1： | 2 |
| 8 | Fine-tune chiroptical activity in discrete chiral Au nanorods显示文摘Accurate researches on the surface plasmon resonance(SPR)-based applications of chiral plasmonic metal nanoparticles(NPs)still remain a great challenge.Herein,a series of chiral plasmonic metal NPs,e.g.,chiral Au nanorods(c-Au NRs),c-Au@Ag core–shell,and c-Au@TiO_(2) core–shell NRs,with different chiroptical activities have been produced.Plasmonic circular dichroism(PCD)bands of c-Au NRs can be precisely tailored by tuning the longitudinal SPR(LSPR)and amount of Au NRs as seeds.Besides,a shift of PCD bands within ultraviolet–visible–near infrared ray(UV–vis–NIR)region can also be achieved through the functionalization of a shell of another metal or semiconductor.Interestingly,chirality transfer from c-Au core to Ag shell leads to new PCD bands at the near-UV region.The tuning of PCD bands and chirality transfer are confirmed by our developed theoretical model.Developing chiral Au NRs-based chiral plasmonic nanomaterials with tunable chiroptical activities will be helpful to understand the structure-direct PCD and to extend circularly polarized-based applications. | Guangchao Zheng Sulin Jiao Wei Zhang Shenli Wang Qinghua Zhang Lin Gu Weixiang Ye Junjun Li Xiaochen Ren Zhicheng Zhang Kwok-yin Wong | 2022 | Nano Research2022，15，7： | 2 |
| 9 | Carbon dots enhanced gelatin/chitosan bio-nanocomposite packaging film for perishable foods显示文摘Carbon dots(CDs)with intriguing fluorescent property,good biocompatibility,high stability,easy interaction with substrates,are burgeoning carbon nanoparticles with large potential in various applications.Incorporating CDs into the polymer matrix is becoming a popular strategy to endow the complex with new functions.Herein,the green-synthesized CDs was integrated into the mixture of gelatin(derived from waste fish scale)and chitosan,and a multifunctional bio-nanocomposite(defined as Gelatin/Chitosan/CDs)film was developed,which showed the excellent antibacterial,antioxidant,pH-sensitivity,UV shielding,and blue-emission properties.The effects of different concentrations of CDs on the physical,mechanical,structural,and functional activity of bio-nanocomposite film were tested.Compared with the Gelatin/Chitosan film,the Gelatin/Chitosan/CDs film with an optimum addition of 20%CDs showed the enhanced antibacterial,antioxidant as well as UV shielding activities.More importantly,it was used as an effective packaging material for fish meat preservation,reducing the loss of nutritional quality consumption,extending the shelf life of food.Besides,the bio-nanocomposite films also possessed the anti-counterfeiting and pH-responsive properties due to the strong fluorescent emission of CDs,and had the great potential in developing the intelligent packaging materials.Our work shed new light on the new application of CDs and the synthesis of bio-nanocomposite film in food industry. | Bofei Fu Qiaoling Liu Minghuan Liu Xiaofang Chen Hetong Lin Zongping Zheng Junqiu Zhu Congjie Dai Xiaochen Dong Da-Peng Yang | 2022 | Chinese Chemical Letters2022，33，10： | 1 |
| 10 | Ternary phase interfacial polymerization of polypyrrole/MWCNT nanocomposites with core–shell structure显示文摘 | Yongqin Han Mingxia Shen Xiaochen Lin Bing Ding Luojiang Zhang Hao Tong Xiaogang Zhang | 2012 | Synthetic Metals . 2012 (9-10)2012，，9： | 1 |
| 11 | Hydrothermal pretreatment of microalgae for production of pyrolytic bio-oil with a low nitrogen content显示文摘 | Zhenyi Du Michael Mohr Xiaochen Ma Yanling Cheng Xiangyang Lin Yuhuan Liu Wenguang Zhou Paul Chen Roger Ruan | 2012 | Bioresource Technology2012，，： | 1 |
| 12 | TGA factors promote plant root growth by modulating redox homeostasis or response显示文摘To identify novel regulators of stem cell renewal,we mined an existing but little explored cell typespecific transcriptome dataset for the Arabidopsis root.A member of the TGA family of transcription factors,TGA8,was found to be specifically expressed in the quiescent center(QC).Mutation in TGA8 caused a subtle root growth phenotype,suggesting functional redundancy with other TGA members.Using a promoter::HGFP transgenic approach,we showed that all TGA factors were expressed in the root,albeit at different levels and with distinct spatial patterns.Mutant analyses revealed that all TGA factors examined contribute to root growth by promoting stem cell renewal,meristem activity,and cell elongation.Combining transcriptome analyses,histochemical assays,and physiological tests,we demonstrated that functional redundancy exists among members of cladesⅡandⅤor those in cladesⅠandⅢ.These two groups of TGA factors act differently,however,as their mutants responded to oxidative stress differently and quantitative reverse transcription polymerase chain reaction assays showed they regulate different sets of genes that are involved in redox homeostasis.Our study has thus uncovered a previously unrecognized broad role and a mechanistic explanation for TGA factors in root growth and development. | Xiaochen Hu Liyun Yang Mengfei Ren Lin Liu Jing Fu Hongchang Cui | 2022 | Journal of Integrative Plant Biology2022，64，8： | 1 |
| 13 | Controlled release and antibacterial activity of nanofibers loaded with basil essential oil-encapsulated cationic liposomes against Listeria monocytogenes显示文摘In recent years,the development of functional packaging from natural active compounds has been a promising strategy for microbial control in foods.In this study,the basil essential oil(BEO)was applied as the principal antibacterial agent,and a controlled-release nanofibrous system was engineered with responsiveness to bacterial phospholipase.It indicated that encapsulation by cationic liposome significantly improved the dispersity and stability of BEO during the electrospinning process,and the prepared BEO-loaded cationic liposomes(BCLs)could maintain structural integrity in polymer nanofibers.The resulting BCLs-loaded nanofibers showed an effective antibacterial activity against L.monocytogenes.Additionally,it is worth noting that incorporation of soybean lecithin in nanofiber substrate could accelerate the release of loaded antibacterial agents when exposed to L.monocytogenes,thus obtaining an enhanced antibacterial activity.This could be attributed to the increased sensitivity of nanofibers to the degradation by bacterial phospholipases after incorporation with soybean lecithin.Finally,the application test showed that the prepared antibacterial nanofibrous mats could help maintain the quality of chilled pork during 4-days storage,which indicated their promising potential as active packaging.Given the serious threat of L.monocytogenes to food safety,the present antibacterial nanofibers have wide application prospect for improving microbial safety of chilled meat. | Changzhu Li Mei Bai Xiaochen Chen Wei Hu Haiying Cui Lin Lin | 2022 | Food Bioscience2022，46，2： | 1 |
| 14 | Cultivation of a microalga Chlorella vulgaris using recycled aqueous phase nutrients from hydrothermal carbonization process显示文摘 | Zhenyi Du Bing Hu Aimin Shi Xiaochen Ma Yanling Cheng Paul Chen Yuhuan Liu Xiangyang Lin Roger Ruan | 2012 | Bioresource Technology2012，，： | 1 |
| 15 | Streaming progressive TIN densification filter for airborne lidar point clouds using multi-core architectures显示文摘 | KANG Xiaochen LIU Jiping LIN Xiangguo | 2014 | Remote Sensing2014，，6： | 1 |
| 16 | Production of aromatic hydrocarbons by catalytic pyrolysis of microalgae with zeolites: Catalyst screening in a pyroprobe显示文摘 | Zhenyi Du Xiaochen Ma Yun Li Paul Chen Yuhuan Liu Xiangyang Lin Hanwu Lei Roger Ruan | 2013 | Bioresource Technology2013，，： | 1 |
| 17 | Bisulfite-free mapping of DNA cytosine modifications:challenges and perspectives显示文摘The mapping of DNA cytosine modifications is crucial for understanding the dynamic landscape of epigenetic regulation.While bisulfite sequencing has been the gold standard for decades,it suffers from limitations such as DNA degradation and low library quality due to harsh chemical treatment.In recent years,bisulfite-free methods have emerged as promising alternatives for detecting and quantifying DNA cytosine modifications.These methods employ enzymatic and chemical strategies to investigate cytosine modifications without the need for bisulfite treatment.This review provides an overview of the historical context of bisulfite-based methods and presents the current landscape of bisulfite-free methods.The advantages and limitations of each approach are discussed,along with insights into their applications.Furthermore,the review explores the existing challenges in the field and presents future perspectives and potential directions for advancing bisulfite-free mapping methods.The continued progress in bisulfite-free techniques holds great promise for unraveling the intricate nature of DNA cytosine modifications and their functional implications in diverse biological processes and diseases. | Yanfang Du Ying Tang Bingqian Lin Xiaochen Xue Yafen Wang Yibin Liu | 2023 | Science China Chemistry2023，66，11： | 0 |
| 18 | 小鼠早期胚胎发育的蛋白质组表达图景显示文摘文章简介胚胎着床前的发育是一个复杂而又精密调控的过程,该过程由合子基因组活化后的母源蛋白质和新合成的蛋白质介导。尽管基因组和转录组的研究使我们对这一过程的遗传学调控程序有了丰富的理解,但是蛋白质表达的动态图景尚有待揭示。利用定量质谱的方法,课题组从8000个小鼠胚胎的6个时期的胚胎中(合子,2-,4-,8-细胞,桑葚胚和囊胚)定量了5000个蛋白质的表达谱。 | 高亚威 刘晓雨 唐彬 李翀 Zhaohui Kou Lin Li Wenqiang Liu You Wu Xiaochen Kou Jingyi Li Yanhong Zhao Jiqing Yin Hong Wang She Chen 廖鲁剑 高绍荣 | 2018 | 科学新闻2018，0，4： | 0 |
| 19 | Altered gene expression in human brain microvascular endothelial cells in response to the infection of influenza H1N1 virus显示文摘Influenza viruses not only cause respiratory illness,but also have been reported to elicit neurological manifestations following acute viral infection.The central nervous system(CNS)has a specific defense mechanism against pathogens structured by cerebral microvasculature lined with brain endothelial cells to form the blood–brain barrier(BBB).To investigate the response of human brain microvascular endothelial cells(hBMECs)to the Influenza A virus(IAV),we inoculated the cells with the A/WSN/33(H1N1)virus.We then conducted an RNAseq experiment to determine the changes in gene expression levels and the activated disease pathways following infection.The analysis revealed an effective activation of the innate immune defense by inducing the pattern recognition receptors(PRRs).Along with the production of proinflammatory cytokines,we detected an upregulation of interferons and interferon-stimulated genes,such as IFN-β/λ,ISG15,CXCL11,CXCL3 and IL-6,etc.Moreover,infected hBMECs exhibited a disruption in the cytoskeletal structure both on the transcriptomic and cytological levels.The RNAseq analysis showed different pathways and candidate genes associated with the neuroactive ligand-receptor interaction,neuroinflammation,and neurodegenerative diseases,together with a predicted activation of the neuroglia.Likewise,some genes linked with the mitochondrial structure and function displayed a significantly altered expression.En masse,this data supports that hBMECs could be infected by the IAV,which induces the innate and inflammatory immune response.The results suggest that the influenza virus infection could potentially induce a subsequent aggravation of neurological disorders. | Doaa Higazy Xianwu Lin Tanghui Xie Ke Wang Xiaochen Gao Min Cui | 2023 | Animal Diseases2023，3，1： | 0 |
| 20 | Mettl5 mediated 18S rRNA N6-methyladenosine(m^(6)A)modification controls stem cell fate determination and neural function显示文摘Ribosome RNA(rRNA)accounts for more than 80%of the cell's total RNA,while the physiological functions of rRNA modifications are poorly understood.Mutations of 18S rRNA m6A methyltransferase METTL5 cause intellectual disability,microcephaly,and facial dysmorphisms in patients,however,little is known about the underlying mechanisms.In this study,we identified METTL5 protein complex and revealed that METTL5 mainly interacts with RNA binding proteins and ribosome proteins.Functionally,we found that Mettl5 knockout in mESCs leads to the abnormal craniofacial and nervous development.Moreover,using Mettl5 knockout mouse model,we further demonstrated that Mettl5 knockout mice exhibit intellectual disability,recapitulating the human phenotype.Mechanistically,we found that Mettl5 maintains brain function and intelligence by regulating the myelination process.Our study uncovered the causal correlation between mis-regulated 18S rRNA m6A modification and neural function defects,supporting the important physiological functions of rRNA modifications in human diseases. | Lu Wang Yu Liang Rongzhi Lin Qiuchan Xiong Peng Yu Jieyi Ma Maosheng Cheng Hui Han Xiaochen Wang Ganping Wang Fengyin Liang Zhong Pei Demeng Chen Quan Yuan Yi-Zhou Jiang Shuibin Lin | 2022 | Genes & Diseases2022，9，1： | 0 |
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