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| 1 | Atypical features and treatment choices in bipolar disorders:a result of the National Bipolar Mania Pathway Survey in China显示文摘In this study,we examined the point prevalence rate of atypical features in bipolar disorder,and estimated the potential impact of these features on treatment practices in China. Using the atypical features criteria of the Diagnostic and Statistical Manual of the American Psychiatric Association(DSM-IV),we documented the atypical symptoms in 3 906 consecutive participants with bipolar disorder enrolled at 26 psychiatric services across China. We further assessed the association between atypical features and the treatment approaches,including the prescription of antidepressants. The overall point prevalence rate of atypical features was 9.1% among patients with various bipolar disorder subtypes. When the definition was broadened to include atypical features B,the overall rate increased to 11.8%. Interestingly,among patients with the mixed state and remission subtypes,there was a significant difference in the rates of antidepressant medication usage between patients who met and those who did not meet the criteria for atypical features B. These fi ndings indicate a trend of using antidepressants for these two types of patients with atypical features. Further,for both mixed state and remission patients,treatment approaches were related to atypicalfeatures B. Our findings provide evidence to assist clinicians to readily recognize atypical features in bipolar subtypes and can propose treatments based on these diagnoses. | Daihui Peng Ting Shen Linda Byrne Chen Zhang Yueqi Huang Xin Yu Jingping Zhao Marita McCabe David Mellor Yiru Fang | 2015 | Neuroscience Bulletin2015，31，1： | 4 |
| 2 | Revisiting mesoscale eddy genesis mechanism of nonlinear advection in a marginal ice zone显示文摘A three-dimensional(3-D) ocean model is coupled with a two-dimensional(2-D) sea ice model, to revisit a nonlinear advection mechanism, one of the most important mesoscale eddy genesis mechanisms in the marginal ice zone. Two-dimensional ocean model simulations suggest nonlinear advection mechanism is more important when the water gets shallower. Instead of considering the ocean as barotropic fluid in the 2-D ocean model, the 3-D ocean model allows the sea ice to affect the current directly in the surface layer via ocean-ice interaction. It is found that both mesoscale eddy and sea surface elevation are sensitive to changes in a water depth in the 3-D simulations. The vertical profile of a current velocity in 3-D experiments suggests that when the water depth gets shallower, the current move faster in each layer, which makes the sea surface elevation be nearly inverse proportional to the water depth with the same wind forcing during the same time. It is also found that because of the vertical motion, the magnitude of variations in the sea surface elevation in the 3-D simulations is very small,being only 1% of the change in the 2-D simulations. And it seems the vertical motion to be the essential reason for the differences between the 3-D and 2-D experiments. | DAI Haijin CUI Jian YU Jingping | 2017 | Acta Oceanologica Sinica2017，36，11： | 2 |
| 3 | The Study of a Micro Channel Integrated Gas Flow Sensor显示文摘 | YU Bolin GAN Zhiyin XU Jingping LIU Sheng | 2009 | Chinese Journal of Electronics2009，18，3： | 2 |
| 4 | In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition显示文摘Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of tumor.We designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and self-assembly.SAP formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of vascularization.In vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy. | Ziming Chen Kuo Zhang Jiaqi Fan Yu Fan Chao Yang Wen Tian Yuan Li Wenliang Li Jingping Zhang Hao Wang Lei Wang | 2020 | Chinese Chemical Letters2020，31，12： | 2 |
| 5 | Arabinose substitution degree in xylan positively affects lignocellulose enzymatic digestibility after various NaOH/H 2 SO 4 pretreatments in Miscanthus显示文摘 | Fengcheng Li Shuangfeng Ren Wei Zhang Zhengdan Xu Guosheng Xie Yan Chen Yuanyuan Tu Qing Li Shiguang Zhou Yu Li Fen Tu Lin Liu Yanting Wang Jianxiong Jiang Jingping Qin Shizhong Li Qiwei Li Hai-Chun Jing Fasong Zhou Neal Gutterson Liangcai Peng | 2012 | Bioresource Technology2012，，： | 1 |
| 6 | DR3TBDTT Based Ternary Blends Containing Conjugated Polymers: Crystallization Determines Morphology and Performance显示文摘 | Jingping Yin Weihua Zhou Qingyun Ai Xiangchuan Meng Siqi Liu Zoukangning Yu Jianrong Zeng Yiwang Chen | 2018 | Chinese Journal of Chemistry2018，36，5： | 1 |
| 7 | Effects of the PARP inhibitor Niraparib on the radiosensitivity of human lung and cervical cancer cells显示文摘ObjectiveTo investigate the effect of Niraparib,a clinically approved PARP inhibitor on the radiosensitivity of human lung and cervical cancer cells,and preliminarily explore the underlying mechanism.MethodsThe human lung cancer cell line A549 and human cervical cancer cell line Siha were both treated with Niraparib for 1h,or X-ray irradiation with 4y,or Niraparib for 1h combined with X-ray irradiation with 4Gy.The effect was examined via measurements of cell proliferation by the cell counting kit-8 assay,and cell viability was detected by clone formation assays.Cell apoptosis and cell cycle distribution were investigated by flow cytometry.ResultsIn human lung and cervical cancer cell lines,Niraparib combined with radiation therapy significantly inhibited cell proliferation.The proportion of apoptotic cells in cell lines treated with Niraparib plus radiation(the combination group)was significantly higher compared with control,radiation,and Niraparib groups(P<0.05).Additionally,the proportion of A549 cells in the G_(2)/M phase was significantly increased in the combination group compared with the radiation group(P<0.05).ConclusionPARP inhibitor Niraparib increases the radiosensitivity of tumorcells,promotes their apoptosis,and induces cell cycle redistribution.The possible mechanism is associated with the inhibition of radiation-induced DNA damage repair. | Yue Feng Shiyi Pi Yuwei Li Yu Zhang Hongwei Zeng Xiangyu E Yang Zhang Jingping Yu | 2023 | Radiation Medicine and Protection2023，4，2： | 1 |
| 8 | Vibration signal processing for gear fault diagnosis based on empirical mode decomposition and nonlinear blind source separation 显示文摘 | Jiang Yu Qin Li Zhang Yuelei Wn Jingping | 2011 | Noise & Vibration Worldwide2011，42，10： | 1 |
| 9 | Anaerobic digestion of sludge by different pretreatments:Changes of amino acids and microbial community显示文摘Many studies have investigated the effects of different pretreatments on the performance of anaerobic digestion of sludge.However,the detailed changes of dissolved organic nitrogen,particularly the release behavior of proteins and the byproducts of protein hydrolysis-amino acids,are rarely known during anaerobic digestion of sludge by different pretreatments.Here we quantified the changes of three types of proteins and 17 types of amino acids in sludge samples solubilized by ultrasonic,thermal,and acid/alkaline pretreatments and their transformation during anaerobic digestion of sludge.Tryptophan protein,aromatic protein I,aromatic protein II,and cysteine were identified as the key dissolved organic nitrogen responsible for methane production during anaerobic digestion of sludge,regardless of the different pretreatment methods.Different from the depletion of other amino acids,cysteine was resistant to degradation after an incubation period of 30 days in all sludge samples.Meanwhile,the“cysteine and methionine metabolism(K00270)”was absent in all sludge samples by identifying 6755 Kyoto Encyclopedia of Genes and Genomes assignments of genes hits.Cysteine contributed to the generation of methane and the degradation of acetic,propionic,and n-butyric acids through decreasing oxidation-reduction potential and enhancing biomass activity.This study provided an alternative strategy to enhance anaerobic digestion of sludge through in situ production of cysteine. | Keke Xiao Zecong Yu Kangyue Pei Mei Sun Yuwei Zhu Sha Liang Huijie Hou Bingchuan Liu Jingping Hu Jiakuan Yang | 2022 | Frontiers of Environmental Science & Engineering2022，16，2： | 1 |
| 10 | Quality Assessment of Frozen Solenocera crassicornis Treated with Sodium Metabisulphite by Soaking or Spraying显示文摘The present work was carried out to evaluate the safety of shrimp(Solenocera crassicornis)treated with different concentrations of sodium metabisulfite(SMB)by soaking or spraying during frozen storage.Shrimps soaked in higher concentrations of SMB showed higher sensory scores,lower total color differences,and better anti-melanosis effects than shrimps in the control and other treatment groups throughout frozen storage(−18℃).Lower total volatile basic nitrogen and thiobarbituric acid reactive substances and higher salt soluble protein contents were detected in shrimp soaked with high doses of SMB compared with other samples.In addition,lower counts of total aerobic plates and psychrotrophic bacteria were observed in shrimp treated by soaking with higher doses of SMB than those in control shrimp and shrimp treated with other methods during frozen storage(−18℃).However,the SO2 content of 5%SMB-soaked samples exceeded the maximum allowable limit of 100mgkg−1.Overall,the use of 1.5%SMB soaking to treat shrimp results in good antioxidant and antimicrobial effects and,thus,may be suggested to preserve S.crassicornis under frozen conditions.The results of this study present important guidance on the use of SMB to maintain the quality of marine-trawling shrimp from manufacturing to consumption. | ZHU Jingping CHEN Yu JIN Lei ZHU Junxiang | 2020 | Journal of Ocean University of China2020，19，1： | 1 |
| 11 | Evaluation of Clinical Efficacy of Combined Use of Acupuncture and Medicine in Treating Sleep Disorder in Patients with Anxiety Disorder显示文摘[Objectives]To evaluate the clinical efficacy of combined acupuncture and medicine in the treatment of sleep disorders in patients with anxiety disorders.[Methods]A total of 300 anxiety patients with sleep disorders were randomly selected and divided into a research group and a control group,with 150 cases in each group.The control group was administered with western medicine,and the research group was treated with acupuncture and medicine to compare their clinical treatment effects.[Results]The total effective rate of treatment in the research group was significantly higher than that in the control group;after treatment,both the PSQI and SAS scores of the two groups were significantly reduced,and the reduction degree of the research group was higher than that of the control group,the difference was statistically significant(P<0.05).[Conclusions]Combined use of acupuncture and medicine to treat sleep disorders in patients with anxiety disorders has better curative effect and fewer adverse reactions,so it has high clinical application value. | Xiangpu LIU Jingping MU Xinhua YU Shun ZENG Nannan LIU Xiaohu ZHU | 2021 | Medicinal Plant2021，12，3： | 1 |
| 12 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 13 | Comparison of different valent iron on anaerobic sludge digestion:Focusing on oxidation reduction potential,dissolved organic nitrogen and microbial community显示文摘This study compared effects of three different valent iron(Fe^(0),Fe(II)and Fe(III))on enhanced anaerobic sludge digestion,focusing on the changes of oxidation reduction potential(ORP),dissolved organic nitrogen(DON),and microbial community.Under the same iron dose in range of 0−160 mg/L after an incubation period of 30 days(d),the maximum methane production rate of sludge samples dosed with respective Fe^(0),Fe(II)and Fe(III)at the same concentration showed indiscernible differences at each iron dose,regardless of the different iron valence.Moreover,their behavior in changes of ORP,DON and microbial community was different:(1)the addition of Fe^(0) made the ORP of sludge more negative,and the addition of Fe(II)and Fe(III)made the ORP of sludge less negative.However,whether being more or less negative,the changes of ORP may show unobservable effects on methane yield when it ranged from−278.71 to−379.80 mV;(2)the degradation of dissolved organic nitrogen,particularly proteins,was less efficient in sludge samples dosed with Fe^(0) compared with those dosed with Fe(II)and Fe(III)after an incubation period of 30 d.At the same dose of 160 mg/L iron,more cysteine was noted in sludge samples dosed with Fe(II)(30.74 mg/L)and Fe(III)(27.92 mg/L)compared with that dosed with Fe^(0)(21.75 mg/L);(3)Fe^(0) particularly promoted the enrichment of Geobacter,and it was 6 times higher than those in sludge samples dosed with Fe(II)and Fe(III)at the same dose of 160 mg/L iron. | Zecong Yu Keke Xiao Yuwei Zhu Mei Sun Sha Liang Jingping Hu Huijie Hou Bingchuan Liu Jiakuan Yang | 2022 | Frontiers of Environmental Science & Engineering2022，16，6： | 0 |
| 14 | Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry显示文摘The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience. | Bin Liu Xuedong Zhou Lin Yue Benxiang Hou Qing Yu Bing Fan Xi Wei Lihong Qiu Zhengwei Huang Wenwei Xia Zhe Sun Hanguo Wang Liuyan Meng Bin Peng Chen Zhang Shuli Deng Zhaojie Lu Deqin Yang Tiezhou Hou Qianzhou Jiang Xiaoli Xie Xuejun Liu Jiyao Li Zuhua Wang Haipeng Lyu Ming Xue Jiuyu Ge Yi Du Jin Zhao Jingping Liang | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 15 | Hope and Academic Procrastination in Adolescents: A Moderated Mediation Model显示文摘Academic procrastination among adolescents is an increasingly prominent problem. It is important to look forinfluences behind academic procrastination in the adolescent population. The present study aimed to revealthe explanatory mechanisms underlying the association between hope and academic procrastination behaviorsamong Chinese adolescents by testing the mediating role of attentional control and the moderating role of traitmindfulness. Participants in the current study were 1156 Chinese adolescents who completed self-report questionnaireson hope, attentional control, academic procrastination, and trait mindfulness. The results indicatedthat adolescent hope was negatively related to academic procrastination and that attentional control partiallymediated this association. In addition, trait mindfulness moderated the direct association between hope and academicprocrastination in the mediated model. In conclusion, identifying the mechanisms by which hope is associatedwith academic procrastination in adolescent populations is of potential value for the prevention of andintervention in this undesirable study habit. | Shoushi Wang Jingping Shi Ruike Sheng Si Yu Wei Xu | 2022 | International Journal of Mental Health Promotion2022，24，6： | 0 |
| 16 | A potential threat from biodegradable microplastics: mechanism of cadmium adsorption and desorption in the simulated gastrointestinal environment显示文摘It has been demonstrated that microplastics (MPs) can accumulate heavy metals from the environment and transfer them into organisms via the food chain. However, adsorption and desorption capacities for biodegradable MPs relative to those for conventional MPs remain poorly understood. In this study, cadmium (Cd(II)) adsorption and desorption characteristics of polylactic acid (PLA), a typical biodegradable MP, were investigated. Two conventional MPs, i.e., polypropylene (PP) and polyamide (PA) were used for comparison. The maximum Cd(II) adsorption capacities of the MPs studied in the adsorption experiments decreased in the order PA (0.96 ± 0.07 mg/g) > PLA (0.64 ± 0.04 mg/g) > PP (0.22 ± 0.03 mg/g). The Pseudo-second-order kinetic model and Freundlich isothermal model described the Cd(II) adsorption behaviors of PLA MPs well. X-ray photoelectron spectroscopy and two-dimensional Fourier transform infrared correlation spectroscopy analysis indicated that oxygen functional groups were the major and preferential binding sites of PLA MPs, which contributed to their high Cd(II) adsorption capacities. Simulated gastric and intestinal fluids both significantly enhanced the desorption capacities of the examined MPs. Notably, degradation of the PLA MPs during in vitro human digestion made the Cd(II) on the PLA MPs more bioaccessible (19% in the gastric phase and 62% in the intestinal phase) than Cd(II) on the PP and PA MPs. These results indicate the remarkable capacities of biodegradable MPs to accumulate Cd(II) and transfer it to the digestive system and show that biodegradable MPs might pose more severe threats to human health than conventional nonbiodegradable MPs. | Timing Jiang Xiang Wu Shushan Yuan Changfei Lai Shijie Bian Wenbo Yu Sha Liang Jingping Hu Liang Huang Huabo Duan Yafei Shi Jiakuan Yang | 2024 | Frontiers of Environmental Science & Engineering2024，18，2： | 0 |
| 17 | Effect of Endostar combined with concurrent chemoradiotherapy in patients with locally advanced cervical cancer显示文摘ObjectiveTo explore the value of Endostar in the clinical application of locally advanced cervical cancer.MethodsA total of 107 patients with locally advanced cervical cancer who received concurrent chemoradiotherapy(CCRT)in the Department of Radiotherapy,the First Affiliated Hospital of Soochow University and Changzhou No.2 People's Hospital between January 2018 and December 2020 were enrolled in this retrospective study.There were 30 cases in the Endostar combined with CCRT(E-CCRT)group and 77 in the CCRT group.Propensity score matching(PSM)was used to reduce confounding factors.The short-term efficacy and long-term survival rate were compared between the E-CCRT group and the CCRT group.ResultsAfter matching,the objective response rates in the E-CCRT group and CCRT group were 86.7%and 63.3%,respectively,with statistically significant difference(χ^(2)=4.356,P=0.037).But there were no statistically significant differences in the disease control rates(96.7%vs.86.7%,χ^(2)=0.873,P=0.350),3-year overall survival(OS)rates(86.7%vs.83.3%,P=0.681),and 3-year disease-free survival(DFS)rates(both 76.7%and 76.7%,P=0.869).There was no statistically significant difference in the incidence of adverse reactions between the two groups.ConclusionsE-CCRT can improve the response of locally advanced cervical cancer patients without increasing the occurrence of adverse reactions,and has the potential to become a new treatment regimen for cervical cancer. | Hengzhao Zhuang Yang Jiao Xin Li Jingping Yu Juying Zhou Lili Wang | 2023 | Radiation Medicine and Protection2023，4，2： | 0 |
| 18 | Expert consensus on digital guided therapy for endodontic diseases显示文摘Digital guided therapy(DGT)has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent decades.The concept of DGT for endodontic diseases is categorized into static guided endodontics(SGE),necessitating a meticulously designed template,and dynamic guided endodontics(DGE),which utilizes an optical triangulation tracking system.Based on cone-beam computed tomography(CBCT)images superimposed with or without oral scan(OS)data,a virtual template is crafted through software and subsequently translated into a 3-dimensional(3D)printing for SGE,while the system guides the drilling path with a real-time navigation in DGE.DGT was reported to resolve a series of challenging endodontic cases,including teeth with pulp obliteration,teeth with anatomical abnormalities,teeth requiring retreatment,posterior teeth needing endodontic microsurgery,and tooth autotransplantation.Case reports and basic researches all demonstrate that DGT stand as a precise,time-saving,and minimally invasive approach in contrast to conventional freehand method.This expert consensus mainly introduces the case selection,general workflow,evaluation,and impact factor of DGT,which could provide an alternative working strategy in endodontic treatment. | Xi Wei Yu Du Xuedong Zhou Lin Yue Qing Yu Benxiang Hou Zhi Chen Jingping Liang Wenxia Chen Lihong Qiu Xiangya Huang Liuyan Meng Dingming Huang Xiaoyan Wang Yu Tian Zisheng Tang Qi Zhang Leiying Miao Jin Zhao Deqin Yang Jian Yang Junqi Ling | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 19 | Present Situation of Enhanced Recovery after Surgery in Shiyan Taihe Hospital and Plan of Establishing Strategic Alliance with General Surgery Department显示文摘The accelerated rehabilitation specialist surgery and general established strategic alliance plan of Taihe hospital is introduced in the paper.The background of strategic alliances established,and the political,environmental and technological factors are introduced,and stakeholder analysis and management plan,risk analysis and management plan are made.Furthermore,a junior coalition problem that may occur in the process and the resulting deep thinking is analyzed,to provide the reference and enlightenment for the management of hospital and establishment of strategic alliance. | Yang YAO Shuwen WANG Chunming MA Chao YU Pengtao ZHOU Qing ZHAO Shuhang ZHANG Jingping MU | 2021 | Medicinal Plant2021，12，6： | 0 |
| 20 | Expert consensus on difficulty assessment of endodontic therapy显示文摘Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics. | Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei Chen Jiyao Li Ling Ye Lei Cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou | 2024 | International Journal of Oral Science2024，16，1： | 0 |
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