|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Development and progress on hydrogen metallurgy显示文摘Hydrogen metallurgy is a technology that applies hydrogen instead of carbon as a reduction agent to reduce CO2 emission,and the use of hydrogen is beneficial to promoting the sustainable development of the steel industry.Hydrogen metallurgy has numerous applications,such as H2reduction ironmaking in Japan,ULCORED and hydrogen-based steelmaking in Europe;hydrogen flash ironmaking technology in the US;HYBRIT in the Nordics;Midrex H2TM by Midrex Technologies,Inc.(United States);H2FUTURE by Voestalpine(Austria);and SALCOS by Salzgitter AG(Germany).Hydrogen-rich blast furnaces(BFs)with COG injection are common in China.Running BFs have been industrially tested by AnSteel,XuSteel,and BenSteel.In a currently under construction pilot plant of a coal gasification–gas-based shaft furnace with an annual output of 10000 t direct reduction iron(DRI),a reducing gas composed of 57 vol%H2 and 38 vol%CO is prepared via the Ende method.The life cycle of the coal gasification–gas-based shaft furnace–electric furnace short process(30 wt%DRI+70 wt%scrap)is assessed with 1 t of molten steel as a functional unit.This plant has a total energy consumption per ton of steel of 263.67 kg standard coal and a CO2 emission per ton of steel of 829.89 kg,which are superior to those of a traditional BF converter process.Considering domestic materials and fuels,hydrogen production and storage,and hydrogen reduction characteristics,we believe that a hydrogen-rich shaft furnace will be suitable in China.Hydrogen production and storage with an economic and large-scale industrialization will promote the further development of a full hydrogen shaft furnace. | Jue Tang Man-sheng Chu Feng Li Cong Feng Zheng-gen Liu Yu-sheng Zhou | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，6： | 34 |
| 2 | Pyroptosis: mechanisms and diseases显示文摘Currently,pyroptosis has received more and more attention because of its association with innate immunity and disease.The research scope of pyroptosis has expanded with the discovery of the gasdermin family.A great deal of evidence shows that pyroptosis can affect the development of tumors.The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds.In this review,we provide basic knowledge of pyroptosis,explain the relationship between pyroptosis and tumors,and focus on the significance of pyroptosis in tumor treatment.In addition,we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis.In brief,pyroptosis is a double-edged sword for tumors.The rational use of this dual effect will help us further explore the formation and development of tumors,and provide ideas for patients to develop new drugs based on pyroptosis. | Pian Yu Xu Zhang Nian Liu Ling Tang Cong Peng Xiang Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 26 |
| 3 | Geochronology and Petrogenesis for the Protolith of Biotite Plagioclase Gneiss at Lianghe,Western Yunnan显示文摘在这份报纸,我们在西方的云南在 Lianghe 从黑云母斜长石片麻岩报导 U-Pb 年龄的综合研究和锆石的 Hf 同位素作文。锆石保存了继承核心和边界质地。火的锆石谷物和边界产出 120.4 的加权的吝啬的 206Pb/238U 年龄 ????晈 吗?? | CONG Feng LIN Shiliang ZOU Guangfu XIE Tao LI Zaihui TANG Fawei PENG Zhimin | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 16 |
| 4 | Enhanced allelopathy and competitive ability of invasive plant Solidago canadensis in its introduced range显示文摘Aims Why invasive plants are more competitive in their introduced range than native range is still an unanswered question in plant invasion ecology.Here,we used the model invasive plant Solidago canaden-sis to test a hypothesis that enhanced production of allelopathic compounds results in greater competitive ability of invasive plants in the invaded range rather than in the native range.We also exam-ined the degree to which the allelopathy contributes increased com-petitive ability of S.canadensis in the invaded range.Methods We compared allelochemical production by S.canadensis growing in its native area(the USA)and invaded area(China)and also by populations that were collected from the two countries and grown together in a'common garden'greenhouse experiment.We also tested the allelopathic effects of S.canadensis collected from either the USA or China on the germination of Kummerowia striata(a native plant in China).Finally,we conducted a common garden,greenhouse experiment in which K.striata was grown in monocul-ture or with S.canadensis from the USA or China to test the effects of allopathy on plant-plant competition with suitable controls such as adding activated carbon to the soil to absorb the allelochemicals and thereby eliminating any corresponding allopathic effects.Important findings Allelochemical contents(total phenolics,total flavones and total saponins)and allelopathic effects were greater in S.canadensis sampled from China than those from the USA as demonstrated in a field survey and a common garden experiment.Inhibition of K.stri-ata germination using S.canadensis extracts or previously grown in soil was greater using samples from China than from the USA.The competitive ability of S.canadensis against K.striata was also greater for plants originating from China than those from the USA.Allelopathy could explain about 46%of the difference.These find-ings demonstrated that S.canadensis has evolved to be more allelo-pathic and competitive in the introduced range and that allelopathy significantly contributes to increased competitiveness for this inva-sive species. | Yongge Yuan Bing Wang Shanshan Zhang Jianjun Tang Cong Tu Shuijin Hu Jean W.H.Yong Xin Chen | 2013 | Journal of Plant Ecology2013，6，3： | 15 |
| 5 | China's provincial CO2 emissions embodied in trade with implications for regional climate policy显示文摘 | Zhangqi ZHONG Rui HUANG Qinneng TANG Xiaonan CONG Zheng WANG | 2015 | Frontiers of Earth Science2015，9，1： | 14 |
| 6 | Characteristics of PM_(2.5) pollution in Beijing after the improvement of air quality显示文摘Following the implementation of the strictest clean air policies to date in Beijing,the physicochemical characteristics and sources of PM_(2.5) have changed over the past few years.To improve pollution reduction policies and subsequent air quality further,it is necessary to explore the changes in PM_(2.5) over time.In this study,over one year(2017-2018)field study based on filter sampling(TH-150C;Wuhan Tianhong,China)was conducted in Fengtai District,Beijing,revealed that the annual average PM_(2.5) concentration(64.8±43.1μg/m^3)was significantly lower than in previous years and the highest PM_(2.5) concentration occurred in spring(84.4±59.9μg/m^3).Secondary nitrate was the largest source and accounted for 25.7%of the measured PM_(2.5).Vehicular emission,the second largest source(17.6%),deserves more attention when considering the increase in the number of motor vehicles and its contribution to gaseous pollutants.In addition,the contribution from coal combustion to PM_(2.5) decreased significantly.During weekends,the contribution from EC and NO3−increased whereas the contributions from SO4^2−,OM,and trace elements decreased,compared with weekdays.During the period of residential heating,PM_(2.5) mass decreased by 23.1%,compared with non-heating period,while the contributions from coal combustion and vehicular emission,and related species increased.With the aggravation of pollution,the contribution of vehicular emission and secondary sulfate increased and then decreased,while the contribution of NO3−and secondary nitrate continued to increase,and accounted for 34.0%and 57.5%of the PM_(2.5) during the heavily polluted days,respectively. | Xiaojuan Huang Guiqian Tang Junke Zhang Baoxian Liu Chao Liu Jin Zhang Leilei Cong Mengtian Cheng Guangxuan Yan Wenkang Gao Yinghong Wang Yuesi Wang | 2021 | Journal of Environmental Sciences2021，33，2： | 14 |
| 7 | Establishment and primary application of a mouse model with hepatitis B virus replication显示文摘瞄准:与肝炎 B (HBV ) 复制建立一个快速、方便的动物模型。方法:HBV-replication-competent 原生质标志的一个裸体 DNA 解决方案经由尾巴静脉被转移到 BALB/C 鼠标,用一个水动力学在活体内 transfection 过程。在注射以后,这些老鼠在 d 上被牺牲 1, 3, 4, 5, 7 和 10。在肝的 HBV DNA 复制中介被南部的污点杂交分析。肝炎 B 核心抗原(HBcAg ) 和在肝的肝炎 B 表面抗原(HBsAg ) 的表示被免疫组织化学检查。浆液 HBsAg 和肝炎 B e 抗原(HBeAg ) 被连接酶的免疫吸着剂试金(ELISA ) 检测。HBV 复制的抑制在与 polyinosinic-polytidylin 酸(polyIC ) intraperitoneally 对待的 HBV 复制模型老鼠被比较或缓冲磷酸盐 saline (PBS ) 。结果:在水动力学在活体内 transfection 以后,在老鼠肝的 HBV DNA 复制中介在 d 上是可检测的 1 并且在 d 上丰富 3 和 4,层次稍微被减少并且在 d 之间仍然保持相对稳定 5 和 7,并且在 d 上是几乎无法发现的 10。HBcAg 和 HBsAg 的表示模式类似于 HBV 复制中介 DNA 的,除了他们在 d 上到达了一座山峰之外 1 在注射以后。在 HBV DNA 复制中介的明显的差别都没在肝的左、正确、中间的脑叶被观察。有 polyIC 的术后疗法,在肝的 HBV 中间的 DNA 的水平在与 PBS 注射的控制老鼠是比那低的。结论:有 HBV 复制的高水平的一个快速、方便的老鼠模型被开发并且过去常在 HBV 复制上调查 polyIC 的禁止的效果,它为未来提供一个有用工具 HBV 染色体的功能的研究。 | Feng-Jun Liu Li Liu Fang He Su Wang Tao-You Zhou Cong Liu Lin-Yu Deng Hong Tang | 2007 | World Journal of Gastroenterology2007，13，40： | 13 |
| 8 | New prospecting progress using information and big data of coal and oil exploration holes on sandstone-type uranium deposit in North China显示文摘1.Objective A series of Mesozoic-Cenozoic continental sedimentary basins exist in North China,coexisting with coal,oil/gas,and salt resources.Many previous drilling projects have been conducted within these basins to explore coal,petroleum,and mineral resources,however,these data have not been integrated due to different industries owners.In order to efficiently explore the large-sized,easily extracted,and environmentally friendly,sandstone-type uranium deposits,previous coal and oil exploration drilling-hole data are systematically collected, processed,and analyzed to improve the sandstone-type uranium prospecting exploitation.At the same time,we also discussed the uranium source,ore-forming process and model for the sandstone-type uranium deposits. | Ruo-shi Jin Pei-sen Miao Xian-zhang Sima Reng-An Yu Yin-hang Cheng Chao Tang Tian-fu Zhang Cong Ao Xue-ming Teng | 2018 | China Geology2018，1，1： | 12 |
| 9 | Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014显示文摘Background:H7N9 continues to cause human infections and remains a pandemic concern.Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation,including infectious disease prevention and control investment.However,there are limited data on such impacts.Methods:Hospitalized laboratory-confirmed H7N9 patients or their families in Jiangsu Province of China were interviewed.Patients’direct medical costs of hospitalization were derived from their hospital bills.A generalized linear model was employed to estimate the mean direct medical costs of patients with different characteristics.Results:The mean direct cost of hospitalization for H7N9 was estimated to be¥71060(95%CI,48180–104820),i.e.,US$10996(95%CI,7455–16220),and was¥12060(US$1861),¥136120(US$21001)and¥218610(US$33728)for those who had mild or severe symptoms or who died,respectively.The principal components of the total fees differed among patients with different disease severity,although medication fees were always the largest contributors.Disease severity,proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient’s direct medical cost of hospitalization.Conclusions:The direct medical costs of hospitalized patients with H7N9 are significant,and far surpass the annual per capita income of Jiangsu Province,China.The influencing factors identified should be taken into account when developing related health insurance policies and making health resource allocation.Trial registration:Not applicable.This is a survey study with no health care intervention implemented on human participants. | Xiang Huo Li-Ling Chen Lei Hong Lun-Hui Xiang Fen-Yang Tang Shan-Hui Chen Qiang Gao Cong Chen Qi-gang Dai Chuan-Wu Sun Ke Xu Wen-Jun Dai Xian Qi Chang-Cheng Li Hui-Yan Yu Yin Zhou Hao-Di Huang Xing-Yang Pan Chang-sha Xu Ming-Hao Zhou Chang-Jun Bao | 2016 | Infectious Diseases of Poverty2016，5，1： | 10 |
| 10 | Study of a Novel Brain Relatively Specific Gene LRRC4 Involved in Glioma Tumorigenesis Suppression Using the Tet-on System显示文摘LRRC4 是新奇相对特定的基因,它在主要大脑肿瘤活体检视显示 significantdown 规定并且有潜力压制大脑 tumorgrowth.In 这研究,我们调查了生长在在由一个四圜素可诱导的表达式系统的 vitro 的房间增长上的 vivoand 的 tumorigencity 上的 LRRC4 的禁止的效果。结果证明 thatLRRC4 显著地减少了生长和从 glioblastomaU251MG 房间产生的异种皮移植的恶意的等级。在 U251MG Tet-on-LRRC4 细胞正式就职 withdoxycycline.Flow cytometry 和蛋白质印迹分析证明 LRRC4 调停了以后,细胞增长显著地被禁止在迟了的 G_1 的细胞周期的延期,可能通过起来调整 p21Wafl/cipl andp27Kipl 的表情并且下面调整 cyclin 依赖的激酶的表情 2, retinoblastoma 蛋白质和表皮的生长因素受体。一起,这些调查结果作为细胞生长的一个否定管理者提供线索给 LRRC4 的功能并且强调在 above-mentionedcyclins,联系 cyclin 的分子和 tumorigenicity 之间的一个连接。 | Qiu-Hong ZHANG Li-Li WANG Li CAO Cong PENG Xiao-Ling LI Ke TANG Wei-Fang LI Ping LIAO Jie-Ru WANG Gui-Yuan LI | 2005 | Acta Biochimica et Biophysica Sinica2005，37，8： | 9 |
| 11 | Study on the mechanism of copper-ammonia complex decomposition in struvite formation process and enhanced ammonia and copper removal显示文摘Heavy metals and ammonia are difficult to remove from wastewater,as they easily combine into refractory complexes.The struvite formation method(SFM) was applied for the complex decomposition and simultaneous removal of heavy metal and ammonia.The results indicated that ammonia deprivation by SFM was the key factor leading to the decomposition of the copper-ammonia complex ion.Ammonia was separated from solution as crystalline struvite,and the copper mainly co-precipitated as copper hydroxide together with struvite.Hydrogen bonding and electrostatic attraction were considered to be the main surface interactions between struvite and copper hydroxide.Hydrogen bonding was concluded to be the key factor leading to the co-precipitation.In addition,incorporation of copper ions into the struvite crystal also occurred during the treatment process. | Cong Peng Liyuan Chai Chongjian Tang Xiaobo Min Yuxia Song Chengshan Duan Cheng Yu | 2017 | Journal of Environmental Sciences2017，29，1： | 9 |
| 12 | Current status and development trends of innovative blast furnace ironmaking technologies aimed to environmental harmony and operation intellectualization显示文摘Blast furnace(BF)ironmaking is dominant for reducing pollution emission and energy consumption in iron and steel industry.Under the increasingly strict environmental pressure,some innovative technologies of BF ironmaking for environmental protection have been developed and applied in actual operating facilities.The current state of BF ironmaking in Europe,America,Japan,and China were briefly overviewed.Moreover,some innovative BF ironmaking technologies aiming at environmental harmony and operation intellectualization in the world,such as waste gas recycling sintering,BF operation with coke oven gas injection,ferro-coke,lime coating coke,BF visualization and intellectualization,were roundly summarized.Finally,some discussion on the technologies was carried out and the development trends of BF ironmaking were pointed out.The review could provide references and supports for the progress of environment-friendly technologies of BF ironmaking,thereby promoting their practical applications and achieving sustainable development of BF ironmaking,especially for Chinese ironmaking industry. | Hong-tao Wang Wei Zhao Man-sheng Chu Cong Feng Zheng-gen Liu Jue Tang | 2017 | Journal of Iron and Steel Research(International)2017，24，8： | 9 |
| 13 | Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition显示文摘The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis,homeostasis and function.Vascular endothelial growth factor-a(VEGFA)has been commonly recognized as a pro-angiogenic factor in vertebrate developmental,physiological and pathological conditions for decades.Here we report a novel finding that genetic ablation of CDP-diacylglycerol synthetase-2(CDS2),a metabolic enzyme that controls phosphoinositide recycling,switches the output of VEGFA signaling from promoting angiogenesis to unexpectedly inducing vessel regression.Live imaging analysis uncovered the presence of reverse migration of the angiogenic endothelium in cds2 mutant zebrafish upon VEGFA stimulation,and endothelium regression also occurred in postnatal retina and implanted tumor models in mice.In tumor models,CDS2 deficiency enhanced the level of tumorsecreted VEGFA,which in-turn trapped tumors into a VEGFA-induced vessel regression situation,leading to suppression of tumor growth.Mechanistically,VEGFA stimulation reduced phosphatidylinositol(4,5)-bisphosphate(PIP2)availability in the absence of CDS2-controlled-phosphoinositide metabolism,subsequently causing phosphatidylinositol(3,4,5)-triphosphate(PIP3)deficiency and F0X01 activation to trigger regression of CDS2-null endothelium.Thus,our data indicate that the effect of VEGFA on vasculature is context-dependent and can be converted from angiogenesis to vascular regression. | Wencao Zhao Le Cao Hanru Ying Wenjuan Zhang Dantong Li Xiaolong Ziiu Wenzhi Xue Shuang Wu Mengye Cao Cong Fu Haonan Qi Yimei Hao Yun-Chi Tang Jun Qin Tao PZhong Xiaoxi Lin Luyang Yu Xuri Li Lin Li Dianqing Wu Weijun Pan | 2019 | Cell Research2019，29，11： | 9 |
| 14 | Cross-talk between NMDA and GABA_A receptors in cultured neurons of the rat inferior colliculus显示文摘Neuronal ion channels of different types often do not function independently but will inhibit or potentiate the activity of other types of channels,a process called cross-talk.The N-methyl-D-aspartate receptor (NMDA receptor) and the γ-aminobutyric acid type A receptor (GABAA receptor) are important excitatory and inhibitory receptors in the central nervous system,respectively.Currently,cross-talk between the NMDA receptor and the GABAA receptor,particularly in the central auditory system,is not well understood.In the present study,we investigated functional interactions between the NMDA receptor and the GABAA receptor using whole-cell patch-clamp techniques in cultured neurons from the inferior colliculus,which is an important nucleus in the central auditory system.We found that the currents induced by aspartate at 100 μmol L-1 were suppressed by the pre-perfusion of GABA at 100 μmol L-1,indicating cross-inhibition of NMDA receptors by activation of GABAA receptors.Moreover,we found that the currents induced by GABA at 100 μmol L-1 (IGABA) were not suppressed by the pre-perfusion of 100 μmol L-1 aspartate,but those induced by GABA at 3 μmol L-1 were suppressed,indicating concentration-dependent cross-inhibition of GABAA receptors by activation of NMDA receptors.In addition,inhibition of IGABA by aspartate was not affected by blockade of voltage-dependent Ca2+ channels with CdCl2 in a solution that contained Ca2+,however,CdCl2 effectively attenuated the inhibition of IGABA by aspartate when it was perfused in a solution that contained Ba2+ instead of Ca2+ or a solution that contained Ca2+ and 10 mmol L-1 BAPTA,a membrane-permeable Ca2+ chelator,suggesting that this inhibition is mediated by Ca2+ influx through NMDA receptors,rather than voltage-dependent Ca2+ channels.Finally,KN-62,a potent inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII),reduced the inhibition of IGABA by aspartate,indicating the involvement of CaMKII in this cross-inhibition.Our study demonstrates a functional interaction between NMDA and GABAA receptors in the inferior colliculus of rats.The presence of cross-talk between these receptors suggests that the mechanisms underlying information processing in the central auditory system may be more complex than previously believed. | CONG DanNi TANG ZhengQuan LI LongZhu HUANG YiNa WANG Jun CHEN Lin | 2011 | Science China(Life Sciences)2011，54，6： | 9 |
| 15 | Gly(82)Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population显示文摘 | Gu, H.J. Yang, L. Sun, Q. M. Zhou, B. Tang, N. P. Cong, R. H. Zeng, Y. Wang, B. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 9 |
| 16 | Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China显示文摘Objective To investigate a potential relationship between Solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients.Methods A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks (104 and 105 patients,respectively).Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment.An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy.Results Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study.Δ value of homeostasis model assessment of beta cell function (HOMA-B)and Δ value of fasting proinsulin levels were statistically significant between three genotype groups (P=0.0149 and 0.0246,respectively) after rosiglitazone treatment.However,no genotype association was observed in the repaglinide or rosiglitazone group with other parameters.Conclusion The SLC30A8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai,China. | JIANG Feng LI Qing HU Cheng ZHANG Rong WANG Cong Rong YU Wei Hui LU Jing Yi TANG Shan Shan BAO Yu Qian XIANG Kun San JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 8 |
| 17 | No association between low-dose reserpine use and depression in older hypertensive patient: result of a multicenter, cross-sectional study显示文摘Background Reserpine is currently used by millions of Chinese hypertensive patients, in spite of the continued concern of its depressogenic effect, even when used in low dose. This study aimed to investigate the association between low-dose reserpine use and depression in older Chinese hypertensive patient. Methods In this cross-sectional, case-control study, we recruited patient aged 60 years or over who had regularly taken one or two tables of “compound reserpine and triamterene tablets (CRTTs)” for more than one year (reserpine user) from 26 community health centers located in 10 provinces in China. For each patient who took CRTTs, we selected an age (within five years) and sex matched hypertensive patient who had never taken any drugs containing reserpine (non-reserpine user) as control. Depressive symptoms were evaluated using a Chinese depression scale adapted from the Zung Self-Rating Depression Scale. Demographic, clinical data and laboratory examination results within six months were collected. Results From August 2018 to December 2018, 787 reserpine user and 787 non-reserpine user were recruited. The mean age of all study subjects was 70.3 years, with about equal numbers of males and females. The mean depression score was 40.4 in reserpine users and 40.6 in non-reserpine users (P = 0.7). The majority of study subject had a depression score < 53 (87.6% in reserpine users and 88.2% in non-reserpine users, respectively). There were no significant differences in the prevalence of mild, moderate or severe depression in reserpine users and non-reserpine users. Conclusions There is no association between low-dose reserpine use and depression in older hypertensive patient. The role of reserpine in the treatment and control of hypertension should be reconsidered;and further studies, especially randomized, controlled clinical trials to compare efficacy and safety of reserpine and other widely recommended anti-hypertensive agents are needed. | Guo-Hua ZHU Xi-Peng SUN Jing LI Lin PI Hai-Qin TANG Hai-Qing GAO Hong-Liang CONG Peng QU Xin-Zheng LU Xin-Jun ZHANG Luo-Sha ZHAO Yi-Fang GUO Dong-Xia LIU Liang-Qing ZHANG Hua TANG Yi-Xin HU Li FAN Qi HUA | 2019 | Journal of Geriatric Cardiology2019，16，8： | 8 |
| 18 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
| 19 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 20 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员